UniProtKB - Q8R2N2 (UTP4_MOUSE)
Protein
U3 small nucleolar RNA-associated protein 4 homolog
Gene
Utp4
Organism
Mus musculus (Mouse)
Status
Functioni
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1.By similarity
GO - Biological processi
- maturation of SSU-rRNA Source: UniProtKB
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- regulation of transcription, DNA-templated Source: MGI
Keywordsi
Biological process | Ribosome biogenesis, rRNA processing, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 4 homologAlternative name(s): Cirhin Testis-expressed gene 292 protein |
Gene namesi | Name:Utp4 Synonyms:Cirh1a, Kiaa1988, Tex292 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096573, Utp4 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Other locations
- Chromosome By similarity
Note: Found predominantly at the fibrillar center.By similarity
Nucleus
- fibrillar center Source: UniProtKB
- nucleolus Source: UniProtKB
- t-UTP complex Source: UniProtKB
Other locations
- 90S preribosome Source: GO_Central
- chromosome Source: UniProtKB
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050909 | 1 – 686 | U3 small nucleolar RNA-associated protein 4 homologAdd BLAST | 686 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 321 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Post-translational modificationi
May be phosphorylated during mitosis; may control the association of this protein with WRD43 and UTP15.By similarity
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8R2N2 |
MaxQBi | Q8R2N2 |
PaxDbi | Q8R2N2 |
PeptideAtlasi | Q8R2N2 |
PRIDEi | Q8R2N2 |
PTM databases
iPTMneti | Q8R2N2 |
PhosphoSitePlusi | Q8R2N2 |
SwissPalmi | Q8R2N2 |
Expressioni
Tissue specificityi
Expressed in liver.2 Publications
Developmental stagei
In 11.5 day embryos, highly and predominantly expressed in liver, with lower expression in somites, brain and craniofacial structures. Expression significantly decreases in 12.5 day embryos and in the newborn.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000041438, Expressed in primary oocyte and 308 other tissues |
ExpressionAtlasi | Q8R2N2, baseline and differential |
Genevisiblei | Q8R2N2, MM |
Interactioni
Subunit structurei
Interacts with HIVEP1.
Interacts with NOL11.
Interacts directly with UTP15 and WDR43. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.
By similarityProtein-protein interaction databases
BioGRIDi | 204134, 1 interactor |
IntActi | Q8R2N2, 1 interactor |
STRINGi | 10090.ENSMUSP00000048377 |
Miscellaneous databases
RNActi | Q8R2N2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 14 – 53 | WD 1Add BLAST | 40 | |
Repeati | 57 – 96 | WD 2Add BLAST | 40 | |
Repeati | 99 – 138 | WD 3Add BLAST | 40 | |
Repeati | 143 – 181 | WD 4Add BLAST | 39 | |
Repeati | 193 – 231 | WD 5Add BLAST | 39 | |
Repeati | 234 – 273 | WD 6Add BLAST | 40 | |
Repeati | 285 – 322 | WD 7Add BLAST | 38 | |
Repeati | 324 – 359 | WD 8Add BLAST | 36 | |
Repeati | 435 – 474 | WD 9Add BLAST | 40 | |
Repeati | 482 – 521 | WD 10Add BLAST | 40 | |
Repeati | 524 – 563 | WD 11Add BLAST | 40 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG2048, Eukaryota |
GeneTreei | ENSGT00940000153533 |
HOGENOMi | CLU_002392_3_0_1 |
InParanoidi | Q8R2N2 |
OMAi | PDANWIC |
OrthoDBi | 376282at2759 |
PhylomeDBi | Q8R2N2 |
TreeFami | TF313159 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 10 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8R2N2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEFKVHRVR FFNYVPSGIR CVAYNNQSNR LAVSRTDGTV EIYNLSANYF
60 70 80 90 100
QEKFFPGHES RGTEALCWAG GQRLFSAGLN GEILEYDLQA LNIKYTLDAF
110 120 130 140 150
GGPIWSMTAS PSGSQLLVGC EDGSVKLFEV TPEKIQFARN FDRQKSRILS
160 170 180 190 200
LCWHPAGTHV AAGSLDYISV FDVKSGSIIR KMVLDRQHLG VTKSRCIVWG
210 220 230 240 250
VAFLSDGTVI SVDSVGKVQL WDSATGTLVK SHLVANADVQ SIAVADQEDS
260 270 280 290 300
FVVGTAEGTV FHFQLVSMTS NSSEKQWVRT KPFQHHTHDV RAVAHSPTAL
310 320 330 340 350
ISGGTDTHLV IRPLMERVEV KNYDAALRKI TFPHRRLISC SKRRQLLLFQ
360 370 380 390 400
FAHHLELWRL GSTSATGKNG DTLPLSKNAD HLLHLKTKGP ENIICSCVSP
410 420 430 440 450
CGSWIAYSTA SRFFLYRLKY ERDNISLQRV SKLPSFLRSA LHILFSEDST
460 470 480 490 500
KLLVASNQGS LHIVHLSEGS FKHLHTFQPQ SGTVEAMCLL AVSPDGNWLA
510 520 530 540 550
ASGTSAGVHV YDLHHLKLHC TVPAYNFPVT ALAIAPNTNN LVIAHSDQQV
560 570 580 590 600
FEFSIPEKQY TEWSRSLQKQ GFHQLWLQRD TPITHISFHP KRPMHILLHD
610 620 630 640 650
AYMFCIIDKS LPLPNEKTVL YNPLPPKNES DVFLRRTTHG FKMSKIYKPL
660 670 680
LFMDLLDERT LVAVERPLDD IIAQLPPPIK KKKFGT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RLM4 | A0A1D5RLM4_MOUSE | U3 small nucleolar RNA-associated p... | Utp4 | 11 | Annotation score: |
Sequence cautioni
The sequence AAH27399 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD32596 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA56628 differs from that shown. Reason: Frameshift.Curated
The sequence CAA56629 differs from that shown. Reason: Frameshift.Curated
The sequence CAA56629 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173318 mRNA Translation: BAD32596.1 Different initiation. BC018262 mRNA Translation: AAH18262.1 BC027399 mRNA Translation: AAH27399.1 Different initiation. BC068113 mRNA Translation: AAH68113.1 X80433 mRNA Translation: CAA56628.1 Frameshift. X80434 mRNA Translation: CAA56629.1 Sequence problems. |
CCDSi | CCDS52664.1 |
PIRi | S46930 |
RefSeqi | NP_035704.2, NM_011574.2 XP_006530905.1, XM_006530842.3 |
Genome annotation databases
Ensembli | ENSMUST00000047629; ENSMUSP00000048377; ENSMUSG00000041438 |
GeneIDi | 21771 |
KEGGi | mmu:21771 |
UCSCi | uc009ngr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173318 mRNA Translation: BAD32596.1 Different initiation. BC018262 mRNA Translation: AAH18262.1 BC027399 mRNA Translation: AAH27399.1 Different initiation. BC068113 mRNA Translation: AAH68113.1 X80433 mRNA Translation: CAA56628.1 Frameshift. X80434 mRNA Translation: CAA56629.1 Sequence problems. |
CCDSi | CCDS52664.1 |
PIRi | S46930 |
RefSeqi | NP_035704.2, NM_011574.2 XP_006530905.1, XM_006530842.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 204134, 1 interactor |
IntActi | Q8R2N2, 1 interactor |
STRINGi | 10090.ENSMUSP00000048377 |
PTM databases
iPTMneti | Q8R2N2 |
PhosphoSitePlusi | Q8R2N2 |
SwissPalmi | Q8R2N2 |
Proteomic databases
EPDi | Q8R2N2 |
MaxQBi | Q8R2N2 |
PaxDbi | Q8R2N2 |
PeptideAtlasi | Q8R2N2 |
PRIDEi | Q8R2N2 |
Protocols and materials databases
Antibodypediai | 29826, 116 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000047629; ENSMUSP00000048377; ENSMUSG00000041438 |
GeneIDi | 21771 |
KEGGi | mmu:21771 |
UCSCi | uc009ngr.2, mouse |
Organism-specific databases
CTDi | 84916 |
MGIi | MGI:1096573, Utp4 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2048, Eukaryota |
GeneTreei | ENSGT00940000153533 |
HOGENOMi | CLU_002392_3_0_1 |
InParanoidi | Q8R2N2 |
OMAi | PDANWIC |
OrthoDBi | 376282at2759 |
PhylomeDBi | Q8R2N2 |
TreeFami | TF313159 |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 21771, 7 hits in 17 CRISPR screens |
ChiTaRSi | Cirh1a, mouse |
PROi | PR:Q8R2N2 |
RNActi | Q8R2N2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041438, Expressed in primary oocyte and 308 other tissues |
ExpressionAtlasi | Q8R2N2, baseline and differential |
Genevisiblei | Q8R2N2, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 10 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UTP4_MOUSE | |
Accessioni | Q8R2N2Primary (citable) accession number: Q8R2N2 Secondary accession number(s): Q62306 Q8VEL5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | August 16, 2005 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot