UniProtKB - Q8R367 (RERG_MOUSE)

BLAST

>sp|Q8R367|RERG_MOUSE Ras-related and estrogen-regulated growth inhibitor OS=Mus musculus OX=10090 GN=Rerg PE=2 SV=1
MAKSAEVKLAIFGRAGVGKSAIVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD
TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEVKKPKNVTLILVGNKA
DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEVFYELCREVRRRRMVQGKTRRR
SSTTHVKQAINKMLTKISS

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History
Entry version 127 (07 Nov 2018)
Sequence version 1 (01 Jun 2002)
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Protein

Ras-related and estrogen-regulated growth inhibitor

Gene

Rerg

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	13 – 20	GTPBy similarity	8
Nucleotide bindingⁱ	60 – 64	GTPBy similarity	5
Nucleotide bindingⁱ	118 – 121	GTPBy similarity	4

GO - Molecular functionⁱ

GTPase activity Source: MGI
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell growth Source: MGI
negative regulation of cell proliferation Source: MGI
response to hormone Source: MGI
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related and estrogen-regulated growth inhibitor
Gene namesⁱ	Name:Rerg
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:2665139 Rerg

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082724	1 – 199	Ras-related and estrogen-regulated growth inhibitorAdd BLAST		199

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R367
PaxDbⁱ	Q8R367
PRIDEⁱ	Q8R367

PTM databases

iPTMnetⁱ	Q8R367
PhosphoSitePlusⁱ	Q8R367

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030222 Expressed in 202 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_RERG
ExpressionAtlasⁱ	Q8R367 baseline and differential
Genevisibleⁱ	Q8R367 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032347

STRINGⁱ

10090.ENSMUSP00000032347

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R367
SMRⁱ	Q8R367
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	168 – 171	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q8R367
KEGG Orthology (KO) More...KOⁱ	K07855
OMAⁱ	MRWGDGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M6D
PhylomeDBⁱ	Q8R367
TreeFamⁱ	TF318030

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q8R367-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAKSAEVKLA IFGRAGVGKS AIVVRFLTKR FIWEYDPTLE STYRHQATID 
        60         70         80         90        100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN 
       110        120        130        140        150
ILDEVKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC 
       160        170        180        190 
TGEGNITEVF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS

Length:199

Mass (Da):22,580

Last modified:June 1, 2002 - v1

Checksum:ⁱB733BC187A9F29A9

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PUF8	E9PUF8_MOUSE	Ras-related and estrogen-regulated ... Ras-related and estrogen-regulated growth inhibitor	Rerg	180	Annotation score:
A0A0N4SUU2	A0A0N4SUU2_MOUSE	Ras-related and estrogen-regulated ... Ras-related and estrogen-regulated growth inhibitor	Rerg	59	Annotation score:
A0A0N4SV09	A0A0N4SV09_MOUSE	Ras-related and estrogen-regulated ... Ras-related and estrogen-regulated growth inhibitor	Rerg	48	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK133734 mRNA Translation: BAE21810.1 BC026463 mRNA Translation: AAH26463.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20663.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001157684.1, NM_001164212.1 NP_001157686.1, NM_001164214.1 NP_871788.1, NM_181988.2
UniGeneⁱ	Mm.46233

Genome annotation databases

Ensemblⁱ	ENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222 ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222
GeneIDⁱ	232441
KEGGⁱ	mmu:232441
UCSC genome browser More...UCSCⁱ	uc009emr.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R367	ras-related and estrogen-regulated growth inhibitor isoform X2		TARSY		200	UniRef90_Q8R367
ras-related and estrogen-regulated growth inhibitor		MESAU		199
RAS like estrogen regulated growth inhibitor		SAIBB		199
RAS-like, estrogen-regulated, growth-inhibitor		RAT		199
Uncharacterized protein		RABIT		199
+11

Protein	Similar proteins		Species	Score	Length	Source
Q8R367	ras-related and estrogen-regulated growth inhibitor isoform X2		TARSY		200	UniRef50_Q8R367
RAS-like, estrogen-regulated, growth-inhibitor		RAT		199
Uncharacterized protein		RABIT		199
ras-related and estrogen-regulated growth inhibitor		MESAU		199
RAS like estrogen regulated growth inhibitor		SAIBB		199
+146

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK133734 mRNA Translation: BAE21810.1 BC026463 mRNA Translation: AAH26463.1
CCDSⁱ	CCDS20663.1
RefSeqⁱ	NP_001157684.1, NM_001164212.1 NP_001157686.1, NM_001164214.1 NP_871788.1, NM_181988.2
UniGeneⁱ	Mm.46233

3D structure databases

ProteinModelPortalⁱ	Q8R367
SMRⁱ	Q8R367
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032347

STRINGⁱ

10090.ENSMUSP00000032347

PTM databases

iPTMnetⁱ	Q8R367
PhosphoSitePlusⁱ	Q8R367

Proteomic databases

MaxQBⁱ	Q8R367
PaxDbⁱ	Q8R367
PRIDEⁱ	Q8R367

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222 ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222
GeneIDⁱ	232441
KEGGⁱ	mmu:232441
UCSCⁱ	uc009emr.2 mouse

Organism-specific databases

CTDⁱ	85004
MGIⁱ	MGI:2665139 Rerg

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q8R367
KOⁱ	K07855
OMAⁱ	MRWGDGF
OrthoDBⁱ	EOG091G0M6D
PhylomeDBⁱ	Q8R367
TreeFamⁱ	TF318030

Miscellaneous databases

ChiTaRSⁱ	Rerg mouse
Protein Ontology More...PROⁱ	PR:Q8R367
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030222 Expressed in 202 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_RERG
ExpressionAtlasⁱ	Q8R367 baseline and differential
Genevisibleⁱ	Q8R367 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RERG_MOUSE
Accessionⁱ	Q8R367Primary (citable) accession number: Q8R367
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R367 (RERG_MOUSE)

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Ras-related and estrogen-regulated growth inhibitor

Rerg

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ