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Protein

Cytoplasmic dynein 1 light intermediate chain 1

Gene

Dync1li1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 81ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • dynein heavy chain binding Source: MGI
  • GDP binding Source: MGI
  • microtubule motor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6798695 Neutrophil degranulation
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 1
Alternative name(s):
Dynein light chain A
Short name:
DLC-A
Dynein light intermediate chain 1, cytosolic
Gene namesi
Name:Dync1li1
Synonyms:Dncli1, Dnclic1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2135610 Dync1li1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Dynein, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146671 – 523Cytoplasmic dynein 1 light intermediate chain 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207PhosphoserineCombined sources1
Modified residuei213PhosphothreonineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei405PhosphoserineCombined sources1
Modified residuei408PhosphothreonineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei421PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei486PhosphoserineBy similarity1
Modified residuei510PhosphoserineCombined sources1
Modified residuei512PhosphothreonineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Modified residuei515PhosphothreonineCombined sources1
Modified residuei516PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis but not in interphase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R1Q8
MaxQBiQ8R1Q8
PaxDbiQ8R1Q8
PRIDEiQ8R1Q8

PTM databases

iPTMnetiQ8R1Q8
PhosphoSitePlusiQ8R1Q8

Expressioni

Gene expression databases

BgeeiENSMUSG00000032435 Expressed in 266 organ(s), highest expression level in forebrain
CleanExiMM_DYNC1LI1
ExpressionAtlasiQ8R1Q8 baseline and differential
GenevisibleiQ8R1Q8 MM

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with PCNT (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231702, 51 interactors
IntActiQ8R1Q8, 52 interactors
MINTiQ8R1Q8
STRINGi10090.ENSMUSP00000035366

Structurei

3D structure databases

ProteinModelPortaliQ8R1Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905 Eukaryota
ENOG410XQS4 LUCA
GeneTreeiENSGT00390000008295
HOGENOMiHOG000236263
HOVERGENiHBG005546
InParanoidiQ8R1Q8
KOiK10416
OMAiLCVVCQN
OrthoDBiEOG091G0B3J
PhylomeDBiQ8R1Q8
TreeFamiTF352602

Family and domain databases

InterProiView protein in InterPro
IPR008467 Dynein1_light_intermed_chain
IPR022780 Dynein_light_int_chain
IPR027417 P-loop_NTPase
PANTHERiPTHR12688 PTHR12688, 1 hit
PfamiView protein in Pfam
PF05783 DLIC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q8R1Q8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVGRVGSF GSSPPGLAST YASGPLANEL ASGSGGPAAG DDEDGQNLWS
60 70 80 90 100
CILSEVSTRS RSKLPTGKNV LLLGEDGAGK TSLIRRIQGI EEYKKGRGLE
110 120 130 140 150
YLYLNVHDED RDDQTRCNVW ILDGDLYHKG LLKFSLDALS LRDTLVMLVV
160 170 180 190 200
DMSKPWTALD SLQKWASVVR EHVDKLKIPP EEMKEMEQKL IRDFQEYVEP
210 220 230 240 250
GEDFPASPQR RTTGAQEDRG DSVVLPLGAD TLTHNLGLPV LVVCTKCDAI
260 270 280 290 300
SVLEKEHDYR DEHFDFIQSH IRKFCLQYGA ALIYTSVKEN KNIDLVYKYI
310 320 330 340 350
VQKLYGFPYK IPAVVVEKDA VFIPAGWDND KKIGILHENF QTLKVEDNFE
360 370 380 390 400
DIITKPPVRK FVHEKEIMAE DDQVFLMKLQ SLLAKQPPTA AGRPVDASPR
410 420 430 440 450
VPGGSPRTPN RSVSSNVASV SPIPAGSKKI DPNMKAGATS EGVLANFFNS
460 470 480 490 500
LLSKKTGSPG GPGVGGSPGG GAAGASPSLP PSAKKSGQKP VLSDVHAELD
510 520
RITRKPASVS PTTPTSPTEG EAS
Length:523
Mass (Da):56,614
Last modified:June 1, 2002 - v1
Checksum:iF080D6865A399498
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023347 mRNA Translation: AAH23347.1
CCDSiCCDS23595.1
RefSeqiNP_666341.1, NM_146229.2
UniGeneiMm.128627

Genome annotation databases

EnsembliENSMUST00000047404; ENSMUSP00000035366; ENSMUSG00000032435
GeneIDi235661
KEGGimmu:235661
UCSCiuc009rxy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023347 mRNA Translation: AAH23347.1
CCDSiCCDS23595.1
RefSeqiNP_666341.1, NM_146229.2
UniGeneiMm.128627

3D structure databases

ProteinModelPortaliQ8R1Q8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231702, 51 interactors
IntActiQ8R1Q8, 52 interactors
MINTiQ8R1Q8
STRINGi10090.ENSMUSP00000035366

PTM databases

iPTMnetiQ8R1Q8
PhosphoSitePlusiQ8R1Q8

Proteomic databases

EPDiQ8R1Q8
MaxQBiQ8R1Q8
PaxDbiQ8R1Q8
PRIDEiQ8R1Q8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047404; ENSMUSP00000035366; ENSMUSG00000032435
GeneIDi235661
KEGGimmu:235661
UCSCiuc009rxy.1 mouse

Organism-specific databases

CTDi51143
MGIiMGI:2135610 Dync1li1

Phylogenomic databases

eggNOGiKOG3905 Eukaryota
ENOG410XQS4 LUCA
GeneTreeiENSGT00390000008295
HOGENOMiHOG000236263
HOVERGENiHBG005546
InParanoidiQ8R1Q8
KOiK10416
OMAiLCVVCQN
OrthoDBiEOG091G0B3J
PhylomeDBiQ8R1Q8
TreeFamiTF352602

Enzyme and pathway databases

ReactomeiR-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2132295 MHC class II antigen presentation
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-6798695 Neutrophil degranulation
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiDync1li1 mouse
PROiPR:Q8R1Q8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032435 Expressed in 266 organ(s), highest expression level in forebrain
CleanExiMM_DYNC1LI1
ExpressionAtlasiQ8R1Q8 baseline and differential
GenevisibleiQ8R1Q8 MM

Family and domain databases

InterProiView protein in InterPro
IPR008467 Dynein1_light_intermed_chain
IPR022780 Dynein_light_int_chain
IPR027417 P-loop_NTPase
PANTHERiPTHR12688 PTHR12688, 1 hit
PfamiView protein in Pfam
PF05783 DLIC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDC1L1_MOUSE
AccessioniPrimary (citable) accession number: Q8R1Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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