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Protein

Rab11 family-interacting protein 5

Gene

Rab11fip5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab11 family-interacting protein 5
Short name:
Rab11-FIP5
Alternative name(s):
Rab11-interacting protein Rip11
Gene namesi
Name:Rab11fip5
Synonyms:D6Ertd32e, Rip11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1098586 Rab11fip5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973081 – 645Rab11 family-interacting protein 5Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei286PhosphoserineBy similarity1
Modified residuei307PhosphoserineCombined sources1
Modified residuei357Phosphoserine1 Publication1
Modified residuei367PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei486PhosphoserineBy similarity1
Modified residuei530PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R361
PaxDbiQ8R361
PeptideAtlasiQ8R361
PRIDEiQ8R361

PTM databases

iPTMnetiQ8R361
PhosphoSitePlusiQ8R361

Expressioni

Gene expression databases

BgeeiENSMUSG00000051343 Expressed in 238 organ(s), highest expression level in substantia nigra
CleanExiMM_RAB11FIP5
ExpressionAtlasiQ8R361 baseline and differential
GenevisibleiQ8R361 MM

Interactioni

Subunit structurei

Forms a heterooligomeric complex with RAB11FIP4. Binds NAPG and TROVE2. Binds RAB11A that has been activated by GTP binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi206353, 3 interactors
IntActiQ8R361, 3 interactors
MINTiQ8R361
STRINGi10090.ENSMUSP00000058305

Structurei

3D structure databases

ProteinModelPortaliQ8R361
SMRiQ8R361
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 128C2PROSITE-ProRule annotationAdd BLAST123
Domaini578 – 640FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 397Ser-richAdd BLAST155

Domaini

Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg2+ rather than Ca2+ (By similarity).By similarity

Phylogenomic databases

eggNOGiENOG410IJ70 Eukaryota
ENOG410XQK9 LUCA
GeneTreeiENSGT00530000063203
HOGENOMiHOG000234700
HOVERGENiHBG079127
InParanoidiQ8R361
KOiK12484
OrthoDBiEOG091G09IV
TreeFamiTF326172

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8R361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALVRDPEPA AGSSRWLPTH VQVTVLRASG LRGKSSGAGS TSDAYTVIQV
60 70 80 90 100
GREKYSTSVV EKTQGCPEWC EECSFELPPG ALDGLLRAQE ADAGPAPWAS
110 120 130 140 150
GPNAACELVL TTMHRSLIGV DKFLGRATVA LDEVFRAGRA QHTQWYRLHS
160 170 180 190 200
KPGKKEKERG EIQVTIQFTR NNLSASMFDL SMKDKPRSPF SKLKDRVKGK
210 220 230 240 250
KKYDLESASA ILPSSALEDP ELGSLGKMGK AKGFFLRNKL RKSSLTQSNT
260 270 280 290 300
SLGSDSTLSS TSGSLVYQGP GAELLTRSPS HSSWLSTEGG RDSIQSPKLL
310 320 330 340 350
THKRTYSDEA SQLRAAPPRA LLELQGHLDG ASRSSLCVNG SHVYNEEPQP
360 370 380 390 400
PLRHRSSISG PFPPSSSLHS VPPRSSEEGS RSSDDSWGRG SHGTSSSEAV
410 420 430 440 450
PGQEELSKQA KGASCSGEEE GARLPEGKPV QVATPMVASS EAVAAEKDRK
460 470 480 490 500
PRMGLFHHHH HQGLSRSEQG RRGSVGEKGS PSLGASPHHS STGEEKAKSS
510 520 530 540 550
WFGLRESKEP TQKPSPHPVK PLTAAPVEAS PDRKQPRTSL STALSSGLER
560 570 580 590 600
LKTVTSGGIQ SVLPASQLGS SVDTKRPKDS AVLDQSAKYY HLTHDELIGL
610 620 630 640
LLQRERELSQ RDEHVQELES YIDRLLVRIM ETSPTLLQIS PGPPK
Length:645
Mass (Da):69,553
Last modified:August 22, 2003 - v2
Checksum:iCBA713E9E68A042A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SW73A0A0N4SW73_MOUSE
Rab11 family-interacting protein 5
Rab11fip5
1,318Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153605 Genomic DNA No translation available.
AC155728 Genomic DNA No translation available.
BC026473 mRNA Translation: AAH26473.1
BC044833 mRNA Translation: AAH44833.2
BC051063 mRNA Translation: AAH51063.3
BC141380 mRNA Translation: AAI41381.1
CCDSiCCDS20292.1
RefSeqiNP_001003955.1, NM_001003955.2
NP_803417.3, NM_177466.4
UniGeneiMm.220334

Genome annotation databases

EnsembliENSMUST00000060837; ENSMUSP00000058305; ENSMUSG00000051343
GeneIDi52055
KEGGimmu:52055
UCSCiuc009cpo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRFIP5_MOUSE
AccessioniPrimary (citable) accession number: Q8R361
Secondary accession number(s): C4IXU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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