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Protein

CXADR-like membrane protein

Gene

Clmp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity).By similarity2 Publications

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CXADR-like membrane protein
Alternative name(s):
Adipocyte adhesion molecule
Adipocyte-specific protein 5
Coxsackie- and adenovirus receptor-like membrane protein
Short name:
CAR-like membrane protein
Gene namesi
Name:Clmp
Synonyms:Acam, Asam, Asp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1918816 Clmp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 234ExtracellularSequence analysisAdd BLAST217
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 373CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000029302718 – 373CXADR-like membrane proteinAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 110PROSITE-ProRule annotation
Glycosylationi72N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi73N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi152 ↔ 207PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8R373
PaxDbiQ8R373
PRIDEiQ8R373

PTM databases

iPTMnetiQ8R373
PhosphoSitePlusiQ8R373

Expressioni

Tissue specificityi

Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in the heart and brain, at intermediate levels in the lung, skeletal muscle, kidney and testis and at low levels in the liver and spleen.2 Publications

Inductioni

Up-regulated in mature adipocytes and adipocyte tissue of obese animals.1 Publication

Gene expression databases

BgeeiENSMUSG00000032024
CleanExiMM_9030425E11RIK
GenevisibleiQ8R373 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034522

Structurei

3D structure databases

ProteinModelPortaliQ8R373
SMRiQ8R373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 126Ig-like C2-type 1Add BLAST109
Domaini134 – 223Ig-like C2-type 2Add BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi287 – 319Ser-richAdd BLAST33

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC5 Eukaryota
ENOG4111I1J LUCA
GeneTreeiENSGT00760000119145
HOVERGENiHBG060225
InParanoidiQ8R373
KOiK06789
OMAiMVPAQTK
OrthoDBiEOG091G05PI
PhylomeDBiQ8R373
TreeFamiTF330875

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFFLWLVS YYVGTLGTHT EIKRVAEEKV TLPCHHQLGL PEKDTLDIEW
60 70 80 90 100
LLTDNEGNQK VVITYSSRHV YNNLTEEQKG RVAFASNFLA GDASLQIEPL
110 120 130 140 150
KPSDEGRYTC KVKNSGRYVW SHVILKVLVR PSKPKCELEG EPTEGSDLTL
160 170 180 190 200
QCESASGTKP IVYYWQRIRE KEGEDEHLPP KSRIDYNNPG RVLLQNLTMA
210 220 230 240 250
SSGLYQCTAG NEAGKESCVV RVTVQYVQSI GMVAGAVTGI VAGALLIFLL
260 270 280 290 300
IWLLIRRKSK DRYEEEDRPN EIREDAEAPR ARLVKPSSSS SGSRSSRSGS
310 320 330 340 350
SSTRSTGNSA SRSQRTLSSE AAPQQPGLAP QAYSLIGPEV RGSEPKKVHH
360 370
TTLTKAETTL STTPSQSKAF QTV
Length:373
Mass (Da):41,215
Last modified:June 1, 2002 - v1
Checksum:i9C6288484AF95512
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127V → A in BAB68503 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY259213 mRNA Translation: AAP15240.1
AY326421 mRNA Translation: AAP88385.1
AB040490 mRNA Translation: BAB68503.1
AK033723 mRNA Translation: BAC28446.1
BC026447 mRNA Translation: AAH26447.1
CCDSiCCDS23082.1
RefSeqiNP_598494.2, NM_133733.4
UniGeneiMm.280560

Genome annotation databases

EnsembliENSMUST00000034522; ENSMUSP00000034522; ENSMUSG00000032024
GeneIDi71566
KEGGimmu:71566
UCSCiuc009ozt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCLMP_MOUSE
AccessioniPrimary (citable) accession number: Q8R373
Secondary accession number(s): Q920S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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