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Entry version 124 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

ER lumen protein-retaining receptor 3

Gene

Kdelr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei193Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6807878, COPI-mediated anterograde transport
R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ER lumen protein-retaining receptor 3
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 3
Short name:
KDEL receptor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kdelr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2145953, Kdelr3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4LumenalCurated4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 24HelicalBy similarityAdd BLAST20
Topological domaini25 – 32CytoplasmicCurated8
Transmembranei33 – 52HelicalBy similarityAdd BLAST20
Topological domaini53 – 58LumenalCurated6
Transmembranei59 – 79HelicalBy similarityAdd BLAST21
Topological domaini80 – 92CytoplasmicCuratedAdd BLAST13
Transmembranei93 – 110HelicalBy similarityAdd BLAST18
Topological domaini111 – 116LumenalCurated6
Transmembranei117 – 135HelicalBy similarityAdd BLAST19
Topological domaini136 – 149CytoplasmicCuratedAdd BLAST14
Transmembranei150 – 168HelicalBy similarityAdd BLAST19
Topological domaini169 – 178LumenalCurated10
Transmembranei179 – 199HelicalBy similarityAdd BLAST21
Topological domaini200 – 214CytoplasmicCuratedAdd BLAST15

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001941591 – 214ER lumen protein-retaining receptor 3Add BLAST214

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R1L4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R1L4

PRoteomics IDEntifications database

More...
PRIDEi
Q8R1L4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275534

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R1L4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000010830, Expressed in humerus cartilage element and 248 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R1L4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Interaction with the K-D-E-L motif on target proteinsBy similarity1
Sitei117Interaction with the K-D-E-L motif on target proteinsBy similarity1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
222922, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000010974

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R1L4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R1L4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 48Interaction with the K-D-E-L motif on target proteinsBy similarity2
Regioni159 – 169Interaction with the K-D-E-L motif on target proteinsBy similarityAdd BLAST11
Regioni204 – 207Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3106, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_057784_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R1L4

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRYHTES

Database of Orthologous Groups

More...
OrthoDBi
1186269at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R1L4

TreeFam database of animal gene trees

More...
TreeFami
TF314792

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000133, ER_ret_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR10585, PTHR10585, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00810, ER_lumen_recept, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00660, ERLUMENR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00951, ER_LUMEN_RECEPTOR_1, 1 hit
PS00952, ER_LUMEN_RECEPTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8R1L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVFRILGDL SHLLAMILLL VKIWRSKSCA GISGKSQILF ALVFTTRYLD
60 70 80 90 100
LFSNFISIYN TVMKVVFLLC AYVTVYMIYW KFRKTFDIEN DTFRLEFLLV
110 120 130 140 150
PVTGLSFLVN YSYTPMEVLW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRL LYLANWIRRY QTENFYDQIS VVSGVVQTIF YCDFFYLYVT
210
KVLKGKKLSL PVPV
Length:214
Mass (Da):25,111
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2546A2CC1EB8708D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141T → P in BAE23198 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK136991 mRNA Translation: BAE23198.1
BC011472 mRNA Translation: AAH11472.1
BC024420 mRNA Translation: AAH24420.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27642.1

NCBI Reference Sequences

More...
RefSeqi
NP_598851.2, NM_134090.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000010974; ENSMUSP00000010974; ENSMUSG00000010830

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
105785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:105785

UCSC genome browser

More...
UCSCi
uc007wto.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136991 mRNA Translation: BAE23198.1
BC011472 mRNA Translation: AAH11472.1
BC024420 mRNA Translation: AAH24420.1
CCDSiCCDS27642.1
RefSeqiNP_598851.2, NM_134090.2

3D structure databases

SMRiQ8R1L4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi222922, 1 interactor
STRINGi10090.ENSMUSP00000010974

PTM databases

PhosphoSitePlusiQ8R1L4

Proteomic databases

MaxQBiQ8R1L4
PaxDbiQ8R1L4
PRIDEiQ8R1L4
ProteomicsDBi275534

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26349, 100 antibodies

The DNASU plasmid repository

More...
DNASUi
105785

Genome annotation databases

EnsembliENSMUST00000010974; ENSMUSP00000010974; ENSMUSG00000010830
GeneIDi105785
KEGGimmu:105785
UCSCiuc007wto.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11015
MGIiMGI:2145953, Kdelr3

Phylogenomic databases

eggNOGiKOG3106, Eukaryota
GeneTreeiENSGT00390000004010
HOGENOMiCLU_057784_0_0_1
InParanoidiQ8R1L4
OMAiWRYHTES
OrthoDBi1186269at2759
PhylomeDBiQ8R1L4
TreeFamiTF314792

Enzyme and pathway databases

ReactomeiR-MMU-6807878, COPI-mediated anterograde transport
R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
105785, 3 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Kdelr3, mouse

Protein Ontology

More...
PROi
PR:Q8R1L4
RNActiQ8R1L4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000010830, Expressed in humerus cartilage element and 248 other tissues
GenevisibleiQ8R1L4, MM

Family and domain databases

InterProiView protein in InterPro
IPR000133, ER_ret_rcpt
PANTHERiPTHR10585, PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810, ER_lumen_recept, 1 hit
PRINTSiPR00660, ERLUMENR
PROSITEiView protein in PROSITE
PS00951, ER_LUMEN_RECEPTOR_1, 1 hit
PS00952, ER_LUMEN_RECEPTOR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERD23_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R1L4
Secondary accession number(s): Q3UVS1, Q91X67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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