Tctn3

Functionⁱ

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.By similarity1 Publication

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cilium assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21725307
positive regulation of apoptotic process Source: MGI
smoothened signaling pathway Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Cilium biogenesis/degradation

Biological process

Apoptosis, Cilium biogenesis/degradation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5620912 Anchoring of the basal body to the plasma membrane

Reactomeⁱ

R-MMU-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tectonic-3
Gene namesⁱ	Name:Tctn3 Synonyms:Tect3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1914840 Tctn3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 575	ExtracellularSequence analysisAdd BLAST	553
Transmembraneⁱ	576 – 594	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	595	CytoplasmicSequence analysis	1

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000229802	23 – 595	Tectonic-3Add BLAST		573

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	167	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	336	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8R2Q6
PRIDEⁱ	Q8R2Q6

PTM databases

iPTMnetⁱ	Q8R2Q6
PhosphoSitePlusⁱ	Q8R2Q6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000025008 Expressed in 239 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)
CleanExⁱ	MM_TCTN3
ExpressionAtlasⁱ	Q8R2Q6 baseline and differential
Genevisibleⁱ	Q8R2Q6 MM

Interactionⁱ

Subunit structureⁱ

Part of the tectonic-like complex (also named B9 complex).1 Publication

Protein-protein interaction databases

BioGridⁱ	212298, 1 interactor
CORUMⁱ	Q8R2Q6
IntActⁱ	Q8R2Q6, 2 interactors
STRINGⁱ	10090.ENSMUSP00000025981

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R2Q6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	78 – 97	Cys-richAdd BLAST		20

Sequence similaritiesⁱ

Belongs to the tectonic family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFR0 Eukaryota ENOG4111GX2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00570000079101
HOGENOMⁱ	HOG000070061
HOVERGENⁱ	HBG094032
InParanoidⁱ	Q8R2Q6
KEGG Orthology (KO) More...KOⁱ	K19382
OMAⁱ	FRAFQQS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03CX
PhylomeDBⁱ	Q8R2Q6
TreeFamⁱ	TF329169

Family and domain databases

InterProⁱ	View protein in InterPro IPR011677 DUF1619
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07773 DUF1619, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8R2Q6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCTLQLHLLL LVVLMLSETA RPQPSSTARA FPTSWGLEPV TPEVPTSAPP 
        60         70         80         90        100
DSSESPTPWT LSMPVNATTD PFPALPICVC DLTPGTCDLN CCCDKDCDLL 
       110        120        130        140        150
HPRTVFSFCL PGSVRSSSWV CVDNSLMFRS NSPFPSRVFT DSSGTTQFCV 
       160        170        180        190        200
RVNNSKANYF QKLQTVNATN FQALAAEFGG QSFPSMPPET QPPVLFYRAG 
       210        220        230        240        250
DPILTYYPSW SVVSLLRQPA AVGAGGLCAE SNPAGFLESK STTCPRFFRD 
       260        270        280        290        300
LASSCTSEPA LDAASYYNFR VLKVPRGVTD LQNMKFQVPV TLASQASPPL 
       310        320        330        340        350
LAGNTCQNIV SQVVYEIETN GTFGIQKVSV SFRQTNLTVK PGVSLQQDFI 
       360        370        380        390        400
VHFRAFQQRK AAAPAAPRSG NPGYLTGKPL LVLTGDTSHS MTLLQSEGNG 
       410        420        430        440        450
LCSAKRHAVQ FGVNAVSGCQ LRPREVNCSH LQEEVYQTLH GRPRPEHVAV 
       460        470        480        490        500
FGNADPAQRG GWTRILSRDC SVSAVNCTSC CLIPVSLEIQ VLWAHLGLQS 
       510        520        530        540        550
NPQAHVAGAR FLYQCKSVQE HQRGIEVSLT TLVNFVDITQ KPEPPRDQPR 
       560        570        580        590 
IDWKLPFDFF FPFKAALSRG ASVQKDSLVL ILCVLLLGLL NSQTK

Length:595

Mass (Da):64,824

Last modified:June 1, 2002 - v1

Checksum:ⁱB317AF1E20F4CDF1

GO

Isoform 2 (identifier: Q8R2Q6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
474-492: AVNCTSCCLIPVSLEIQVL → VRKEATTAWWLVFHLCNYA
493-595: Missing.

« Hide

        10         20         30         40         50
MCTLQLHLLL LVVLMLSETA RPQPSSTARA FPTSWGLEPV TPEVPTSAPP 
        60         70         80         90        100
DSSESPTPWT LSMPVNATTD PFPALPICVC DLTPGTCDLN CCCDKDCDLL 
       110        120        130        140        150
HPRTVFSFCL PGSVRSSSWV CVDNSLMFRS NSPFPSRVFT DSSGTTQFCV 
       160        170        180        190        200
RVNNSKANYF QKLQTVNATN FQALAAEFGG QSFPSMPPET QPPVLFYRAG 
       210        220        230        240        250
DPILTYYPSW SVVSLLRQPA AVGAGGLCAE SNPAGFLESK STTCPRFFRD 
       260        270        280        290        300
LASSCTSEPA LDAASYYNFR VLKVPRGVTD LQNMKFQVPV TLASQASPPL 
       310        320        330        340        350
LAGNTCQNIV SQVVYEIETN GTFGIQKVSV SFRQTNLTVK PGVSLQQDFI 
       360        370        380        390        400
VHFRAFQQRK AAAPAAPRSG NPGYLTGKPL LVLTGDTSHS MTLLQSEGNG 
       410        420        430        440        450
LCSAKRHAVQ FGVNAVSGCQ LRPREVNCSH LQEEVYQTLH GRPRPEHVAV 
       460        470        480        490 
FGNADPAQRG GWTRILSRDC SVSVRKEATT AWWLVFHLCN YA

Note: No experimental confirmation available.

Show »

Length:492

Mass (Da):53,516

Checksum:ⁱ02EC9F6914E2B929

GO

Isoform 3 (identifier: Q8R2Q6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
355-392: AFQQRKAAAP...LTGDTSHSMT → VSSLPSERVQ...VCLSEYLLFL
393-595: Missing.

« Hide

        10         20         30         40         50
MCTLQLHLLL LVVLMLSETA RPQPSSTARA FPTSWGLEPV TPEVPTSAPP 
        60         70         80         90        100
DSSESPTPWT LSMPVNATTD PFPALPICVC DLTPGTCDLN CCCDKDCDLL 
       110        120        130        140        150
HPRTVFSFCL PGSVRSSSWV CVDNSLMFRS NSPFPSRVFT DSSGTTQFCV 
       160        170        180        190        200
RVNNSKANYF QKLQTVNATN FQALAAEFGG QSFPSMPPET QPPVLFYRAG 
       210        220        230        240        250
DPILTYYPSW SVVSLLRQPA AVGAGGLCAE SNPAGFLESK STTCPRFFRD 
       260        270        280        290        300
LASSCTSEPA LDAASYYNFR VLKVPRGVTD LQNMKFQVPV TLASQASPPL 
       310        320        330        340        350
LAGNTCQNIV SQVVYEIETN GTFGIQKVSV SFRQTNLTVK PGVSLQQDFI 
       360        370        380        390 
VHFRVSSLPS ERVQRLSPRN STLQSQYPHC LSVCLSEYLL FL

Note: No experimental confirmation available.

Show »

Length:392

Mass (Da):42,801

Checksum:ⁱ351EFB18E48406D4

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0R4J1W4	A0A0R4J1W4_MOUSE		Tectonic-3 Tectonic-3	Tctn3	393	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_017767	355 – 392	AFQQR…SHSMT → VSSLPSERVQRLSPRNSTLQ SQYPHCLSVCLSEYLLFL in isoform 3. 1 PublicationAdd BLAST	38
Alternative sequenceⁱVSP_017768	393 – 595	Missing in isoform 3. 1 PublicationAdd BLAST	203
Alternative sequenceⁱVSP_017769	474 – 492	AVNCT…EIQVL → VRKEATTAWWLVFHLCNYA in isoform 2. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_017770	493 – 595	Missing in isoform 2. 1 PublicationAdd BLAST	103

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ278871 mRNA Translation: ABB90563.1 AK015861 mRNA Translation: BAB30004.1 AK016982 mRNA Translation: BAB30537.1 AK030156 mRNA Translation: BAC26813.1 BC027335 mRNA Translation: AAH27335.1 BC080805 mRNA Translation: AAH80805.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29804.1 [Q8R2Q6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_080536.2, NM_026260.2 [Q8R2Q6-1]
UniGeneⁱ	Mm.60758

Genome annotation databases

Ensemblⁱ	ENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008 [Q8R2Q6-1] ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008 [Q8R2Q6-2]
GeneIDⁱ	67590
KEGGⁱ	mmu:67590
UCSC genome browser More...UCSCⁱ	uc008hla.1 mouse [Q8R2Q6-1] uc008hlb.1 mouse [Q8R2Q6-2] uc008hlc.1 mouse [Q8R2Q6-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R2Q6-3	Tectonic-3		MOUSE		393	UniRef90_A0A0R4J1W4

Protein	Similar proteins		Species	Score	Length	Source
Q8R2Q6	Tectonic-3		HUMAN		607	UniRef50_Q6NUS6
Tectonic-3		MACFA		608
Tectonic family member 3		GORGO		625
Uncharacterized protein (Fragment)		MACMU		625
Uncharacterized protein		CERAT		624
+218
Q8R2Q6-3	Tectonic-3		MOUSE		393	UniRef50_A0A0R4J1W4
TCTN3 isoform 4		PANTR		362

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ278871 mRNA Translation: ABB90563.1 AK015861 mRNA Translation: BAB30004.1 AK016982 mRNA Translation: BAB30537.1 AK030156 mRNA Translation: BAC26813.1 BC027335 mRNA Translation: AAH27335.1 BC080805 mRNA Translation: AAH80805.1
CCDSⁱ	CCDS29804.1 [Q8R2Q6-1]
RefSeqⁱ	NP_080536.2, NM_026260.2 [Q8R2Q6-1]
UniGeneⁱ	Mm.60758

3D structure databases

ProteinModelPortalⁱ	Q8R2Q6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	212298, 1 interactor
CORUMⁱ	Q8R2Q6
IntActⁱ	Q8R2Q6, 2 interactors
STRINGⁱ	10090.ENSMUSP00000025981

PTM databases

iPTMnetⁱ	Q8R2Q6
PhosphoSitePlusⁱ	Q8R2Q6

Proteomic databases

PaxDbⁱ	Q8R2Q6
PRIDEⁱ	Q8R2Q6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008 [Q8R2Q6-1] ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008 [Q8R2Q6-2]
GeneIDⁱ	67590
KEGGⁱ	mmu:67590
UCSCⁱ	uc008hla.1 mouse [Q8R2Q6-1] uc008hlb.1 mouse [Q8R2Q6-2] uc008hlc.1 mouse [Q8R2Q6-3]

Organism-specific databases

CTDⁱ	26123
MGIⁱ	MGI:1914840 Tctn3

Phylogenomic databases

eggNOGⁱ	ENOG410IFR0 Eukaryota ENOG4111GX2 LUCA
GeneTreeⁱ	ENSGT00570000079101
HOGENOMⁱ	HOG000070061
HOVERGENⁱ	HBG094032
InParanoidⁱ	Q8R2Q6
KOⁱ	K19382
OMAⁱ	FRAFQQS
OrthoDBⁱ	EOG091G03CX
PhylomeDBⁱ	Q8R2Q6
TreeFamⁱ	TF329169

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5620912 Anchoring of the basal body to the plasma membrane

Reactomeⁱ

R-MMU-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8R2Q6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025008 Expressed in 239 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)
CleanExⁱ	MM_TCTN3
ExpressionAtlasⁱ	Q8R2Q6 baseline and differential
Genevisibleⁱ	Q8R2Q6 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011677 DUF1619
Pfamⁱ	View protein in Pfam PF07773 DUF1619, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TECT3_MOUSE
Accessionⁱ	Q8R2Q6Primary (citable) accession number: Q8R2Q6 Secondary accession number(s): Q8CDF3, Q9CRC5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R2Q6 (TECT3_MOUSE)

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Tectonic-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ