UniProtKB - Q8R373 (CLMP_MOUSE)
Protein
CXADR-like membrane protein
Gene
Clmp
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity).By similarity2 Publications
GO - Biological processi
- digestive tract development Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: CXADR-like membrane proteinAlternative name(s): Adipocyte adhesion molecule Adipocyte-specific protein 5 Coxsackie- and adenovirus receptor-like membrane protein Short name: CAR-like membrane protein |
Gene namesi | Name:Clmp Synonyms:Acam, Asam, Asp5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918816, Clmp |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Other locations
- tight junction 1 Publication
Cytoskeleton
- cytoplasmic microtubule Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 234 | ExtracellularSequence analysisAdd BLAST | 217 | |
Transmembranei | 235 – 255 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 256 – 373 | CytoplasmicSequence analysisAdd BLAST | 118 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Tight junctionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000293027 | 18 – 373 | CXADR-like membrane proteinAdd BLAST | 356 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 110 | PROSITE-ProRule annotation | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 152 ↔ 207 | PROSITE-ProRule annotation | ||
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q8R373 |
PaxDbi | Q8R373 |
PRIDEi | Q8R373 |
PTM databases
GlyGeni | Q8R373, 2 sites |
iPTMneti | Q8R373 |
PhosphoSitePlusi | Q8R373 |
Expressioni
Tissue specificityi
Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue. Expressed at high levels in the heart and brain, at intermediate levels in the lung, skeletal muscle, kidney and testis and at low levels in the liver and spleen.2 Publications
Inductioni
Up-regulated in mature adipocytes and adipocyte tissue of obese animals.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000032024, Expressed in undifferentiated genital tubercle and 282 other tissues |
Genevisiblei | Q8R373, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034522 |
Miscellaneous databases
RNActi | Q8R373, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 126 | Ig-like C2-type 1Add BLAST | 109 | |
Domaini | 134 – 223 | Ig-like C2-type 2Add BLAST | 90 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 287 – 319 | Ser-richAdd BLAST | 33 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3866, Eukaryota |
GeneTreei | ENSGT00940000161031 |
HOGENOMi | CLU_040549_0_1_1 |
InParanoidi | Q8R373 |
OMAi | SRHVYSN |
OrthoDBi | 995551at2759 |
PhylomeDBi | Q8R373 |
TreeFami | TF330875 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR042454, CLMP IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR44783, PTHR44783, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8R373-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLFFLWLVS YYVGTLGTHT EIKRVAEEKV TLPCHHQLGL PEKDTLDIEW
60 70 80 90 100
LLTDNEGNQK VVITYSSRHV YNNLTEEQKG RVAFASNFLA GDASLQIEPL
110 120 130 140 150
KPSDEGRYTC KVKNSGRYVW SHVILKVLVR PSKPKCELEG EPTEGSDLTL
160 170 180 190 200
QCESASGTKP IVYYWQRIRE KEGEDEHLPP KSRIDYNNPG RVLLQNLTMA
210 220 230 240 250
SSGLYQCTAG NEAGKESCVV RVTVQYVQSI GMVAGAVTGI VAGALLIFLL
260 270 280 290 300
IWLLIRRKSK DRYEEEDRPN EIREDAEAPR ARLVKPSSSS SGSRSSRSGS
310 320 330 340 350
SSTRSTGNSA SRSQRTLSSE AAPQQPGLAP QAYSLIGPEV RGSEPKKVHH
360 370
TTLTKAETTL STTPSQSKAF QTV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 127 | V → A in BAB68503 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY259213 mRNA Translation: AAP15240.1 AY326421 mRNA Translation: AAP88385.1 AB040490 mRNA Translation: BAB68503.1 AK033723 mRNA Translation: BAC28446.1 BC026447 mRNA Translation: AAH26447.1 |
CCDSi | CCDS23082.1 |
RefSeqi | NP_598494.2, NM_133733.4 |
Genome annotation databases
Ensembli | ENSMUST00000034522; ENSMUSP00000034522; ENSMUSG00000032024 |
GeneIDi | 71566 |
KEGGi | mmu:71566 |
UCSCi | uc009ozt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY259213 mRNA Translation: AAP15240.1 AY326421 mRNA Translation: AAP88385.1 AB040490 mRNA Translation: BAB68503.1 AK033723 mRNA Translation: BAC28446.1 BC026447 mRNA Translation: AAH26447.1 |
CCDSi | CCDS23082.1 |
RefSeqi | NP_598494.2, NM_133733.4 |
3D structure databases
SMRi | Q8R373 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034522 |
PTM databases
GlyGeni | Q8R373, 2 sites |
iPTMneti | Q8R373 |
PhosphoSitePlusi | Q8R373 |
Proteomic databases
MaxQBi | Q8R373 |
PaxDbi | Q8R373 |
PRIDEi | Q8R373 |
Protocols and materials databases
Antibodypediai | 1118, 218 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034522; ENSMUSP00000034522; ENSMUSG00000032024 |
GeneIDi | 71566 |
KEGGi | mmu:71566 |
UCSCi | uc009ozt.1, mouse |
Organism-specific databases
CTDi | 79827 |
MGIi | MGI:1918816, Clmp |
Phylogenomic databases
eggNOGi | KOG3866, Eukaryota |
GeneTreei | ENSGT00940000161031 |
HOGENOMi | CLU_040549_0_1_1 |
InParanoidi | Q8R373 |
OMAi | SRHVYSN |
OrthoDBi | 995551at2759 |
PhylomeDBi | Q8R373 |
TreeFami | TF330875 |
Miscellaneous databases
BioGRID-ORCSi | 71566, 2 hits in 17 CRISPR screens |
ChiTaRSi | Clmp, mouse |
PROi | PR:Q8R373 |
RNActi | Q8R373, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032024, Expressed in undifferentiated genital tubercle and 282 other tissues |
Genevisiblei | Q8R373, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR042454, CLMP IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
PANTHERi | PTHR44783, PTHR44783, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLMP_MOUSE | |
Accessioni | Q8R373Primary (citable) accession number: Q8R373 Secondary accession number(s): Q920S5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot