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Protein

HMG box-containing protein 1

Gene

Hbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi436 – 504HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box-containing protein 1
Alternative name(s):
HMG box transcription factor 1
High mobility group box transcription factor 1
Gene namesi
Name:Hbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:894659 Hbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi370L → D: Strongly reduces Sin3A binding. 1 Publication1
Mutagenesisi373M → D: Strongly reduces Sin3A binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485471 – 516HMG box-containing protein 1Add BLAST516

Post-translational modificationi

Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ8R316
PRIDEiQ8R316

PTM databases

iPTMnetiQ8R316
PhosphoSitePlusiQ8R316

Expressioni

Gene expression databases

CleanExiMM_HBP1

Interactioni

Subunit structurei

Binds TCF4 (By similarity). Binds RB1 (PubMed:9178770). Binds the second PAH repeat of SIN3A (PubMed:15235594).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131158

Structurei

Secondary structure

1516
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8R316
SMRiQ8R316
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R316

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini203 – 345AXHPROSITE-ProRule annotationAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 161Poly-Ser6
Compositional biasi197 – 200Poly-Asp4
Compositional biasi394 – 432Ser-richAdd BLAST39

Phylogenomic databases

eggNOGiENOG410IFNF Eukaryota
ENOG410XPPV LUCA
HOGENOMiHOG000065753
HOVERGENiHBG052810
InParanoidiQ8R316
KOiK21644
PhylomeDBiQ8R316

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR003652 Ataxin_AXH_dom
IPR036096 Ataxin_AXH_dom_sf
IPR039655 HBP1
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PANTHERiPTHR15499 PTHR15499, 1 hit
PfamiView protein in Pfam
PF08517 AXH, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00536 AXH, 1 hit
SM00398 HMG, 1 hit
SUPFAMiSSF102031 SSF102031, 1 hit
SSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS51148 AXH, 1 hit
PS50118 HMG_BOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R316-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVWEVKTNQM PNAVQKLLLV MDKRAPGMSD SLELLQCNEN LPSSPGYNSC
60 70 80 90 100
DEHMELDDLP ELQAVQSDPT QSAIYQLSSD VSHQEYPRSS WSQNTSDIPE
110 120 130 140 150
NTHREDEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA
160 170 180 190 200
RPPPVSSSSK SGPAFPHDHW KEETPVRHER ANSESESGIF CMSSLSDDDD
210 220 230 240 250
LGWCNSWPST IWHCFLKGTR LCFHKESNKE WQDVEDFARA ASCDNEEEIQ
260 270 280 290 300
MGTHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH
310 320 330 340 350
PFYVKNKGWS SFYPSLTVVQ HGIPCCEIHI GDVCLPPGHP DAINFDDSGV
360 370 380 390 400
FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGGPGTG QEFSGSEFSK
410 420 430 440 450
SCGSPGSSQL SSSSLYAKAV KSHSSGTVSA TSPNKCKRPM NAFMLFAKKY
460 470 480 490 500
RVEYTQMYPG KDNRAISVIL GDRWKKMKNE ERRMYTLEAK ALAEEQKRLN
510
PDCWKRKRTN SGSQQH
Length:516
Mass (Da):57,645
Last modified:June 1, 2002 - v1
Checksum:i2DC6D40FE41543B0
GO
Isoform 2 (identifier: Q8R316-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-516: Missing.

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):51,433
Checksum:iB40F04F670C60E19
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1A8E9Q1A8_MOUSE
HMG box-containing protein 1
Hbp1
526Annotation score:
E9Q469E9Q469_MOUSE
HMG box-containing protein 1
Hbp1
474Annotation score:
H3BJQ4H3BJQ4_MOUSE
HMG box-containing protein 1
Hbp1
375Annotation score:
H3BKS6H3BKS6_MOUSE
HMG box-containing protein 1
Hbp1
271Annotation score:
H3BKV0H3BKV0_MOUSE
HMG box-containing protein 1
Hbp1
256Annotation score:
H3BJW8H3BJW8_MOUSE
HMG box-containing protein 1
Hbp1
288Annotation score:
H3BKQ9H3BKQ9_MOUSE
HMG box-containing protein 1
Hbp1
230Annotation score:

Sequence cautioni

The sequence BAC38611 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014657465 – 516Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026853 mRNA Translation: AAH26853.1
AK028674 mRNA Translation: BAC26060.1
AK082770 mRNA Translation: BAC38611.1 Different initiation.
AK133127 mRNA Translation: BAE21520.1
RefSeqiNP_694878.2, NM_153198.2
NP_818774.2, NM_177993.3
XP_017170701.1, XM_017315212.1
UniGeneiMm.390461
Mm.458534

Genome annotation databases

GeneIDi73389
KEGGimmu:73389

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026853 mRNA Translation: AAH26853.1
AK028674 mRNA Translation: BAC26060.1
AK082770 mRNA Translation: BAC38611.1 Different initiation.
AK133127 mRNA Translation: BAE21520.1
RefSeqiNP_694878.2, NM_153198.2
NP_818774.2, NM_177993.3
XP_017170701.1, XM_017315212.1
UniGeneiMm.390461
Mm.458534

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S5RNMR-A358-380[»]
1V06NMR-A208-345[»]
ProteinModelPortaliQ8R316
SMRiQ8R316
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131158

PTM databases

iPTMnetiQ8R316
PhosphoSitePlusiQ8R316

Proteomic databases

PaxDbiQ8R316
PRIDEiQ8R316

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi73389
KEGGimmu:73389

Organism-specific databases

CTDi26959
MGIiMGI:894659 Hbp1

Phylogenomic databases

eggNOGiENOG410IFNF Eukaryota
ENOG410XPPV LUCA
HOGENOMiHOG000065753
HOVERGENiHBG052810
InParanoidiQ8R316
KOiK21644
PhylomeDBiQ8R316

Miscellaneous databases

EvolutionaryTraceiQ8R316
PROiPR:Q8R316
SOURCEiSearch...

Gene expression databases

CleanExiMM_HBP1

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR003652 Ataxin_AXH_dom
IPR036096 Ataxin_AXH_dom_sf
IPR039655 HBP1
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PANTHERiPTHR15499 PTHR15499, 1 hit
PfamiView protein in Pfam
PF08517 AXH, 1 hit
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00536 AXH, 1 hit
SM00398 HMG, 1 hit
SUPFAMiSSF102031 SSF102031, 1 hit
SSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS51148 AXH, 1 hit
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBP1_MOUSE
AccessioniPrimary (citable) accession number: Q8R316
Secondary accession number(s): Q3V0I4, Q8BUS3, Q8C199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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