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Protein

Bone marrow stromal antigen 2

Gene

Bst2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.8 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Bone marrow stromal antigen 2
Short name:
BST-2
Alternative name(s):
HM1.24 antigen
CD_antigen: CD317
Gene namesi
Name:Bst2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916800 Bst2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini52 – 152ExtracellularSequence analysisAdd BLAST101

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535531 – 152Bone marrow stromal antigen 2Add BLAST152
PropeptideiPRO_0000253554153 – 172Removed in mature formSequence analysisAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58Interchain1 Publication
Disulfide bondi68Interchain1 Publication
Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi94N-linked (GlcNAc...) asparagine; atypical1 Publication1
Disulfide bondi96Interchain1 Publication
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi152GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ8R2Q8
MaxQBiQ8R2Q8
PaxDbiQ8R2Q8
PeptideAtlasiQ8R2Q8
PRIDEiQ8R2Q8

PTM databases

iPTMnetiQ8R2Q8
PhosphoSitePlusiQ8R2Q8
SwissPalmiQ8R2Q8

Expressioni

Tissue specificityi

In naive mice, specifically expressed on type I interferon-producing cells (at protein level).1 Publication

Inductioni

By viral or other interferon-inducing stimulation in most cell types (at protein level). Down-regulated by ebola virus GP protein.2 Publications

Gene expression databases

BgeeiENSMUSG00000046718 Expressed in 184 organ(s), highest expression level in left lobe of liver
CleanExiMM_BST2
GenevisibleiQ8R2Q8 MM

Interactioni

Subunit structurei

Parallel homodimer; disulfide-linked. May form homotetramers under reducing conditions. Dimerization is essential for its antiviral activity. Interacts (via cytoplasmic domain) with ARHGAP44 (By similarity). Interacts with MMP14 (via C-terminal cytoplasmic tail) (By similarity). Interacts with LILRA4/ILT7 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8R2Q8, 1 interactor
STRINGi10090.ENSMUSP00000051921

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8R2Q8
SMRiQ8R2Q8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R2Q8

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 1471 PublicationAdd BLAST74

Domaini

The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading.By similarity

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JE1U Eukaryota
ENOG41115GP LUCA
GeneTreeiENSGT00390000013782
HOGENOMiHOG000013084
HOVERGENiHBG004902
InParanoidiQ8R2Q8
KOiK06731
OMAiLNHKLQD
OrthoDBiEOG091G1B7U
PhylomeDBiQ8R2Q8
TreeFamiTF338345

Family and domain databases

InterProiView protein in InterPro
IPR024886 BST2
PANTHERiPTHR15190 PTHR15190, 1 hit
PfamiView protein in Pfam
PF16716 BST2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R2Q8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSFYHYLP VPMDEMGGKQ GWGSHRQWLG AAILVVLFGV TLVILTIYFA
60 70 80 90 100
VTANSVACRD GLRAQAECRN TTHLLQRQLT RTQDSLLQAE TQANSCNLTV
110 120 130 140 150
VTLQESLEKK VSQALEQQAR IKELENEVTK LNQELENLRI QKETSSTVQV
160 170
NSGSSMVVSS LLVLKVSLFL LF
Length:172
Mass (Da):19,152
Last modified:June 1, 2002 - v1
Checksum:iA2032FD01FAF601A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009361 mRNA Translation: BAC25254.1
AK154399 mRNA Translation: BAE32560.1
BC027328 mRNA Translation: AAH27328.1
BC056638 mRNA Translation: AAH56638.1
BC087949 mRNA Translation: AAH87949.1
CCDSiCCDS22397.1
RefSeqiNP_932763.1, NM_198095.2
UniGeneiMm.260325

Genome annotation databases

EnsembliENSMUST00000051672; ENSMUSP00000051921; ENSMUSG00000046718
GeneIDi69550
KEGGimmu:69550
UCSCiuc009mdr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009361 mRNA Translation: BAC25254.1
AK154399 mRNA Translation: BAE32560.1
BC027328 mRNA Translation: AAH27328.1
BC056638 mRNA Translation: AAH56638.1
BC087949 mRNA Translation: AAH87949.1
CCDSiCCDS22397.1
RefSeqiNP_932763.1, NM_198095.2
UniGeneiMm.260325

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NI0X-ray1.60A/B53-151[»]
ProteinModelPortaliQ8R2Q8
SMRiQ8R2Q8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R2Q8, 1 interactor
STRINGi10090.ENSMUSP00000051921

PTM databases

iPTMnetiQ8R2Q8
PhosphoSitePlusiQ8R2Q8
SwissPalmiQ8R2Q8

Proteomic databases

EPDiQ8R2Q8
MaxQBiQ8R2Q8
PaxDbiQ8R2Q8
PeptideAtlasiQ8R2Q8
PRIDEiQ8R2Q8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051672; ENSMUSP00000051921; ENSMUSG00000046718
GeneIDi69550
KEGGimmu:69550
UCSCiuc009mdr.1 mouse

Organism-specific databases

CTDi684
MGIiMGI:1916800 Bst2

Phylogenomic databases

eggNOGiENOG410JE1U Eukaryota
ENOG41115GP LUCA
GeneTreeiENSGT00390000013782
HOGENOMiHOG000013084
HOVERGENiHBG004902
InParanoidiQ8R2Q8
KOiK06731
OMAiLNHKLQD
OrthoDBiEOG091G1B7U
PhylomeDBiQ8R2Q8
TreeFamiTF338345

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiBst2 mouse
EvolutionaryTraceiQ8R2Q8
PROiPR:Q8R2Q8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046718 Expressed in 184 organ(s), highest expression level in left lobe of liver
CleanExiMM_BST2
GenevisibleiQ8R2Q8 MM

Family and domain databases

InterProiView protein in InterPro
IPR024886 BST2
PANTHERiPTHR15190 PTHR15190, 1 hit
PfamiView protein in Pfam
PF16716 BST2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBST2_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Q8
Secondary accession number(s): Q8CEY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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