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Protein

Conserved oligomeric Golgi complex subunit 4

Gene

Cog4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 4
Short name:
COG complex subunit 4
Alternative name(s):
Component of oligomeric Golgi complex 4
Gene namesi
Name:Cog4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142808 Cog4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002135052 – 785Conserved oligomeric Golgi complex subunit 4Add BLAST784

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8R1U1
MaxQBiQ8R1U1
PaxDbiQ8R1U1
PeptideAtlasiQ8R1U1
PRIDEiQ8R1U1

PTM databases

iPTMnetiQ8R1U1
PhosphoSitePlusiQ8R1U1

Expressioni

Gene expression databases

BgeeiENSMUSG00000031753 Expressed in 278 organ(s), highest expression level in dorsal pancreas
CleanExiMM_COG4
ExpressionAtlasiQ8R1U1 baseline and differential
GenevisibleiQ8R1U1 MM

Interactioni

Subunit structurei

Monomer. Component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Mediates interaction of SCFD1 with the COG complex. Interacts with STX5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8R1U1, 1 interactor
STRINGi10090.ENSMUSP00000034203

Structurei

3D structure databases

ProteinModelPortaliQ8R1U1
SMRiQ8R1U1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 84Interaction with SCFD1By similarityAdd BLAST83
Regioni85 – 153Interaction with STX5By similarityAdd BLAST69
Regioni618 – 740D domainBy similarityAdd BLAST123
Regioni741 – 785E domain; essential for proper cell surface glycosylationBy similarityAdd BLAST45

Sequence similaritiesi

Belongs to the COG4 family.Curated

Phylogenomic databases

eggNOGiKOG0412 Eukaryota
ENOG410XS60 LUCA
GeneTreeiENSGT00390000003662
HOGENOMiHOG000006874
HOVERGENiHBG031403
InParanoidiQ8R1U1
KOiK20291
OrthoDBiEOG091G02P2
PhylomeDBiQ8R1U1
TreeFamiTF105835

Family and domain databases

InterProiView protein in InterPro
IPR013167 COG_su4
PfamiView protein in Pfam
PF08318 COG4, 1 hit
SMARTiView protein in SMART
SM00762 Cog4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q8R1U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVESPLKL SGAPPPPEGV GGGHCSEIST ELIRSLTELQ ELEAVYERLC
60 70 80 90 100
GEEKAVEKEL DALLEQQNTI ESKMVTLHRM GPSLQLIEGD AKQLAGMITF
110 120 130 140 150
TCSLAENVSS KVRQLDLAKN RLYQAIQRAD DILDLKFCMD GVQTALRNED
160 170 180 190 200
YEQAAAHIHR YLCLDKSVIE LSRQGKEGSM IDANLKLLQE AEQRLKAIVA
210 220 230 240 250
EKFAIATKEG DLPQVERFFK IFPLLGLHED GLSKFSEYLC KQVASKAEEN
260 270 280 290 300
LLLVLGSDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLF
310 320 330 340 350
TLIKYLQVEC DTQVEKVVNK FIKQRDYHQQ FRLVQSNLMR NSATEKIEPR
360 370 380 390 400
ELDPVLTEVT LMNARSELYL RFLRKRISAD FEVGDSMASE EVKQEHQKCL
410 420 430 440 450
DKLLNNCLLS CTMQELIGFY ITMEEYFMRE TVNKAVALDT YEKGQLTSSM
460 470 480 490 500
VDDVFYIVKK CIGRALSSSN IDCLCAMINL ATRELEADFR DVLCNKLRMG
510 520 530 540 550
FPATTLQDIQ RGVTSAVNIM HSSLQQGKFD TKGIESTDEA KLSFLVTLNN
560 570 580 590 600
VEVCSENIST LKKTLESDCT KLFSQGIGGE QAQAKFDSCL SDLAAVSNKF
610 620 630 640 650
RDLLQEGLAE LNSSAVKPQV QPWINTFLSV SHSIEEEEFN DYEANDPWVQ
660 670 680 690 700
QFILNLEQQM AEFKASLSPV IYDSLTGLMT SLVAVELEKV VLKSTFNRLG
710 720 730 740 750
GLQFDKELRS LIAYLTTVTT WTIRDKFARL SQMATILNLE RVTEILDYWG
760 770 780
ANSGPLTWRL TPAEVRQVLA LRIDFRNEDI KRLRL
Length:785
Mass (Da):88,661
Last modified:June 1, 2002 - v1
Checksum:i057D846C5319E4EE
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TSQ9Q7TSQ9_MOUSE
Component of oligomeric golgi compl...
Cog4
712Annotation score:
G3UWH9G3UWH9_MOUSE
Conserved oligomeric Golgi complex ...
Cog4
763Annotation score:
G3UWX2G3UWX2_MOUSE
Conserved oligomeric Golgi complex ...
Cog4
180Annotation score:
G3UWY4G3UWY4_MOUSE
Conserved oligomeric Golgi complex ...
Cog4
96Annotation score:
G3UZ15G3UZ15_MOUSE
Conserved oligomeric Golgi complex ...
Cog4
76Annotation score:
G3UYW8G3UYW8_MOUSE
Conserved oligomeric Golgi complex ...
Cog4
117Annotation score:
G3XA67G3XA67_MOUSE
Conserved oligomeric Golgi complex ...
Cog4
157Annotation score:
G3UX78G3UX78_MOUSE
Conserved oligomeric Golgi complex ...
Cog4
59Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172465 mRNA Translation: BAE43019.1
CH466525 Genomic DNA Translation: EDL11474.1
BC023120 mRNA Translation: AAH23120.1
CCDSiCCDS40477.1
RefSeqiNP_598734.1, NM_133973.2
UniGeneiMm.272930

Genome annotation databases

EnsembliENSMUST00000034203; ENSMUSP00000034203; ENSMUSG00000031753
GeneIDi102339
KEGGimmu:102339
UCSCiuc009nle.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172465 mRNA Translation: BAE43019.1
CH466525 Genomic DNA Translation: EDL11474.1
BC023120 mRNA Translation: AAH23120.1
CCDSiCCDS40477.1
RefSeqiNP_598734.1, NM_133973.2
UniGeneiMm.272930

3D structure databases

ProteinModelPortaliQ8R1U1
SMRiQ8R1U1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R1U1, 1 interactor
STRINGi10090.ENSMUSP00000034203

PTM databases

iPTMnetiQ8R1U1
PhosphoSitePlusiQ8R1U1

Proteomic databases

EPDiQ8R1U1
MaxQBiQ8R1U1
PaxDbiQ8R1U1
PeptideAtlasiQ8R1U1
PRIDEiQ8R1U1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034203; ENSMUSP00000034203; ENSMUSG00000031753
GeneIDi102339
KEGGimmu:102339
UCSCiuc009nle.1 mouse

Organism-specific databases

CTDi25839
MGIiMGI:2142808 Cog4

Phylogenomic databases

eggNOGiKOG0412 Eukaryota
ENOG410XS60 LUCA
GeneTreeiENSGT00390000003662
HOGENOMiHOG000006874
HOVERGENiHBG031403
InParanoidiQ8R1U1
KOiK20291
OrthoDBiEOG091G02P2
PhylomeDBiQ8R1U1
TreeFamiTF105835

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

PROiPR:Q8R1U1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031753 Expressed in 278 organ(s), highest expression level in dorsal pancreas
CleanExiMM_COG4
ExpressionAtlasiQ8R1U1 baseline and differential
GenevisibleiQ8R1U1 MM

Family and domain databases

InterProiView protein in InterPro
IPR013167 COG_su4
PfamiView protein in Pfam
PF08318 COG4, 1 hit
SMARTiView protein in SMART
SM00762 Cog4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOG4_MOUSE
AccessioniPrimary (citable) accession number: Q8R1U1
Secondary accession number(s): Q3T9K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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