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Protein

Torsin-2A

Gene

Tor2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 100ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-2A
Alternative name(s):
Torsin family 2 member A
Gene namesi
Name:Tor2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1353596 Tor2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi162E → Q: Localizes in the nuclear envelope. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000022883027 – 321Torsin-2AAdd BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8R1J9
MaxQBiQ8R1J9
PaxDbiQ8R1J9
PeptideAtlasiQ8R1J9
PRIDEiQ8R1J9

PTM databases

PhosphoSitePlusiQ8R1J9

Expressioni

Tissue specificityi

Expressed at similar levels in liver, muscle and brain (at protein level).1 Publication

Developmental stagei

At E16, widely expressed in all tissues tested.2 Publications

Gene expression databases

BgeeiENSMUSG00000009563 Expressed in 273 organ(s), highest expression level in placenta
CleanExiMM_TOR2A
ExpressionAtlasiQ8R1J9 baseline and differential
GenevisibleiQ8R1J9 MM

Interactioni

Subunit structurei

Homohexamer. Interacts with TOR1AIP1.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009707

Structurei

3D structure databases

ProteinModelPortaliQ8R1J9
SMRiQ8R1J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpA/ClpB family. Torsin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2170 Eukaryota
ENOG410XR06 LUCA
GeneTreeiENSGT00390000001920
HOGENOMiHOG000115770
HOVERGENiHBG054188
InParanoidiQ8R1J9
OMAiNLTACSR
OrthoDBiEOG091G0B5F
PhylomeDBiQ8R1J9
TreeFamiTF314941

Family and domain databases

InterProiView protein in InterPro
IPR001270 ClpA/B
IPR027417 P-loop_NTPase
IPR010448 Torsin
IPR017378 Torsin_1/2
PANTHERiPTHR10760 PTHR10760, 1 hit
PfamiView protein in Pfam
PF06309 Torsin, 1 hit
PIRSFiPIRSF038079 Torsin_2A, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R1J9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVARHGYRP WGSILGLLGL ALAAAAAWDV ASLRCTFGSF CECDFWPDLP
60 70 80 90 100
GLECDLAQHL AGQHLAKALV VKSLKAFVQD PAPSKPLVLS LHGWTGTGKS
110 120 130 140 150
YVSSLLAQHL FRDGLRSPHV HHFSPIIHFP HPSRTEQYKK ELKSWVQGNL
160 170 180 190 200
TACGRSLFLF DEMDKLPPGL MEVLQPFLGP SWVVYGTNYR KAIFIFISNA
210 220 230 240 250
GGEQINQVAL EAWRSHRDRE EISLQEVEPV ISRAVMDNPQ HGFWRSGIME
260 270 280 290 300
EHLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPSEEVVQA VLDSTTYFPE
310 320
VEQLFSSNGC KTVASRLTFF L
Length:321
Mass (Da):35,897
Last modified:June 1, 2002 - v1
Checksum:i5D8C8988DEB91813
GO
Isoform 2 (identifier: Q8R1J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: Missing.

Note: No experimental confirmation available.
Show »
Length:159
Mass (Da):18,088
Checksum:i3646173AF6DD9365
GO
Isoform 3 (identifier: P0C7W3-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0C7W3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Salusin-beta peptide is derived from isoform 3.
Length:231
Mass (Da):25,377
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJF8H3BJF8_MOUSE
Prosalusin
Tor2a
101Annotation score:
H3BK73H3BK73_MOUSE
Prosalusin
Tor2a
268Annotation score:
H3BL93H3BL93_MOUSE
Prosalusin
Tor2a
72Annotation score:
E9QAU3E9QAU3_MOUSE
Prosalusin
Tor2a
73Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177051 – 162Missing in isoform 2. 1 PublicationAdd BLAST162

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003976 mRNA Translation: BAE43155.1
AK162719 mRNA Translation: BAE37036.1
AK170979 mRNA Translation: BAE42156.1
AK171247 mRNA Translation: BAE42340.1
BC023085 mRNA Translation: AAH23085.1
BC024469 mRNA Translation: AAH24469.1
BC003466 mRNA Translation: AAH03466.1
CCDSiCCDS15929.1 [Q8R1J9-1]
RefSeqiNP_690013.1, NM_152800.3 [Q8R1J9-1]
UniGeneiMm.200695

Genome annotation databases

EnsembliENSMUST00000009707; ENSMUSP00000009707; ENSMUSG00000009563 [Q8R1J9-1]
GeneIDi30933
KEGGimmu:30933
UCSCiuc008jgs.2 mouse [Q8R1J9-2]
uc008jgt.2 mouse [Q8R1J9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003976 mRNA Translation: BAE43155.1
AK162719 mRNA Translation: BAE37036.1
AK170979 mRNA Translation: BAE42156.1
AK171247 mRNA Translation: BAE42340.1
BC023085 mRNA Translation: AAH23085.1
BC024469 mRNA Translation: AAH24469.1
BC003466 mRNA Translation: AAH03466.1
CCDSiCCDS15929.1 [Q8R1J9-1]
RefSeqiNP_690013.1, NM_152800.3 [Q8R1J9-1]
UniGeneiMm.200695

3D structure databases

ProteinModelPortaliQ8R1J9
SMRiQ8R1J9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009707

PTM databases

PhosphoSitePlusiQ8R1J9

Proteomic databases

EPDiQ8R1J9
MaxQBiQ8R1J9
PaxDbiQ8R1J9
PeptideAtlasiQ8R1J9
PRIDEiQ8R1J9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009707; ENSMUSP00000009707; ENSMUSG00000009563 [Q8R1J9-1]
GeneIDi30933
KEGGimmu:30933
UCSCiuc008jgs.2 mouse [Q8R1J9-2]
uc008jgt.2 mouse [Q8R1J9-1]

Organism-specific databases

CTDi27433
MGIiMGI:1353596 Tor2a

Phylogenomic databases

eggNOGiKOG2170 Eukaryota
ENOG410XR06 LUCA
GeneTreeiENSGT00390000001920
HOGENOMiHOG000115770
HOVERGENiHBG054188
InParanoidiQ8R1J9
OMAiNLTACSR
OrthoDBiEOG091G0B5F
PhylomeDBiQ8R1J9
TreeFamiTF314941

Miscellaneous databases

ChiTaRSiTor2a mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009563 Expressed in 273 organ(s), highest expression level in placenta
CleanExiMM_TOR2A
ExpressionAtlasiQ8R1J9 baseline and differential
GenevisibleiQ8R1J9 MM

Family and domain databases

InterProiView protein in InterPro
IPR001270 ClpA/B
IPR027417 P-loop_NTPase
IPR010448 Torsin
IPR017378 Torsin_1/2
PANTHERiPTHR10760 PTHR10760, 1 hit
PfamiView protein in Pfam
PF06309 Torsin, 1 hit
PIRSFiPIRSF038079 Torsin_2A, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOR2A_MOUSE
AccessioniPrimary (citable) accession number: Q8R1J9
Secondary accession number(s): Q3TBH0
, Q3TC01, Q3V4D1, Q8R5B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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