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Protein

Tripartite motif-containing protein 29

Gene

Trim29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • identical protein binding Source: MGI
  • p53 binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 29
Gene namesi
Name:Trim29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1919419 Trim29

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lysosome

Pathology & Biotechi

Disruption phenotypei

Absence of TRIM29 enhances macrophage production of type I interferons and protects mice from infection with influenza virus.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562431 – 587Tripartite motif-containing protein 29Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei104PhosphoserineCombined sources1
Modified residuei106PhosphotyrosineBy similarity1
Modified residuei476PhosphothreonineBy similarity1
Modified residuei489PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8R2Q0
PaxDbiQ8R2Q0
PeptideAtlasiQ8R2Q0
PRIDEiQ8R2Q0

PTM databases

iPTMnetiQ8R2Q0
PhosphoSitePlusiQ8R2Q0

Expressioni

Gene expression databases

BgeeiENSMUSG00000032013 Expressed in 112 organ(s), highest expression level in ear
CleanExiMM_TRIM29
GenevisibleiQ8R2Q0 MM

Interactioni

Subunit structurei

Interacts with VIM and HINT1. Interacts with IKBKG/NEMO. Interacts with TMEM173/STING.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215196, 13 interactors
IntActiQ8R2Q0, 1 interactor
STRINGi10090.ENSMUSP00000034511

Structurei

3D structure databases

ProteinModelPortaliQ8R2Q0
SMRiQ8R2Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 348Sequence analysisAdd BLAST90

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK88 Eukaryota
ENOG410YEFV LUCA
GeneTreeiENSGT00930000151013
HOGENOMiHOG000154677
HOVERGENiHBG061597
InParanoidiQ8R2Q0
KOiK12010
OMAiGDHRYMN
OrthoDBiEOG091G056X
PhylomeDBiQ8R2Q0
TreeFamiTF351086

Family and domain databases

CDDicd00021 BBOX, 1 hit
InterProiView protein in InterPro
IPR000315 Znf_B-box
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R2Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGADACRSN GASPEARDTR SPPGPSGSLE NGTKADSKDT KTTNGHSGEV
60 70 80 90 100
TEGKTLGSAL KSGEGKSGLF SSNEWRRPII QFVESVDDKG SSYFSMDSAE
110 120 130 140 150
GRRSPYAGLQ LGASKKPPVT FAEKGELRKS IFSEPRKPTV TIVEPGEVRR
160 170 180 190 200
NSYPRADSSL LARAKSGSEE VLCDSCIGNK QKAVKSCLVC QASFCELHLK
210 220 230 240 250
PHLEGAAFRD HQLLEPIRDF EARKCPLHGK TMELFCQTDQ TCICYLCMFQ
260 270 280 290 300
EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDDVE KWQKEKDRIK
310 320 330 340 350
SFTTNEKAIL EQNFRDLVRE LEKQKEEVRA ALEQREQDAV DQVKVIVDAL
360 370 380 390 400
DERAKVLHED KQTREQLHNI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL
410 420 430 440 450
EGEGLGQSLG NCKDDLLNVC MRHVEKMCKA DLSRNFIERN HMENGGDHRY
460 470 480 490 500
MNSYTSSYGN EWSTPDTMKR YSMYLTPKGG GRTSYQPSSP SRLSKETNQK
510 520 530 540 550
NFNNLYGTKG NYTSRVWEYT STVQNSEDMP TVQGNSSFSL KGFPSLLRSQ
560 570 580
VPKAQPQTWK SGKQTLLSHY RPFYVNKGSG IGSNEAP
Length:587
Mass (Da):65,820
Last modified:June 1, 2002 - v1
Checksum:iD6E5C65F6A05EA98
GO

Sequence cautioni

The sequence BAC25956 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220 – 227FEARKCPL → SRPENVPC (PubMed:16141072).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006699 mRNA Translation: AAH06699.1
BC027353 mRNA Translation: AAH27353.1
AK013219 mRNA Translation: BAB28721.1
AK028448 mRNA Translation: BAC25956.1 Different initiation.
AF230390 mRNA Translation: AAG50169.1
CCDSiCCDS52775.1
RefSeqiNP_076144.2, NM_023655.2
UniGeneiMm.273277

Genome annotation databases

EnsembliENSMUST00000034511; ENSMUSP00000034511; ENSMUSG00000032013
GeneIDi72169
KEGGimmu:72169
UCSCiuc009pbi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006699 mRNA Translation: AAH06699.1
BC027353 mRNA Translation: AAH27353.1
AK013219 mRNA Translation: BAB28721.1
AK028448 mRNA Translation: BAC25956.1 Different initiation.
AF230390 mRNA Translation: AAG50169.1
CCDSiCCDS52775.1
RefSeqiNP_076144.2, NM_023655.2
UniGeneiMm.273277

3D structure databases

ProteinModelPortaliQ8R2Q0
SMRiQ8R2Q0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215196, 13 interactors
IntActiQ8R2Q0, 1 interactor
STRINGi10090.ENSMUSP00000034511

PTM databases

iPTMnetiQ8R2Q0
PhosphoSitePlusiQ8R2Q0

Proteomic databases

MaxQBiQ8R2Q0
PaxDbiQ8R2Q0
PeptideAtlasiQ8R2Q0
PRIDEiQ8R2Q0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034511; ENSMUSP00000034511; ENSMUSG00000032013
GeneIDi72169
KEGGimmu:72169
UCSCiuc009pbi.2 mouse

Organism-specific databases

CTDi23650
MGIiMGI:1919419 Trim29

Phylogenomic databases

eggNOGiENOG410IK88 Eukaryota
ENOG410YEFV LUCA
GeneTreeiENSGT00930000151013
HOGENOMiHOG000154677
HOVERGENiHBG061597
InParanoidiQ8R2Q0
KOiK12010
OMAiGDHRYMN
OrthoDBiEOG091G056X
PhylomeDBiQ8R2Q0
TreeFamiTF351086

Miscellaneous databases

PROiPR:Q8R2Q0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032013 Expressed in 112 organ(s), highest expression level in ear
CleanExiMM_TRIM29
GenevisibleiQ8R2Q0 MM

Family and domain databases

CDDicd00021 BBOX, 1 hit
InterProiView protein in InterPro
IPR000315 Znf_B-box
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
PROSITEiView protein in PROSITE
PS50119 ZF_BBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI29_MOUSE
AccessioniPrimary (citable) accession number: Q8R2Q0
Secondary accession number(s): Q8CEE2
, Q922Y3, Q99PN5, Q9CSC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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