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Protein

Metastasis suppressor protein 1

Gene

Mtss1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the nucleation of actin filaments in vitro.1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: MGI
  • actin monomer binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis suppressor protein 1
Alternative name(s):
Missing in metastasis protein
Gene namesi
Name:Mtss1
Synonyms:Mim
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384818 Mtss1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi746K → A: Loss of actin-binding. 1 Publication1
Mutagenesisi747K → A: Loss of actin-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966401 – 759Metastasis suppressor protein 1Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphothreonineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei429PhosphothreonineCombined sources1
Modified residuei607PhosphothreonineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei651PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8R1S4
PRIDEiQ8R1S4

PTM databases

iPTMnetiQ8R1S4
PhosphoSitePlusiQ8R1S4

Expressioni

Tissue specificityi

Strongly expressed in the developing neurons and skeletal and cardiac muscles in embryos. Strongly expressed also in liver, outer layers of the kidney, and in the Purkinje cells of the brain.1 Publication

Gene expression databases

CleanExiMM_MTSS1

Interactioni

Subunit structurei

Binds to actin.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229230, 2 interactors
DIPiDIP-29271N
IntActiQ8R1S4, 4 interactors
STRINGi10090.ENSMUSP00000079239

Structurei

Secondary structure

1759
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8R1S4
SMRiQ8R1S4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R1S4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 254IMDPROSITE-ProRule annotationAdd BLAST254
Domaini731 – 748WH2PROSITE-ProRule annotationCuratedAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 157Sequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 363Ser-richAdd BLAST122
Compositional biasi612 – 730Pro-richAdd BLAST119

Domaini

The WH2 motif at the C-terminus binds to actin monomers.1 Publication

Sequence similaritiesi

Belongs to the MTSS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGVU Eukaryota
ENOG410XRT4 LUCA
HOGENOMiHOG000113691
HOVERGENiHBG052530
InParanoidiQ8R1S4
KOiK20128
PhylomeDBiQ8R1S4

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR027682 MIM
IPR030127 MIM/ABBA
IPR003124 WH2_dom
PANTHERiPTHR15708 PTHR15708, 1 hit
PTHR15708:SF10 PTHR15708:SF10, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF02205 WH2, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS51082 WH2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q8R1S4-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA
60 70 80 90 100
AAAFLDAFQK VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL
110 120 130 140 150
IDCLINPLQE QMEEWKKVAN QLDKDHAKEY KKARQEIKNK SSDTLKLQKK
160 170 180 190 200
AKKVDAQGRG DIQPQLDSAL QDVNDKYLLL EETEKQAVRK ALIEERGRFC
210 220 230 240 250
TFISMLRPVI EEEISMLGEI THLQTISEDL KSLTMDPHKL PSSSEQVILD
260 270 280 290 300
LKGSDYSWSY QTPPSSPSTT MSRKSSVCSS LNSVNSSDSR SSGSHSHSPS
310 320 330 340 350
SHYRYRSSNL AQQAPVRLSS VSSHDSGFIS QDAFQSKSPS PMPPEAANQL
360 370 380 390 400
SNGFSHCSLS SESHAGPVGA GPFPHCLPAS RLLPRVTSVH LPDYAHYYTI
410 420 430 440 450
GPGMFPSSQI PSWKDWAKPG PYDQPLVNTL QRRKEKREPD SNGGGPTTTG
460 470 480 490 500
GPPAGAEEAQ RPRSMTVSAA TRPGEEMAAC EELTLALSRG LQLDVQRSSR
510 520 530 540 550
DSLQCSSGYS TQTTTPCCSE DTIPSQVSDY DYFSVSGDQE AEQQEFDKSS
560 570 580 590 600
TIPRNSDISQ SYRRMFQAKR PASTAGLPTT LGPAMVTPGV ATIRRTPSTK
610 620 630 640 650
PSVRRGTIGA GPIPIKTPVI PVKTPTVPDL PGVLPSPPDG PEERGEHSPE
660 670 680 690 700
SPSAGEGPQG VSNIPSSLWS GQAPVNPPLP GPKPSIPEEH RQAIPESEAE
710 720 730 740 750
DQERDPPSAT VSPGPIPESD PADLSPRESP QGEDMLNAIR RGVKLKKTTT

NDRSAPRFS
Length:759
Mass (Da):82,408
Last modified:June 1, 2002 - v1
Checksum:i3E9008065FF78439
GO
Isoform 2Curated (identifier: Q8R1S4-2) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     483-483: L → P
     487-487: L → P
     646-681: Missing.

Show »
Length:723
Mass (Da):78,829
Checksum:i52B227AA050AB392
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9H7G3X9H7_MOUSE
Metastasis suppressor 1, isoform CR...
Mtss1 mCG_116708
759Annotation score:
A0A2I3BPM9A0A2I3BPM9_MOUSE
Metastasis suppressor protein 1
Mtss1
204Annotation score:
A0A2I3BQ67A0A2I3BQ67_MOUSE
Metastasis suppressor protein 1
Mtss1
242Annotation score:
A0A2I3BQ92A0A2I3BQ92_MOUSE
Metastasis suppressor protein 1
Mtss1
162Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139N → K in BAC27008 (PubMed:16141072).Curated1
Sequence conflicti758F → L in BAC27008 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050527483L → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_050528487L → P in isoform 2. 1 Publication1
Alternative sequenceiVSP_050529646 – 681Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214918 mRNA Translation: AAO52743.1
BC003483 mRNA Translation: AAH03483.1
BC024131 mRNA Translation: AAH24131.1
BC042632 mRNA Translation: AAH42632.1
AK030533 mRNA Translation: BAC27008.1
CCDSiCCDS27496.1 [Q8R1S4-1]
RefSeqiNP_659049.2, NM_144800.2
UniGeneiMm.215481
Mm.394414

Genome annotation databases

GeneIDi211401
KEGGimmu:211401

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY214918 mRNA Translation: AAO52743.1
BC003483 mRNA Translation: AAH03483.1
BC024131 mRNA Translation: AAH24131.1
BC042632 mRNA Translation: AAH42632.1
AK030533 mRNA Translation: BAC27008.1
CCDSiCCDS27496.1 [Q8R1S4-1]
RefSeqiNP_659049.2, NM_144800.2
UniGeneiMm.215481
Mm.394414

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D1LX-ray1.85A/B1-250[»]
ProteinModelPortaliQ8R1S4
SMRiQ8R1S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229230, 2 interactors
DIPiDIP-29271N
IntActiQ8R1S4, 4 interactors
STRINGi10090.ENSMUSP00000079239

PTM databases

iPTMnetiQ8R1S4
PhosphoSitePlusiQ8R1S4

Proteomic databases

PaxDbiQ8R1S4
PRIDEiQ8R1S4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi211401
KEGGimmu:211401

Organism-specific databases

CTDi9788
MGIiMGI:2384818 Mtss1

Phylogenomic databases

eggNOGiENOG410IGVU Eukaryota
ENOG410XRT4 LUCA
HOGENOMiHOG000113691
HOVERGENiHBG052530
InParanoidiQ8R1S4
KOiK20128
PhylomeDBiQ8R1S4

Miscellaneous databases

ChiTaRSiMtss1 mouse
EvolutionaryTraceiQ8R1S4
PROiPR:Q8R1S4
SOURCEiSearch...

Gene expression databases

CleanExiMM_MTSS1

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR027682 MIM
IPR030127 MIM/ABBA
IPR003124 WH2_dom
PANTHERiPTHR15708 PTHR15708, 1 hit
PTHR15708:SF10 PTHR15708:SF10, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF02205 WH2, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS51082 WH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTSS1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1S4
Secondary accession number(s): Q8BMM3, Q99LB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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