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Protein

Tectonic-3

Gene

Tctn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.By similarity1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cilium assembly Source: UniProtKB
  • positive regulation of apoptotic process Source: MGI
  • smoothened signaling pathway Source: MGI

Keywordsi

Biological processApoptosis, Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Tectonic-3
Gene namesi
Name:Tctn3
Synonyms:Tect3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914840 Tctn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 575ExtracellularSequence analysisAdd BLAST553
Transmembranei576 – 594HelicalSequence analysisAdd BLAST19
Topological domaini595CytoplasmicSequence analysis1

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000022980223 – 595Tectonic-3Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R2Q6
PRIDEiQ8R2Q6

PTM databases

iPTMnetiQ8R2Q6
PhosphoSitePlusiQ8R2Q6

Expressioni

Gene expression databases

BgeeiENSMUSG00000025008 Expressed in 239 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)
CleanExiMM_TCTN3
ExpressionAtlasiQ8R2Q6 baseline and differential
GenevisibleiQ8R2Q6 MM

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex).1 Publication

Protein-protein interaction databases

BioGridi212298, 1 interactor
CORUMiQ8R2Q6
IntActiQ8R2Q6, 2 interactors
STRINGi10090.ENSMUSP00000025981

Structurei

3D structure databases

ProteinModelPortaliQ8R2Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 97Cys-richAdd BLAST20

Sequence similaritiesi

Belongs to the tectonic family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFR0 Eukaryota
ENOG4111GX2 LUCA
GeneTreeiENSGT00570000079101
HOGENOMiHOG000070061
HOVERGENiHBG094032
InParanoidiQ8R2Q6
KOiK19382
OMAiFRAFQQS
OrthoDBiEOG091G03CX
PhylomeDBiQ8R2Q6
TreeFamiTF329169

Family and domain databases

InterProiView protein in InterPro
IPR011677 DUF1619
PfamiView protein in Pfam
PF07773 DUF1619, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R2Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCTLQLHLLL LVVLMLSETA RPQPSSTARA FPTSWGLEPV TPEVPTSAPP
60 70 80 90 100
DSSESPTPWT LSMPVNATTD PFPALPICVC DLTPGTCDLN CCCDKDCDLL
110 120 130 140 150
HPRTVFSFCL PGSVRSSSWV CVDNSLMFRS NSPFPSRVFT DSSGTTQFCV
160 170 180 190 200
RVNNSKANYF QKLQTVNATN FQALAAEFGG QSFPSMPPET QPPVLFYRAG
210 220 230 240 250
DPILTYYPSW SVVSLLRQPA AVGAGGLCAE SNPAGFLESK STTCPRFFRD
260 270 280 290 300
LASSCTSEPA LDAASYYNFR VLKVPRGVTD LQNMKFQVPV TLASQASPPL
310 320 330 340 350
LAGNTCQNIV SQVVYEIETN GTFGIQKVSV SFRQTNLTVK PGVSLQQDFI
360 370 380 390 400
VHFRAFQQRK AAAPAAPRSG NPGYLTGKPL LVLTGDTSHS MTLLQSEGNG
410 420 430 440 450
LCSAKRHAVQ FGVNAVSGCQ LRPREVNCSH LQEEVYQTLH GRPRPEHVAV
460 470 480 490 500
FGNADPAQRG GWTRILSRDC SVSAVNCTSC CLIPVSLEIQ VLWAHLGLQS
510 520 530 540 550
NPQAHVAGAR FLYQCKSVQE HQRGIEVSLT TLVNFVDITQ KPEPPRDQPR
560 570 580 590
IDWKLPFDFF FPFKAALSRG ASVQKDSLVL ILCVLLLGLL NSQTK
Length:595
Mass (Da):64,824
Last modified:June 1, 2002 - v1
Checksum:iB317AF1E20F4CDF1
GO
Isoform 2 (identifier: Q8R2Q6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-492: AVNCTSCCLIPVSLEIQVL → VRKEATTAWWLVFHLCNYA
     493-595: Missing.

Note: No experimental confirmation available.
Show »
Length:492
Mass (Da):53,516
Checksum:i02EC9F6914E2B929
GO
Isoform 3 (identifier: Q8R2Q6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-392: AFQQRKAAAP...LTGDTSHSMT → VSSLPSERVQ...VCLSEYLLFL
     393-595: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):42,801
Checksum:i351EFB18E48406D4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1W4A0A0R4J1W4_MOUSE
Tectonic-3
Tctn3
393Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017767355 – 392AFQQR…SHSMT → VSSLPSERVQRLSPRNSTLQ SQYPHCLSVCLSEYLLFL in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_017768393 – 595Missing in isoform 3. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_017769474 – 492AVNCT…EIQVL → VRKEATTAWWLVFHLCNYA in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_017770493 – 595Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ278871 mRNA Translation: ABB90563.1
AK015861 mRNA Translation: BAB30004.1
AK016982 mRNA Translation: BAB30537.1
AK030156 mRNA Translation: BAC26813.1
BC027335 mRNA Translation: AAH27335.1
BC080805 mRNA Translation: AAH80805.1
CCDSiCCDS29804.1 [Q8R2Q6-1]
RefSeqiNP_080536.2, NM_026260.2 [Q8R2Q6-1]
UniGeneiMm.60758

Genome annotation databases

EnsembliENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008 [Q8R2Q6-1]
ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008 [Q8R2Q6-2]
GeneIDi67590
KEGGimmu:67590
UCSCiuc008hla.1 mouse [Q8R2Q6-1]
uc008hlb.1 mouse [Q8R2Q6-2]
uc008hlc.1 mouse [Q8R2Q6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ278871 mRNA Translation: ABB90563.1
AK015861 mRNA Translation: BAB30004.1
AK016982 mRNA Translation: BAB30537.1
AK030156 mRNA Translation: BAC26813.1
BC027335 mRNA Translation: AAH27335.1
BC080805 mRNA Translation: AAH80805.1
CCDSiCCDS29804.1 [Q8R2Q6-1]
RefSeqiNP_080536.2, NM_026260.2 [Q8R2Q6-1]
UniGeneiMm.60758

3D structure databases

ProteinModelPortaliQ8R2Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212298, 1 interactor
CORUMiQ8R2Q6
IntActiQ8R2Q6, 2 interactors
STRINGi10090.ENSMUSP00000025981

PTM databases

iPTMnetiQ8R2Q6
PhosphoSitePlusiQ8R2Q6

Proteomic databases

PaxDbiQ8R2Q6
PRIDEiQ8R2Q6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008 [Q8R2Q6-1]
ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008 [Q8R2Q6-2]
GeneIDi67590
KEGGimmu:67590
UCSCiuc008hla.1 mouse [Q8R2Q6-1]
uc008hlb.1 mouse [Q8R2Q6-2]
uc008hlc.1 mouse [Q8R2Q6-3]

Organism-specific databases

CTDi26123
MGIiMGI:1914840 Tctn3

Phylogenomic databases

eggNOGiENOG410IFR0 Eukaryota
ENOG4111GX2 LUCA
GeneTreeiENSGT00570000079101
HOGENOMiHOG000070061
HOVERGENiHBG094032
InParanoidiQ8R2Q6
KOiK19382
OMAiFRAFQQS
OrthoDBiEOG091G03CX
PhylomeDBiQ8R2Q6
TreeFamiTF329169

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

PROiPR:Q8R2Q6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025008 Expressed in 239 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)
CleanExiMM_TCTN3
ExpressionAtlasiQ8R2Q6 baseline and differential
GenevisibleiQ8R2Q6 MM

Family and domain databases

InterProiView protein in InterPro
IPR011677 DUF1619
PfamiView protein in Pfam
PF07773 DUF1619, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTECT3_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Q6
Secondary accession number(s): Q8CDF3, Q9CRC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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