Utp4

Functionⁱ

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1.By similarity

GO - Biological processⁱ

maturation of SSU-rRNA Source: UniProtKB
regulation of transcription, DNA-templated Source: MGI
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ribosome biogenesis, rRNA processing, Transcription, Transcription regulation

Biological process

Ribosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U3 small nucleolar RNA-associated protein 4 homolog Alternative name(s): Cirhin Testis-expressed gene 292 protein
Gene namesⁱ	Name:Utp4 Synonyms:Cirh1a, Kiaa1988, Tex292
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:1096573 Utp4

Keywords - Cellular componentⁱ

Chromosome, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050909	1 – 686	U3 small nucleolar RNA-associated protein 4 homologAdd BLAST		686

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	321	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8R2N2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8R2N2
PaxDbⁱ	Q8R2N2
PeptideAtlas More...PeptideAtlasⁱ	Q8R2N2
PRIDEⁱ	Q8R2N2

PTM databases

iPTMnetⁱ	Q8R2N2
PhosphoSitePlusⁱ	Q8R2N2
SwissPalmⁱ	Q8R2N2

Expressionⁱ

Tissue specificityⁱ

Expressed in liver.2 Publications

Developmental stageⁱ

In 11.5 day embryos, highly and predominantly expressed in liver, with lower expression in somites, brain and craniofacial structures. Expression significantly decreases in 12.5 day embryos and in the newborn.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000041438 Expressed in 292 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_CIRH1A
ExpressionAtlasⁱ	Q8R2N2 baseline and differential
Genevisibleⁱ	Q8R2N2 MM

Interactionⁱ

Subunit structureⁱ

Interacts with HIVEP1. Interacts with NOL11. Interacts directly with UTP15 and WDR43. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.By similarity

Protein-protein interaction databases

BioGridⁱ	204134, 1 interactor
IntActⁱ	Q8R2N2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000048377

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R2N2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	14 – 53	WD 1Add BLAST	40
Repeatⁱ	57 – 96	WD 2Add BLAST	40
Repeatⁱ	99 – 138	WD 3Add BLAST	40
Repeatⁱ	143 – 181	WD 4Add BLAST	39
Repeatⁱ	193 – 231	WD 5Add BLAST	39
Repeatⁱ	234 – 273	WD 6Add BLAST	40
Repeatⁱ	285 – 322	WD 7Add BLAST	38
Repeatⁱ	324 – 359	WD 8Add BLAST	36
Repeatⁱ	435 – 474	WD 9Add BLAST	40
Repeatⁱ	482 – 521	WD 10Add BLAST	40
Repeatⁱ	524 – 563	WD 11Add BLAST	40

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG2048 Eukaryota ENOG410XQNR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008662
HOGENOMⁱ	HOG000095656
HOVERGENⁱ	HBG050963
InParanoidⁱ	Q8R2N2
KEGG Orthology (KO) More...KOⁱ	K14548
OMAⁱ	VQKQGFH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06F9
PhylomeDBⁱ	Q8R2N2
TreeFamⁱ	TF313159

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 2 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 10 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q8R2N2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEFKVHRVR FFNYVPSGIR CVAYNNQSNR LAVSRTDGTV EIYNLSANYF 
        60         70         80         90        100
QEKFFPGHES RGTEALCWAG GQRLFSAGLN GEILEYDLQA LNIKYTLDAF 
       110        120        130        140        150
GGPIWSMTAS PSGSQLLVGC EDGSVKLFEV TPEKIQFARN FDRQKSRILS 
       160        170        180        190        200
LCWHPAGTHV AAGSLDYISV FDVKSGSIIR KMVLDRQHLG VTKSRCIVWG 
       210        220        230        240        250
VAFLSDGTVI SVDSVGKVQL WDSATGTLVK SHLVANADVQ SIAVADQEDS 
       260        270        280        290        300
FVVGTAEGTV FHFQLVSMTS NSSEKQWVRT KPFQHHTHDV RAVAHSPTAL 
       310        320        330        340        350
ISGGTDTHLV IRPLMERVEV KNYDAALRKI TFPHRRLISC SKRRQLLLFQ 
       360        370        380        390        400
FAHHLELWRL GSTSATGKNG DTLPLSKNAD HLLHLKTKGP ENIICSCVSP 
       410        420        430        440        450
CGSWIAYSTA SRFFLYRLKY ERDNISLQRV SKLPSFLRSA LHILFSEDST 
       460        470        480        490        500
KLLVASNQGS LHIVHLSEGS FKHLHTFQPQ SGTVEAMCLL AVSPDGNWLA 
       510        520        530        540        550
ASGTSAGVHV YDLHHLKLHC TVPAYNFPVT ALAIAPNTNN LVIAHSDQQV 
       560        570        580        590        600
FEFSIPEKQY TEWSRSLQKQ GFHQLWLQRD TPITHISFHP KRPMHILLHD 
       610        620        630        640        650
AYMFCIIDKS LPLPNEKTVL YNPLPPKNES DVFLRRTTHG FKMSKIYKPL 
       660        670        680 
LFMDLLDERT LVAVERPLDD IIAQLPPPIK KKKFGT

Length:686

Mass (Da):76,909

Last modified:August 16, 2005 - v3

Checksum:ⁱE927C1338E948BD7

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1D5RLM4	A0A1D5RLM4_MOUSE		U3 small nucleolar RNA-associated p... U3 small nucleolar RNA-associated protein 4 homolog	Utp4	11	Annotation score:

Sequence cautionⁱ

The sequence AAH27399 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAD32596 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA56628 differs from that shown. Reason: Frameshift at positions 648, 645, 668 and 679.Curated

The sequence CAA56629 differs from that shown. Reason: Frameshift at positions 6, 7 and 11.Curated

The sequence CAA56629 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK173318 mRNA Translation: BAD32596.1 Different initiation. BC018262 mRNA Translation: AAH18262.1 BC027399 mRNA Translation: AAH27399.1 Different initiation. BC068113 mRNA Translation: AAH68113.1 X80433 mRNA Translation: CAA56628.1 Frameshift. X80434 mRNA Translation: CAA56629.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS52664.1
PIRⁱ	S46930
NCBI Reference Sequences More...RefSeqⁱ	NP_035704.2, NM_011574.2 XP_006530905.1, XM_006530842.3
UniGeneⁱ	Mm.10665

Genome annotation databases

Ensemblⁱ	ENSMUST00000047629; ENSMUSP00000048377; ENSMUSG00000041438
GeneIDⁱ	21771
KEGGⁱ	mmu:21771
UCSC genome browser More...UCSCⁱ	uc009ngr.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R2N2	Uncharacterized protein		MOUSE		686	UniRef90_Q8R2N2
UPI000A319B3F		MUSCR		685
UPI00038BCAC5		MICOH		669

Protein	Similar proteins		Species	Score	Length	Source
Q8R2N2	U3 small nucleolar RNA-associated protein 4 homolog		HUMAN		686	UniRef50_Q969X6
UTP4 isoform 10 (Fragment)		PONAB		148
UTP4 isoform 15 (Fragment)		PANTR		148
UTP4, small subunit processome component		CHLSB		763
Uncharacterized protein		RHIBE		757
+214

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK173318 mRNA Translation: BAD32596.1 Different initiation. BC018262 mRNA Translation: AAH18262.1 BC027399 mRNA Translation: AAH27399.1 Different initiation. BC068113 mRNA Translation: AAH68113.1 X80433 mRNA Translation: CAA56628.1 Frameshift. X80434 mRNA Translation: CAA56629.1 Sequence problems.
CCDSⁱ	CCDS52664.1
PIRⁱ	S46930
RefSeqⁱ	NP_035704.2, NM_011574.2 XP_006530905.1, XM_006530842.3
UniGeneⁱ	Mm.10665

3D structure databases

ProteinModelPortalⁱ	Q8R2N2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204134, 1 interactor
IntActⁱ	Q8R2N2, 1 interactor
STRINGⁱ	10090.ENSMUSP00000048377

PTM databases

iPTMnetⁱ	Q8R2N2
PhosphoSitePlusⁱ	Q8R2N2
SwissPalmⁱ	Q8R2N2

Proteomic databases

EPDⁱ	Q8R2N2
MaxQBⁱ	Q8R2N2
PaxDbⁱ	Q8R2N2
PeptideAtlasⁱ	Q8R2N2
PRIDEⁱ	Q8R2N2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047629; ENSMUSP00000048377; ENSMUSG00000041438
GeneIDⁱ	21771
KEGGⁱ	mmu:21771
UCSCⁱ	uc009ngr.2 mouse

Organism-specific databases

CTDⁱ	84916
MGIⁱ	MGI:1096573 Utp4
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2048 Eukaryota ENOG410XQNR LUCA
GeneTreeⁱ	ENSGT00390000008662
HOGENOMⁱ	HOG000095656
HOVERGENⁱ	HBG050963
InParanoidⁱ	Q8R2N2
KOⁱ	K14548
OMAⁱ	VQKQGFH
OrthoDBⁱ	EOG091G06F9
PhylomeDBⁱ	Q8R2N2
TreeFamⁱ	TF313159

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	Cirh1a mouse
Protein Ontology More...PROⁱ	PR:Q8R2N2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000041438 Expressed in 292 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_CIRH1A
ExpressionAtlasⁱ	Q8R2N2 baseline and differential
Genevisibleⁱ	Q8R2N2 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00400 WD40, 2 hits
SMARTⁱ	View protein in SMART SM00320 WD40, 10 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UTP4_MOUSE
Accessionⁱ	Q8R2N2Primary (citable) accession number: Q8R2N2 Secondary accession number(s): Q62306 , Q62307, Q69Z48, Q6NVG9, Q8VEL5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	August 16, 2005
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R2N2 (UTP4_MOUSE)

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U3 small nucleolar RNA-associated protein 4 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ