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Entry version 136 (12 Aug 2020)
Sequence version 2 (25 Jul 2006)
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Protein

Transcription factor 25

Gene

Tcf25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor 25
Short name:
TCF-25
Alternative name(s):
Nuclear localized protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tcf25
Synonyms:D8Ertd325e, Nulp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914105, Tcf25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000872661 – 676Transcription factor 25Add BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei602PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8R3L2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R3L2

PeptideAtlas

More...
PeptideAtlasi
Q8R3L2

PRoteomics IDEntifications database

More...
PRIDEi
Q8R3L2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R3L2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R3L2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed in the embryo during the early stages of organogenesis with highest levels in dorsal root ganglia and little or no expression in liver and skin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001472, Expressed in pontine nuclear group and 320 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R3L2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R3L2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with XIAP.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
211765, 7 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000056485

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R3L2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R3L2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region mediates transcriptional repression.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCF25 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2422, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005563

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008321_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R3L2

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRIQEDQ

Database of Orthologous Groups

More...
OrthoDBi
1428505at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R3L2

TreeFam database of animal gene trees

More...
TreeFami
TF106155

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006994, TCF25/Rqc1
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22684, PTHR22684, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04910, Tcf25, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R3L2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRALRRLR GEQRGQEPLG PDALKFVLLD DDDAEEEGPK PGLGGRRPGG
60 70 80 90 100
AGKEGVRVNN RFELINTEDL EDDLVVNGER SDCTLPDSVS SGNKGRAKHG
110 120 130 140 150
NAETKQDGGA TKAGSSEQSN ASGKLRKKKK KQKNKKSCTG ESSENGLEDI
160 170 180 190 200
DRILERIEDS SGFSHPGPPP LSSRKHVLYV EHRHLNPDTE LKRYFGARAV
210 220 230 240 250
LGEQRPRQRQ RVYPKCTWLT TPKSTWPRYS KPGLSMRLLE SKKGLSFFAF
260 270 280 290 300
DHNEEYQQAQ HKFLVAVESM EPNNIVVLLQ TSPYHVDSLL QLSDACRFQE
310 320 330 340 350
DQEMARDLIE RALYSMECAF HPLFSLTSGT CRLDYRRPEN RSFYLTLYKQ
360 370 380 390 400
MSFLEKRGCP RTALEYCKLI LSLEPDEDPL CMLLLIDHLA LRARNYEYLI
410 420 430 440 450
RLFQEWEAHR NLSQLPNFAF SVPLAYFLLS QQTDLPEHEL SSARQQASLL
460 470 480 490 500
IQQALTMFPG VLMPLLEYCS VRPDATVSNH RFFGPDAEIS QPPALGQLVS
510 520 530 540 550
LYLGRSHFLW KEPAIMSWLE ENVHEVLQAV DAGDPAVEAC ENRRKVLYQR
560 570 580 590 600
APRNIHRHVI LSEIKEAVAA LPSDVTTQSV MGFDPLPPLD TIYSYVRPER
610 620 630 640 650
LSPVSHGNTI ALFFRSLLPN YTTEGERLEE GVAGGPNRNQ GLNRLMLAVR
660 670
DMMANFHFND LEVPREDNPE GEGDWD
Length:676
Mass (Da):76,685
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i095539BBAA3E8535
GO
Isoform 2 (identifier: Q8R3L2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-625: G → L
     626-676: Missing.

Show »
Length:625
Mass (Da):70,947
Checksum:iA1D9660C0CC03B8D
GO
Isoform 3 (identifier: Q8R3L2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-68: Missing.
     625-626: GE → QL
     627-676: Missing.

Show »
Length:611
Mass (Da):69,303
Checksum:i6414B325F5E17E8E
GO
Isoform 4 (identifier: Q8R3L2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-143: Missing.
     625-625: G → L
     626-676: Missing.

Show »
Length:600
Mass (Da):68,213
Checksum:i37E46BB654EC8347
GO
Isoform 5 (identifier: Q8R3L2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-626: GE → QL
     627-676: Missing.

Show »
Length:626
Mass (Da):71,075
Checksum:iB50029660C0CC03B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2ZAC8B2ZAC8_MOUSE
Nuclear localized protein-1 isoform...
Tcf25
651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RM90A0A1D5RM90_MOUSE
Transcription factor 25
Tcf25
626Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLU0A0A1D5RLU0_MOUSE
Transcription factor 25
Tcf25
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB28983 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC32344 differs from that shown. Reason: Frameshift.Curated
The sequence BAC36220 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti129K → E in BAE29956 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE29977 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE30150 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE31009 (PubMed:16141072).Curated1
Sequence conflicti129K → E in BAE31265 (PubMed:16141072).Curated1
Sequence conflicti176H → L in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti204Q → E in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti219L → R in BAE39858 (PubMed:16141072).Curated1
Sequence conflicti219L → R in BAE40128 (PubMed:16141072).Curated1
Sequence conflicti243K → E in BAE28334 (PubMed:16141072).Curated1
Sequence conflicti370I → T in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti407E → V in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti454A → T in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti539A → V in BAE28334 (PubMed:16141072).Curated1
Sequence conflicti539A → V in AAH25071 (PubMed:15489334).Curated1
Sequence conflicti560I → M in AAG27133 (PubMed:12107429).Curated1
Sequence conflicti597R → G in BAE39858 (PubMed:16141072).Curated1
Sequence conflicti597R → G in BAE40128 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02002354 – 68Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_020024119 – 143Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_020025625 – 626GE → QL in isoform 3 and isoform 5. 1 Publication2
Alternative sequenceiVSP_020026625G → L in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_020027626 – 676Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST51
Alternative sequenceiVSP_020028627 – 676Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U94988 mRNA Translation: AAG27133.1
AK013754 mRNA Translation: BAB28983.2 Different initiation.
AK045397 mRNA Translation: BAC32344.1 Frameshift.
AK076151 mRNA Translation: BAC36220.1 Different initiation.
AK088360 mRNA Translation: BAC40301.1
AK089964 mRNA Translation: BAC41018.1
AK148082 mRNA Translation: BAE28334.1
AK150232 mRNA Translation: BAE29397.1
AK150918 mRNA Translation: BAE29956.1
AK150942 mRNA Translation: BAE29977.1
AK151143 mRNA Translation: BAE30150.1
AK152178 mRNA Translation: BAE31009.1
AK152494 mRNA Translation: BAE31265.1
AK161627 mRNA Translation: BAE36500.1
AK167837 mRNA Translation: BAE39858.1
AK168167 mRNA Translation: BAE40128.1
BC025071 mRNA Translation: AAH25071.1
BC046768 mRNA Translation: AAH46768.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22755.1 [Q8R3L2-1]
CCDS52700.1 [Q8R3L2-5]
CCDS85630.1 [Q8R3L2-2]
CCDS85631.1 [Q8R3L2-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001032966.1, NM_001037877.3 [Q8R3L2-5]
NP_001032967.1, NM_001037878.3 [Q8R3L2-1]
NP_001273291.1, NM_001286362.1 [Q8R3L2-4]
NP_080080.2, NM_025804.3 [Q8R3L2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000057934; ENSMUSP00000056485; ENSMUSG00000001472 [Q8R3L2-1]
ENSMUST00000108840; ENSMUSP00000104468; ENSMUSG00000001472 [Q8R3L2-5]
ENSMUST00000212470; ENSMUSP00000148344; ENSMUSG00000001472 [Q8R3L2-4]
ENSMUST00000212571; ENSMUSP00000148531; ENSMUSG00000001472 [Q8R3L2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66855

UCSC genome browser

More...
UCSCi
uc009nvl.2, mouse [Q8R3L2-1]
uc009nvn.2, mouse [Q8R3L2-2]
uc009nvo.2, mouse [Q8R3L2-4]
uc009nvp.2, mouse [Q8R3L2-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94988 mRNA Translation: AAG27133.1
AK013754 mRNA Translation: BAB28983.2 Different initiation.
AK045397 mRNA Translation: BAC32344.1 Frameshift.
AK076151 mRNA Translation: BAC36220.1 Different initiation.
AK088360 mRNA Translation: BAC40301.1
AK089964 mRNA Translation: BAC41018.1
AK148082 mRNA Translation: BAE28334.1
AK150232 mRNA Translation: BAE29397.1
AK150918 mRNA Translation: BAE29956.1
AK150942 mRNA Translation: BAE29977.1
AK151143 mRNA Translation: BAE30150.1
AK152178 mRNA Translation: BAE31009.1
AK152494 mRNA Translation: BAE31265.1
AK161627 mRNA Translation: BAE36500.1
AK167837 mRNA Translation: BAE39858.1
AK168167 mRNA Translation: BAE40128.1
BC025071 mRNA Translation: AAH25071.1
BC046768 mRNA Translation: AAH46768.2
CCDSiCCDS22755.1 [Q8R3L2-1]
CCDS52700.1 [Q8R3L2-5]
CCDS85630.1 [Q8R3L2-2]
CCDS85631.1 [Q8R3L2-4]
RefSeqiNP_001032966.1, NM_001037877.3 [Q8R3L2-5]
NP_001032967.1, NM_001037878.3 [Q8R3L2-1]
NP_001273291.1, NM_001286362.1 [Q8R3L2-4]
NP_080080.2, NM_025804.3 [Q8R3L2-2]

3D structure databases

SMRiQ8R3L2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211765, 7 interactors
STRINGi10090.ENSMUSP00000056485

PTM databases

iPTMnetiQ8R3L2
PhosphoSitePlusiQ8R3L2

Proteomic databases

EPDiQ8R3L2
PaxDbiQ8R3L2
PeptideAtlasiQ8R3L2
PRIDEiQ8R3L2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30955, 187 antibodies

Genome annotation databases

EnsembliENSMUST00000057934; ENSMUSP00000056485; ENSMUSG00000001472 [Q8R3L2-1]
ENSMUST00000108840; ENSMUSP00000104468; ENSMUSG00000001472 [Q8R3L2-5]
ENSMUST00000212470; ENSMUSP00000148344; ENSMUSG00000001472 [Q8R3L2-4]
ENSMUST00000212571; ENSMUSP00000148531; ENSMUSG00000001472 [Q8R3L2-2]
GeneIDi66855
KEGGimmu:66855
UCSCiuc009nvl.2, mouse [Q8R3L2-1]
uc009nvn.2, mouse [Q8R3L2-2]
uc009nvo.2, mouse [Q8R3L2-4]
uc009nvp.2, mouse [Q8R3L2-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22980
MGIiMGI:1914105, Tcf25

Phylogenomic databases

eggNOGiKOG2422, Eukaryota
GeneTreeiENSGT00390000005563
HOGENOMiCLU_008321_3_2_1
InParanoidiQ8R3L2
OMAiCRIQEDQ
OrthoDBi1428505at2759
PhylomeDBiQ8R3L2
TreeFamiTF106155

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
66855, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tcf25, mouse

Protein Ontology

More...
PROi
PR:Q8R3L2
RNActiQ8R3L2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000001472, Expressed in pontine nuclear group and 320 other tissues
ExpressionAtlasiQ8R3L2, baseline and differential
GenevisibleiQ8R3L2, MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006994, TCF25/Rqc1
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR22684, PTHR22684, 1 hit
PfamiView protein in Pfam
PF04910, Tcf25, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCF25_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R3L2
Secondary accession number(s): Q3THR8
, Q3UBI7, Q3UD64, Q3UG75, Q80ZX3, Q8BR80, Q8C200, Q8C2M3, Q8C6B4, Q9CUW0, Q9ER19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 25, 2006
Last modified: August 12, 2020
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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