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Protein

Adipolin

Gene

C1qtnf12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (PubMed:21849507, PubMed:22275362).2 Publications
Adipolin fC1QTNF12: Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes (PubMed:22942287).1 Publication
Adipolin gC1QTNF12: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes (PubMed:22942287).1 Publication

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Adipolin1 Publication
Alternative name(s):
Adipose-derived insulin-sensitizing factor1 Publication
Complement C1q tumor necrosis factor-related protein 12
Cleaved into the following 2 chains:
Alternative name(s):
Adipolin fCTRP121 Publication
Adipolin full-length form
Alternative name(s):
Adipolin cleaved form
Adipolin gCTRP121 Publication
Gene namesi
Name:C1qtnf12
Synonyms:C1qdc2, Ctrp12, Fam132a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914639 C1qtnf12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39N → A: Decreased N-glycosylation. 1 Publication1
Mutagenesisi85C → A: Abolishes multimeric complex formation. 1 Publication1
Mutagenesisi90 – 93KKSR → AASA: Nearly abolishes protein processing. 2 Publications4
Mutagenesisi90 – 93Missing : Abolishes protein processing. 2 Publications4
Mutagenesisi93R → A: Enhances protein processing. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000028435522 – 308Adipolin fC1QTNF12Add BLAST287
ChainiPRO_000043024992 – 308Adipolin gC1QTNF12Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN (PubMed:22942287). Insulin enhances endogenous C1QTNF12 cleavage (PubMed:22942287).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei91 – 92Cleavage; by FURIN1 Publication2
Sitei287Not glycosylated1 Publication1
Sitei297Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8R2Z0
PaxDbiQ8R2Z0
PeptideAtlasiQ8R2Z0
PRIDEiQ8R2Z0

PTM databases

iPTMnetiQ8R2Z0

Expressioni

Tissue specificityi

Widely expressed, with high expression in subcutaneous and epididymal white adipose tissues and brown adipose tissue. Expressed in adipocytes (at protein level).2 Publications

Inductioni

During adipogenesis. Upon insulin treatment. Up-regulated in obeses mice. Transcription is activated by KLF3 and KLF15.5 Publications

Gene expression databases

BgeeiENSMUSG00000023571 Expressed in 278 organ(s), highest expression level in metanephric renal vesicle
GenevisibleiQ8R2Z0 MM

Interactioni

Subunit structurei

Homomultimer; disulfide-linked (PubMed:22942287). Adipolin fC1QTNF12: homotrimer; disulfide-linked (PubMed:22942287). Adipolin gC1QTNF12: homodimer; disulfide-linked (PubMed:22942287). May interact with ERFE.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024338

Structurei

3D structure databases

ProteinModelPortaliQ8R2Z0
SMRiQ8R2Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 308C1qPROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 114Pro-richAdd BLAST16

Sequence similaritiesi

Belongs to the adipolin/erythroferrone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF62 Eukaryota
ENOG4110RD3 LUCA
GeneTreeiENSGT00390000007846
HOGENOMiHOG000112436
HOVERGENiHBG107865
InParanoidiQ8R2Z0
KOiK21410
OMAiRCRGRDK
OrthoDBiEOG091G0HNK
PhylomeDBiQ8R2Z0
TreeFamiTF331282

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R2Z0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWAWGWAAAA LLWLQTAGAG ARQELKKSRQ LFARVDSPNI TTSNREGFPG
60 70 80 90 100
SVKPPEASGP ELSDAHMTWL NFVRRPDDGS SRKRCRGRDK KSRGLSGLPG
110 120 130 140 150
PPGPPGPPGP PGSPGVGVTP EALLQEFQEI LKEATELRFS GLPDTLLPQE
160 170 180 190 200
PSQRLVVEAF YCRLKGPVLV DKKTLVELQG FQAPTTQGAF LRGSGLSLSL
210 220 230 240 250
GRFTAPVSAI FQFSASLHVD HSELQGRGRL RTRDMVRVLI CIESLCHRHT
260 270 280 290 300
SLEAVSGLES NSRVFTVQVQ GLLHLQSGQY VSVFVDNSSG AVLTIQNTSS

FSGMLLGT
Length:308
Mass (Da):33,267
Last modified:April 17, 2007 - v2
Checksum:i888681DBDCDD5835
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117G → D in AAH26939 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002404 mRNA Translation: AAY21936.1
AK002876 mRNA Translation: BAB22423.1
AK004116 mRNA Translation: BAB23178.1
AL627204 Genomic DNA No translation available.
BC026939 mRNA Translation: AAH26939.1
CCDSiCCDS19052.1
RefSeqiNP_080401.1, NM_026125.3
UniGeneiMm.29140

Genome annotation databases

EnsembliENSMUST00000024338; ENSMUSP00000024338; ENSMUSG00000023571
GeneIDi67389
KEGGimmu:67389
UCSCiuc008wfp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ002404 mRNA Translation: AAY21936.1
AK002876 mRNA Translation: BAB22423.1
AK004116 mRNA Translation: BAB23178.1
AL627204 Genomic DNA No translation available.
BC026939 mRNA Translation: AAH26939.1
CCDSiCCDS19052.1
RefSeqiNP_080401.1, NM_026125.3
UniGeneiMm.29140

3D structure databases

ProteinModelPortaliQ8R2Z0
SMRiQ8R2Z0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024338

PTM databases

iPTMnetiQ8R2Z0

Proteomic databases

MaxQBiQ8R2Z0
PaxDbiQ8R2Z0
PeptideAtlasiQ8R2Z0
PRIDEiQ8R2Z0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024338; ENSMUSP00000024338; ENSMUSG00000023571
GeneIDi67389
KEGGimmu:67389
UCSCiuc008wfp.2 mouse

Organism-specific databases

CTDi388581
MGIiMGI:1914639 C1qtnf12

Phylogenomic databases

eggNOGiENOG410IF62 Eukaryota
ENOG4110RD3 LUCA
GeneTreeiENSGT00390000007846
HOGENOMiHOG000112436
HOVERGENiHBG107865
InParanoidiQ8R2Z0
KOiK21410
OMAiRCRGRDK
OrthoDBiEOG091G0HNK
PhylomeDBiQ8R2Z0
TreeFamiTF331282

Miscellaneous databases

ChiTaRSiFam132a mouse
PROiPR:Q8R2Z0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023571 Expressed in 278 organ(s), highest expression level in metanephric renal vesicle
GenevisibleiQ8R2Z0 MM

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADIPL_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Z0
Secondary accession number(s): Q9CQI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 12, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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