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Protein

Kelch-like protein 25

Gene

Klhl25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processTranslation regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 25
Alternative name(s):
Ectoderm-neural cortex protein 2
Short name:
ENC-2
Gene namesi
Name:Klhl25
Synonyms:Enc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2668031 Klhl25

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002723091 – 589Kelch-like protein 25Add BLAST589

Proteomic databases

EPDiQ8R2P1
MaxQBiQ8R2P1
PaxDbiQ8R2P1
PeptideAtlasiQ8R2P1
PRIDEiQ8R2P1

PTM databases

iPTMnetiQ8R2P1
PhosphoSitePlusiQ8R2P1

Expressioni

Gene expression databases

BgeeiENSMUSG00000055652
CleanExiMM_KLHL25
ExpressionAtlasiQ8R2P1 baseline and differential
GenevisibleiQ8R2P1 MM

Interactioni

Subunit structurei

Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated) (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089707

Structurei

3D structure databases

ProteinModelPortaliQ8R2P1
SMRiQ8R2P1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 114BTBPROSITE-ProRule annotationAdd BLAST69
Domaini149 – 250BACKAdd BLAST102
Repeati296 – 340Kelch 1Add BLAST45
Repeati341 – 388Kelch 2Add BLAST48
Repeati389 – 444Kelch 3Add BLAST56
Repeati446 – 492Kelch 4Add BLAST47
Repeati493 – 538Kelch 5Add BLAST46
Repeati539 – 585Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00910000143979
HOGENOMiHOG000232171
HOVERGENiHBG000905
InParanoidiQ8R2P1
KOiK10462
OMAiTSDTWNC
OrthoDBiEOG091G03JU
PhylomeDBiQ8R2P1
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030565 KLHL25
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24410:SF10 PTHR24410:SF10, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 4 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R2P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSVHETRK SRSSTGSMNI SVFHKASHPD CVLAHLNTLR KHCMFTDVTL
60 70 80 90 100
WAGDRAFPCH RAVLAASSRY FEAMFSHGLR ESRDDTVNFQ DNLHPEVLEL
110 120 130 140 150
LLDFAYSSRI VINEENAESL LEAGDMLQFH DVRDAAAEFL EKNLSPSNCL
160 170 180 190 200
GMMVLSDAHQ CRRLYEFSCR MSLVHFETVR QSEDFNSLSR DTLLDLISRD
210 220 230 240 250
ELETEDERVV FEAILQWVKH DLEQRKAHLP LLLRNVRLAL LPSDCLKNAV
260 270 280 290 300
SGEALLMADE CTKLILDEAF RCKTKILLND GVVTSPFARP RKAGHTLLIL
310 320 330 340 350
GGQTFMCDKI YQVDHKAKEI IPKADLPSPR KEFSASAIGC KVYVTGGRGS
360 370 380 390 400
ENGVSKDVWV YDTVHEEWSK AAPMLIARFG HGSAELENCL YVVGGHTSLA
410 420 430 440 450
GIFPASPSVS LKQVEKYDPG DNKWTMVAPM RDGVSNAAVV SAKLKLFVFG
460 470 480 490 500
GTSIHRDMVS KVQCFDPSEN RWTIKAECPQ PWRYTAAAVL GSQIFIMGGD
510 520 530 540 550
TEYTAASAYR FDCETNQWTR IGDMTAKRMS CHAVASGNKL YVVGGYFGTQ
560 570 580
RCKTLDCYDP TSDTWNCITT VPYSLIPTAF VSTWKHLPA
Length:589
Mass (Da):65,826
Last modified:June 1, 2002 - v1
Checksum:i5B8C746A80287C20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143086 mRNA Translation: BAE25266.1
BC027373 mRNA Translation: AAH27373.1
CCDSiCCDS21369.1
RefSeqiNP_001116252.1, NM_001122780.1
NP_083928.1, NM_029652.1
NP_877583.1, NM_182782.2
XP_011249134.1, XM_011250832.2
UniGeneiMm.206223

Genome annotation databases

EnsembliENSMUST00000092073; ENSMUSP00000089707; ENSMUSG00000055652
ENSMUST00000171155; ENSMUSP00000133175; ENSMUSG00000055652
ENSMUST00000206019; ENSMUSP00000146102; ENSMUSG00000055652
GeneIDi207952
KEGGimmu:207952
UCSCiuc009hwy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLH25_MOUSE
AccessioniPrimary (citable) accession number: Q8R2P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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