Batf2

Functionⁱ

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CYR61 promoter (By similarity). Following infection, participates in the differentiation of CD8⁺ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.By similarity1 Publication

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: InterPro
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

defense response to protozoan
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22992524
myeloid dendritic cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22992524
regulation of transcription by RNA polymerase II Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Basic leucine zipper transcriptional factor ATF-like 2 Short name: B-ATF-2
Gene namesⁱ	Name:Batf2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1921731 Batf2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice display normal development of natural killer (NK), T- and B-cells, plasmacytoid dendritic cells (pDCs), neutrophils, resting CD8-alpha⁺ classical dendritic cells (cDCs), and peritoneal, liver and lung macrophages. However, they show significantly decreased survival after infection by T.gondii. Notably, mice show significantly decreased numbers of lung-resident CD103⁺CD11b^- dendritic cells and CD103⁺CD11b^- macrophages after infection.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000288682	1 – 277	Basic leucine zipper transcriptional factor ATF-like 2Add BLAST		277

Proteomic databases

PaxDbⁱ	Q8R1H8
PRIDEⁱ	Q8R1H8

PTM databases

iPTMnetⁱ	Q8R1H8
PhosphoSitePlusⁱ	Q8R1H8

Expressionⁱ

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000039699 Expressed in 63 organ(s), highest expression level in colon
Genevisibleⁱ	Q8R1H8 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer; heterodimerizes with JUN family proteins.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000045744

STRINGⁱ

10090.ENSMUSP00000045744

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R1H8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 81	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	20 – 42	Basic motifPROSITE-ProRule annotationAdd BLAST		23
Regionⁱ	46 – 67	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		22

Sequence similaritiesⁱ

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016869
HOGENOMⁱ	HOG000070120
HOVERGENⁱ	HBG103463
InParanoidⁱ	Q8R1H8
KEGG Orthology (KO) More...KOⁱ	K09034
OMAⁱ	LHQQHES
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YSM
PhylomeDBⁱ	Q8R1H8
TreeFamⁱ	TF332340

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR029857 BATF2 IPR004827 bZIP
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF11 PTHR23351:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8R1H8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLCGSSELL TETDLGESQK QLKKKQKNRV AAQRSRQKHT SKADALHQQH 
        60         70         80         90        100
ESLEKQNHAL RKEIQALQTE LAGWGRTLHL HERLCRVDCD PCPVLLPSGC 
       110        120        130        140        150
PIQAKQPSGQ PAPLGYNGCQ EQLGLFQTPG SSPRAQHLSP GPCSHESPGL 
       160        170        180        190        200
LPSLLPSLAF DPLMVRTPLA QLSPSPVLSA SSPSGSSLLG SFSKLDPLIP 
       210        220        230        240        250
SPQDQLAPPQ PLRQEQPTSG RLASSDSPAA LGPECSQNRE HLPALPGSST 
       260        270 
HWQKSSVAPS PQALMAFPLL SSAKVHF

Length:277

Mass (Da):29,703

Last modified:June 1, 2002 - v1

Checksum:ⁱA7FA4E1A0A8249C9

GO

Isoform 2 (identifier: Q8R1H8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
48-48: Missing.

« Hide

        10         20         30         40         50
MQLCGSSELL TETDLGESQK QLKKKQKNRV AAQRSRQKHT SKADALHQHE 
        60         70         80         90        100
SLEKQNHALR KEIQALQTEL AGWGRTLHLH ERLCRVDCDP CPVLLPSGCP 
       110        120        130        140        150
IQAKQPSGQP APLGYNGCQE QLGLFQTPGS SPRAQHLSPG PCSHESPGLL 
       160        170        180        190        200
PSLLPSLAFD PLMVRTPLAQ LSPSPVLSAS SPSGSSLLGS FSKLDPLIPS 
       210        220        230        240        250
PQDQLAPPQP LRQEQPTSGR LASSDSPAAL GPECSQNREH LPALPGSSTH 
       260        270 
WQKSSVAPSP QALMAFPLLS SAKVHF

Show »

Length:276

Mass (Da):29,575

Checksum:ⁱ4ABE8233699AB9F2

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_025753	48	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK150133 mRNA Translation: BAE29330.1 AK171828 mRNA Translation: BAE42686.1 BC024521 mRNA Translation: AAH24521.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29497.1 [Q8R1H8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_083243.1, NM_028967.1 [Q8R1H8-1] XP_006531914.1, XM_006531851.2
UniGeneⁱ	Mm.159219 Mm.491643

Genome annotation databases

Ensemblⁱ	ENSMUST00000045042; ENSMUSP00000045744; ENSMUSG00000039699 [Q8R1H8-1]
GeneIDⁱ	74481
KEGGⁱ	mmu:74481
UCSC genome browser More...UCSCⁱ	uc008ghp.1 mouse [Q8R1H8-2] uc008ghq.1 mouse [Q8R1H8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8R1H8	Isoform 2 of Basic leucine zipper transcriptional factor ATF-like 2		MOUSE		276	UniRef90_Q8R1H8
UPI000A318A6D		MUSCR		277
UPI000A30F914		MUSPA		273
UPI000154CE2A		MOUSE		274
UPI000A30CC1E		MUSPA		272

Protein	Similar proteins		Species	Score	Length	Source
Q8R1H8	Isoform 2 of Basic leucine zipper transcriptional factor ATF-like 2		MOUSE		276	UniRef50_Q8R1H8
Basic leucine zipper transcriptional factor ATF-like 2		wild yak		275
Basic leucine zipper ATF-like transcription factor 2		BOVIN		275
Basic leucine zipper ATF-like transcription factor 2		SHEEP		272
Uncharacterized protein		ICTTR		274
+133

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK150133 mRNA Translation: BAE29330.1 AK171828 mRNA Translation: BAE42686.1 BC024521 mRNA Translation: AAH24521.1
CCDSⁱ	CCDS29497.1 [Q8R1H8-1]
RefSeqⁱ	NP_083243.1, NM_028967.1 [Q8R1H8-1] XP_006531914.1, XM_006531851.2
UniGeneⁱ	Mm.159219 Mm.491643

3D structure databases

ProteinModelPortalⁱ	Q8R1H8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000045744

STRINGⁱ

10090.ENSMUSP00000045744

PTM databases

iPTMnetⁱ	Q8R1H8
PhosphoSitePlusⁱ	Q8R1H8

Proteomic databases

PaxDbⁱ	Q8R1H8
PRIDEⁱ	Q8R1H8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000045042; ENSMUSP00000045744; ENSMUSG00000039699 [Q8R1H8-1]
GeneIDⁱ	74481
KEGGⁱ	mmu:74481
UCSCⁱ	uc008ghp.1 mouse [Q8R1H8-2] uc008ghq.1 mouse [Q8R1H8-1]

Organism-specific databases

CTDⁱ	116071
MGIⁱ	MGI:1921731 Batf2

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
GeneTreeⁱ	ENSGT00390000016869
HOGENOMⁱ	HOG000070120
HOVERGENⁱ	HBG103463
InParanoidⁱ	Q8R1H8
KOⁱ	K09034
OMAⁱ	LHQQHES
OrthoDBⁱ	EOG091G0YSM
PhylomeDBⁱ	Q8R1H8
TreeFamⁱ	TF332340

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8R1H8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039699 Expressed in 63 organ(s), highest expression level in colon
Genevisibleⁱ	Q8R1H8 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR029857 BATF2 IPR004827 bZIP
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF11 PTHR23351:SF11, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BATF2_MOUSE
Accessionⁱ	Q8R1H8Primary (citable) accession number: Q8R1H8 Secondary accession number(s): Q3TAI2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R1H8 (BATF2_MOUSE)

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Basic leucine zipper transcriptional factor ATF-like 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ