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Protein

Interphotoreceptor matrix proteoglycan 1

Gene

Impg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.By similarity

Keywordsi

Molecular functionReceptor
LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Interphotoreceptor matrix proteoglycan 1
Alternative name(s):
Interphotoreceptor matrix proteoglycan of 150 kDa
Short name:
IPM-150
Sialoprotein associated with cones and rods
Gene namesi
Name:Impg1Imported
Synonyms:Spacr1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926876 Impg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025223921 – 798Interphotoreceptor matrix proteoglycan 1Sequence analysisAdd BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi186O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi457O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi473O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi474O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi477O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi559O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi634N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi652N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Highly glycosylated (N- and O-linked carbohydrates and sialic acid).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8R1W8
PRIDEiQ8R1W8

PTM databases

iPTMnetiQ8R1W8
PhosphoSitePlusiQ8R1W8

Expressioni

Tissue specificityi

Abundantly expressed in retina.2 Publications

Gene expression databases

BgeeiENSMUSG00000032343 Expressed in 32 organ(s), highest expression level in retina
CleanExiMM_IMPG1
ExpressionAtlasiQ8R1W8 baseline and differential
GenevisibleiQ8R1W8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108876

Structurei

3D structure databases

ProteinModelPortaliQ8R1W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 357SEA 1PROSITE-ProRule annotationAdd BLAST123
Domaini575 – 688SEA 2PROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH0G Eukaryota
ENOG410Y9FF LUCA
GeneTreeiENSGT00530000063503
HOGENOMiHOG000113063
HOVERGENiHBG081793
InParanoidiQ8R1W8
KOiK19016
OMAiEIHVLGF
OrthoDBiEOG091G094N
PhylomeDBiQ8R1W8
TreeFamiTF331340

Family and domain databases

Gene3Di3.30.70.960, 2 hits
InterProiView protein in InterPro
IPR039861 IMPG
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PANTHERiPTHR12199 PTHR12199, 1 hit
PfamiView protein in Pfam
PF01390 SEA, 2 hits
SMARTiView protein in SMART
SM00200 SEA, 2 hits
SUPFAMiSSF82671 SSF82671, 2 hits
PROSITEiView protein in PROSITE
PS50024 SEA, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: Q8R1W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLQIKHAIF VLGIFLQVQG IKDTSIKIFS SEIKNIDKTP RIETIESTST
60 70 80 90 100
VHKVSTMKRI FDLPKLRTKR SALFPAANIC PQESLRQILA SLQEYYRLRV
110 120 130 140 150
CQEVVWEAYR IFLDRIPDTE EYQDWVSLCQ KETFCLFDIG KNFSNSQEHL
160 170 180 190 200
DLLQQRIKQR SFPGRKDETA SMETLEAPTE APVVPTDVSR MSLGPFPLPS
210 220 230 240 250
DDTDLKEILS VTLKDIQKPT TESKTEPIHV SEFSSEEKVE FSISLPNHRF
260 270 280 290 300
KAELTNSGSP YYQELVGQSQ LQLQKIFKKL PGFGEIRVLG FRPKKEEDGS
310 320 330 340 350
SSTEIQLMAI FKRDHAEAKS PDSHLLSLDS NKIESERIHH GVIEDKQPET
360 370 380 390 400
YLTATDLKKL IIQLLDGDLS LVEGKIPFGD EVTGTLFRPV TEPDLPKPLA
410 420 430 440 450
DVTEDATLSP ELPFVEPRLE AVDREGSELP GMSSKDSSWS PPVSASISRS
460 470 480 490 500
ENLPSFTPSI FSLDAQSPPP LMTTGPTALI PKPTLPTIDY STIRQLPLES
510 520 530 540 550
SHWPASSSDR ELITSSHDTI RDLDGMDVSD TPALSEISEL SGYDSASGQF
560 570 580 590 600
LEMTTPIPTV RFITTSSETI ATKGQELVVF FSLRVANMPF SYDLFNKSSL
610 620 630 640 650
EYQALEQRFT DLLVPYLRSN LTGFKQLEIL SFRNGSVIVN SKVRFAKAVP
660 670 680 690 700
YNLTQAVRGV LEDLRSTAAQ GLNLEIESYS LDIEPADQAD PCKLLDCGKF
710 720 730 740 750
AQCVKNEWTE EAECRCRQGH ESHGTLDYQT LNLCPPGKTC VAGREQATPC
760 770 780 790
RPPDHSTNQA QEPGVKKLRQ QNKVVKKRNS KLSAIGFEEF EDQDWEGN
Length:798
Mass (Da):89,474
Last modified:June 1, 2002 - v1
Checksum:iE875FB5587389D4C
GO
Isoform 21 Publication (identifier: Q8R1W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:742
Mass (Da):83,193
Checksum:i73BDF075786A9B61
GO
Isoform 31 Publication (identifier: Q8R1W8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-99: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:721
Mass (Da):80,568
Checksum:i5EA086C3CDD59DD7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8V8A0A140T8V8_MOUSE
Interphotoreceptor matrix proteogly...
Impg1
215Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → F in AAG00796 (PubMed:10958699).Curated1
Sequence conflicti12L → F in AAG00796 (PubMed:10958699).Curated1
Sequence conflicti224K → I in AAG32162 (PubMed:10995555).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0521711 – 56Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_05217223 – 99Missing in isoform 3. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229929 mRNA Translation: AAG32162.1
AF266478 mRNA Translation: AAG00796.1
BC022970 mRNA Translation: AAH22970.1
AK020862 mRNA Translation: BAB32231.3
CCDSiCCDS57685.1 [Q8R1W8-1]
RefSeqiNP_071299.3, NM_022016.3 [Q8R1W8-1]
XP_006511391.1, XM_006511328.3 [Q8R1W8-1]
UniGeneiMm.422780

Genome annotation databases

EnsembliENSMUST00000085289; ENSMUSP00000082395; ENSMUSG00000032343 [Q8R1W8-3]
ENSMUST00000113250; ENSMUSP00000108876; ENSMUSG00000032343 [Q8R1W8-1]
GeneIDi63859
KEGGimmu:63859
UCSCiuc009qvi.2 mouse [Q8R1W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229929 mRNA Translation: AAG32162.1
AF266478 mRNA Translation: AAG00796.1
BC022970 mRNA Translation: AAH22970.1
AK020862 mRNA Translation: BAB32231.3
CCDSiCCDS57685.1 [Q8R1W8-1]
RefSeqiNP_071299.3, NM_022016.3 [Q8R1W8-1]
XP_006511391.1, XM_006511328.3 [Q8R1W8-1]
UniGeneiMm.422780

3D structure databases

ProteinModelPortaliQ8R1W8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108876

PTM databases

iPTMnetiQ8R1W8
PhosphoSitePlusiQ8R1W8

Proteomic databases

PaxDbiQ8R1W8
PRIDEiQ8R1W8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085289; ENSMUSP00000082395; ENSMUSG00000032343 [Q8R1W8-3]
ENSMUST00000113250; ENSMUSP00000108876; ENSMUSG00000032343 [Q8R1W8-1]
GeneIDi63859
KEGGimmu:63859
UCSCiuc009qvi.2 mouse [Q8R1W8-1]

Organism-specific databases

CTDi3617
MGIiMGI:1926876 Impg1

Phylogenomic databases

eggNOGiENOG410IH0G Eukaryota
ENOG410Y9FF LUCA
GeneTreeiENSGT00530000063503
HOGENOMiHOG000113063
HOVERGENiHBG081793
InParanoidiQ8R1W8
KOiK19016
OMAiEIHVLGF
OrthoDBiEOG091G094N
PhylomeDBiQ8R1W8
TreeFamiTF331340

Miscellaneous databases

PROiPR:Q8R1W8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032343 Expressed in 32 organ(s), highest expression level in retina
CleanExiMM_IMPG1
ExpressionAtlasiQ8R1W8 baseline and differential
GenevisibleiQ8R1W8 MM

Family and domain databases

Gene3Di3.30.70.960, 2 hits
InterProiView protein in InterPro
IPR039861 IMPG
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PANTHERiPTHR12199 PTHR12199, 1 hit
PfamiView protein in Pfam
PF01390 SEA, 2 hits
SMARTiView protein in SMART
SM00200 SEA, 2 hits
SUPFAMiSSF82671 SSF82671, 2 hits
PROSITEiView protein in PROSITE
PS50024 SEA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIMPG1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1W8
Secondary accession number(s): Q9CTP8, Q9ES62, Q9ET31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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