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Entry version 117 (02 Dec 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Nucleolar protein 14

Gene

Nop14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 14
Alternative name(s):
Nucleolar complex protein 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nop14
Synonyms:Nol14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1922666, Nop14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001371561 – 860Nucleolar protein 14Add BLAST860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei96PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8R3N1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8R3N1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R3N1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R3N1

PeptideAtlas

More...
PeptideAtlasi
Q8R3N1

PRoteomics IDEntifications database

More...
PRIDEi
Q8R3N1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R3N1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R3N1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036693, Expressed in undifferentiated genital tubercle and 281 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R3N1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ribosomal small subunit (SSU) processome.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
217464, 50 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000038382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R3N1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R3N1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOP14 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2147, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008874_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R3N1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DKHYDPD

Database of Orthologous Groups

More...
OrthoDBi
950459at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105698

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007276, Nop14

The PANTHER Classification System

More...
PANTHERi
PTHR23183, PTHR23183, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04147, Nop14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R3N1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKAKRTGAR RQVHKAPAGA SGGPAKTNPN PFEVKVNRQK FQILGRKTRH
60 70 80 90 100
DVGLPGVSRA RAIRKRTQTL LKEYKERNKS NVFADKRFGE YNSNISPEEK
110 120 130 140 150
MMKRFALEQQ RYHEKKNIYN LNEDEELTHY GQSLADIEKH NDIVDSDSDT
160 170 180 190 200
EDRGALSAEL TASHFGGGVH KNSSQKEGED GDKPKTRKEL IEELIAKSKQ
210 220 230 240 250
EKRERQAQRE DALELTEKLD QDWKEIQILM SRKPKKSEDK EKKEKPQPDE
260 270 280 290 300
YDMMVRELGF EMKAQPSNRM KTEEELAKEE QERLKKLEAE RLRRMLGKDE
310 320 330 340 350
HENKKKPKHT SADDLNDGFI LDKDDRRLLS YKDGKMNIED VQEEQSKEAD
360 370 380 390 400
GQENDQKEGE DDSEEEDESH EDSEESEDPD SHSDLESNIE SEEENETPKK
410 420 430 440 450
EQRQTPGGKL PKDDQKAQKA VAAELPYVFA APESFEELKF LLSGRSMEEQ
460 470 480 490 500
LLVVERIQKC NHPSLAVGNK AKLEKLFGFL LQYIGDLATD STPDLKTIDK
510 520 530 540 550
LVVHLYSLCQ MFPESASDSI RFVLRDAMHE MEEMIETKGR AAFPGLDVLI
560 570 580 590 600
YLKITGLLFP TSDFWHPVVT PALLCMSQML TKCPVMSLQD VIKGLFVCCL
610 620 630 640 650
FLEYVSLSRR FIPELFNFLL GILYIATPNT KSQGSTLVHP FRALGKNSEL
660 670 680 690 700
LVVSDKADVT TWQRGSLPLH WANRLSTLTA TEANHTRLSC VASCLSLMKH
710 720 730 740 750
CVLMYQALPS FHAIFRPHQA LLSKHLADCS LPQELQELAQ SILSAMEGQK
760 770 780 790 800
QHCRPLVCEK SKPVPLKQFT PRLVKVLEFG RKQGSSKEEQ ERKRLIHKHK
810 820 830 840 850
REFKGAVREI RKDNQFLARM QLSEIMERDA ERKRKVKQLF NSLATQEGEW
860
KALKRKKFKK
Length:860
Mass (Da):98,769
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA30767F90C65F6AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YU38A0A0J9YU38_MOUSE
Nucleolar protein 14
Nop14
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18A → T in AAH24998 (Ref. 1) Curated1
Sequence conflicti239D → N in AAH24998 (Ref. 1) Curated1
Sequence conflicti362D → E in AAH24998 (Ref. 1) Curated1
Sequence conflicti489T → I in AAH24998 (Ref. 1) Curated1
Sequence conflicti503V → M in AAH24998 (Ref. 1) Curated1
Sequence conflicti520I → L in AAH24998 (Ref. 1) Curated1
Sequence conflicti660T → A in AAH24998 (Ref. 1) Curated1
Sequence conflicti693S → L in AAH24998 (Ref. 1) Curated1
Sequence conflicti715F → V in AAH24998 (Ref. 1) Curated1
Sequence conflicti723S → A in AAH24998 (Ref. 1) Curated1
Sequence conflicti736Q → K in AAH24998 (Ref. 1) Curated1
Sequence conflicti749Q → L in AAH24998 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH466524 Genomic DNA Translation: EDL37463.1
BC024998 mRNA Translation: AAH24998.1
BC043043 mRNA Translation: AAH43043.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19218.1

NCBI Reference Sequences

More...
RefSeqi
NP_083554.2, NM_029278.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000041364; ENSMUSP00000038382; ENSMUSG00000036693

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
75416

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:75416

UCSC genome browser

More...
UCSCi
uc008xcx.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466524 Genomic DNA Translation: EDL37463.1
BC024998 mRNA Translation: AAH24998.1
BC043043 mRNA Translation: AAH43043.1
CCDSiCCDS19218.1
RefSeqiNP_083554.2, NM_029278.2

3D structure databases

SMRiQ8R3N1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi217464, 50 interactors
STRINGi10090.ENSMUSP00000038382

PTM databases

iPTMnetiQ8R3N1
PhosphoSitePlusiQ8R3N1

Proteomic databases

EPDiQ8R3N1
jPOSTiQ8R3N1
MaxQBiQ8R3N1
PaxDbiQ8R3N1
PeptideAtlasiQ8R3N1
PRIDEiQ8R3N1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22420, 62 antibodies

Genome annotation databases

EnsembliENSMUST00000041364; ENSMUSP00000038382; ENSMUSG00000036693
GeneIDi75416
KEGGimmu:75416
UCSCiuc008xcx.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8602
MGIiMGI:1922666, Nop14

Phylogenomic databases

eggNOGiKOG2147, Eukaryota
GeneTreeiENSGT00390000017459
HOGENOMiCLU_008874_1_1_1
InParanoidiQ8R3N1
OMAiDKHYDPD
OrthoDBi950459at2759
TreeFamiTF105698

Enzyme and pathway databases

ReactomeiR-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
75416, 6 hits in 16 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nop14, mouse

Protein Ontology

More...
PROi
PR:Q8R3N1
RNActiQ8R3N1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036693, Expressed in undifferentiated genital tubercle and 281 other tissues
GenevisibleiQ8R3N1, MM

Family and domain databases

InterProiView protein in InterPro
IPR007276, Nop14
PANTHERiPTHR23183, PTHR23183, 1 hit
PfamiView protein in Pfam
PF04147, Nop14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOP14_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R3N1
Secondary accession number(s): Q5RL78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 27, 2011
Last modified: December 2, 2020
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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