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Protein

Basic leucine zipper transcriptional factor ATF-like 2

Gene

Batf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CYR61 promoter (By similarity). Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • defense response to protozoan Source: UniProtKB
  • myeloid dendritic cell differentiation Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: InterPro

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper transcriptional factor ATF-like 2
Short name:
B-ATF-2
Gene namesi
Name:Batf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1921731 Batf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display normal development of natural killer (NK), T- and B-cells, plasmacytoid dendritic cells (pDCs), neutrophils, resting CD8-alpha+ classical dendritic cells (cDCs), and peritoneal, liver and lung macrophages. However, they show significantly decreased survival after infection by T.gondii. Notably, mice show significantly decreased numbers of lung-resident CD103+CD11b- dendritic cells and CD103+CD11b- macrophages after infection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886821 – 277Basic leucine zipper transcriptional factor ATF-like 2Add BLAST277

Proteomic databases

PaxDbiQ8R1H8
PRIDEiQ8R1H8

PTM databases

iPTMnetiQ8R1H8
PhosphoSitePlusiQ8R1H8

Expressioni

Inductioni

By cytokines in response to infection. By IFN-gamma.1 Publication

Gene expression databases

BgeeiENSMUSG00000039699 Expressed in 63 organ(s), highest expression level in colon
GenevisibleiQ8R1H8 MM

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with JUN family proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045744

Structurei

3D structure databases

ProteinModelPortaliQ8R1H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 81bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 42Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni46 – 67Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000016869
HOGENOMiHOG000070120
HOVERGENiHBG103463
InParanoidiQ8R1H8
KOiK09034
OMAiLHQQHES
OrthoDBiEOG091G0YSM
PhylomeDBiQ8R1H8
TreeFamiTF332340

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR029857 BATF2
IPR004827 bZIP
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF11 PTHR23351:SF11, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8R1H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQLCGSSELL TETDLGESQK QLKKKQKNRV AAQRSRQKHT SKADALHQQH
60 70 80 90 100
ESLEKQNHAL RKEIQALQTE LAGWGRTLHL HERLCRVDCD PCPVLLPSGC
110 120 130 140 150
PIQAKQPSGQ PAPLGYNGCQ EQLGLFQTPG SSPRAQHLSP GPCSHESPGL
160 170 180 190 200
LPSLLPSLAF DPLMVRTPLA QLSPSPVLSA SSPSGSSLLG SFSKLDPLIP
210 220 230 240 250
SPQDQLAPPQ PLRQEQPTSG RLASSDSPAA LGPECSQNRE HLPALPGSST
260 270
HWQKSSVAPS PQALMAFPLL SSAKVHF
Length:277
Mass (Da):29,703
Last modified:June 1, 2002 - v1
Checksum:iA7FA4E1A0A8249C9
GO
Isoform 2 (identifier: Q8R1H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-48: Missing.

Show »
Length:276
Mass (Da):29,575
Checksum:i4ABE8233699AB9F2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02575348Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150133 mRNA Translation: BAE29330.1
AK171828 mRNA Translation: BAE42686.1
BC024521 mRNA Translation: AAH24521.1
CCDSiCCDS29497.1 [Q8R1H8-1]
RefSeqiNP_083243.1, NM_028967.1 [Q8R1H8-1]
XP_006531914.1, XM_006531851.2
UniGeneiMm.159219
Mm.491643

Genome annotation databases

EnsembliENSMUST00000045042; ENSMUSP00000045744; ENSMUSG00000039699 [Q8R1H8-1]
GeneIDi74481
KEGGimmu:74481
UCSCiuc008ghp.1 mouse [Q8R1H8-2]
uc008ghq.1 mouse [Q8R1H8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150133 mRNA Translation: BAE29330.1
AK171828 mRNA Translation: BAE42686.1
BC024521 mRNA Translation: AAH24521.1
CCDSiCCDS29497.1 [Q8R1H8-1]
RefSeqiNP_083243.1, NM_028967.1 [Q8R1H8-1]
XP_006531914.1, XM_006531851.2
UniGeneiMm.159219
Mm.491643

3D structure databases

ProteinModelPortaliQ8R1H8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045744

PTM databases

iPTMnetiQ8R1H8
PhosphoSitePlusiQ8R1H8

Proteomic databases

PaxDbiQ8R1H8
PRIDEiQ8R1H8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045042; ENSMUSP00000045744; ENSMUSG00000039699 [Q8R1H8-1]
GeneIDi74481
KEGGimmu:74481
UCSCiuc008ghp.1 mouse [Q8R1H8-2]
uc008ghq.1 mouse [Q8R1H8-1]

Organism-specific databases

CTDi116071
MGIiMGI:1921731 Batf2

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00390000016869
HOGENOMiHOG000070120
HOVERGENiHBG103463
InParanoidiQ8R1H8
KOiK09034
OMAiLHQQHES
OrthoDBiEOG091G0YSM
PhylomeDBiQ8R1H8
TreeFamiTF332340

Miscellaneous databases

PROiPR:Q8R1H8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039699 Expressed in 63 organ(s), highest expression level in colon
GenevisibleiQ8R1H8 MM

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR029857 BATF2
IPR004827 bZIP
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF11 PTHR23351:SF11, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBATF2_MOUSE
AccessioniPrimary (citable) accession number: Q8R1H8
Secondary accession number(s): Q3TAI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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