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Protein

Phosphoethanolamine/phosphocholine phosphatase

Gene

Phospho1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.1 Publication

Catalytic activityi

O-phosphoethanolamine + H2O = ethanolamine + phosphate.
Phosphocholine + H2O = choline + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32NucleophileBy similarity1
Metal bindingi32MagnesiumBy similarity1
Active sitei34Proton donorBy similarity1
Metal bindingi34MagnesiumBy similarity1
Binding sitei43SubstrateBy similarity1
Binding sitei123SubstrateBy similarity1
Metal bindingi203MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • bone mineralization involved in bone maturation Source: MGI
  • endochondral ossification Source: MGI
  • regulation of bone mineralization Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processMineral balance
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.75 3474
ReactomeiR-MMU-1483191 Synthesis of PC
R-MMU-1483213 Synthesis of PE

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoethanolamine/phosphocholine phosphatase (EC:3.1.3.75)
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2447348 Phospho1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688301 – 267Phosphoethanolamine/phosphocholine phosphataseAdd BLAST267

Proteomic databases

MaxQBiQ8R2H9
PaxDbiQ8R2H9
PRIDEiQ8R2H9

PTM databases

PhosphoSitePlusiQ8R2H9

Expressioni

Tissue specificityi

Has a 120-fold higher level of expression in bone compared with a range of soft tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000050860 Expressed in 45 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ8R2H9 baseline and differential
GenevisibleiQ8R2H9 MM

Interactioni

Protein-protein interaction databases

BioGridi231927, 7 interactors
IntActiQ8R2H9, 7 interactors
STRINGi10090.ENSMUSP00000057858

Structurei

3D structure databases

ProteinModelPortaliQ8R2H9
SMRiQ8R2H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3120 Eukaryota
ENOG4111NAQ LUCA
GeneTreeiENSGT00390000007741
HOGENOMiHOG000231038
HOVERGENiHBG080058
InParanoidiQ8R2H9
KOiK06124
OMAiCFPVAGL
OrthoDBiEOG091G0GZ1
PhylomeDBiQ8R2H9
TreeFamiTF300112

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR016965 Pase_PHOSPHO-typ
IPR006384 PyrdxlP_Pase-rel
PANTHERiPTHR20889 PTHR20889, 1 hit
PfamiView protein in Pfam
PF06888 Put_Phosphatase, 1 hit
PIRSFiPIRSF031051 PyrdxlP_Pase_PHOSPHO2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01489 DKMTPPase-SF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8R2H9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGCFPAVGL RCLSRDGRMA APGAPRFLLT FDFDETIVDE NSDDSIVRAA
60 70 80 90 100
PGQQLPESLR ATYREGYYNE YMQRVFKYLG EQGVRPRDLR AVYETIPLSP
110 120 130 140 150
GMGDLLQFIA KQGSCFEVIL ISDANTFGVE SALRAAGHHS LFRRILSNPS
160 170 180 190 200
GPDARGLLTL RPFHTHSCSR CPANMCKHKV LSEYLRERAR DGVHFERLFY
210 220 230 240 250
VGDGANDFCP MGLLAGGDVA FPRRGYPMHR LIQEAQKAEP SSFRAHVVPW
260
ETAADVRQHL QQVLKMC
Length:267
Mass (Da):29,911
Last modified:June 1, 2002 - v1
Checksum:i0CEEE66019C0CEA7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BLB1H3BLB1_MOUSE
Phosphoethanolamine/phosphocholine ...
Phospho1
191Annotation score:
F6Y6Q2F6Y6Q2_MOUSE
Phosphoethanolamine/phosphocholine ...
Phospho1
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457190 mRNA Translation: CAD29804.1
AL593858 Genomic DNA Translation: CAM15510.1
CCDSiCCDS36288.1
RefSeqiNP_694744.1, NM_153104.3
UniGeneiMm.133075

Genome annotation databases

EnsembliENSMUST00000054173; ENSMUSP00000057858; ENSMUSG00000050860
GeneIDi237928
KEGGimmu:237928
UCSCiuc007las.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457190 mRNA Translation: CAD29804.1
AL593858 Genomic DNA Translation: CAM15510.1
CCDSiCCDS36288.1
RefSeqiNP_694744.1, NM_153104.3
UniGeneiMm.133075

3D structure databases

ProteinModelPortaliQ8R2H9
SMRiQ8R2H9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231927, 7 interactors
IntActiQ8R2H9, 7 interactors
STRINGi10090.ENSMUSP00000057858

PTM databases

PhosphoSitePlusiQ8R2H9

Proteomic databases

MaxQBiQ8R2H9
PaxDbiQ8R2H9
PRIDEiQ8R2H9

Protocols and materials databases

DNASUi237928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054173; ENSMUSP00000057858; ENSMUSG00000050860
GeneIDi237928
KEGGimmu:237928
UCSCiuc007las.2 mouse

Organism-specific databases

CTDi162466
MGIiMGI:2447348 Phospho1

Phylogenomic databases

eggNOGiKOG3120 Eukaryota
ENOG4111NAQ LUCA
GeneTreeiENSGT00390000007741
HOGENOMiHOG000231038
HOVERGENiHBG080058
InParanoidiQ8R2H9
KOiK06124
OMAiCFPVAGL
OrthoDBiEOG091G0GZ1
PhylomeDBiQ8R2H9
TreeFamiTF300112

Enzyme and pathway databases

BRENDAi3.1.3.75 3474
ReactomeiR-MMU-1483191 Synthesis of PC
R-MMU-1483213 Synthesis of PE

Miscellaneous databases

PROiPR:Q8R2H9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050860 Expressed in 45 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ8R2H9 baseline and differential
GenevisibleiQ8R2H9 MM

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR016965 Pase_PHOSPHO-typ
IPR006384 PyrdxlP_Pase-rel
PANTHERiPTHR20889 PTHR20889, 1 hit
PfamiView protein in Pfam
PF06888 Put_Phosphatase, 1 hit
PIRSFiPIRSF031051 PyrdxlP_Pase_PHOSPHO2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01489 DKMTPPase-SF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHOP1_MOUSE
AccessioniPrimary (citable) accession number: Q8R2H9
Secondary accession number(s): A2A619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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