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Protein

NF-kappa-B inhibitor-like protein 1

Gene

Nfkbil1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-like protein 1
Alternative name(s):
Inhibitor of kappa B-like protein
Short name:
I-kappa-B-like protein
Short name:
IkappaBL
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Gene namesi
Name:Nfkbil1
Synonyms:Ikbl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303310 Nfkbil1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670141 – 381NF-kappa-B inhibitor-like protein 1Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R2H1
PRIDEiQ8R2H1

Expressioni

Gene expression databases

BgeeiENSRNOG00000000839
ExpressionAtlasiQ8R2H1 baseline and differential
GenevisibleiQ8R2H1 RN

Interactioni

Subunit structurei

Interacts with CACTIN (via N-terminal domain); the interaction occurs in a proinflammatory-independent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001113

Structurei

3D structure databases

ProteinModelPortaliQ8R2H1
SMRiQ8R2H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 93ANK 1Add BLAST30
Repeati97 – 133ANK 2Add BLAST37

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IZ7E Eukaryota
ENOG4111NZ2 LUCA
GeneTreeiENSGT00390000013929
HOGENOMiHOG000043101
HOVERGENiHBG048799
InParanoidiQ8R2H1
KOiK09256
OMAiQIETWEL
OrthoDBiEOG091G0HSG
PhylomeDBiQ8R2H1
TreeFamiTF333242

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038753 NFKBIL1
PANTHERiPTHR15263 PTHR15263, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R2H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPSPQAPE EEASTSVCRP QSSMASVSRR HRRERRFRRY LSAGRLVRAQ
60 70 80 90 100
ALLQRHPGLD VDAGQPPPLH RACARHDAPA LCLLLRLGAD PAHQDRHGDT
110 120 130 140 150
ALHAAARQGP NAYTDFFLPL LSRCPSAMGI KNKDGETPGQ ILGWGPPWDS
160 170 180 190 200
AEEEEDEEVS KEREWRQKLQ GELEDEWQEV IGRFEDDASR ETQEPESFSA
210 220 230 240 250
WSERLAREHA QKQRRQQLEA EGSRRPPRAE GSSHSWRQQE EEQRLFRERA
260 270 280 290 300
RVKEKELCES RARRAQEAQG DRGPAPPRAR PRAEHPRGAG RGSLWRFGDV
310 320 330 340 350
PWPCPGGGDP EAMAAALVAR GPPLEEQGAL KRYLRVQQVR WHPDRFLQRF
360 370 380
RNQIETWELG RVMGAVTALS QALNRHAEAL K
Length:381
Mass (Da):43,293
Last modified:March 1, 2004 - v2
Checksum:i21C415DEA6F9617B
GO

Sequence cautioni

The sequence AAL98918 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA Translation: CAE84005.1
BC099772 mRNA Translation: AAH99772.1
AF387339 Genomic DNA Translation: AAL98918.1 Sequence problems.
RefSeqiNP_997674.1, NM_212509.2
UniGeneiRn.38632

Genome annotation databases

EnsembliENSRNOT00000001113; ENSRNOP00000001113; ENSRNOG00000000839
GeneIDi361794
KEGGirno:361794
UCSCiRGD:1303310 rat

Similar proteinsi

Entry informationi

Entry nameiIKBL1_RAT
AccessioniPrimary (citable) accession number: Q8R2H1
Secondary accession number(s): Q499T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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