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Protein

ER lumen protein-retaining receptor 3

Gene

Kdelr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • protein retention in ER lumen Source: GO_Central
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 3
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 3
Short name:
KDEL receptor 3
Gene namesi
Name:Kdelr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145953 Kdelr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 214CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941591 – 214ER lumen protein-retaining receptor 3Add BLAST214

Proteomic databases

MaxQBiQ8R1L4
PaxDbiQ8R1L4
PRIDEiQ8R1L4

PTM databases

PhosphoSitePlusiQ8R1L4

Expressioni

Gene expression databases

BgeeiENSMUSG00000010830 Expressed in 223 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8R1L4 MM

Interactioni

Protein-protein interaction databases

BioGridi222922, 1 interactor
STRINGi10090.ENSMUSP00000010974

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106 Eukaryota
COG5196 LUCA
GeneTreeiENSGT00390000004010
HOGENOMiHOG000231400
HOVERGENiHBG001398
InParanoidiQ8R1L4
KOiK10949
OMAiIWRSKSC
OrthoDBiEOG091G0Q1H
PhylomeDBiQ8R1L4
TreeFamiTF314792

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R1L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVFRILGDL SHLLAMILLL VKIWRSKSCA GISGKSQILF ALVFTTRYLD
60 70 80 90 100
LFSNFISIYN TVMKVVFLLC AYVTVYMIYW KFRKTFDIEN DTFRLEFLLV
110 120 130 140 150
PVTGLSFLVN YSYTPMEVLW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRL LYLANWIRRY QTENFYDQIS VVSGVVQTIF YCDFFYLYVT
210
KVLKGKKLSL PVPV
Length:214
Mass (Da):25,111
Last modified:June 1, 2002 - v1
Checksum:i2546A2CC1EB8708D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141T → P in BAE23198 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136991 mRNA Translation: BAE23198.1
BC011472 mRNA Translation: AAH11472.1
BC024420 mRNA Translation: AAH24420.1
CCDSiCCDS27642.1
RefSeqiNP_598851.2, NM_134090.2
UniGeneiMm.298199

Genome annotation databases

EnsembliENSMUST00000010974; ENSMUSP00000010974; ENSMUSG00000010830
GeneIDi105785
KEGGimmu:105785
UCSCiuc007wto.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136991 mRNA Translation: BAE23198.1
BC011472 mRNA Translation: AAH11472.1
BC024420 mRNA Translation: AAH24420.1
CCDSiCCDS27642.1
RefSeqiNP_598851.2, NM_134090.2
UniGeneiMm.298199

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222922, 1 interactor
STRINGi10090.ENSMUSP00000010974

PTM databases

PhosphoSitePlusiQ8R1L4

Proteomic databases

MaxQBiQ8R1L4
PaxDbiQ8R1L4
PRIDEiQ8R1L4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010974; ENSMUSP00000010974; ENSMUSG00000010830
GeneIDi105785
KEGGimmu:105785
UCSCiuc007wto.2 mouse

Organism-specific databases

CTDi11015
MGIiMGI:2145953 Kdelr3

Phylogenomic databases

eggNOGiKOG3106 Eukaryota
COG5196 LUCA
GeneTreeiENSGT00390000004010
HOGENOMiHOG000231400
HOVERGENiHBG001398
InParanoidiQ8R1L4
KOiK10949
OMAiIWRSKSC
OrthoDBiEOG091G0Q1H
PhylomeDBiQ8R1L4
TreeFamiTF314792

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:Q8R1L4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010830 Expressed in 223 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8R1L4 MM

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERD23_MOUSE
AccessioniPrimary (citable) accession number: Q8R1L4
Secondary accession number(s): Q3UVS1, Q91X67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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