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Entry version 96 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Usher syndrome type-1C protein-binding protein 1

Gene

Ushbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Usher syndrome type-1C protein-binding protein 1
Short name:
USH1C-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ushbp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1922920, Ushbp1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002521101 – 680Usher syndrome type-1C protein-binding protein 1Add BLAST680

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R370

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R370

PRoteomics IDEntifications database

More...
PRIDEi
Q8R370

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
297900

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R370

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R370

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034911, Expressed in heart left ventricle and 170 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8R370, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R370, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts via its C-terminus with the first PDZ domain of USH1C.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045668

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R370, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R370

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 51DisorderedSequence analysisAdd BLAST51
Regioni134 – 161DisorderedSequence analysisAdd BLAST28
Regioni220 – 247DisorderedSequence analysisAdd BLAST28
Regioni384 – 405DisorderedSequence analysisAdd BLAST22
Regioni524 – 549DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili179 – 218Sequence analysisAdd BLAST40
Coiled coili363 – 386Sequence analysisAdd BLAST24
Coiled coili467 – 506Sequence analysisAdd BLAST40
Coiled coili573 – 662Sequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi134 – 159Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi225 – 242Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCC family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3512, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024579_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R370

Identification of Orthologs from Complete Genome Data

More...
OMAi
APEMHIM

Database of Orthologous Groups

More...
OrthoDBi
787084at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105384

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040171, USBP1-like
IPR019536, USH1C-bd_PDZ_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23347, PTHR23347, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10506, MCC-bdg_PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSARATRPRS RRGRHPLPGE LDPVAESSEE VDANNGRFET KPELHQEYLG
60 70 80 90 100
PGLQSPRNWI KEGCDVGSHA VLSLSPEEQC EPEVEAHQVL QEAPLDSGPA
110 120 130 140 150
EISVPSVYET LQCRLSSLEA VVAALRHHSL SFPKSVEAED RDQGAPGPFG
160 170 180 190 200
DEKEDAGPGQ QEAARLIERN AWLRLALCNR EDELACTQAS LQDAQAEKET
210 220 230 240 250
LQRQVQELED SLMQMEASPP TPILRAGRRN SNSSTSGAER RPWVPQDSSM
260 270 280 290 300
AHPFLQRLRS DSSTQSFGCL STQHPAPETY LMEDQMGQLQ GSIEKLKCFN
310 320 330 340 350
RLLLAVLQGY KGRCESLSIK LAKREAEATA LRLALQYSED CEEVYEVLLA
360 370 380 390 400
LKMAGLGTGV GTTKGDLQAA EKEASRLLMK KEATMEVETP QPSSEGSGVD
410 420 430 440 450
KPTPEELASQ LHGYVQHLRE RWALVKIPEE LGPVTAPKAT MPHAEATVQA
460 470 480 490 500
ILEIQPGPTL PHLEKSQIQQ DLAATRDRLA DLVLRLQLTQ REKRGLELRE
510 520 530 540 550
AALRAQGPAH QLLLQQLRWE RAHFAGDGSS GGSSEDPSSE EEAGEDRQQH
560 570 580 590 600
YQGPLALLDG QMGKVWDSEN VSQELSASLA RAIDLRAQLQ SLRQQLEQVT
610 620 630 640 650
QKGRTRRVQS AELSRELCKA HSALALAFRG AHRKQEEQRL KLEQQVARLQ
660 670 680
AQQAEELAVL TATARALGKP GAPQPAQTFL
Length:680
Mass (Da):74,906
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4A8419B843FAE2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLD3A0A1D5RLD3_MOUSE
Usher syndrome type-1C protein-bind...
Ushbp1
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37R → C in AAH26453 (PubMed:15489334).Curated1
Sequence conflicti249S → P in AAH26453 (PubMed:15489334).Curated1
Sequence conflicti379M → V in AAH26453 (PubMed:15489334).Curated1
Sequence conflicti409S → V in AAH26453 (PubMed:15489334).Curated1
Sequence conflicti478R → S in AAH26453 (PubMed:15489334).Curated1
Sequence conflicti540E → D in AAH26453 (PubMed:15489334).Curated1
Sequence conflicti594Q → R in AAH26453 (PubMed:15489334).Curated1
Sequence conflicti640L → R in AAH26453 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC127416 Genomic DNA No translation available.
BC026453 mRNA Translation: AAH26453.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22393.1

NCBI Reference Sequences

More...
RefSeqi
NP_852083.2, NM_181418.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000049184; ENSMUSP00000045668; ENSMUSG00000034911

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
234395

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:234395

UCSC genome browser

More...
UCSCi
uc009mcz.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127416 Genomic DNA No translation available.
BC026453 mRNA Translation: AAH26453.1
CCDSiCCDS22393.1
RefSeqiNP_852083.2, NM_181418.3

3D structure databases

SMRiQ8R370
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045668

PTM databases

iPTMnetiQ8R370
PhosphoSitePlusiQ8R370

Proteomic databases

MaxQBiQ8R370
PaxDbiQ8R370
PRIDEiQ8R370
ProteomicsDBi297900

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
65308, 35 antibodies

The DNASU plasmid repository

More...
DNASUi
234395

Genome annotation databases

EnsembliENSMUST00000049184; ENSMUSP00000045668; ENSMUSG00000034911
GeneIDi234395
KEGGimmu:234395
UCSCiuc009mcz.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83878
MGIiMGI:1922920, Ushbp1

Phylogenomic databases

eggNOGiKOG3512, Eukaryota
GeneTreeiENSGT00530000063974
HOGENOMiCLU_024579_0_0_1
InParanoidiQ8R370
OMAiAPEMHIM
OrthoDBi787084at2759
TreeFamiTF105384

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
234395, 3 hits in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8R370
RNActiQ8R370, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034911, Expressed in heart left ventricle and 170 other tissues
ExpressionAtlasiQ8R370, baseline and differential
GenevisibleiQ8R370, MM

Family and domain databases

InterProiView protein in InterPro
IPR040171, USBP1-like
IPR019536, USH1C-bd_PDZ_domain
PANTHERiPTHR23347, PTHR23347, 1 hit
PfamiView protein in Pfam
PF10506, MCC-bdg_PDZ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSBP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R370
Secondary accession number(s): E9QKT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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