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Protein

Tetratricopeptide repeat protein 4

Gene

Ttc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 4
Short name:
TPR repeat protein 4
Gene namesi
Name:Ttc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919604 Ttc4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063801 – 386Tetratricopeptide repeat protein 4Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8R3H9
MaxQBiQ8R3H9
PaxDbiQ8R3H9
PeptideAtlasiQ8R3H9
PRIDEiQ8R3H9

PTM databases

iPTMnetiQ8R3H9
PhosphoSitePlusiQ8R3H9

Expressioni

Gene expression databases

BgeeiENSMUSG00000025413 Expressed in 265 organ(s), highest expression level in brain
CleanExiMM_TTC4
ExpressionAtlasiQ8R3H9 baseline and differential
GenevisibleiQ8R3H9 MM

Interactioni

Protein-protein interaction databases

BioGridi215330, 2 interactors
STRINGi10090.ENSMUSP00000026480

Structurei

3D structure databases

ProteinModelPortaliQ8R3H9
SMRiQ8R3H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati79 – 112TPR 1Add BLAST34
Repeati117 – 150TPR 2Add BLAST34
Repeati151 – 184TPR 3Add BLAST34

Sequence similaritiesi

Belongs to the TTC4 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0551 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00510000049371
HOGENOMiHOG000230541
HOVERGENiHBG030742
InParanoidiQ8R3H9
OMAiDRWQEEM
OrthoDBiEOG091G0B2R
PhylomeDBiQ8R3H9
TreeFamiTF314657

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8R3H9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESSEPEPTE DASMDAFLEK FQSQPYRGGF REDQWEEEFD KIPLFMKKAP
60 70 80 90 100
SEIDPEEFPD LACLQSMIFD DDRYPEEQAK TYKDEGNDYF KEKDYKKAVL
110 120 130 140 150
SYSEGLKKKC ADPDLNAVLY TNRAAAQYYL GNVRSSLNDV LAAKKLKPGH
160 170 180 190 200
LKAIIRGALC HLELKHFAEA VNWCDEGLQI DAKEKKLLEI RAKADKLKRM
210 220 230 240 250
EERDLRKAKL KEKKEQHQNE ALLQAIKARN IRLVSESAGE DEDSASNGPA
260 270 280 290 300
EILLDGLSSE NPYGARLSID DQGRLSWPVL FLYPEYAQSD FISAFHEDTR
310 320 330 340 350
FIDHLMAMFS EAPSWDSEHK YHPENLEVYF EDEDRAELYQ VSPDSTLLQV
360 370 380
LQHPRCCVKA LTPAFLVCVG SSPFCRNYLQ GKKVHR
Length:386
Mass (Da):44,339
Last modified:June 1, 2002 - v1
Checksum:i8343EDDBAB57E710
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AVQ9A2AVQ9_MOUSE
Tetratricopeptide repeat protein 4
Ttc4
286Annotation score:
A2AVR1A2AVR1_MOUSE
Tetratricopeptide repeat protein 4
Ttc4
241Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025435 mRNA Translation: AAH25435.1
CCDSiCCDS18424.1
RefSeqiNP_082485.1, NM_028209.2
UniGeneiMm.25806

Genome annotation databases

EnsembliENSMUST00000026480; ENSMUSP00000026480; ENSMUSG00000025413
GeneIDi72354
KEGGimmu:72354
UCSCiuc008tyr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025435 mRNA Translation: AAH25435.1
CCDSiCCDS18424.1
RefSeqiNP_082485.1, NM_028209.2
UniGeneiMm.25806

3D structure databases

ProteinModelPortaliQ8R3H9
SMRiQ8R3H9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215330, 2 interactors
STRINGi10090.ENSMUSP00000026480

PTM databases

iPTMnetiQ8R3H9
PhosphoSitePlusiQ8R3H9

Proteomic databases

EPDiQ8R3H9
MaxQBiQ8R3H9
PaxDbiQ8R3H9
PeptideAtlasiQ8R3H9
PRIDEiQ8R3H9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026480; ENSMUSP00000026480; ENSMUSG00000025413
GeneIDi72354
KEGGimmu:72354
UCSCiuc008tyr.2 mouse

Organism-specific databases

CTDi7268
MGIiMGI:1919604 Ttc4

Phylogenomic databases

eggNOGiKOG0551 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00510000049371
HOGENOMiHOG000230541
HOVERGENiHBG030742
InParanoidiQ8R3H9
OMAiDRWQEEM
OrthoDBiEOG091G0B2R
PhylomeDBiQ8R3H9
TreeFamiTF314657

Miscellaneous databases

PROiPR:Q8R3H9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025413 Expressed in 265 organ(s), highest expression level in brain
CleanExiMM_TTC4
ExpressionAtlasiQ8R3H9 baseline and differential
GenevisibleiQ8R3H9 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTC4_MOUSE
AccessioniPrimary (citable) accession number: Q8R3H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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