Clmp

Functionⁱ

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity).By similarity2 Publications

GO - Biological processⁱ

digestive tract development Source: MGI

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CXADR-like membrane protein Alternative name(s): Adipocyte adhesion molecule Adipocyte-specific protein 5 Coxsackie- and adenovirus receptor-like membrane protein Short name: CAR-like membrane protein
Gene namesⁱ	Name:Clmp Synonyms:Acam, Asam, Asp5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1918816 Clmp

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 234	ExtracellularSequence analysisAdd BLAST	217
Transmembraneⁱ	235 – 255	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	256 – 373	CytoplasmicSequence analysisAdd BLAST	118

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000293027	18 – 373	CXADR-like membrane proteinAdd BLAST		356

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	34 ↔ 110	PROSITE-ProRule annotation
Glycosylationⁱ	72	N-linked (GlcNAc...) asparagine; atypical1 Publication	1
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	152 ↔ 207	PROSITE-ProRule annotation
Glycosylationⁱ	196	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R373
PaxDbⁱ	Q8R373
PRIDEⁱ	Q8R373

PTM databases

iPTMnetⁱ	Q8R373
PhosphoSitePlusⁱ	Q8R373

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in the heart and brain, at intermediate levels in the lung, skeletal muscle, kidney and testis and at low levels in the liver and spleen.2 Publications

Inductionⁱ

Up-regulated in mature adipocytes and adipocyte tissue of obese animals.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000032024
CleanExⁱ	MM_9030425E11RIK
Genevisibleⁱ	Q8R373 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000034522

STRINGⁱ

10090.ENSMUSP00000034522

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R373
SMRⁱ	Q8R373
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 126	Ig-like C2-type 1Add BLAST		109
Domainⁱ	134 – 223	Ig-like C2-type 2Add BLAST		90

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	287 – 319	Ser-richAdd BLAST		33

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEC5 Eukaryota ENOG4111I1J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119145
HOVERGENⁱ	HBG060225
InParanoidⁱ	Q8R373
KEGG Orthology (KO) More...KOⁱ	K06789
OMAⁱ	MVPAQTK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PI
PhylomeDBⁱ	Q8R373
TreeFamⁱ	TF330875

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8R373-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLFFLWLVS YYVGTLGTHT EIKRVAEEKV TLPCHHQLGL PEKDTLDIEW 
        60         70         80         90        100
LLTDNEGNQK VVITYSSRHV YNNLTEEQKG RVAFASNFLA GDASLQIEPL 
       110        120        130        140        150
KPSDEGRYTC KVKNSGRYVW SHVILKVLVR PSKPKCELEG EPTEGSDLTL 
       160        170        180        190        200
QCESASGTKP IVYYWQRIRE KEGEDEHLPP KSRIDYNNPG RVLLQNLTMA 
       210        220        230        240        250
SSGLYQCTAG NEAGKESCVV RVTVQYVQSI GMVAGAVTGI VAGALLIFLL 
       260        270        280        290        300
IWLLIRRKSK DRYEEEDRPN EIREDAEAPR ARLVKPSSSS SGSRSSRSGS 
       310        320        330        340        350
SSTRSTGNSA SRSQRTLSSE AAPQQPGLAP QAYSLIGPEV RGSEPKKVHH 
       360        370 
TTLTKAETTL STTPSQSKAF QTV

Length:373

Mass (Da):41,215

Last modified:June 1, 2002 - v1

Checksum:ⁱ9C6288484AF95512

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	127	V → A in BAB68503 (Ref. 3) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY259213 mRNA Translation: AAP15240.1 AY326421 mRNA Translation: AAP88385.1 AB040490 mRNA Translation: BAB68503.1 AK033723 mRNA Translation: BAC28446.1 BC026447 mRNA Translation: AAH26447.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23082.1
NCBI Reference Sequences More...RefSeqⁱ	NP_598494.2, NM_133733.4
UniGeneⁱ	Mm.280560

Genome annotation databases

Ensemblⁱ	ENSMUST00000034522; ENSMUSP00000034522; ENSMUSG00000032024
GeneIDⁱ	71566
KEGGⁱ	mmu:71566
UCSC genome browser More...UCSCⁱ	uc009ozt.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8R373	UPI000B4E94BF		MERUN		436
CXADR like membrane protein		AOTNA		373
UPI000A30FCF8		MUSPA		373
UPI0003D787A7		MOUSE		372
UPI0003F0FDE3		PTEAL		372
+15

Protein	Similar proteins		Species	Score	Length
Q8R373	UPI000B4E94BF		MERUN		436
UPI000A30FCF8		MUSPA		373
CXADR like membrane protein		AOTNA		373
UPI000819D9F7		NANGA		372
CXADR like membrane protein		RHIRO		372
+176

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY259213 mRNA Translation: AAP15240.1 AY326421 mRNA Translation: AAP88385.1 AB040490 mRNA Translation: BAB68503.1 AK033723 mRNA Translation: BAC28446.1 BC026447 mRNA Translation: AAH26447.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23082.1
NCBI Reference Sequences More...RefSeqⁱ	NP_598494.2, NM_133733.4
UniGeneⁱ	Mm.280560

3D structure databases

ProteinModelPortalⁱ	Q8R373
SMRⁱ	Q8R373
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000034522

STRINGⁱ

10090.ENSMUSP00000034522

PTM databases

iPTMnetⁱ	Q8R373
PhosphoSitePlusⁱ	Q8R373

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R373
PaxDbⁱ	Q8R373
PRIDEⁱ	Q8R373

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034522; ENSMUSP00000034522; ENSMUSG00000032024
GeneIDⁱ	71566
KEGGⁱ	mmu:71566
UCSC genome browser More...UCSCⁱ	uc009ozt.1 mouse

Organism-specific databases

CTDⁱ	79827
MGIⁱ	MGI:1918816 Clmp

Phylogenomic databases

eggNOGⁱ	ENOG410IEC5 Eukaryota ENOG4111I1J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119145
HOVERGENⁱ	HBG060225
InParanoidⁱ	Q8R373
KEGG Orthology (KO) More...KOⁱ	K06789
OMAⁱ	MVPAQTK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PI
PhylomeDBⁱ	Q8R373
TreeFamⁱ	TF330875

Miscellaneous databases

ChiTaRSⁱ	Clmp mouse
Protein Ontology More...PROⁱ	PR:Q8R373
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032024
CleanExⁱ	MM_9030425E11RIK
Genevisibleⁱ	Q8R373 MM

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLMP_MOUSE
Accessionⁱ	Q8R373Primary (citable) accession number: Q8R373 Secondary accession number(s): Q920S5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	June 1, 2002
	Last modified:	June 20, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R373 (CLMP_MOUSE)

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CXADR-like membrane protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytoskeleton

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ