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Protein

Ras-related and estrogen-regulated growth inhibitor

Gene

Rerg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPBy similarity8
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related and estrogen-regulated growth inhibitor
Gene namesi
Name:Rerg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2665139 Rerg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827241 – 199Ras-related and estrogen-regulated growth inhibitorAdd BLAST199

Proteomic databases

MaxQBiQ8R367
PaxDbiQ8R367
PRIDEiQ8R367

PTM databases

iPTMnetiQ8R367
PhosphoSitePlusiQ8R367

Expressioni

Gene expression databases

BgeeiENSMUSG00000030222 Expressed in 202 organ(s), highest expression level in adrenal gland
CleanExiMM_RERG
ExpressionAtlasiQ8R367 baseline and differential
GenevisibleiQ8R367 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032347

Structurei

3D structure databases

ProteinModelPortaliQ8R367
SMRiQ8R367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 171Poly-Arg4

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ8R367
KOiK07855
OMAiMRWGDGF
OrthoDBiEOG091G0M6D
PhylomeDBiQ8R367
TreeFamiTF318030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8R367-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSAEVKLA IFGRAGVGKS AIVVRFLTKR FIWEYDPTLE STYRHQATID
60 70 80 90 100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN
110 120 130 140 150
ILDEVKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC
160 170 180 190
TGEGNITEVF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
Length:199
Mass (Da):22,580
Last modified:June 1, 2002 - v1
Checksum:iB733BC187A9F29A9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUF8E9PUF8_MOUSE
Ras-related and estrogen-regulated ...
Rerg
180Annotation score:
A0A0N4SUU2A0A0N4SUU2_MOUSE
Ras-related and estrogen-regulated ...
Rerg
59Annotation score:
A0A0N4SV09A0A0N4SV09_MOUSE
Ras-related and estrogen-regulated ...
Rerg
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133734 mRNA Translation: BAE21810.1
BC026463 mRNA Translation: AAH26463.1
CCDSiCCDS20663.1
RefSeqiNP_001157684.1, NM_001164212.1
NP_001157686.1, NM_001164214.1
NP_871788.1, NM_181988.2
UniGeneiMm.46233

Genome annotation databases

EnsembliENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222
ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222
GeneIDi232441
KEGGimmu:232441
UCSCiuc009emr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133734 mRNA Translation: BAE21810.1
BC026463 mRNA Translation: AAH26463.1
CCDSiCCDS20663.1
RefSeqiNP_001157684.1, NM_001164212.1
NP_001157686.1, NM_001164214.1
NP_871788.1, NM_181988.2
UniGeneiMm.46233

3D structure databases

ProteinModelPortaliQ8R367
SMRiQ8R367
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032347

PTM databases

iPTMnetiQ8R367
PhosphoSitePlusiQ8R367

Proteomic databases

MaxQBiQ8R367
PaxDbiQ8R367
PRIDEiQ8R367

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222
ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222
GeneIDi232441
KEGGimmu:232441
UCSCiuc009emr.2 mouse

Organism-specific databases

CTDi85004
MGIiMGI:2665139 Rerg

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ8R367
KOiK07855
OMAiMRWGDGF
OrthoDBiEOG091G0M6D
PhylomeDBiQ8R367
TreeFamiTF318030

Miscellaneous databases

ChiTaRSiRerg mouse
PROiPR:Q8R367
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030222 Expressed in 202 organ(s), highest expression level in adrenal gland
CleanExiMM_RERG
ExpressionAtlasiQ8R367 baseline and differential
GenevisibleiQ8R367 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRERG_MOUSE
AccessioniPrimary (citable) accession number: Q8R367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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