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Protein

Gastrin-releasing peptide

Gene

Grp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (PubMed:28280205, PubMed:17653196, PubMed:26658875). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). Contributes to long-term fear memory, but not normal spatial memory (PubMed:12526815). Contributes to the regulation of food intake (PubMed:12176666).By similarity5 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:Grp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95833 Grp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Disruption phenotypei

Contrary to wild-type, mutant mice do not display imitative scratching after observing spontaneous scratching behavior in another mouse (PubMed:28280205).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PeptideiPRO_000026247224 – 52Gastrin-releasing peptideAdd BLAST29
PeptideiPRO_000026247343 – 52Neuromedin-C10
PropeptideiPRO_000026247456 – 146By similarityAdd BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

MaxQBiQ8R1I2
PaxDbiQ8R1I2
PRIDEiQ8R1I2

PTM databases

PhosphoSitePlusiQ8R1I2

Expressioni

Tissue specificityi

Detected in the suprachiasmatic nucleus in the hypothalamus (PubMed:28280205). Detected in peptidergic dorsal root ganglion neurons (at protein level) (PubMed:17653196). Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus (PubMed:12526815).3 Publications

Gene expression databases

BgeeiENSMUSG00000024517 Expressed in 124 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_GRP
ExpressionAtlasiQ8R1I2 baseline and differential
GenevisibleiQ8R1I2 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025395

Structurei

3D structure databases

SMRiQ8R1I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ53 Eukaryota
ENOG4111D8H LUCA
GeneTreeiENSGT00390000017865
HOGENOMiHOG000112821
HOVERGENiHBG005912
InParanoidiQ8R1I2
KOiK05224
OMAiLTKMYPR
OrthoDBiEOG091G0VOZ
PhylomeDBiQ8R1I2
TreeFamiTF336391

Family and domain databases

InterProiView protein in InterPro
IPR000874 Bombesin
IPR015674 Gastrin-RP
PANTHERiPTHR16866:SF2 PTHR16866:SF2, 1 hit
PfamiView protein in Pfam
PF02044 Bombesin, 1 hit
PROSITEiView protein in PROSITE
PS00257 BOMBESIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8R1I2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH
60 70 80 90 100
LMGKKSTDES PSLYAADRDG LKEQLRGYVR WEEAARDLLD LLEAAGNQSH
110 120 130 140
QPPQHPPLSL QPTWDPEDGS YFNDVQTAKL VDSLLQVLKE KGGTAS
Length:146
Mass (Da):15,659
Last modified:June 1, 2002 - v1
Checksum:i83FD03C40E670CA5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GX72V9GX72_MOUSE
Gastrin-releasing peptide
Grp
136Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134L → Q in BAE23968 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133508 mRNA Translation: BAE21694.1
AK139345 mRNA Translation: BAE23968.1
BC024515 mRNA Translation: AAH24515.1
CCDSiCCDS29310.1
RefSeqiNP_778177.1, NM_175012.4
XP_006525949.1, XM_006525886.3
UniGeneiMm.20298
Mm.394498

Genome annotation databases

EnsembliENSMUST00000025395; ENSMUSP00000025395; ENSMUSG00000024517
ENSMUST00000173985; ENSMUSP00000133437; ENSMUSG00000024517
GeneIDi225642
KEGGimmu:225642
UCSCiuc008ffk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133508 mRNA Translation: BAE21694.1
AK139345 mRNA Translation: BAE23968.1
BC024515 mRNA Translation: AAH24515.1
CCDSiCCDS29310.1
RefSeqiNP_778177.1, NM_175012.4
XP_006525949.1, XM_006525886.3
UniGeneiMm.20298
Mm.394498

3D structure databases

SMRiQ8R1I2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025395

PTM databases

PhosphoSitePlusiQ8R1I2

Proteomic databases

MaxQBiQ8R1I2
PaxDbiQ8R1I2
PRIDEiQ8R1I2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025395; ENSMUSP00000025395; ENSMUSG00000024517
ENSMUST00000173985; ENSMUSP00000133437; ENSMUSG00000024517
GeneIDi225642
KEGGimmu:225642
UCSCiuc008ffk.2 mouse

Organism-specific databases

CTDi2922
MGIiMGI:95833 Grp

Phylogenomic databases

eggNOGiENOG410IZ53 Eukaryota
ENOG4111D8H LUCA
GeneTreeiENSGT00390000017865
HOGENOMiHOG000112821
HOVERGENiHBG005912
InParanoidiQ8R1I2
KOiK05224
OMAiLTKMYPR
OrthoDBiEOG091G0VOZ
PhylomeDBiQ8R1I2
TreeFamiTF336391

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:Q8R1I2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024517 Expressed in 124 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_GRP
ExpressionAtlasiQ8R1I2 baseline and differential
GenevisibleiQ8R1I2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000874 Bombesin
IPR015674 Gastrin-RP
PANTHERiPTHR16866:SF2 PTHR16866:SF2, 1 hit
PfamiView protein in Pfam
PF02044 Bombesin, 1 hit
PROSITEiView protein in PROSITE
PS00257 BOMBESIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRP_MOUSE
AccessioniPrimary (citable) accession number: Q8R1I2
Secondary accession number(s): Q3UTL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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