UniProtKB - Q8R1H8 (BATF2_MOUSE)
Basic leucine zipper transcriptional factor ATF-like 2
Batf2
Functioni
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CCN1 promoter (By similarity).
Following infection, participates in the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
By similarity1 PublicationGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- defense response to protozoan Source: UniProtKB
- myeloid dendritic cell differentiation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Basic leucine zipper transcriptional factor ATF-like 2Short name: B-ATF-2 |
Gene namesi | Name:Batf2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921731, Batf2 |
VEuPathDBi | HostDB:ENSMUSG00000039699 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
- RNA polymerase II transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288682 | 1 – 277 | Basic leucine zipper transcriptional factor ATF-like 2Add BLAST | 277 |
Proteomic databases
PaxDbi | Q8R1H8 |
PRIDEi | Q8R1H8 |
ProteomicsDBi | 273650 [Q8R1H8-1] 273651 [Q8R1H8-2] |
PTM databases
iPTMneti | Q8R1H8 |
PhosphoSitePlusi | Q8R1H8 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000039699, Expressed in duodenum and 104 other tissues |
Genevisiblei | Q8R1H8, MM |
Interactioni
Subunit structurei
Heterodimer; heterodimerizes with JUN family proteins.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045744 |
Miscellaneous databases
RNActi | Q8R1H8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 81 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 15 – 50 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 20 – 42 | Basic motifPROSITE-ProRule annotationAdd BLAST | 23 | |
Regioni | 46 – 67 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 22 | |
Regioni | 126 – 146 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 191 – 256 | DisorderedSequence analysisAdd BLAST | 66 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 208 – 225 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 242 – 256 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000162373 |
HOGENOMi | CLU_088611_0_0_1 |
InParanoidi | Q8R1H8 |
OMAi | HGCQEQP |
OrthoDBi | 1269564at2759 |
PhylomeDBi | Q8R1H8 |
TreeFami | TF332340 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR029857, BATF2 IPR004827, bZIP IPR046347, bZIP_sf |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF11, PTHR23351:SF11, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQLCGSSELL TETDLGESQK QLKKKQKNRV AAQRSRQKHT SKADALHQQH
60 70 80 90 100
ESLEKQNHAL RKEIQALQTE LAGWGRTLHL HERLCRVDCD PCPVLLPSGC
110 120 130 140 150
PIQAKQPSGQ PAPLGYNGCQ EQLGLFQTPG SSPRAQHLSP GPCSHESPGL
160 170 180 190 200
LPSLLPSLAF DPLMVRTPLA QLSPSPVLSA SSPSGSSLLG SFSKLDPLIP
210 220 230 240 250
SPQDQLAPPQ PLRQEQPTSG RLASSDSPAA LGPECSQNRE HLPALPGSST
260 270
HWQKSSVAPS PQALMAFPLL SSAKVHF
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025753 | 48 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK150133 mRNA Translation: BAE29330.1 AK171828 mRNA Translation: BAE42686.1 BC024521 mRNA Translation: AAH24521.1 |
CCDSi | CCDS29497.1 [Q8R1H8-1] CCDS89321.1 [Q8R1H8-2] |
RefSeqi | NP_083243.1, NM_028967.1 [Q8R1H8-1] XP_006531914.1, XM_006531851.2 |
Genome annotation databases
Ensembli | ENSMUST00000045042; ENSMUSP00000045744; ENSMUSG00000039699 [Q8R1H8-1] ENSMUST00000237511; ENSMUSP00000158113; ENSMUSG00000039699 [Q8R1H8-2] |
GeneIDi | 74481 |
KEGGi | mmu:74481 |
UCSCi | uc008ghp.1, mouse [Q8R1H8-2] uc008ghq.1, mouse [Q8R1H8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK150133 mRNA Translation: BAE29330.1 AK171828 mRNA Translation: BAE42686.1 BC024521 mRNA Translation: AAH24521.1 |
CCDSi | CCDS29497.1 [Q8R1H8-1] CCDS89321.1 [Q8R1H8-2] |
RefSeqi | NP_083243.1, NM_028967.1 [Q8R1H8-1] XP_006531914.1, XM_006531851.2 |
3D structure databases
AlphaFoldDBi | Q8R1H8 |
SMRi | Q8R1H8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045744 |
PTM databases
iPTMneti | Q8R1H8 |
PhosphoSitePlusi | Q8R1H8 |
Proteomic databases
PaxDbi | Q8R1H8 |
PRIDEi | Q8R1H8 |
ProteomicsDBi | 273650 [Q8R1H8-1] 273651 [Q8R1H8-2] |
Protocols and materials databases
Antibodypediai | 29580, 197 antibodies from 28 providers |
DNASUi | 74481 |
Genome annotation databases
Ensembli | ENSMUST00000045042; ENSMUSP00000045744; ENSMUSG00000039699 [Q8R1H8-1] ENSMUST00000237511; ENSMUSP00000158113; ENSMUSG00000039699 [Q8R1H8-2] |
GeneIDi | 74481 |
KEGGi | mmu:74481 |
UCSCi | uc008ghp.1, mouse [Q8R1H8-2] uc008ghq.1, mouse [Q8R1H8-1] |
Organism-specific databases
CTDi | 116071 |
MGIi | MGI:1921731, Batf2 |
VEuPathDBi | HostDB:ENSMUSG00000039699 |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000162373 |
HOGENOMi | CLU_088611_0_0_1 |
InParanoidi | Q8R1H8 |
OMAi | HGCQEQP |
OrthoDBi | 1269564at2759 |
PhylomeDBi | Q8R1H8 |
TreeFami | TF332340 |
Miscellaneous databases
BioGRID-ORCSi | 74481, 2 hits in 73 CRISPR screens |
ChiTaRSi | Batf2, mouse |
PROi | PR:Q8R1H8 |
RNActi | Q8R1H8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039699, Expressed in duodenum and 104 other tissues |
Genevisiblei | Q8R1H8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR029857, BATF2 IPR004827, bZIP IPR046347, bZIP_sf |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF11, PTHR23351:SF11, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BATF2_MOUSE | |
Accessioni | Q8R1H8Primary (citable) accession number: Q8R1H8 Secondary accession number(s): Q3TAI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families