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Protein

Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein

Gene

Hmces

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (PubMed:23434322). May act as a peptidase; experimental evidences are however required to confirm this prediction.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
Short name:
ES cell-specific 5hmC-binding protein
Alternative name(s):
Putative peptidase SRAPD1 (EC:3.4.-.-)
SRAP domain-containing protein 1
Gene namesi
Name:Hmces
Synonyms:Srapd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914053 Hmces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643951 – 353Embryonic stem cell-specific 5-hydroxymethylcytosine-binding proteinAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei160PhosphoserineBy similarity1
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei294PhosphoserineBy similarity1
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei321PhosphoserineBy similarity1
Cross-linki339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki342Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8R1M0
MaxQBiQ8R1M0
PaxDbiQ8R1M0
PeptideAtlasiQ8R1M0
PRIDEiQ8R1M0

PTM databases

iPTMnetiQ8R1M0
PhosphoSitePlusiQ8R1M0

Expressioni

Gene expression databases

BgeeiENSMUSG00000030060 Expressed in 273 organ(s), highest expression level in secondary oocyte
CleanExiMM_8430410A17RIK
ExpressionAtlasiQ8R1M0 baseline and differential
GenevisibleiQ8R1M0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032141

Structurei

3D structure databases

ProteinModelPortaliQ8R1M0
SMRiQ8R1M0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2618 Eukaryota
COG2135 LUCA
GeneTreeiENSGT00390000018439
HOGENOMiHOG000104694
HOVERGENiHBG081414
InParanoidiQ8R1M0
OMAiQKMLQWL
OrthoDBiEOG091G09R0
PhylomeDBiQ8R1M0
TreeFamiTF324343

Family and domain databases

Gene3Di3.90.1680.10, 1 hit
InterProiView protein in InterPro
IPR003738 SRAP
IPR036590 SRAP-like
PANTHERiPTHR13604 PTHR13604, 1 hit
PfamiView protein in Pfam
PF02586 SRAP, 1 hit
SUPFAMiSSF143081 SSF143081, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R1M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGRTSCHLP REVLTRACAY QDRQGRRRLP QWRDPDKYCP SYNKSPQSSS
60 70 80 90 100
PVLLSRLHFE KDADSSDRII IPMRWGLVPS WFKESDPSKL QFNTTNCRSD
110 120 130 140 150
TIMEKQSFKV PLGKGRRCVV LADGFYEWQR CQGTNQRQPY FIYFPQIKTE
160 170 180 190 200
KSGGNDASDS SDNKEKVWDN WRLLTMAGIF DCWEAPGGEC LYSYSIITVD
210 220 230 240 250
SCRGLSDIHS RMPAILDGEE AVSKWLDFGE VATQEALKLI HPIDNITFHP
260 270 280 290 300
VSPVVNNSRN NTPECLAPAD LLVKKEPKAN GSSQRMMQWL ATKSPKKEVP
310 320 330 340 350
DSPKKDASGL PQWSSQFLQK SPLPAKRGAT SSFLDRWLKQ EKEDEPMAKK

PNS
Length:353
Mass (Da):40,169
Last modified:June 1, 2002 - v1
Checksum:i3A34829AFD4603C2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SWG0A0A0N4SWG0_MOUSE
Embryonic stem cell-specific 5-hydr...
Hmces
76Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024401 mRNA Translation: AAH24401.1
BC064070 mRNA Translation: AAH64070.1
CCDSiCCDS39551.1
RefSeqiNP_776098.1, NM_173737.2
UniGeneiMm.246241

Genome annotation databases

EnsembliENSMUST00000032141; ENSMUSP00000032141; ENSMUSG00000030060
ENSMUST00000113606; ENSMUSP00000109236; ENSMUSG00000030060
GeneIDi232210
KEGGimmu:232210
UCSCiuc009cuh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024401 mRNA Translation: AAH24401.1
BC064070 mRNA Translation: AAH64070.1
CCDSiCCDS39551.1
RefSeqiNP_776098.1, NM_173737.2
UniGeneiMm.246241

3D structure databases

ProteinModelPortaliQ8R1M0
SMRiQ8R1M0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032141

PTM databases

iPTMnetiQ8R1M0
PhosphoSitePlusiQ8R1M0

Proteomic databases

EPDiQ8R1M0
MaxQBiQ8R1M0
PaxDbiQ8R1M0
PeptideAtlasiQ8R1M0
PRIDEiQ8R1M0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032141; ENSMUSP00000032141; ENSMUSG00000030060
ENSMUST00000113606; ENSMUSP00000109236; ENSMUSG00000030060
GeneIDi232210
KEGGimmu:232210
UCSCiuc009cuh.1 mouse

Organism-specific databases

CTDi56941
MGIiMGI:1914053 Hmces

Phylogenomic databases

eggNOGiKOG2618 Eukaryota
COG2135 LUCA
GeneTreeiENSGT00390000018439
HOGENOMiHOG000104694
HOVERGENiHBG081414
InParanoidiQ8R1M0
OMAiQKMLQWL
OrthoDBiEOG091G09R0
PhylomeDBiQ8R1M0
TreeFamiTF324343

Miscellaneous databases

ChiTaRSiHmces mouse
PROiPR:Q8R1M0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030060 Expressed in 273 organ(s), highest expression level in secondary oocyte
CleanExiMM_8430410A17RIK
ExpressionAtlasiQ8R1M0 baseline and differential
GenevisibleiQ8R1M0 MM

Family and domain databases

Gene3Di3.90.1680.10, 1 hit
InterProiView protein in InterPro
IPR003738 SRAP
IPR036590 SRAP-like
PANTHERiPTHR13604 PTHR13604, 1 hit
PfamiView protein in Pfam
PF02586 SRAP, 1 hit
SUPFAMiSSF143081 SSF143081, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMCES_MOUSE
AccessioniPrimary (citable) accession number: Q8R1M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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