UniProtKB - Q8R2V5 (ADAP2_MOUSE)
Protein
Arf-GAP with dual PH domain-containing protein 2
Gene
Adap2
Organism
Mus musculus (Mouse)
Status
Functioni
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity).By similarityCurated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 25 – 48 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- 1-phosphatidylinositol binding Source: MGI
- GTPase activator activity Source: UniProtKB-KW
- inositol 1,3,4,5 tetrakisphosphate binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
- phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
GO - Biological processi
- heart development Source: UniProtKB
- inositol lipid-mediated signaling Source: MGI
Keywordsi
Molecular function | GTPase activation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Arf-GAP with dual PH domain-containing protein 2Alternative name(s): Centaurin-alpha-2 Short name: Cnt-a2 |
Gene namesi | Name:Adap2 Synonyms:Centa2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2663075, Adap2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Constitutively associated with the plasma membrane. Excluded from the nucleus (By similarity).By similarity
Mitochondrion
- mitochondrial envelope Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074207 | 1 – 381 | Arf-GAP with dual PH domain-containing protein 2Add BLAST | 381 |
Proteomic databases
EPDi | Q8R2V5 |
MaxQBi | Q8R2V5 |
PaxDbi | Q8R2V5 |
PRIDEi | Q8R2V5 |
ProteomicsDBi | 296061 |
PTM databases
iPTMneti | Q8R2V5 |
PhosphoSitePlusi | Q8R2V5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020709, Expressed in bone marrow macrophage and 168 other tissues |
ExpressionAtlasi | Q8R2V5, baseline and differential |
Genevisiblei | Q8R2V5, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229830, 1 interactor |
STRINGi | 10090.ENSMUSP00000021050 |
Miscellaneous databases
RNActi | Q8R2V5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 132 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 124 | |
Domaini | 132 – 233 | PH 1PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 255 – 361 | PH 2PROSITE-ProRule annotationAdd BLAST | 107 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 25 – 48 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0703, Eukaryota |
GeneTreei | ENSGT00940000156498 |
HOGENOMi | CLU_061583_0_0_1 |
InParanoidi | Q8R2V5 |
OMAi | DFWENDL |
OrthoDBi | 1274375at2759 |
TreeFami | TF324540 |
Family and domain databases
CDDi | cd13252, PH1_ADAP, 1 hit cd01251, PH2_ADAP, 1 hit |
Gene3Di | 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR011993, PH-like_dom_sf IPR037849, PH1_ADAP IPR037851, PH2_ADAP IPR001849, PH_domain |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit PF00169, PH, 2 hits |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8R2V5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDRERNKKR LLELLQAAGT GNGHCADCGA ADPDWASYKL GIFICLHCSG
60 70 80 90 100
VHRNFPDISK VKSVRLDFWD DSMVEFMTHH GNLNVKAKFE ARVPAFYYVP
110 120 130 140 150
QANDCLVLKE QWIRAKYERQ EFTAIDKAVS HPGNREGFLW KRGRDNAQFL
160 170 180 190 200
RRRFVLLSRE GLLKYYTKEE GKAPKAVISI KDLNATFQTE KIGHPHGLQI
210 220 230 240 250
TYRKEGHTRN LFVYHDSGKE IVDWFNALRA ARLQYLKLAF PDLPESELVP
260 270 280 290 300
LITRNYLKQG FMEKTGPKHR EPFKKRWFAL DPQERRLLYY KNPLDAFELG
310 320 330 340 350
QVFLGSNEQG YEVWEDLPKG IRGNRWKAGL TVITPERKFI FTCPTEKEQR
360 370 380
EWLESLRGVL SSPLSPLHLL TTSAETGCGL G
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9QAL8 | E9QAL8_MOUSE | Arf-GAP with dual PH domain-contain... | Adap2 | 133 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC027165 mRNA Translation: AAH27165.1 |
CCDSi | CCDS25128.1 |
RefSeqi | NP_742145.1, NM_172133.1 |
Genome annotation databases
Ensembli | ENSMUST00000021050; ENSMUSP00000021050; ENSMUSG00000020709 |
GeneIDi | 216991 |
KEGGi | mmu:216991 |
UCSCi | uc007klk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC027165 mRNA Translation: AAH27165.1 |
CCDSi | CCDS25128.1 |
RefSeqi | NP_742145.1, NM_172133.1 |
3D structure databases
SMRi | Q8R2V5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229830, 1 interactor |
STRINGi | 10090.ENSMUSP00000021050 |
PTM databases
iPTMneti | Q8R2V5 |
PhosphoSitePlusi | Q8R2V5 |
Proteomic databases
EPDi | Q8R2V5 |
MaxQBi | Q8R2V5 |
PaxDbi | Q8R2V5 |
PRIDEi | Q8R2V5 |
ProteomicsDBi | 296061 |
Protocols and materials databases
Antibodypediai | 26908, 179 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021050; ENSMUSP00000021050; ENSMUSG00000020709 |
GeneIDi | 216991 |
KEGGi | mmu:216991 |
UCSCi | uc007klk.1, mouse |
Organism-specific databases
CTDi | 55803 |
MGIi | MGI:2663075, Adap2 |
Phylogenomic databases
eggNOGi | KOG0703, Eukaryota |
GeneTreei | ENSGT00940000156498 |
HOGENOMi | CLU_061583_0_0_1 |
InParanoidi | Q8R2V5 |
OMAi | DFWENDL |
OrthoDBi | 1274375at2759 |
TreeFami | TF324540 |
Miscellaneous databases
BioGRID-ORCSi | 216991, 3 hits in 52 CRISPR screens |
ChiTaRSi | Adap2, mouse |
PROi | PR:Q8R2V5 |
RNActi | Q8R2V5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020709, Expressed in bone marrow macrophage and 168 other tissues |
ExpressionAtlasi | Q8R2V5, baseline and differential |
Genevisiblei | Q8R2V5, MM |
Family and domain databases
CDDi | cd13252, PH1_ADAP, 1 hit cd01251, PH2_ADAP, 1 hit |
Gene3Di | 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR011993, PH-like_dom_sf IPR037849, PH1_ADAP IPR037851, PH2_ADAP IPR001849, PH_domain |
Pfami | View protein in Pfam PF01412, ArfGap, 1 hit PF00169, PH, 2 hits |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAP2_MOUSE | |
Accessioni | Q8R2V5Primary (citable) accession number: Q8R2V5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot