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Protein

Transcription factor 25

Gene

Tcf25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 25
Short name:
TCF-25
Alternative name(s):
Nuclear localized protein 1
Gene namesi
Name:Tcf25
Synonyms:D8Ertd325e, Nulp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914105 Tcf25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872661 – 676Transcription factor 25Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei602PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R3L2
PaxDbiQ8R3L2
PeptideAtlasiQ8R3L2
PRIDEiQ8R3L2

PTM databases

iPTMnetiQ8R3L2
PhosphoSitePlusiQ8R3L2

Expressioni

Tissue specificityi

Broadly expressed in the embryo during the early stages of organogenesis with highest levels in dorsal root ganglia and little or no expression in liver and skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000001472 Expressed in 305 organ(s), highest expression level in pontine nuclear group
CleanExiMM_TCF25
ExpressionAtlasiQ8R3L2 baseline and differential
GenevisibleiQ8R3L2 MM

Interactioni

Subunit structurei

Interacts with XIAP.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056485

Structurei

3D structure databases

ProteinModelPortaliQ8R3L2
SMRiQ8R3L2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C-terminal region mediates transcriptional repression.By similarity

Sequence similaritiesi

Belongs to the TCF25 family.Curated

Phylogenomic databases

eggNOGiKOG2422 Eukaryota
ENOG410XQ1Q LUCA
GeneTreeiENSGT00390000005563
HOVERGENiHBG070024
InParanoidiQ8R3L2
OMAiKGTYRTA
OrthoDBiEOG091G0HZK
PhylomeDBiQ8R3L2
TreeFamiTF106155

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006994 TCF25
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR22684 PTHR22684, 1 hit
PfamiView protein in Pfam
PF04910 Tcf25, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R3L2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRALRRLR GEQRGQEPLG PDALKFVLLD DDDAEEEGPK PGLGGRRPGG
60 70 80 90 100
AGKEGVRVNN RFELINTEDL EDDLVVNGER SDCTLPDSVS SGNKGRAKHG
110 120 130 140 150
NAETKQDGGA TKAGSSEQSN ASGKLRKKKK KQKNKKSCTG ESSENGLEDI
160 170 180 190 200
DRILERIEDS SGFSHPGPPP LSSRKHVLYV EHRHLNPDTE LKRYFGARAV
210 220 230 240 250
LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF
260 270 280 290 300
DHNEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE
310 320 330 340 350
DQEMARDLIE RALYSMECAF HPLFSLTSGT CRLDYRRPEN RSFYLTLYKQ
360 370 380 390 400
MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI
410 420 430 440 450
RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPEHEL SSARQQASLL
460 470 480 490 500
IQQALTMFPG VLMPLLEYCS VRPDATVSNH RFFGPDAEIS QPPALGQLVS
510 520 530 540 550
LYLGRSHFLW KEPAIMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR
560 570 580 590 600
APRNIHRHVI LSEIKEAVAA LPSDVTTQSV MGFDPLPPLD TIYSYVRPER
610 620 630 640 650
LSPVSHGNTI ALFFRSLLPN YTTEGERLEE GVAGGPNRNQ GLNRLMLAVR
660 670
DMMANFHFND LEVPREDNPE GEGDWD
Length:676
Mass (Da):76,685
Last modified:July 25, 2006 - v2
Checksum:i095539BBAA3E8535
GO
Isoform 2 (identifier: Q8R3L2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-625: G → L
     626-676: Missing.

Show »
Length:625
Mass (Da):70,947
Checksum:iA1D9660C0CC03B8D
GO
Isoform 3 (identifier: Q8R3L2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-68: Missing.
     625-626: GE → QL
     627-676: Missing.

Note: No experimental confirmation available.
Show »
Length:611
Mass (Da):69,303
Checksum:i6414B325F5E17E8E
GO
Isoform 4 (identifier: Q8R3L2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-143: Missing.
     625-625: G → L
     626-676: Missing.

Note: No experimental confirmation available.
Show »
Length:600
Mass (Da):68,213
Checksum:i37E46BB654EC8347
GO
Isoform 5 (identifier: Q8R3L2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-626: GE → QL
     627-676: Missing.

Note: No experimental confirmation available.
Show »
Length:626
Mass (Da):71,075
Checksum:iB50029660C0CC03B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2ZAC8B2ZAC8_MOUSE
Nuclear localized protein-1 isoform...
Tcf25
651Annotation score:
A0A1D5RM90A0A1D5RM90_MOUSE
Transcription factor 25
Tcf25
626Annotation score:
A0A1D5RLU0A0A1D5RLU0_MOUSE
Transcription factor 25
Tcf25
110Annotation score:

Sequence cautioni

The sequence BAB28983 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC32344 differs from that shown. Reason: Frameshift at position 598.Curated
The sequence BAC36220 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129K → E in BAE29956 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE29977 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE30150 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE31009 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE31265 (PubMed:16141072).Curated1
Sequence conflicti176H → L in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti204Q → E in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti219L → R in BAE39858 (PubMed:16141072).Curated1
Sequence conflicti219L → R in BAE40128 (PubMed:16141072).Curated1
Sequence conflicti243K → E in BAE28334 (PubMed:16141072).Curated1
Sequence conflicti370I → T in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti407E → V in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti454A → T in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti539A → V in BAE28334 (PubMed:16141072).Curated1
Sequence conflicti539A → V in AAH25071 (PubMed:15489334).Curated1
Sequence conflicti560I → M in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti597R → G in BAE39858 (PubMed:16141072).Curated1
Sequence conflicti597R → G in BAE40128 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02002354 – 68Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_020024119 – 143Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_020025625 – 626GE → QL in isoform 3 and isoform 5. 1 Publication2
Alternative sequenceiVSP_020026625G → L in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_020027626 – 676Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST51
Alternative sequenceiVSP_020028627 – 676Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94988 mRNA Translation: AAG27133.1
AK013754 mRNA Translation: BAB28983.2 Different initiation.
AK045397 mRNA Translation: BAC32344.1 Frameshift.
AK076151 mRNA Translation: BAC36220.1 Different initiation.
AK088360 mRNA Translation: BAC40301.1
AK089964 mRNA Translation: BAC41018.1
AK148082 mRNA Translation: BAE28334.1
AK150232 mRNA Translation: BAE29397.1
AK150918 mRNA Translation: BAE29956.1
AK150942 mRNA Translation: BAE29977.1
AK151143 mRNA Translation: BAE30150.1
AK152178 mRNA Translation: BAE31009.1
AK152494 mRNA Translation: BAE31265.1
AK161627 mRNA Translation: BAE36500.1
AK167837 mRNA Translation: BAE39858.1
AK168167 mRNA Translation: BAE40128.1
BC025071 mRNA Translation: AAH25071.1
BC046768 mRNA Translation: AAH46768.2
CCDSiCCDS22755.1 [Q8R3L2-1]
CCDS52700.1 [Q8R3L2-5]
CCDS85630.1 [Q8R3L2-2]
CCDS85631.1 [Q8R3L2-4]
RefSeqiNP_001032966.1, NM_001037877.3 [Q8R3L2-5]
NP_001032967.1, NM_001037878.3 [Q8R3L2-1]
NP_001273291.1, NM_001286362.1 [Q8R3L2-4]
NP_080080.2, NM_025804.3 [Q8R3L2-2]
UniGeneiMm.178818
Mm.295438

Genome annotation databases

EnsembliENSMUST00000057934; ENSMUSP00000056485; ENSMUSG00000001472 [Q8R3L2-1]
ENSMUST00000108840; ENSMUSP00000104468; ENSMUSG00000001472 [Q8R3L2-5]
ENSMUST00000212470; ENSMUSP00000148344; ENSMUSG00000001472 [Q8R3L2-4]
ENSMUST00000212571; ENSMUSP00000148531; ENSMUSG00000001472 [Q8R3L2-2]
GeneIDi66855
KEGGimmu:66855
UCSCiuc009nvl.2 mouse [Q8R3L2-1]
uc009nvn.2 mouse [Q8R3L2-2]
uc009nvo.2 mouse [Q8R3L2-4]
uc009nvp.2 mouse [Q8R3L2-5]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94988 mRNA Translation: AAG27133.1
AK013754 mRNA Translation: BAB28983.2 Different initiation.
AK045397 mRNA Translation: BAC32344.1 Frameshift.
AK076151 mRNA Translation: BAC36220.1 Different initiation.
AK088360 mRNA Translation: BAC40301.1
AK089964 mRNA Translation: BAC41018.1
AK148082 mRNA Translation: BAE28334.1
AK150232 mRNA Translation: BAE29397.1
AK150918 mRNA Translation: BAE29956.1
AK150942 mRNA Translation: BAE29977.1
AK151143 mRNA Translation: BAE30150.1
AK152178 mRNA Translation: BAE31009.1
AK152494 mRNA Translation: BAE31265.1
AK161627 mRNA Translation: BAE36500.1
AK167837 mRNA Translation: BAE39858.1
AK168167 mRNA Translation: BAE40128.1
BC025071 mRNA Translation: AAH25071.1
BC046768 mRNA Translation: AAH46768.2
CCDSiCCDS22755.1 [Q8R3L2-1]
CCDS52700.1 [Q8R3L2-5]
CCDS85630.1 [Q8R3L2-2]
CCDS85631.1 [Q8R3L2-4]
RefSeqiNP_001032966.1, NM_001037877.3 [Q8R3L2-5]
NP_001032967.1, NM_001037878.3 [Q8R3L2-1]
NP_001273291.1, NM_001286362.1 [Q8R3L2-4]
NP_080080.2, NM_025804.3 [Q8R3L2-2]
UniGeneiMm.178818
Mm.295438

3D structure databases

ProteinModelPortaliQ8R3L2
SMRiQ8R3L2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056485

PTM databases

iPTMnetiQ8R3L2
PhosphoSitePlusiQ8R3L2

Proteomic databases

EPDiQ8R3L2
PaxDbiQ8R3L2
PeptideAtlasiQ8R3L2
PRIDEiQ8R3L2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057934; ENSMUSP00000056485; ENSMUSG00000001472 [Q8R3L2-1]
ENSMUST00000108840; ENSMUSP00000104468; ENSMUSG00000001472 [Q8R3L2-5]
ENSMUST00000212470; ENSMUSP00000148344; ENSMUSG00000001472 [Q8R3L2-4]
ENSMUST00000212571; ENSMUSP00000148531; ENSMUSG00000001472 [Q8R3L2-2]
GeneIDi66855
KEGGimmu:66855
UCSCiuc009nvl.2 mouse [Q8R3L2-1]
uc009nvn.2 mouse [Q8R3L2-2]
uc009nvo.2 mouse [Q8R3L2-4]
uc009nvp.2 mouse [Q8R3L2-5]

Organism-specific databases

CTDi22980
MGIiMGI:1914105 Tcf25

Phylogenomic databases

eggNOGiKOG2422 Eukaryota
ENOG410XQ1Q LUCA
GeneTreeiENSGT00390000005563
HOVERGENiHBG070024
InParanoidiQ8R3L2
OMAiKGTYRTA
OrthoDBiEOG091G0HZK
PhylomeDBiQ8R3L2
TreeFamiTF106155

Miscellaneous databases

ChiTaRSiTcf25 mouse
PROiPR:Q8R3L2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001472 Expressed in 305 organ(s), highest expression level in pontine nuclear group
CleanExiMM_TCF25
ExpressionAtlasiQ8R3L2 baseline and differential
GenevisibleiQ8R3L2 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006994 TCF25
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR22684 PTHR22684, 1 hit
PfamiView protein in Pfam
PF04910 Tcf25, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCF25_MOUSE
AccessioniPrimary (citable) accession number: Q8R3L2
Secondary accession number(s): Q3THR8
, Q3UBI7, Q3UD64, Q3UG75, Q80ZX3, Q8BR80, Q8C200, Q8C2M3, Q8C6B4, Q9CUW0, Q9ER19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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