Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 1 regulatory subunit 42

Gene

Ppp1r42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • dynein complex binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

GO - Biological processi

  • regulation of phosphatase activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 42
Alternative name(s):
Leucine-rich repeat-containing protein 67
Testis leucine-rich repeat protein
Short name:
TLRR
Gene namesi
Name:Ppp1r42
Synonyms:Lrrc67
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921138 Ppp1r42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003261771 – 357Protein phosphatase 1 regulatory subunit 42Add BLAST357

Post-translational modificationi

Phosphorylated; during the first round of spermatogenesis with a marginal increase at 21 days after birth.1 Publication

Proteomic databases

PaxDbiQ8R1Z4
PRIDEiQ8R1Z4

PTM databases

iPTMnetiQ8R1Z4
PhosphoSitePlusiQ8R1Z4

Expressioni

Tissue specificityi

Testis-specific. Expressed in spermatids (at protein level). Testis-specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000025916
ExpressionAtlasiQ8R1Z4 baseline and differential
GenevisibleiQ8R1Z4 MM

Interactioni

Subunit structurei

Interacts with PPP1CC isoform gamma-2; the interaction is direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin. Associates with microtubules.3 Publications

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027049

Structurei

3D structure databases

ProteinModelPortaliQ8R1Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 50LRR 1Add BLAST22
Repeati51 – 72LRR 2Add BLAST22
Repeati73 – 94LRR 3Add BLAST22
Repeati95 – 116LRR 4Add BLAST22
Repeati117 – 138LRR 5Add BLAST22
Repeati147 – 168LRR 6Add BLAST22
Repeati169 – 190LRR 7Add BLAST22
Domaini204 – 242LRRCTAdd BLAST39

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG2769 Eukaryota
ENOG410XQV0 LUCA
GeneTreeiENSGT00910000144294
HOGENOMiHOG000068029
HOVERGENiHBG061602
InParanoidiQ8R1Z4
KOiK17579
OMAiLYLYDNC
OrthoDBiEOG091G09ZV
PhylomeDBiQ8R1Z4
TreeFamiTF329227

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12799 LRR_4, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R1Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRLTVDLIA KNSNLKPRKE ETLAQCLKKI THINFSDRNI DSIDDLSLCR
60 70 80 90 100
NLSVLYLYDN RISQVTNLNY TTNLTHLYLQ NNCISCIENL SSLKKLEKLY
110 120 130 140 150
LGGNYIAVIE GLEGLEELRE LHVESQRLPL GEKLLFDPRT LRSLAKSLST
160 170 180 190 200
LNISNNNIDD IKDLEILENL NHLIAVDNQL MHVKDLELLL KKLMKLWKMD
210 220 230 240 250
LNGNPVCLKP KYRDKLILTS KSLEFLDGKE IKDMERQFLM NWKASKDAKK
260 270 280 290 300
ISKKRRSRSE DASNSYISNF ETVHHIVPVY YPQVGKPKVI FFSDVQRYLV
310 320 330 340 350
HGNASSKCSQ EDKTTITEDI GNLSLKESES SLTKNDIHEP HLLQNPKVKE

NLSEKKE
Length:357
Mass (Da):41,151
Last modified:June 1, 2002 - v1
Checksum:i46C5A57D53A604E1
GO
Isoform 2 (identifier: Q8R1Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-186: DL → VT
     187-357: Missing.

Show »
Length:186
Mass (Da):21,289
Checksum:iAF2991E547B8458F
GO
Isoform 3 (identifier: Q8R1Z4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-357: Missing.

Show »
Length:145
Mass (Da):16,663
Checksum:iF587814771732FA5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032589146 – 357Missing in isoform 3. 1 PublicationAdd BLAST212
Alternative sequenceiVSP_032590185 – 186DL → VT in isoform 2. 1 Publication2
Alternative sequenceiVSP_032591187 – 357Missing in isoform 2. 1 PublicationAdd BLAST171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005871 mRNA Translation: BAB24290.1
AK015164 mRNA Translation: BAB29732.1
AK076637 mRNA Translation: BAC36427.1
BC022722 mRNA Translation: AAH22722.1
CCDSiCCDS14817.1 [Q8R1Z4-1]
RefSeqiNP_663730.1, NM_145692.2 [Q8R1Z4-1]
UniGeneiMm.386795

Genome annotation databases

EnsembliENSMUST00000027049; ENSMUSP00000027049; ENSMUSG00000025916 [Q8R1Z4-1]
ENSMUST00000130102; ENSMUSP00000115030; ENSMUSG00000025916 [Q8R1Z4-3]
GeneIDi69312
KEGGimmu:69312
UCSCiuc007ahb.2 mouse [Q8R1Z4-1]
uc007ahd.2 mouse [Q8R1Z4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPPR42_MOUSE
AccessioniPrimary (citable) accession number: Q8R1Z4
Secondary accession number(s): Q9D5M1, Q9DAF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2002
Last modified: February 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health