UniProtKB - Q8R367 (RERG_MOUSE)
Protein
Ras-related and estrogen-regulated growth inhibitor
Gene
Rerg
Organism
Mus musculus (Mouse)
Status
Functioni
Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP (By similarity).By similarity
Catalytic activityi
- EC:3.6.5.2By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 13 – 20 | GTPBy similarity | 8 | |
Nucleotide bindingi | 60 – 64 | GTPBy similarity | 5 | |
Nucleotide bindingi | 118 – 121 | GTPBy similarity | 4 |
GO - Molecular functioni
- GDP binding Source: GO_Central
- GTPase activity Source: MGI
- GTP binding Source: GO_Central
GO - Biological processi
- negative regulation of cell growth Source: MGI
- negative regulation of cell population proliferation Source: MGI
- Ras protein signal transduction Source: GO_Central
- response to hormone Source: MGI
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Rerg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2665139, Rerg |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082724 | 1 – 199 | Ras-related and estrogen-regulated growth inhibitorAdd BLAST | 199 |
Proteomic databases
MaxQBi | Q8R367 |
PaxDbi | Q8R367 |
PRIDEi | Q8R367 |
PTM databases
iPTMneti | Q8R367 |
PhosphoSitePlusi | Q8R367 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030222, Expressed in adrenal gland and 224 other tissues |
ExpressionAtlasi | Q8R367, baseline and differential |
Genevisiblei | Q8R367, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000113105 |
Miscellaneous databases
RNActi | Q8R367, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 168 – 171 | Poly-Arg | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159750 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q8R367 |
OMAi | AADMACA |
OrthoDBi | 1384728at2759 |
PhylomeDBi | Q8R367 |
TreeFami | TF318030 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8R367-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKSAEVKLA IFGRAGVGKS AIVVRFLTKR FIWEYDPTLE STYRHQATID
60 70 80 90 100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN
110 120 130 140 150
ILDEVKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC
160 170 180 190
TGEGNITEVF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PUF8 | E9PUF8_MOUSE | Ras-related and estrogen-regulated ... | Rerg | 180 | Annotation score: | ||
A0A0N4SUU2 | A0A0N4SUU2_MOUSE | Ras-related and estrogen-regulated ... | Rerg | 59 | Annotation score: | ||
A0A0N4SV09 | A0A0N4SV09_MOUSE | Ras-related and estrogen-regulated ... | Rerg | 48 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK133734 mRNA Translation: BAE21810.1 BC026463 mRNA Translation: AAH26463.1 |
CCDSi | CCDS20663.1 |
RefSeqi | NP_001157684.1, NM_001164212.1 NP_001157686.1, NM_001164214.1 NP_871788.1, NM_181988.2 |
Genome annotation databases
Ensembli | ENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222 ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222 |
GeneIDi | 232441 |
KEGGi | mmu:232441 |
UCSCi | uc009emr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK133734 mRNA Translation: BAE21810.1 BC026463 mRNA Translation: AAH26463.1 |
CCDSi | CCDS20663.1 |
RefSeqi | NP_001157684.1, NM_001164212.1 NP_001157686.1, NM_001164214.1 NP_871788.1, NM_181988.2 |
3D structure databases
SMRi | Q8R367 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000113105 |
PTM databases
iPTMneti | Q8R367 |
PhosphoSitePlusi | Q8R367 |
Proteomic databases
MaxQBi | Q8R367 |
PaxDbi | Q8R367 |
PRIDEi | Q8R367 |
Protocols and materials databases
Antibodypediai | 23714, 132 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000032347; ENSMUSP00000032347; ENSMUSG00000030222 ENSMUST00000117919; ENSMUSP00000113105; ENSMUSG00000030222 |
GeneIDi | 232441 |
KEGGi | mmu:232441 |
UCSCi | uc009emr.2, mouse |
Organism-specific databases
CTDi | 85004 |
MGIi | MGI:2665139, Rerg |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000159750 |
HOGENOMi | CLU_041217_9_7_1 |
InParanoidi | Q8R367 |
OMAi | AADMACA |
OrthoDBi | 1384728at2759 |
PhylomeDBi | Q8R367 |
TreeFami | TF318030 |
Miscellaneous databases
BioGRID-ORCSi | 232441, 0 hits in 17 CRISPR screens |
ChiTaRSi | Rerg, mouse |
PROi | PR:Q8R367 |
RNActi | Q8R367, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030222, Expressed in adrenal gland and 224 other tissues |
ExpressionAtlasi | Q8R367, baseline and differential |
Genevisiblei | Q8R367, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RERG_MOUSE | |
Accessioni | Q8R367Primary (citable) accession number: Q8R367 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families