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Protein

General transcription factor 3C polypeptide 5

Gene

Gtf3c5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • RNA polymerase III preinitiation complex assembly Source: GOC
  • skeletal muscle cell differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 5
Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name:
TFIIIC 63 kDa subunit
Short name:
TFIIIC63
Transcription factor IIIC subunit epsilon
Gene namesi
Name:Gtf3c5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917489 Gtf3c5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002097162 – 520General transcription factor 3C polypeptide 5Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8R2T8
PRIDEiQ8R2T8

PTM databases

iPTMnetiQ8R2T8
PhosphoSitePlusiQ8R2T8

Expressioni

Gene expression databases

BgeeiENSMUSG00000026816 Expressed in 260 organ(s), highest expression level in pancreas
CleanExiMM_GTF3C5
ExpressionAtlasiQ8R2T8 baseline and differential
GenevisibleiQ8R2T8 MM

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP (By similarity).By similarity

Protein-protein interaction databases

BioGridi213934, 1 interactor
STRINGi10090.ENSMUSP00000028157

Structurei

3D structure databases

ProteinModelPortaliQ8R2T8
SMRiQ8R2T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 96Poly-Arg10
Compositional biasi478 – 515Glu-richAdd BLAST38
Compositional biasi486 – 500Poly-GluAdd BLAST15

Sequence similaritiesi

Belongs to the TFIIIC subunit 5 family.Curated

Phylogenomic databases

eggNOGiKOG2473 Eukaryota
ENOG4111DXH LUCA
GeneTreeiENSGT00390000004458
HOGENOMiHOG000220825
HOVERGENiHBG058445
InParanoidiQ8R2T8
KOiK15202
OMAiAVCNERT
OrthoDBiEOG091G0990
PhylomeDBiQ8R2T8
TreeFamiTF313581

Family and domain databases

InterProiView protein in InterPro
IPR019136 TF_IIIC_su-5
PANTHERiPTHR13230 PTHR13230, 1 hit
PfamiView protein in Pfam
PF09734 Tau95, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R2T8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS
60 70 80 90 100
RIYTDPTKRL ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG
110 120 130 140 150
DEAHPQVTFN LEIIGIISTI YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL
160 170 180 190 200
MRKPEKEEFF HQELPLYIPP PIFSRLDTPV DYFYRPETQH REGYHNPTIS
210 220 230 240 250
GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK ACTNPIDQKV
260 270 280 290 300
EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW
310 320 330 340 350
IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP
360 370 380 390 400
ITVKKTSNQP GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL
410 420 430 440 450
PPYRQMFYQL CDLNVEELQK IVHRNDGTET VCTERDGWCL PKTTDHLRDT
460 470 480 490 500
MSLMILQTIR SERPALFSNT GKADRGKEQL MFESGEEEEE EEEEEEEEEE
510 520
DFKPSDGSEN EMETEILDYV
Length:520
Mass (Da):60,502
Last modified:May 24, 2004 - v2
Checksum:i02687D323638FD0B
GO
Isoform 2 (identifier: Q8R2T8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-470: Missing.

Note: No experimental confirmation available.
Show »
Length:514
Mass (Da):59,868
Checksum:i39806677F99F4765
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJX5H3BJX5_MOUSE
General transcription factor 3C pol...
Gtf3c5
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145M → T in AAH27247 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010356465 – 470Missing in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027055 mRNA Translation: AAH27055.1
BC027247 mRNA Translation: AAH27247.1
BC039171 mRNA Translation: AAH39171.1
AK045419 mRNA Translation: BAC32354.1
CCDSiCCDS15842.1 [Q8R2T8-2]
CCDS71012.1 [Q8R2T8-1]
RefSeqiNP_001277413.1, NM_001290484.1 [Q8R2T8-1]
NP_683730.1, NM_148928.3 [Q8R2T8-2]
UniGeneiMm.274120

Genome annotation databases

EnsembliENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816 [Q8R2T8-2]
ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816 [Q8R2T8-1]
GeneIDi70239
KEGGimmu:70239
UCSCiuc012bsz.2 mouse [Q8R2T8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC027055 mRNA Translation: AAH27055.1
BC027247 mRNA Translation: AAH27247.1
BC039171 mRNA Translation: AAH39171.1
AK045419 mRNA Translation: BAC32354.1
CCDSiCCDS15842.1 [Q8R2T8-2]
CCDS71012.1 [Q8R2T8-1]
RefSeqiNP_001277413.1, NM_001290484.1 [Q8R2T8-1]
NP_683730.1, NM_148928.3 [Q8R2T8-2]
UniGeneiMm.274120

3D structure databases

ProteinModelPortaliQ8R2T8
SMRiQ8R2T8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213934, 1 interactor
STRINGi10090.ENSMUSP00000028157

PTM databases

iPTMnetiQ8R2T8
PhosphoSitePlusiQ8R2T8

Proteomic databases

PaxDbiQ8R2T8
PRIDEiQ8R2T8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816 [Q8R2T8-2]
ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816 [Q8R2T8-1]
GeneIDi70239
KEGGimmu:70239
UCSCiuc012bsz.2 mouse [Q8R2T8-1]

Organism-specific databases

CTDi9328
MGIiMGI:1917489 Gtf3c5

Phylogenomic databases

eggNOGiKOG2473 Eukaryota
ENOG4111DXH LUCA
GeneTreeiENSGT00390000004458
HOGENOMiHOG000220825
HOVERGENiHBG058445
InParanoidiQ8R2T8
KOiK15202
OMAiAVCNERT
OrthoDBiEOG091G0990
PhylomeDBiQ8R2T8
TreeFamiTF313581

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

PROiPR:Q8R2T8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026816 Expressed in 260 organ(s), highest expression level in pancreas
CleanExiMM_GTF3C5
ExpressionAtlasiQ8R2T8 baseline and differential
GenevisibleiQ8R2T8 MM

Family and domain databases

InterProiView protein in InterPro
IPR019136 TF_IIIC_su-5
PANTHERiPTHR13230 PTHR13230, 1 hit
PfamiView protein in Pfam
PF09734 Tau95, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C5_MOUSE
AccessioniPrimary (citable) accession number: Q8R2T8
Secondary accession number(s): Q8BLE3, Q8R0D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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