UniProtKB - Q8R2Z3 (S26A7_MOUSE)
Protein
Anion exchange transporter
Gene
Slc26a7
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion.By similarity3 Publications
Miscellaneous
Regulated by pH. Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2-carboxylic acid and glybenclamide.
GO - Molecular functioni
- anion:anion antiporter activity Source: GO_Central
- anion channel activity Source: MGI
- bicarbonate transmembrane transporter activity Source: UniProtKB
- chloride channel activity Source: MGI
- chloride transmembrane transporter activity Source: GO_Central
- oxalate transmembrane transporter activity Source: MGI
- secondary active sulfate transmembrane transporter activity Source: InterPro
- sulfate transmembrane transporter activity Source: MGI
GO - Biological processi
- anion transport Source: MGI
- bicarbonate transport Source: UniProtKB
- chloride transport Source: MGI
- gastric acid secretion Source: UniProtKB
- oxalate transport Source: MGI
- sulfate transport Source: MGI
Keywordsi
Biological process | Anion exchange, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-427601, Multifunctional anion exchangers |
Names & Taxonomyi
Protein namesi | Recommended name: Anion exchange transporterAlternative name(s): Solute carrier family 26 member 7 |
Gene namesi | Name:Slc26a7Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384791, Slc26a7 |
Subcellular locationi
Plasma membrane
- Basolateral cell membrane ; Multi-pass membrane protein 3 Publications
Endosome
- Recycling endosome membrane ; Multi-pass membrane protein 3 Publications
Note: Expressed on the basolateral membrane of acid-secreting gastric parietal cells, distal nephron segments and apical domains of proximal tubules and in the glomerulus. Expressed in the cytoplasm in recycling endosomes of kidney outer medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion.By similarity3 Publications
Endosome
- endosome Source: MGI
- recycling endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: MGI
- integral component of membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 75 | CytoplasmicSequence analysisAdd BLAST | 75 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 144 | ExtracellularSequence analysisAdd BLAST | 48 | |
Transmembranei | 145 – 165 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 166 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 199 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 222 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 223 – 243 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 244 – 254 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 255 – 275 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 276 – 306 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 307 – 327 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 328 – 343 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 344 – 364 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 365 – 383 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 384 – 404 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 405 – 425 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 426 – 448 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 449 – 469 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 470 – 656 | CytoplasmicSequence analysisAdd BLAST | 187 |
Keywords - Cellular componenti
Cell membrane, Endosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320682 | 1 – 656 | Anion exchange transporterAdd BLAST | 656 |
Proteomic databases
jPOSTi | Q8R2Z3 |
PaxDbi | Q8R2Z3 |
PeptideAtlasi | Q8R2Z3 |
PRIDEi | Q8R2Z3 |
PTM databases
PhosphoSitePlusi | Q8R2Z3 |
Expressioni
Tissue specificityi
Abundantly expressed in parietal cells on the glandular portion of the stomach. Lower levels are observed in the kidney, with expression in the proximal tubule and thick ascending limb of the loop of Henle. Also expressed in distal segments of nephron, in extraglomerular mesagial cells and a subpopulation of intercalated cells of outer medullary collecting ducts.3 Publications
Gene expression databases
Bgeei | ENSMUSG00000040569, Expressed in vestibular membrane of cochlear duct and 212 other tissues |
ExpressionAtlasi | Q8R2Z3, baseline and differential |
Genevisiblei | Q8R2Z3, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229021, 12 interactors |
STRINGi | 10090.ENSMUSP00000041789 |
Miscellaneous databases
RNActi | Q8R2Z3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 492 – 641 | STASPROSITE-ProRule annotationAdd BLAST | 150 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 641 – 656 | Membrane targetingBy similarityAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01010000222385 |
HOGENOMi | CLU_003182_9_5_1 |
InParanoidi | Q8R2Z3 |
OMAi | YMDCKNR |
OrthoDBi | 690428at2759 |
TreeFami | TF313784 |
Family and domain databases
Gene3Di | 3.30.750.24, 1 hit |
InterProi | View protein in InterPro IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR030329, SLC26A7 IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF75, PTHR11814:SF75, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
PROSITEi | View protein in PROSITE PS50801, STAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8R2Z3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGAKRKKRS VLWGKMHTPH REDIKQWCKR RLPILEWAPQ YNLKENLLPD
60 70 80 90 100
TVSGIMLAVQ QVAQGLSFAM LSSVHPVFGL YGSLFPAIIY AIFGMGRHVA
110 120 130 140 150
TGTFALTSLI SANAVERLVP QSSRNLTTQS NSSVLGLSEF ELQRIGVAAA
160 170 180 190 200
VSFLGGVIQL VMFVLQLGSA TFLLTEPVIS AMTTGAATHV VTSQVKYLLG
210 220 230 240 250
IKMPYISGPL GFFYIYAYVF ENIKSVQLEA LLFSLLSIIV LVLVKELNEQ
260 270 280 290 300
FKRKIKVVLP VDLVLIIAAS FACYCTNMEN TYGLEVVGHI PNGIPPPRAP
310 320 330 340 350
PMNILSAVLT EAFGVALVGY VASLALAQGS AKKFKYSVDD NQEFLAHGLS
360 370 380 390 400
NVIPSFLFCI PSAAAMGRTA GLYSTGAKTQ VACLISCIFV LIVIYAIGPL
410 420 430 440 450
LYWLPMCVLA SIIVVGLKGM LIQFRDLKKY WNVDKIDWGI WISTYIFTIC
460 470 480 490 500
FAANVGLLFG VICTIAIVLG RFPRAKTLSI TDMKEMELKV KTEMHDETSQ
510 520 530 540 550
QIKIISINNP LVFLNAKKFS ADLMKIILKE SDSNQPLDDV SKCEQNTLLS
560 570 580 590 600
SLSNGNCNEE ASQPCSSEKC SLVLNCSGLT FFDYTGVSTL VELYLDCKSR
610 620 630 640 650
SVDVFLANCT ASLIKAMTYY GDLDTEKPIF FDSVPAAISI IQSNKNLSKA
SDHSEV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AJZ6 | A2AJZ6_MOUSE | Anion exchange transporter | Slc26a7 | 99 | Annotation score: | ||
A2AJZ5 | A2AJZ5_MOUSE | Anion exchange transporter | Slc26a7 | 200 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 233 | F → L in AAO49172 (Ref. 1) Curated | 1 | |
Sequence conflicti | 233 | F → L in AAH26928 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 639 | S → T in AAO49172 (Ref. 1) Curated | 1 | |
Sequence conflicti | 639 | S → T in AAH26928 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF345194 mRNA Translation: AAO49172.1 AL772236 Genomic DNA No translation available. AL772270 Genomic DNA No translation available. CH466538 Genomic DNA Translation: EDL05611.1 BC026928 mRNA Translation: AAH26928.1 |
CCDSi | CCDS17979.1 |
RefSeqi | NP_666059.2, NM_145947.2 |
Genome annotation databases
Ensembli | ENSMUST00000042221; ENSMUSP00000041789; ENSMUSG00000040569 |
GeneIDi | 208890 |
KEGGi | mmu:208890 |
UCSCi | uc008saz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF345194 mRNA Translation: AAO49172.1 AL772236 Genomic DNA No translation available. AL772270 Genomic DNA No translation available. CH466538 Genomic DNA Translation: EDL05611.1 BC026928 mRNA Translation: AAH26928.1 |
CCDSi | CCDS17979.1 |
RefSeqi | NP_666059.2, NM_145947.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 229021, 12 interactors |
STRINGi | 10090.ENSMUSP00000041789 |
PTM databases
PhosphoSitePlusi | Q8R2Z3 |
Proteomic databases
jPOSTi | Q8R2Z3 |
PaxDbi | Q8R2Z3 |
PeptideAtlasi | Q8R2Z3 |
PRIDEi | Q8R2Z3 |
Protocols and materials databases
Antibodypediai | 25657, 68 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042221; ENSMUSP00000041789; ENSMUSG00000040569 |
GeneIDi | 208890 |
KEGGi | mmu:208890 |
UCSCi | uc008saz.2, mouse |
Organism-specific databases
CTDi | 115111 |
MGIi | MGI:2384791, Slc26a7 |
Phylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01010000222385 |
HOGENOMi | CLU_003182_9_5_1 |
InParanoidi | Q8R2Z3 |
OMAi | YMDCKNR |
OrthoDBi | 690428at2759 |
TreeFami | TF313784 |
Enzyme and pathway databases
Reactomei | R-MMU-427601, Multifunctional anion exchangers |
Miscellaneous databases
BioGRID-ORCSi | 208890, 1 hit in 17 CRISPR screens |
PROi | PR:Q8R2Z3 |
RNActi | Q8R2Z3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040569, Expressed in vestibular membrane of cochlear duct and 212 other tissues |
ExpressionAtlasi | Q8R2Z3, baseline and differential |
Genevisiblei | Q8R2Z3, MM |
Family and domain databases
Gene3Di | 3.30.750.24, 1 hit |
InterProi | View protein in InterPro IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR030329, SLC26A7 IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF75, PTHR11814:SF75, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
PROSITEi | View protein in PROSITE PS50801, STAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S26A7_MOUSE | |
Accessioni | Q8R2Z3Primary (citable) accession number: Q8R2Z3 Secondary accession number(s): A2AJZ4, B1AWS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families