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Protein

Transmembrane emp24 domain-containing protein 4

Gene

Tmed4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vesicular protein trafficking, mainly in the early secretory pathway. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).By similarity1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • Golgi organization Source: GO_Central
  • intracellular protein transport Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 4
Alternative name(s):
Endoplasmic reticulum stress-response protein 25
Short name:
ERS25
p24 family protein alpha-3
Short name:
p24alpha3
p26
Gene namesi
Name:Tmed4
Synonyms:Ers25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915070 Tmed4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 194LumenalSequence analysisAdd BLAST165
Transmembranei195 – 212HelicalSequence analysisAdd BLAST18
Topological domaini213 – 227CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001038830 – 227Transmembrane emp24 domain-containing protein 4Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8R1V4
MaxQBiQ8R1V4
PaxDbiQ8R1V4
PeptideAtlasiQ8R1V4
PRIDEiQ8R1V4

PTM databases

iPTMnetiQ8R1V4
PhosphoSitePlusiQ8R1V4

Expressioni

Inductioni

By brefeldin A, oxidative stress and heat shock, but not by tunicamycin, hypersomotic stress or serum starvation.1 Publication

Gene expression databases

BgeeiENSMUSG00000004394 Expressed in 288 organ(s), highest expression level in white adipose tissue
ExpressionAtlasiQ8R1V4 baseline and differential
GenevisibleiQ8R1V4 MM

Interactioni

Protein-protein interaction databases

IntActiQ8R1V4, 3 interactors
MINTiQ8R1V4
STRINGi10090.ENSMUSP00000004508

Structurei

3D structure databases

SMRiQ8R1V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 137GOLDPROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili147 – 176Sequence analysisAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi220 – 227COPI vesicle coat-bindingSequence analysis8
Motifi220 – 221COPII vesicle coat-bindingSequence analysis2

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1690 Eukaryota
ENOG410XPUW LUCA
GeneTreeiENSGT00430000030848
HOGENOMiHOG000160228
HOVERGENiHBG105357
InParanoidiQ8R1V4
KOiK20346
OMAiIRREQQY
OrthoDBiEOG091G0JDW
PhylomeDBiQ8R1V4
TreeFamiTF314123

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R1V4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGVGVGPLQ GMVRFGLLVL TVCAACARGL YFHIGETEKR CFIEEIPDET
60 70 80 90 100
MVIGNYRTQM WDKQKEVFLP STPGLGMHVE VKDPDGKVVL SRQYGSEGRF
110 120 130 140 150
TFTSHTPGDH QICLHSNSTR MALFAGGKLR VHLDIQVGEH ANNYPEIAAK
160 170 180 190 200
DKLTELQLRA RQLLDQVEQI QKEQDYQRYR EERFRLTSES TNQRVLWWSI
210 220
AQTVILILTG IWQMRHLKSF FEAKKLV
Length:227
Mass (Da):26,022
Last modified:June 1, 2002 - v1
Checksum:i38BF0C8475C954BD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SVW9Q5SVW9_MOUSE
Transmembrane emp24 domain-containi...
Tmed4
170Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368921 mRNA Translation: AAM20821.1
AK078425 mRNA Translation: BAC37268.1
AK158876 mRNA Translation: BAE34708.1
AL607152 Genomic DNA No translation available.
BC023041 mRNA Translation: AAH23041.1
CCDSiCCDS24415.1
RefSeqiNP_598781.1, NM_134020.1
UniGeneiMm.254495
Mm.471082

Genome annotation databases

EnsembliENSMUST00000004508; ENSMUSP00000004508; ENSMUSG00000004394
GeneIDi103694
KEGGimmu:103694
UCSCiuc007hye.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368921 mRNA Translation: AAM20821.1
AK078425 mRNA Translation: BAC37268.1
AK158876 mRNA Translation: BAE34708.1
AL607152 Genomic DNA No translation available.
BC023041 mRNA Translation: AAH23041.1
CCDSiCCDS24415.1
RefSeqiNP_598781.1, NM_134020.1
UniGeneiMm.254495
Mm.471082

3D structure databases

SMRiQ8R1V4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R1V4, 3 interactors
MINTiQ8R1V4
STRINGi10090.ENSMUSP00000004508

PTM databases

iPTMnetiQ8R1V4
PhosphoSitePlusiQ8R1V4

Proteomic databases

EPDiQ8R1V4
MaxQBiQ8R1V4
PaxDbiQ8R1V4
PeptideAtlasiQ8R1V4
PRIDEiQ8R1V4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004508; ENSMUSP00000004508; ENSMUSG00000004394
GeneIDi103694
KEGGimmu:103694
UCSCiuc007hye.1 mouse

Organism-specific databases

CTDi222068
MGIiMGI:1915070 Tmed4

Phylogenomic databases

eggNOGiKOG1690 Eukaryota
ENOG410XPUW LUCA
GeneTreeiENSGT00430000030848
HOGENOMiHOG000160228
HOVERGENiHBG105357
InParanoidiQ8R1V4
KOiK20346
OMAiIRREQQY
OrthoDBiEOG091G0JDW
PhylomeDBiQ8R1V4
TreeFamiTF314123

Miscellaneous databases

PROiPR:Q8R1V4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004394 Expressed in 288 organ(s), highest expression level in white adipose tissue
ExpressionAtlasiQ8R1V4 baseline and differential
GenevisibleiQ8R1V4 MM

Family and domain databases

InterProiView protein in InterPro
IPR009038 GOLD_dom
IPR015720 TMP21-related
PANTHERiPTHR22811 PTHR22811, 1 hit
PfamiView protein in Pfam
PF01105 EMP24_GP25L, 1 hit
SMARTiView protein in SMART
SM01190 EMP24_GP25L, 1 hit
PROSITEiView protein in PROSITE
PS50866 GOLD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMED4_MOUSE
AccessioniPrimary (citable) accession number: Q8R1V4
Secondary accession number(s): Q3TY55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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