Adap2

Functionⁱ

GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity).By similarityCurated

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	25 – 48	C4-typePROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

1-phosphatidylinositol binding Source: MGI
GTPase activator activity Source: UniProtKB-KW
inositol 1,3,4,5 tetrakisphosphate binding Source: UniProtKB
metal ion binding Source: UniProtKB-KW
phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

heart development
Source: UniProtKB
Non-traceable author statementⁱ
- 16138909
inositol lipid-mediated signaling Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arf-GAP with dual PH domain-containing protein 2 Alternative name(s): Centaurin-alpha-2 Short name: Cnt-a2
Gene namesⁱ	Name:Adap2 Synonyms:Centa2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:2663075 Adap2

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000074207	1 – 381	Arf-GAP with dual PH domain-containing protein 2Add BLAST		381

Proteomic databases

EPDⁱ	Q8R2V5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R2V5
PaxDbⁱ	Q8R2V5
PRIDEⁱ	Q8R2V5

PTM databases

iPTMnetⁱ	Q8R2V5
PhosphoSitePlusⁱ	Q8R2V5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020709 Expressed in 147 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasⁱ	Q8R2V5 baseline and differential
Genevisibleⁱ	Q8R2V5 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000021050

STRINGⁱ

10090.ENSMUSP00000021050

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R2V5
SMRⁱ	Q8R2V5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	9 – 132	Arf-GAPPROSITE-ProRule annotationAdd BLAST	124
Domainⁱ	132 – 233	PH 1PROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	255 – 361	PH 2PROSITE-ProRule annotationAdd BLAST	107

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	25 – 48	C4-typePROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0703 Eukaryota COG5347 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140892
HOVERGENⁱ	HBG050888
InParanoidⁱ	Q8R2V5
OMAⁱ	FICLNCC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0789
TreeFamⁱ	TF324540

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13252 PH1_ADAP, 1 hit cd01251 PH2_ADAP, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR011993 PH-like_dom_sf IPR037849 PH1_ADAP IPR037851 PH2_ADAP IPR001849 PH_domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit PF00169 PH, 2 hits
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8R2V5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGDRERNKKR LLELLQAAGT GNGHCADCGA ADPDWASYKL GIFICLHCSG 
        60         70         80         90        100
VHRNFPDISK VKSVRLDFWD DSMVEFMTHH GNLNVKAKFE ARVPAFYYVP 
       110        120        130        140        150
QANDCLVLKE QWIRAKYERQ EFTAIDKAVS HPGNREGFLW KRGRDNAQFL 
       160        170        180        190        200
RRRFVLLSRE GLLKYYTKEE GKAPKAVISI KDLNATFQTE KIGHPHGLQI 
       210        220        230        240        250
TYRKEGHTRN LFVYHDSGKE IVDWFNALRA ARLQYLKLAF PDLPESELVP 
       260        270        280        290        300
LITRNYLKQG FMEKTGPKHR EPFKKRWFAL DPQERRLLYY KNPLDAFELG 
       310        320        330        340        350
QVFLGSNEQG YEVWEDLPKG IRGNRWKAGL TVITPERKFI FTCPTEKEQR 
       360        370        380 
EWLESLRGVL SSPLSPLHLL TTSAETGCGL G

Length:381

Mass (Da):43,989

Last modified:June 1, 2002 - v1

Checksum:ⁱ2E504CEF0ACD84D5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9QAL8	E9QAL8_MOUSE		Arf-GAP with dual PH domain-contain... Arf-GAP with dual PH domain-containing protein 2	Adap2	133	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC027165 mRNA Translation: AAH27165.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25128.1
NCBI Reference Sequences More...RefSeqⁱ	NP_742145.1, NM_172133.1
UniGeneⁱ	Mm.341520

Genome annotation databases

Ensemblⁱ	ENSMUST00000021050; ENSMUSP00000021050; ENSMUSG00000020709
GeneIDⁱ	216991
KEGGⁱ	mmu:216991
UCSC genome browser More...UCSCⁱ	uc007klk.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R2V5	Centaurin, alpha 2		MOUSE		381	UniRef100_Q8R2V5

Protein	Similar proteins		Species	Score	Length	Source
Q8R2V5	Arf-GAP with dual PH domain-containing protein 2		RAT		376	UniRef90_Q9JK15
arf-GAP with dual PH domain-containing protein 2 isoform X1		MESAU		434
Uncharacterized protein		MOUSE		382
UPI000A306ED9		MUSPA		382
UPI00038BB9BF		MICOH		381
+10

Protein	Similar proteins		Species	Score	Length	Source
Q8R2V5	Arf-GAP with dual PH domain-containing protein 2		RAT		376	UniRef50_Q9JK15
arf-GAP with dual PH domain-containing protein 2 isoform X1		MESAU		434
Uncharacterized protein		MOUSE		382
Arf-GAP with dual PH domain-containing protein 2 (Fragment)		NEOVI		325
Uncharacterized protein		BOVIN		383
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC027165 mRNA Translation: AAH27165.1
CCDSⁱ	CCDS25128.1
RefSeqⁱ	NP_742145.1, NM_172133.1
UniGeneⁱ	Mm.341520

3D structure databases

ProteinModelPortalⁱ	Q8R2V5
SMRⁱ	Q8R2V5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000021050

STRINGⁱ

10090.ENSMUSP00000021050

PTM databases

iPTMnetⁱ	Q8R2V5
PhosphoSitePlusⁱ	Q8R2V5

Proteomic databases

EPDⁱ	Q8R2V5
MaxQBⁱ	Q8R2V5
PaxDbⁱ	Q8R2V5
PRIDEⁱ	Q8R2V5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021050; ENSMUSP00000021050; ENSMUSG00000020709
GeneIDⁱ	216991
KEGGⁱ	mmu:216991
UCSCⁱ	uc007klk.1 mouse

Organism-specific databases

CTDⁱ	55803
MGIⁱ	MGI:2663075 Adap2

Phylogenomic databases

eggNOGⁱ	KOG0703 Eukaryota COG5347 LUCA
GeneTreeⁱ	ENSGT00900000140892
HOVERGENⁱ	HBG050888
InParanoidⁱ	Q8R2V5
OMAⁱ	FICLNCC
OrthoDBⁱ	EOG091G0789
TreeFamⁱ	TF324540

Miscellaneous databases

ChiTaRSⁱ	Adap2 mouse
Protein Ontology More...PROⁱ	PR:Q8R2V5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020709 Expressed in 147 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasⁱ	Q8R2V5 baseline and differential
Genevisibleⁱ	Q8R2V5 MM

Family and domain databases

CDDⁱ	cd13252 PH1_ADAP, 1 hit cd01251 PH2_ADAP, 1 hit
Gene3Dⁱ	2.30.29.30, 2 hits 3.30.40.160, 1 hit
InterProⁱ	View protein in InterPro IPR037278 ARFGAP/RecO IPR001164 ArfGAP_dom IPR038508 ArfGAP_dom_sf IPR011993 PH-like_dom_sf IPR037849 PH1_ADAP IPR037851 PH2_ADAP IPR001849 PH_domain
Pfamⁱ	View protein in Pfam PF01412 ArfGap, 1 hit PF00169 PH, 2 hits
PRINTSⁱ	PR00405 REVINTRACTNG
SMARTⁱ	View protein in SMART SM00105 ArfGap, 1 hit SM00233 PH, 2 hits
SUPFAMⁱ	SSF57863 SSF57863, 1 hit
PROSITEⁱ	View protein in PROSITE PS50115 ARFGAP, 1 hit PS50003 PH_DOMAIN, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADAP2_MOUSE
Accessionⁱ	Q8R2V5Primary (citable) accession number: Q8R2V5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R2V5 (ADAP2_MOUSE)

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Arf-GAP with dual PH domain-containing protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Mitochondrion

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ