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Protein

Peptidyl-tRNA hydrolase 2, mitochondrial

Gene

Ptrh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.By similarity

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolase 2, mitochondrial (EC:3.1.1.29)
Short name:
PTH 2
Gene namesi
Name:Ptrh2
Synonyms:Pth2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2444848 Ptrh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 64MitochondrionSequence analysisAdd BLAST64
ChainiPRO_000002986365 – 181Peptidyl-tRNA hydrolase 2, mitochondrialAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki83Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8R2Y8
MaxQBiQ8R2Y8
PaxDbiQ8R2Y8
PeptideAtlasiQ8R2Y8
PRIDEiQ8R2Y8

PTM databases

iPTMnetiQ8R2Y8
PhosphoSitePlusiQ8R2Y8
SwissPalmiQ8R2Y8

Expressioni

Gene expression databases

BgeeiENSMUSG00000072582
CleanExiMM_PTH2
MM_PTRH2
GenevisibleiQ8R2Y8 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ8R2Y8, 2 interactors
MINTiQ8R2Y8
STRINGi10090.ENSMUSP00000103656

Structurei

3D structure databases

ProteinModelPortaliQ8R2Y8
SMRiQ8R2Y8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3282 Eukaryota
COG1990 LUCA
GeneTreeiENSGT00390000015991
HOGENOMiHOG000227349
HOVERGENiHBG049458
InParanoidiQ8R2Y8
KOiK04794
OMAiKQVIVVR
OrthoDBiEOG091G0WC2
PhylomeDBiQ8R2Y8
TreeFamiTF324583

Family and domain databases

CDDicd02430 PTH2, 1 hit
Gene3Di3.40.1490.10, 1 hit
InterProiView protein in InterPro
IPR023476 Pep_tRNA_hydro_II_dom_sf
IPR002833 PTH2
PfamiView protein in Pfam
PF01981 PTH2, 1 hit
SUPFAMiSSF102462 SSF102462, 1 hit
TIGRFAMsiTIGR00283 arch_pth2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R2Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKFLTMEY LVHPGTLSLA AGVACGMCLG WGLRSHLGMF PQNSTSEANR
60 70 80 90 100
DTETGTEASI LGESGEYKMI LVVRTDLKMG KGKVAAQCSH AAVSAYKQTQ
110 120 130 140 150
RRSPQVLKEW EYCGQPKVVV KAPDEDTLIQ LLTHAKTLGL TVSLIQDAGR
160 170 180
TQIEPGSRTV LGIGPGPVEL IDEVTGHLKL Y
Length:181
Mass (Da):19,527
Last modified:June 1, 2002 - v1
Checksum:iC341176DE560C2B8
GO

Sequence cautioni

The sequence BAC26006 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171I → T in BAC30159 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028555 mRNA Translation: BAC26006.1 Different initiation.
AK031620 mRNA Translation: BAC27482.1
AK038888 mRNA Translation: BAC30159.1
BC026947 mRNA Translation: AAH26947.1
CCDSiCCDS48876.1
RefSeqiNP_001092280.1, NM_001098810.2
NP_778169.1, NM_175004.2
UniGeneiMm.24868

Genome annotation databases

EnsembliENSMUST00000108021; ENSMUSP00000103656; ENSMUSG00000072582
ENSMUST00000108022; ENSMUSP00000103657; ENSMUSG00000072582
GeneIDi217057
KEGGimmu:217057
UCSCiuc007ksy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPTH2_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Y8
Secondary accession number(s): Q8BI01, Q8BI31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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