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Protein

Tetraspanin-8

Gene

Tspan8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • negative regulation of blood coagulation Source: MGI
  • regulation of gene expression Source: MGI
  • spermatogenesis Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Gene namesi
Name:Tspan8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384918 Tspan8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 52ExtracellularSequence analysisAdd BLAST19
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 84CytoplasmicSequence analysisAdd BLAST11
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 203ExtracellularSequence analysisAdd BLAST98
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 235CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158111 – 235Tetraspanin-8Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8R3G9
PaxDbiQ8R3G9
PeptideAtlasiQ8R3G9
PRIDEiQ8R3G9

PTM databases

iPTMnetiQ8R3G9
PhosphoSitePlusiQ8R3G9

Expressioni

Gene expression databases

BgeeiENSMUSG00000034127 Expressed in 172 organ(s), highest expression level in ileum
ExpressionAtlasiQ8R3G9 baseline and differential
GenevisibleiQ8R3G9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R3G9, 1 interactor
STRINGi10090.ENSMUSP00000049243

Structurei

3D structure databases

ProteinModelPortaliQ8R3G9
SMRiQ8R3G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ8R3G9
KOiK17349
OMAiIWIRVSK
OrthoDBiEOG091G0K9H
PhylomeDBiQ8R3G9
TreeFamiTF352895

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R3G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGVSSCLKY SMFFFNFLFW VCGTLILGLA IWVRVSKDGK EIITSGDSST
60 70 80 90 100
NPFIAVNILI AVGSIIMVLG FLGCCGAVKE SRCMLLLFFI GLLLILILQV
110 120 130 140 150
AAGILGAAFK PEYNRILNET LYENAKLLSD NTDEAKDFQK AMIVFQSEFK
160 170 180 190 200
CCGLENGAAD WGNNFVEAKE SCQCTGTDCA TYQGSSVYPK TCLSLIKDLF
210 220 230
EKNIIIVIGI AFGLAVIEIL GLVFSMVLYC QIGSK
Length:235
Mass (Da):25,582
Last modified:June 1, 2002 - v1
Checksum:i1660D73299D7B2EB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P749A0A1W2P749_MOUSE
Tetraspanin-8
Tspan8
83Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126270 Genomic DNA No translation available.
AC153364 Genomic DNA No translation available.
CH466539 Genomic DNA Translation: EDL21777.1
CH466539 Genomic DNA Translation: EDL21778.1
CH466539 Genomic DNA Translation: EDL21779.1
CH466539 Genomic DNA Translation: EDL21780.1
BC025461 mRNA Translation: AAH25461.1
BC027777 mRNA Translation: AAH27777.1
BC029068 mRNA Translation: AAH29068.1
BC029808 mRNA Translation: AAH29808.1
BC034198 mRNA Translation: AAH34198.1
CCDSiCCDS24181.1
RefSeqiNP_001162150.1, NM_001168679.1
NP_001162151.1, NM_001168680.1
NP_666122.1, NM_146010.2
XP_006513605.1, XM_006513542.2
UniGeneiMm.22270

Genome annotation databases

EnsembliENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127
ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127
ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127
GeneIDi216350
KEGGimmu:216350
UCSCiuc007hbm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126270 Genomic DNA No translation available.
AC153364 Genomic DNA No translation available.
CH466539 Genomic DNA Translation: EDL21777.1
CH466539 Genomic DNA Translation: EDL21778.1
CH466539 Genomic DNA Translation: EDL21779.1
CH466539 Genomic DNA Translation: EDL21780.1
BC025461 mRNA Translation: AAH25461.1
BC027777 mRNA Translation: AAH27777.1
BC029068 mRNA Translation: AAH29068.1
BC029808 mRNA Translation: AAH29808.1
BC034198 mRNA Translation: AAH34198.1
CCDSiCCDS24181.1
RefSeqiNP_001162150.1, NM_001168679.1
NP_001162151.1, NM_001168680.1
NP_666122.1, NM_146010.2
XP_006513605.1, XM_006513542.2
UniGeneiMm.22270

3D structure databases

ProteinModelPortaliQ8R3G9
SMRiQ8R3G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R3G9, 1 interactor
STRINGi10090.ENSMUSP00000049243

PTM databases

iPTMnetiQ8R3G9
PhosphoSitePlusiQ8R3G9

Proteomic databases

MaxQBiQ8R3G9
PaxDbiQ8R3G9
PeptideAtlasiQ8R3G9
PRIDEiQ8R3G9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035563; ENSMUSP00000049243; ENSMUSG00000034127
ENSMUST00000080630; ENSMUSP00000079463; ENSMUSG00000034127
ENSMUST00000179196; ENSMUSP00000136645; ENSMUSG00000034127
GeneIDi216350
KEGGimmu:216350
UCSCiuc007hbm.2 mouse

Organism-specific databases

CTDi7103
MGIiMGI:2384918 Tspan8

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ8R3G9
KOiK17349
OMAiIWIRVSK
OrthoDBiEOG091G0K9H
PhylomeDBiQ8R3G9
TreeFamiTF352895

Miscellaneous databases

PROiPR:Q8R3G9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034127 Expressed in 172 organ(s), highest expression level in ileum
ExpressionAtlasiQ8R3G9 baseline and differential
GenevisibleiQ8R3G9 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN8_MOUSE
AccessioniPrimary (citable) accession number: Q8R3G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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