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UniProtKB - Q8R1K4 (AT2L2_MOUSE)
Protein
5-phosphohydroxy-L-lysine phospho-lyase
Gene
Phykpl
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde.
By similarityCaution
Does not seem to possess aminotransferase activity.By similarity
Catalytic activityi
- EC:4.2.3.134
Cofactori
pyridoxal 5'-phosphateBy similarity
GO - Molecular functioni
- identical protein binding Source: MGI
- lyase activity Source: UniProtKB-KW
- pyridoxal phosphate binding Source: InterPro
- transaminase activity Source: InterPro
Keywordsi
Molecular function | Lyase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
Reactomei | R-MMU-1442490, Collagen degradation R-MMU-71064, Lysine catabolism |
Names & Taxonomyi
Protein namesi | Recommended name: 5-phosphohydroxy-L-lysine phospho-lyase (EC:4.2.3.134)Alternative name(s): Alanine--glyoxylate aminotransferase 2-like 2 |
Gene namesi | Name:Phykpl Synonyms:Agxt2l2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920197, Phykpl |
VEuPathDBi | HostDB:ENSMUSG00000020359 |
Subcellular locationi
Mitochondrion
- Mitochondrion Curated
Mitochondrion
- mitochondrion Source: MGI
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287668 | 1 – 467 | 5-phosphohydroxy-L-lysine phospho-lyaseAdd BLAST | 467 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 278 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Proteomic databases
EPDi | Q8R1K4 |
MaxQBi | Q8R1K4 |
PaxDbi | Q8R1K4 |
PeptideAtlasi | Q8R1K4 |
PRIDEi | Q8R1K4 |
ProteomicsDBi | 277266 [Q8R1K4-1] 277267 [Q8R1K4-2] 277268 [Q8R1K4-3] |
PTM databases
iPTMneti | Q8R1K4 |
PhosphoSitePlusi | Q8R1K4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020359, Expressed in adult mammalian kidney and 290 other tissues |
ExpressionAtlasi | Q8R1K4, baseline and differential |
Genevisiblei | Q8R1K4, MM |
Interactioni
Subunit structurei
Homotetramer.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000132190 |
Miscellaneous databases
RNActi | Q8R1K4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | KOG1403, Eukaryota |
GeneTreei | ENSGT00940000159222 |
HOGENOMi | CLU_016922_8_0_1 |
InParanoidi | Q8R1K4 |
OMAi | TSGQMSC |
OrthoDBi | 145181at2759 |
PhylomeDBi | Q8R1K4 |
TreeFami | TF320468 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8R1K4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAADTRAKAV TLDLRRRLLS SSCRLFFPED PVKIIRGQGQ YLYDEQGREY
60 70 80 90 100
LDCINNVAHV GHCHPTVVQA AHEQNLVLNT NSRYLHDNIV DYAQRLSETL
110 120 130 140 150
PEQLSVFYFL NSGSEANDLA LRLARQYTGH QDVVVLDHAY HGHLSSLIDI
160 170 180 190 200
SPYKFRNLGG QKEWVHVAPL PDTYRGPYRE DHPNPAEAYA NEVKHVISSA
210 220 230 240 250
QQKGRKIAAF FAESLPSVSG QIIPPAGYFS QVAEHIHRAG GLFVADEIQV
260 270 280 290 300
GFGRIGKHFW AFQLEGEDFV PDIVTMGKSI GNGHPVACMA TTQAVSRAFE
310 320 330 340 350
ATGVEYFNTF GGNPVSCAVG LAVLDVLKTE QLQAHATNVG SFLLEHLTQQ
360 370 380 390 400
KAKHPIIGDV RGTGLFIGVD LIKDETLRTP ATEEAEYLVS RLKENYILLS
410 420 430 440 450
IDGPGKNILK FKPPMCFNVD NAQHVVAKLD DILTDMEEKV RSCETLRIKH
460
PPEDTHPTQI LLTRQQD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WHK6 | F8WHK6_MOUSE | 5-phosphohydroxy-L-lysine phospho-l... | Phykpl Agxt2l2 | 231 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025586 | 168 – 184 | APLPD…EDHPN → VCIPTISNRSVSIPKPG in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_025587 | 185 – 467 | Missing in isoform 3. 1 PublicationAdd BLAST | 283 | |
Alternative sequenceiVSP_025588 | 453 – 467 | EDTHP…TRQQD → GSTGPGCRAATGNRPS in isoform 2. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK085984 mRNA Translation: BAC39584.1 AK087703 mRNA Translation: BAC39972.1 AK133235 mRNA Translation: BAE21570.1 AK160557 mRNA Translation: BAE35872.1 AL645602 Genomic DNA No translation available. AL662843 Genomic DNA No translation available. BC024461 mRNA Translation: AAH24461.1 |
CCDSi | CCDS24653.1 [Q8R1K4-1] |
RefSeqi | NP_082674.1, NM_028398.2 [Q8R1K4-1] |
Genome annotation databases
Ensembli | ENSMUST00000020625; ENSMUSP00000020625; ENSMUSG00000020359 [Q8R1K4-2] ENSMUST00000167797; ENSMUSP00000132190; ENSMUSG00000020359 [Q8R1K4-1] |
GeneIDi | 72947 |
KEGGi | mmu:72947 |
UCSCi | uc007itw.1, mouse [Q8R1K4-3] uc007itx.1, mouse [Q8R1K4-2] uc007ity.1, mouse [Q8R1K4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK085984 mRNA Translation: BAC39584.1 AK087703 mRNA Translation: BAC39972.1 AK133235 mRNA Translation: BAE21570.1 AK160557 mRNA Translation: BAE35872.1 AL645602 Genomic DNA No translation available. AL662843 Genomic DNA No translation available. BC024461 mRNA Translation: AAH24461.1 |
CCDSi | CCDS24653.1 [Q8R1K4-1] |
RefSeqi | NP_082674.1, NM_028398.2 [Q8R1K4-1] |
3D structure databases
SMRi | Q8R1K4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000132190 |
PTM databases
iPTMneti | Q8R1K4 |
PhosphoSitePlusi | Q8R1K4 |
Proteomic databases
EPDi | Q8R1K4 |
MaxQBi | Q8R1K4 |
PaxDbi | Q8R1K4 |
PeptideAtlasi | Q8R1K4 |
PRIDEi | Q8R1K4 |
ProteomicsDBi | 277266 [Q8R1K4-1] 277267 [Q8R1K4-2] 277268 [Q8R1K4-3] |
Protocols and materials databases
Antibodypediai | 29429, 154 antibodies from 26 providers |
DNASUi | 72947 |
Genome annotation databases
Ensembli | ENSMUST00000020625; ENSMUSP00000020625; ENSMUSG00000020359 [Q8R1K4-2] ENSMUST00000167797; ENSMUSP00000132190; ENSMUSG00000020359 [Q8R1K4-1] |
GeneIDi | 72947 |
KEGGi | mmu:72947 |
UCSCi | uc007itw.1, mouse [Q8R1K4-3] uc007itx.1, mouse [Q8R1K4-2] uc007ity.1, mouse [Q8R1K4-1] |
Organism-specific databases
CTDi | 85007 |
MGIi | MGI:1920197, Phykpl |
VEuPathDBi | HostDB:ENSMUSG00000020359 |
Phylogenomic databases
eggNOGi | KOG1403, Eukaryota |
GeneTreei | ENSGT00940000159222 |
HOGENOMi | CLU_016922_8_0_1 |
InParanoidi | Q8R1K4 |
OMAi | TSGQMSC |
OrthoDBi | 145181at2759 |
PhylomeDBi | Q8R1K4 |
TreeFami | TF320468 |
Enzyme and pathway databases
Reactomei | R-MMU-1442490, Collagen degradation R-MMU-71064, Lysine catabolism |
Miscellaneous databases
BioGRID-ORCSi | 72947, 0 hits in 64 CRISPR screens |
ChiTaRSi | Phykpl, mouse |
PROi | PR:Q8R1K4 |
RNActi | Q8R1K4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020359, Expressed in adult mammalian kidney and 290 other tissues |
ExpressionAtlasi | Q8R1K4, baseline and differential |
Genevisiblei | Q8R1K4, MM |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT2L2_MOUSE | |
Accessioni | Q8R1K4Primary (citable) accession number: Q8R1K4 Secondary accession number(s): Q3TUU9, Q8BG04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families