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Entry version 125 (08 May 2019)
Sequence version 3 (01 Jul 2008)
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Protein

SMC5-SMC6 complex localization factor protein 1

Gene

Slf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SMC5-SMC6 complex localization factor protein 1Imported
Alternative name(s):
Ankyrin repeat domain-containing protein 32
BRCT domain-containing protein 1
Protein BRCTx1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slf1Imported
Synonyms:Ankrd32, Brctd1, Brctx1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2145448 Slf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice develop normally, display no pathological abnormalities and are fertile (PubMed:15632077).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002439071 – 1054SMC5-SMC6 complex localization factor protein 1Add BLAST1054

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8R3P9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R3P9

PRoteomics IDEntifications database

More...
PRIDEi
Q8R3P9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R3P9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R3P9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:15632077). Expressed in testis (PubMed:15632077). Expressed in spermatocytes (PubMed:15632077).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing embryo (PubMed:15632077).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021597 Expressed in 262 organ(s), highest expression level in cerebral cortex marginal layer

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R3P9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R3P9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via BRCT domains) with RAD18 (via C-terminus and phosphorylated form); this interaction is required for efficient repair of UV-induced DNA damage (PubMed:15632077, PubMed:22036607). Interacts (via N-terminus) with SLF2; this interaction links RAD18 to the SMC5-SMC6 complex. Interacts (via BRCT domains) with RAD18; this interaction occurs in a SLF2-independent manner. Interacts with SMC6.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
222830, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000118312

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 80BRCT 1Add BLAST79
Domaini121 – 199BRCT 2Add BLAST79
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati802 – 832ANK 1Add BLAST31
Repeati836 – 865ANK 2Add BLAST30
Repeati870 – 900ANK 3Add BLAST31

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

BRCT domains are necessary for its targeting to ionizing radiation-induced nuclear foci (PubMed:22036607).1 Publication

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG1929 Eukaryota
ENOG410XPFH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000200317

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R3P9

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSCLFNE

Database of Orthologous Groups

More...
OrthoDBi
1003628at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R3P9

TreeFam database of animal gene trees

More...
TreeFami
TF329705

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit
cd00027 BRCT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.40.50.10190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF16770 RTT107_BRCT_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM00292 BRCT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF52113 SSF52113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R3P9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDSATKHII QMTGFKMEEK EALVKLLLKL DCTFIKSEKY KNCTHLIAER
60 70 80 90 100
LCKSEKFLAA CAAGKWVLTK DYIIHSAKSG RWLDETTYEW GYKIEKDSHY
110 120 130 140 150
SPQMQSAPKR WREELKRTGA PGAFHRWKVV LLVRADKRSD SLVRVLEAGK
160 170 180 190 200
ANVILPKNSP SGITHVIASN ARISAEREQE NFKAPFYPIQ YLGDFLLEKE
210 220 230 240 250
IQNDEHSQIS PAWTKYNNQE KGNDVGFPEM KGAGENMYRT QNKMENHNKN
260 270 280 290 300
VSDRFVLSEH HKKKFKDFRK DIRSVKKRNT LRRHGLENQK ETKKKDKNIQ
310 320 330 340 350
RSYILRKKNK KEGYCKTDDA HDTIRSMLKK RGHYREQKEM KNPLLTDGTK
360 370 380 390 400
ESKTKDVKTN MNLIEIKNAL KKQIYKDIYR AQAVRYNCIR VDKQPVYNVE
410 420 430 440 450
VKNSEFPRGI LNLIENLIEG QFFKEAIEEL SSLQAHYIPP VCLLHAILEN
460 470 480 490 500
VLQDKIDTFS GRYFHILSAL LHLHPPWKSP AMLKYYLELF QCPTCMKGAW
510 520 530 540 550
DFTEVLIRSC LFNEDFCHQI SENISTKVVN LTLLKFFFNL LEGEVRHLSQ
560 570 580 590 600
KLCDWSDSQS LKVTEKAILH EIFWSGSETS GLLTKPVNML LEWTIYSHKE
610 620 630 640 650
KCKSNDVFKH ELSYLLTGIL GAAVDYWIFL GIQMGRNVIR HMSDDLGSYI
660 670 680 690 700
SLSCDDFSSK ELEIFICSFS SSWLQMFVAE AIFKKLCLQG PTSTCTEPLS
710 720 730 740 750
LQKIIDSYLP ILGKMDIHGA GKMQSPKKLC QRPCLESQRA LLMLNGAKRK
760 770 780 790 800
QAEGRPELLE LNRAKCSSSL KKLKKKSEEL SCSKENCPSL VTKMNFHKTN
810 820 830 840 850
LKGETALHRV CIKNQVEKLI ILLSLPGIDI NVKDNAGWTP LHEACNYGNT
860 870 880 890 900
ECVQEILQRC PEVDLLTQVD GVTPLHDALS NGHVEIGKLL LQRGGPELLQ
910 920 930 940 950
QRNSKGELPL DYVLSPKDKE ELFAITNIDD TVDNFHAKTQ KHFYHQQLEF
960 970 980 990 1000
GSFLLSRMLI NFCSIFDLSS EFILAFKGLG HLNELLMACN SDTEASNAHT
1010 1020 1030 1040 1050
DWLLDVYARN IKTLKKLPSV LKELPENLNV CPGVHTEALL VTLKMMCQSI

TELS
Length:1,054
Mass (Da):121,004
Last modified:July 1, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i248B6D44E221D6CF
GO
Isoform 2 (identifier: Q8R3P9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-250: NKMENHNKN → VKFCELEIL
     251-1054: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):28,777
Checksum:iEC437E521752D0D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CX75E0CX75_MOUSE
SMC5-SMC6 complex localization fact...
Slf1 Ankrd32
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8C211Q8C211_MOUSE
SMC5-SMC6 complex localization fact...
Slf1 Ankrd32, Brctd1
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0M3HEQ6A0A0M3HEQ6_MOUSE
SMC5-SMC6 complex localization fact...
Slf1
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH09101 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH24900 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH83095 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti711I → V in AAH09101 (PubMed:15489334).Curated1
Sequence conflicti711I → V in AAH24900 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034415242 – 250NKMENHNKN → VKFCELEIL in isoform 2. 1 Publication9
Alternative sequenceiVSP_034416251 – 1054Missing in isoform 2. 1 PublicationAdd BLAST804

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122418 Genomic DNA No translation available.
AC161266 Genomic DNA No translation available.
BC009101 mRNA Translation: AAH09101.1 Different initiation.
BC024900 mRNA Translation: AAH24900.1 Different initiation.
BC083095 mRNA Translation: AAH83095.1 Different initiation.
BC100362 mRNA Translation: AAI00363.1
AK047775 mRNA Translation: BAC33152.1
AK050168 mRNA Translation: BAC34106.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26657.2 [Q8R3P9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_598832.3, NM_134071.3 [Q8R3P9-1]
XP_017170840.1, XM_017315351.1 [Q8R3P9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000151524; ENSMUSP00000118312; ENSMUSG00000021597 [Q8R3P9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105377

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:105377

UCSC genome browser

More...
UCSCi
uc007rgs.2 mouse [Q8R3P9-1]
uc007rgv.2 mouse [Q8R3P9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122418 Genomic DNA No translation available.
AC161266 Genomic DNA No translation available.
BC009101 mRNA Translation: AAH09101.1 Different initiation.
BC024900 mRNA Translation: AAH24900.1 Different initiation.
BC083095 mRNA Translation: AAH83095.1 Different initiation.
BC100362 mRNA Translation: AAI00363.1
AK047775 mRNA Translation: BAC33152.1
AK050168 mRNA Translation: BAC34106.1
CCDSiCCDS26657.2 [Q8R3P9-1]
RefSeqiNP_598832.3, NM_134071.3 [Q8R3P9-1]
XP_017170840.1, XM_017315351.1 [Q8R3P9-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi222830, 4 interactors
STRINGi10090.ENSMUSP00000118312

PTM databases

iPTMnetiQ8R3P9
PhosphoSitePlusiQ8R3P9

Proteomic databases

EPDiQ8R3P9
PaxDbiQ8R3P9
PRIDEiQ8R3P9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000151524; ENSMUSP00000118312; ENSMUSG00000021597 [Q8R3P9-1]
GeneIDi105377
KEGGimmu:105377
UCSCiuc007rgs.2 mouse [Q8R3P9-1]
uc007rgv.2 mouse [Q8R3P9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84250
MGIiMGI:2145448 Slf1

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG1929 Eukaryota
ENOG410XPFH LUCA
GeneTreeiENSGT00940000158953
HOGENOMiHOG000200317
InParanoidiQ8R3P9
OMAiRSCLFNE
OrthoDBi1003628at2759
PhylomeDBiQ8R3P9
TreeFamiTF329705

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8R3P9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000021597 Expressed in 262 organ(s), highest expression level in cerebral cortex marginal layer
ExpressionAtlasiQ8R3P9 baseline and differential
GenevisibleiQ8R3P9 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
cd00027 BRCT, 1 hit
Gene3Di1.25.40.20, 1 hit
3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF16770 RTT107_BRCT_5, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00292 BRCT, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R3P9
Secondary accession number(s): Q497V2
, Q5XK30, Q8BHY5, Q8BQM6, Q921Y9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 1, 2008
Last modified: May 8, 2019
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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