UniProtKB - Q8R2H7 (TRAK2_RAT)
Protein
Trafficking kinesin-binding protein 2
Gene
Trak2
Organism
Rattus norvegicus (Rat)
Status
Functioni
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.1 Publication
GO - Molecular functioni
- enzyme binding Source: RGD
- GABA receptor binding Source: MGI
- kinesin binding Source: RGD
- myosin binding Source: GO_Central
- signaling receptor binding Source: UniProtKB
- TPR domain binding Source: RGD
GO - Biological processi
- anterograde axonal transport Source: GO_Central
- anterograde axonal transport of mitochondrion Source: GO_Central
- anterograde dendritic transport of mitochondrion Source: RGD
- dendrite morphogenesis Source: RGD
- dendritic transport of mitochondrion Source: RGD
- endosome to lysosome transport Source: RGD
- mitochondrion distribution Source: GO_Central
- negative regulation of axonogenesis Source: RGD
- neurogenesis Source: GO_Central
- neurotransmitter transport Source: UniProtKB
- protein localization Source: GO_Central
- protein O-linked glycosylation Source: UniProtKB
- protein targeting Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- vesicle transport along microtubule Source: GO_Central
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking kinesin-binding protein 2Alternative name(s): Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog GABA-A receptor-interacting factor 1 Short name: GRIF-1 O-GlcNAc transferase-interacting protein of 98 kDa |
Gene namesi | Name:Trak2 Synonyms:Als2cr3, Grif1, Oip98 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620915, Trak2 |
Subcellular locationi
Mitochondrion
Endosome
Other locations
Note: Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner.
Endosome
- early endosome Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- axon cytoplasm Source: GOC
- axonal growth cone Source: RGD
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: GO_Central
- dendrite Source: RGD
- dendrite cytoplasm Source: GOC
- neuron projection Source: RGD
- neuronal cell body Source: RGD
Keywords - Cellular componenti
Cytoplasm, Endosome, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064539 | 1 – 913 | Trafficking kinesin-binding protein 2Add BLAST | 913 |
Post-translational modificationi
O-glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8R2H7 |
PRIDEi | Q8R2H7 |
PTM databases
iPTMneti | Q8R2H7 |
PhosphoSitePlusi | Q8R2H7 |
Expressioni
Tissue specificityi
Present in heart and brain (at protein level).1 Publication
Gene expression databases
Bgeei | ENSRNOG00000010881, Expressed in brain and 21 other tissues |
ExpressionAtlasi | Q8R2H7, baseline and differential |
Genevisiblei | Q8R2H7, RN |
Interactioni
Subunit structurei
Interacts with RHOT1/Miro-1 and RHOT2/Miro-2 (By similarity).
Interacts with GABA-A receptor and O-GlcNAc transferase.
Interacts with HGS.
By similarity3 PublicationsBinary interactionsi
Q8R2H7
With | #Exp. | IntAct |
---|---|---|
KIF5A [Q12840] from Homo sapiens. | 2 | EBI-1396483,EBI-713468 |
GO - Molecular functioni
- enzyme binding Source: RGD
- GABA receptor binding Source: MGI
- kinesin binding Source: RGD
- myosin binding Source: GO_Central
- signaling receptor binding Source: UniProtKB
- TPR domain binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 251098, 5 interactors |
IntActi | Q8R2H7, 4 interactors |
MINTi | Q8R2H7 |
STRINGi | 10116.ENSRNOP00000015035 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 353 | HAP1 N-terminalAdd BLAST | 306 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 359 – 507 | Interaction with HGS1 PublicationAdd BLAST | 149 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 134 – 355 | Sequence analysisAdd BLAST | 222 | |
Coiled coili | 502 – 519 | Sequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the milton family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4360, Eukaryota |
GeneTreei | ENSGT00940000158202 |
HOGENOMi | CLU_013450_0_1_1 |
InParanoidi | Q8R2H7 |
OMAi | RSKKACH |
OrthoDBi | 1003820at2759 |
PhylomeDBi | Q8R2H7 |
TreeFami | TF323495 |
Family and domain databases
InterProi | View protein in InterPro IPR006933, HAP1_N IPR022154, TRAK1/2_C |
Pfami | View protein in Pfam PF04849, HAP1_N, 1 hit PF12448, Milton, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8R2H7-1) [UniParc]FASTAAdd to basket
Also known as: GRIF-1a
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLSQNAIFK SQTGEENLMS SNHRDSESIT DVCSNEDLPE VELVNLLEEQ
60 70 80 90 100
LPQYKLRVDS LFLYENQDWS QSSHQQQDAS ETLSPVLAEE TFRYMILGTD
110 120 130 140 150
RVEQMTKTYN DIDMVTHLLA ERDRDLELAA RIGQALLKRN HVLSEQNESL
160 170 180 190 200
EEQLGQAFDQ VNQLQHELSK KEELLRIVSI ASEESETDSS CSTPLRFNES
210 220 230 240 250
FSLSQGLLQL DMMHEKLKEL EEENMALRSK ACHIKTETFT YEEKEQKLIN
260 270 280 290 300
DCVNELRETN AQMSRMTEEL SGKSDELLRY QEEISSLLSQ IVDLQHKLKE
310 320 330 340 350
HVIEKEELRL HLQASKDAQR QLTMELHELQ DRNMECLGML HESQEEIKEL
360 370 380 390 400
RNKAGPSAHL CFSQAYGVFA GESLAAEIEG TMRKKLSLDE ESVFKQKAQQ
410 420 430 440 450
KRVFDTVKVA NDTRGRSVTF PVLLPIPGSN RSSVIMTAKP FESGVQQTED
460 470 480 490 500
KTLPNQGSST EVPGNSHPRD PPGLPEDSDL ATALHRLSLR RQNYLSEKQF
510 520 530 540 550
FAEEWERKLQ ILAEQEEEVS SCEALTENLA SFCTDQSETT ELGSAGCLRG
560 570 580 590 600
FMPEKLQIVK PLEGSQTLHH WQQLAQPNLG TILDPRPGVI TKGFTQMPKD
610 620 630 640 650
AVYHISDLEE DEEVGITFQV QQPLQLEQKP APPPPVTGIF LPPMTSAGGP
660 670 680 690 700
VSVATSNPGK CLSFTNSTFT FTTCRILHPS DITQVTPSSG FPSLSCGSSA
710 720 730 740 750
GSASNTAVNS PAASYRLSIG ESITNRRDST ITFSSTRSLA KLLQERGISA
760 770 780 790 800
KVYHSPASEN PLLQLRPKAL ATPSTPPNSP SQSPCSSPVP FEPRVHVSEN
810 820 830 840 850
FLASRPAETF LQEMYGLRPS RAPPDVGQLK MNLVDRLKRL GIARVVKTPV
860 870 880 890 900
PRENGKSREA EMGLQKPDSA VYLNSGGSLL GGLRRNQSLP VMMGSFGAPV
910
CTTSPKMGIL KED
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K434 | A0A0G2K434_RAT | Trafficking kinesin-binding protein... | Trak2 | 877 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 609 | E → V1 Publication | 1 | |
Natural varianti | 820 | S → P1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003786 | 653 – 672 | VATSN…TFTFT → ALVSHHCPVEAVRAVHPTRL in isoform 2. 2 PublicationsAdd BLAST | 20 | |
Alternative sequenceiVSP_003787 | 673 – 913 | Missing in isoform 2. 2 PublicationsAdd BLAST | 241 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ288898 mRNA Translation: CAC81785.2 AJ288898 mRNA Translation: CAC81786.2 AF474163 mRNA Translation: AAL84588.1 Frameshift. BC088393 mRNA Translation: AAH88393.1 |
RefSeqi | NP_598244.2, NM_133560.2 [Q8R2H7-1] |
Genome annotation databases
Ensembli | ENSRNOT00000014939; ENSRNOP00000014939; ENSRNOG00000010881 [Q8R2H7-1] ENSRNOT00000015034; ENSRNOP00000015035; ENSRNOG00000010881 [Q8R2H7-1] |
GeneIDi | 171086 |
KEGGi | rno:171086 |
UCSCi | RGD:620915, rat [Q8R2H7-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ288898 mRNA Translation: CAC81785.2 AJ288898 mRNA Translation: CAC81786.2 AF474163 mRNA Translation: AAL84588.1 Frameshift. BC088393 mRNA Translation: AAH88393.1 |
RefSeqi | NP_598244.2, NM_133560.2 [Q8R2H7-1] |
3D structure databases
SMRi | Q8R2H7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 251098, 5 interactors |
IntActi | Q8R2H7, 4 interactors |
MINTi | Q8R2H7 |
STRINGi | 10116.ENSRNOP00000015035 |
PTM databases
iPTMneti | Q8R2H7 |
PhosphoSitePlusi | Q8R2H7 |
Proteomic databases
PaxDbi | Q8R2H7 |
PRIDEi | Q8R2H7 |
Protocols and materials databases
ABCDi | Q8R2H7, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSRNOT00000014939; ENSRNOP00000014939; ENSRNOG00000010881 [Q8R2H7-1] ENSRNOT00000015034; ENSRNOP00000015035; ENSRNOG00000010881 [Q8R2H7-1] |
GeneIDi | 171086 |
KEGGi | rno:171086 |
UCSCi | RGD:620915, rat [Q8R2H7-1] |
Organism-specific databases
CTDi | 66008 |
RGDi | 620915, Trak2 |
Phylogenomic databases
eggNOGi | KOG4360, Eukaryota |
GeneTreei | ENSGT00940000158202 |
HOGENOMi | CLU_013450_0_1_1 |
InParanoidi | Q8R2H7 |
OMAi | RSKKACH |
OrthoDBi | 1003820at2759 |
PhylomeDBi | Q8R2H7 |
TreeFami | TF323495 |
Miscellaneous databases
PROi | PR:Q8R2H7 |
Gene expression databases
Bgeei | ENSRNOG00000010881, Expressed in brain and 21 other tissues |
ExpressionAtlasi | Q8R2H7, baseline and differential |
Genevisiblei | Q8R2H7, RN |
Family and domain databases
InterProi | View protein in InterPro IPR006933, HAP1_N IPR022154, TRAK1/2_C |
Pfami | View protein in Pfam PF04849, HAP1_N, 1 hit PF12448, Milton, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAK2_RAT | |
Accessioni | Q8R2H7Primary (citable) accession number: Q8R2H7 Secondary accession number(s): Q8R2H6, Q8R4G3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2002 |
Last sequence update: | November 21, 2003 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families