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Entry version 108 (16 Oct 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Deoxynucleotidyltransferase terminal-interacting protein 2

Gene

Dnttip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (By similarity).By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxynucleotidyltransferase terminal-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnttip2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923173 Dnttip2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003185061 – 758Deoxynucleotidyltransferase terminal-interacting protein 2Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei183PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei229PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei248PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei324PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki384Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei476PhosphoserineCombined sources1
Modified residuei512PhosphoserineBy similarity1
Cross-linki560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki586Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki608Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei612PhosphothreonineBy similarity1
Cross-linki628Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki660Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki688Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki733Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8R2M2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8R2M2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R2M2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R2M2

PeptideAtlas

More...
PeptideAtlasi
Q8R2M2

PRoteomics IDEntifications database

More...
PRIDEi
Q8R2M2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R2M2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R2M2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8R2M2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039756 Expressed in 299 organ(s), highest expression level in morula

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R2M2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex.

Interacts with ESR1, ESR2, PPARG and RXRA (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
221260, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8R2M2, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8R2M2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045043

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni550 – 607TdBR region; mediates interaction with DNTTBy similarityAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili512 – 541Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3100 Eukaryota
ENOG410Z9Q4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048142

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154536

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R2M2

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRSMQKK

Database of Orthologous Groups

More...
OrthoDBi
887634at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R2M2

TreeFam database of animal gene trees

More...
TreeFami
TF105964

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039883 Fcf2/DNTTIP2
IPR014810 Fcf2_C

The PANTHER Classification System

More...
PANTHERi
PTHR21686 PTHR21686, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08698 Fcf2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8R2M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVTRSGLSR TRLQESSQQK RSAPRRIGTH LESTKESGSD GSTAESQPAE
60 70 80 90 100
KQHSRSSSRT TGPAEIIVLI SDDEASETES HTSGVTSVLE DQEPIVRVTR
110 120 130 140 150
KRQIVIASTS KSTVRKRQKV APQHASADEV VVSEAESHVS GVSMVVPSTE
160 170 180 190 200
RSSRNKANSQ RDSSQESQSG TVSDAELSCS GISSLEILPR TTARNVKKKL
210 220 230 240 250
QFPAEKNDTK ITPGNKKQIV GMSVCSEDSD ATQLSARPLS QRNMPNVSDS
260 270 280 290 300
ETYNSDFDDS SPRNSGKKLT AQNHQNLHIQ EEKRANVVSL TEVRKENCKS
310 320 330 340 350
LDEEDLKITE EKVINEKDSQ RSLSEAQDTS LQQSVSQNHS STPNKKPTFQ
360 370 380 390 400
LSSPDRKALM KSLEHKFAVV NVERWNDKRG GSGKKSDLAQ LGGGGGGGDD
410 420 430 440 450
NEPTGAGISD DKSSQSGVPL ECDTKPCKSE LSMTQDTTDS PVLLFLSSDE
460 470 480 490 500
SQQSDSSENE RDTLCSVENN GQKEASAEDL EDAACDSALF VIDKTPGLSA
510 520 530 540 550
DKNFYLEDKA PSEVAIEEEK EEEEKEEENS EEDSSDSDEN KDESSDEEDL
560 570 580 590 600
LSNTKSKLLK LTSSSIDPGL NIKQLGGLYI NFNVDKLQPH KETLTQIKEK
610 620 630 640 650
KKNELLQKAV ITPDFEKKHC VPPYSESKHR LQKQRRKERQ KTAGNGWFGM
660 670 680 690 700
KAPELTDELK NDLRALKMRA GMDPKRFYKK NDRDGFPKYF QVGTIVDNPA
710 720 730 740 750
DFYHSRIPKK QRKKTIVEEL LADSEFRRFN RRKYSEIMAE KAANAEGKKF

KKKKKFRN
Length:758
Mass (Da):84,277
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B6A7EED68F8A0EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti517E → D in BAE37264 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK135957 mRNA Translation: BAE22744.1
AK163260 mRNA Translation: BAE37264.1
AK168536 mRNA Translation: BAE40414.1
BC028305 mRNA Translation: AAH28305.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17809.1

NCBI Reference Sequences

More...
RefSeqi
NP_722501.1, NM_153806.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035776; ENSMUSP00000045043; ENSMUSG00000039756

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
99480

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:99480

UCSC genome browser

More...
UCSCi
uc008rep.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135957 mRNA Translation: BAE22744.1
AK163260 mRNA Translation: BAE37264.1
AK168536 mRNA Translation: BAE40414.1
BC028305 mRNA Translation: AAH28305.1
CCDSiCCDS17809.1
RefSeqiNP_722501.1, NM_153806.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi221260, 2 interactors
IntActiQ8R2M2, 1 interactor
MINTiQ8R2M2
STRINGi10090.ENSMUSP00000045043

PTM databases

iPTMnetiQ8R2M2
PhosphoSitePlusiQ8R2M2
SwissPalmiQ8R2M2

Proteomic databases

EPDiQ8R2M2
jPOSTiQ8R2M2
MaxQBiQ8R2M2
PaxDbiQ8R2M2
PeptideAtlasiQ8R2M2
PRIDEiQ8R2M2

Genome annotation databases

EnsembliENSMUST00000035776; ENSMUSP00000045043; ENSMUSG00000039756
GeneIDi99480
KEGGimmu:99480
UCSCiuc008rep.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30836
MGIiMGI:1923173 Dnttip2

Phylogenomic databases

eggNOGiKOG3100 Eukaryota
ENOG410Z9Q4 LUCA
GeneTreeiENSGT00510000048142
HOGENOMiHOG000154536
InParanoidiQ8R2M2
OMAiTRSMQKK
OrthoDBi887634at2759
PhylomeDBiQ8R2M2
TreeFamiTF105964

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dnttip2 mouse

Protein Ontology

More...
PROi
PR:Q8R2M2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039756 Expressed in 299 organ(s), highest expression level in morula
GenevisibleiQ8R2M2 MM

Family and domain databases

InterProiView protein in InterPro
IPR039883 Fcf2/DNTTIP2
IPR014810 Fcf2_C
PANTHERiPTHR21686 PTHR21686, 1 hit
PfamiView protein in Pfam
PF08698 Fcf2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDIF2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R2M2
Secondary accession number(s): Q3TQW8, Q3UX19
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2002
Last modified: October 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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