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Entry version 133 (12 Aug 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Tripartite motif-containing protein 29

Gene

Trim29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trim29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919419, Trim29

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Absence of TRIM29 enhances macrophage production of type I interferons and protects mice from infection with influenza virus.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562431 – 587Tripartite motif-containing protein 29Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21PhosphoserineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei104PhosphoserineCombined sources1
Modified residuei106PhosphotyrosineBy similarity1
Modified residuei476PhosphothreonineBy similarity1
Modified residuei489PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R2Q0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R2Q0

PeptideAtlas

More...
PeptideAtlasi
Q8R2Q0

PRoteomics IDEntifications database

More...
PRIDEi
Q8R2Q0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R2Q0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R2Q0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032013, Expressed in lip and 133 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R2Q0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VIM and HINT1.

Interacts with IKBKG/NEMO.

Interacts with STING1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
215196, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q8R2Q0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034511

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R2Q0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R2Q0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili259 – 348Sequence analysisAdd BLAST90

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWDV, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161416

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039304_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R2Q0

KEGG Orthology (KO)

More...
KOi
K12010

Identification of Orthologs from Complete Genome Data

More...
OMAi
TNGHSGE

Database of Orthologous Groups

More...
OrthoDBi
429763at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R2Q0

TreeFam database of animal gene trees

More...
TreeFami
TF351086

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021, BBOX, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000315, Znf_B-box

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00643, zf-B_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336, BBOX, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50119, ZF_BBOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8R2Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGADACRSN GASPEARDTR SPPGPSGSLE NGTKADSKDT KTTNGHSGEV
60 70 80 90 100
TEGKTLGSAL KSGEGKSGLF SSNEWRRPII QFVESVDDKG SSYFSMDSAE
110 120 130 140 150
GRRSPYAGLQ LGASKKPPVT FAEKGELRKS IFSEPRKPTV TIVEPGEVRR
160 170 180 190 200
NSYPRADSSL LARAKSGSEE VLCDSCIGNK QKAVKSCLVC QASFCELHLK
210 220 230 240 250
PHLEGAAFRD HQLLEPIRDF EARKCPLHGK TMELFCQTDQ TCICYLCMFQ
260 270 280 290 300
EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDDVE KWQKEKDRIK
310 320 330 340 350
SFTTNEKAIL EQNFRDLVRE LEKQKEEVRA ALEQREQDAV DQVKVIVDAL
360 370 380 390 400
DERAKVLHED KQTREQLHNI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL
410 420 430 440 450
EGEGLGQSLG NCKDDLLNVC MRHVEKMCKA DLSRNFIERN HMENGGDHRY
460 470 480 490 500
MNSYTSSYGN EWSTPDTMKR YSMYLTPKGG GRTSYQPSSP SRLSKETNQK
510 520 530 540 550
NFNNLYGTKG NYTSRVWEYT STVQNSEDMP TVQGNSSFSL KGFPSLLRSQ
560 570 580
VPKAQPQTWK SGKQTLLSHY RPFYVNKGSG IGSNEAP
Length:587
Mass (Da):65,820
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6E5C65F6A05EA98
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC25956 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti220 – 227FEARKCPL → SRPENVPC (PubMed:16141072).Curated8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC006699 mRNA Translation: AAH06699.1
BC027353 mRNA Translation: AAH27353.1
AK013219 mRNA Translation: BAB28721.1
AK028448 mRNA Translation: BAC25956.1 Different initiation.
AF230390 mRNA Translation: AAG50169.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52775.1

NCBI Reference Sequences

More...
RefSeqi
NP_076144.2, NM_023655.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034511; ENSMUSP00000034511; ENSMUSG00000032013

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72169

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72169

UCSC genome browser

More...
UCSCi
uc009pbi.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006699 mRNA Translation: AAH06699.1
BC027353 mRNA Translation: AAH27353.1
AK013219 mRNA Translation: BAB28721.1
AK028448 mRNA Translation: BAC25956.1 Different initiation.
AF230390 mRNA Translation: AAG50169.1
CCDSiCCDS52775.1
RefSeqiNP_076144.2, NM_023655.2

3D structure databases

SMRiQ8R2Q0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi215196, 17 interactors
IntActiQ8R2Q0, 1 interactor
STRINGi10090.ENSMUSP00000034511

PTM databases

iPTMnetiQ8R2Q0
PhosphoSitePlusiQ8R2Q0

Proteomic databases

MaxQBiQ8R2Q0
PaxDbiQ8R2Q0
PeptideAtlasiQ8R2Q0
PRIDEiQ8R2Q0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18856, 581 antibodies

Genome annotation databases

EnsembliENSMUST00000034511; ENSMUSP00000034511; ENSMUSG00000032013
GeneIDi72169
KEGGimmu:72169
UCSCiuc009pbi.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23650
MGIiMGI:1919419, Trim29

Phylogenomic databases

eggNOGiENOG502QWDV, Eukaryota
GeneTreeiENSGT00940000161416
HOGENOMiCLU_039304_0_0_1
InParanoidiQ8R2Q0
KOiK12010
OMAiTNGHSGE
OrthoDBi429763at2759
PhylomeDBiQ8R2Q0
TreeFamiTF351086

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
72169, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Trim29, mouse

Protein Ontology

More...
PROi
PR:Q8R2Q0
RNActiQ8R2Q0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032013, Expressed in lip and 133 other tissues
GenevisibleiQ8R2Q0, MM

Family and domain databases

CDDicd00021, BBOX, 1 hit
InterProiView protein in InterPro
IPR000315, Znf_B-box
PfamiView protein in Pfam
PF00643, zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336, BBOX, 1 hit
PROSITEiView protein in PROSITE
PS50119, ZF_BBOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI29_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R2Q0
Secondary accession number(s): Q8CEE2
, Q922Y3, Q99PN5, Q9CSC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2002
Last modified: August 12, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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