UniProtKB - Q8R2Q6 (TECT3_MOUSE)
Protein
Tectonic-3
Gene
Tctn3
Organism
Mus musculus (Mouse)
Status
Functioni
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.By similarity1 Publication
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cilium assembly Source: UniProtKB
- positive regulation of apoptotic process Source: MGI
- smoothened signaling pathway Source: MGI
Keywordsi
Biological process | Apoptosis, Cilium biogenesis/degradation |
Enzyme and pathway databases
Reactomei | R-MMU-5620912, Anchoring of the basal body to the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Tectonic-3 |
Gene namesi | Name:Tctn3 Synonyms:Tect3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914840, Tctn3 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Nucleus
- nucleus Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 575 | ExtracellularSequence analysisAdd BLAST | 553 | |
Transmembranei | 576 – 594 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 595 | CytoplasmicSequence analysis | 1 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000229802 | 23 – 595 | Tectonic-3Add BLAST | 573 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 167 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 336 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8R2Q6 |
PRIDEi | Q8R2Q6 |
PTM databases
GlyGeni | Q8R2Q6, 2 sites |
iPTMneti | Q8R2Q6 |
PhosphoSitePlusi | Q8R2Q6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000025008, Expressed in spermatocyte and 258 other tissues |
ExpressionAtlasi | Q8R2Q6, baseline and differential |
Genevisiblei | Q8R2Q6, MM |
Interactioni
Subunit structurei
Part of the tectonic-like complex (also named B9 complex).
1 PublicationProtein-protein interaction databases
BioGRIDi | 212298, 1 interactor |
CORUMi | Q8R2Q6 |
IntActi | Q8R2Q6, 2 interactors |
STRINGi | 10090.ENSMUSP00000025981 |
Miscellaneous databases
RNActi | Q8R2Q6, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 78 – 97 | Cys-richAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the tectonic family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RKDI, Eukaryota |
GeneTreei | ENSGT00570000079101 |
HOGENOMi | CLU_016974_1_0_1 |
InParanoidi | Q8R2Q6 |
OMAi | CPMRTPQ |
OrthoDBi | 446525at2759 |
PhylomeDBi | Q8R2Q6 |
TreeFami | TF329169 |
Family and domain databases
InterProi | View protein in InterPro IPR011677, DUF1619 IPR040354, Tectonic |
PANTHERi | PTHR14611, PTHR14611, 1 hit |
Pfami | View protein in Pfam PF07773, DUF1619, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8R2Q6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCTLQLHLLL LVVLMLSETA RPQPSSTARA FPTSWGLEPV TPEVPTSAPP
60 70 80 90 100
DSSESPTPWT LSMPVNATTD PFPALPICVC DLTPGTCDLN CCCDKDCDLL
110 120 130 140 150
HPRTVFSFCL PGSVRSSSWV CVDNSLMFRS NSPFPSRVFT DSSGTTQFCV
160 170 180 190 200
RVNNSKANYF QKLQTVNATN FQALAAEFGG QSFPSMPPET QPPVLFYRAG
210 220 230 240 250
DPILTYYPSW SVVSLLRQPA AVGAGGLCAE SNPAGFLESK STTCPRFFRD
260 270 280 290 300
LASSCTSEPA LDAASYYNFR VLKVPRGVTD LQNMKFQVPV TLASQASPPL
310 320 330 340 350
LAGNTCQNIV SQVVYEIETN GTFGIQKVSV SFRQTNLTVK PGVSLQQDFI
360 370 380 390 400
VHFRAFQQRK AAAPAAPRSG NPGYLTGKPL LVLTGDTSHS MTLLQSEGNG
410 420 430 440 450
LCSAKRHAVQ FGVNAVSGCQ LRPREVNCSH LQEEVYQTLH GRPRPEHVAV
460 470 480 490 500
FGNADPAQRG GWTRILSRDC SVSAVNCTSC CLIPVSLEIQ VLWAHLGLQS
510 520 530 540 550
NPQAHVAGAR FLYQCKSVQE HQRGIEVSLT TLVNFVDITQ KPEPPRDQPR
560 570 580 590
IDWKLPFDFF FPFKAALSRG ASVQKDSLVL ILCVLLLGLL NSQTK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J1W4 | A0A0R4J1W4_MOUSE | Tectonic-3 | Tctn3 | 393 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017767 | 355 – 392 | AFQQR…SHSMT → VSSLPSERVQRLSPRNSTLQ SQYPHCLSVCLSEYLLFL in isoform 3. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_017768 | 393 – 595 | Missing in isoform 3. 1 PublicationAdd BLAST | 203 | |
Alternative sequenceiVSP_017769 | 474 – 492 | AVNCT…EIQVL → VRKEATTAWWLVFHLCNYA in isoform 2. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_017770 | 493 – 595 | Missing in isoform 2. 1 PublicationAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ278871 mRNA Translation: ABB90563.1 AK015861 mRNA Translation: BAB30004.1 AK016982 mRNA Translation: BAB30537.1 AK030156 mRNA Translation: BAC26813.1 BC027335 mRNA Translation: AAH27335.1 BC080805 mRNA Translation: AAH80805.1 |
CCDSi | CCDS29804.1 [Q8R2Q6-1] |
RefSeqi | NP_080536.2, NM_026260.2 [Q8R2Q6-1] |
Genome annotation databases
Ensembli | ENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008 [Q8R2Q6-1] ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008 [Q8R2Q6-2] |
GeneIDi | 67590 |
KEGGi | mmu:67590 |
UCSCi | uc008hla.1, mouse [Q8R2Q6-1] uc008hlb.1, mouse [Q8R2Q6-2] uc008hlc.1, mouse [Q8R2Q6-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ278871 mRNA Translation: ABB90563.1 AK015861 mRNA Translation: BAB30004.1 AK016982 mRNA Translation: BAB30537.1 AK030156 mRNA Translation: BAC26813.1 BC027335 mRNA Translation: AAH27335.1 BC080805 mRNA Translation: AAH80805.1 |
CCDSi | CCDS29804.1 [Q8R2Q6-1] |
RefSeqi | NP_080536.2, NM_026260.2 [Q8R2Q6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 212298, 1 interactor |
CORUMi | Q8R2Q6 |
IntActi | Q8R2Q6, 2 interactors |
STRINGi | 10090.ENSMUSP00000025981 |
PTM databases
GlyGeni | Q8R2Q6, 2 sites |
iPTMneti | Q8R2Q6 |
PhosphoSitePlusi | Q8R2Q6 |
Proteomic databases
PaxDbi | Q8R2Q6 |
PRIDEi | Q8R2Q6 |
Protocols and materials databases
Antibodypediai | 30655, 193 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008 [Q8R2Q6-1] ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008 [Q8R2Q6-2] |
GeneIDi | 67590 |
KEGGi | mmu:67590 |
UCSCi | uc008hla.1, mouse [Q8R2Q6-1] uc008hlb.1, mouse [Q8R2Q6-2] uc008hlc.1, mouse [Q8R2Q6-3] |
Organism-specific databases
CTDi | 26123 |
MGIi | MGI:1914840, Tctn3 |
Phylogenomic databases
eggNOGi | ENOG502RKDI, Eukaryota |
GeneTreei | ENSGT00570000079101 |
HOGENOMi | CLU_016974_1_0_1 |
InParanoidi | Q8R2Q6 |
OMAi | CPMRTPQ |
OrthoDBi | 446525at2759 |
PhylomeDBi | Q8R2Q6 |
TreeFami | TF329169 |
Enzyme and pathway databases
Reactomei | R-MMU-5620912, Anchoring of the basal body to the plasma membrane |
Miscellaneous databases
BioGRID-ORCSi | 67590, 2 hits in 17 CRISPR screens |
ChiTaRSi | Tctn3, mouse |
PROi | PR:Q8R2Q6 |
RNActi | Q8R2Q6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025008, Expressed in spermatocyte and 258 other tissues |
ExpressionAtlasi | Q8R2Q6, baseline and differential |
Genevisiblei | Q8R2Q6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011677, DUF1619 IPR040354, Tectonic |
PANTHERi | PTHR14611, PTHR14611, 1 hit |
Pfami | View protein in Pfam PF07773, DUF1619, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TECT3_MOUSE | |
Accessioni | Q8R2Q6Primary (citable) accession number: Q8R2Q6 Secondary accession number(s): Q8CDF3, Q9CRC5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families