Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PDZ and LIM domain protein 2

Gene

Pdlim2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity).By similarity

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ and LIM domain protein 2
Alternative name(s):
PDZ-LIM protein mystique
Gene namesi
Name:Pdlim2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2384850 Pdlim2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758641 – 349PDZ and LIM domain protein 2Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei142PhosphothreonineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei163PhosphoserineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei210PhosphoserineBy similarity1
Modified residuei263PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8R1G6
MaxQBiQ8R1G6
PaxDbiQ8R1G6
PeptideAtlasiQ8R1G6
PRIDEiQ8R1G6

PTM databases

iPTMnetiQ8R1G6
PhosphoSitePlusiQ8R1G6

Expressioni

Tissue specificityi

Highly expressed in lung. Expressed at intermediate level in kidney, testis and spleen. Weakly expressed in heart and brain.1 Publication

Inductioni

Regulated by IGF-1.1 Publication

Gene expression databases

BgeeiENSMUSG00000022090 Expressed in 216 organ(s), highest expression level in right lung
CleanExiMM_PDLIM2
ExpressionAtlasiQ8R1G6 baseline and differential
GenevisibleiQ8R1G6 MM

Interactioni

Subunit structurei

Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229389, 4 interactors
IntActiQ8R1G6, 2 interactors
MINTiQ8R1G6
STRINGi10090.ENSMUSP00000022681

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8R1G6
SMRiQ8R1G6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8R1G6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 84PDZPROSITE-ProRule annotationAdd BLAST84
Domaini281 – 341LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00590000082980
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiQ8R1G6
OMAiFQSLAHS
OrthoDBiEOG091G0A6C
PhylomeDBiQ8R1G6
TreeFamiTF106408

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R1G6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALTVDVAGP APWGFRISGG RDFHTPIIVT KVTERGKAEA ADLRPGDIIV
60 70 80 90 100
AINGQSAENM LHAEAQSKIR QSASPLRLQL DRSQTASPGQ TNGEGSLEVL
110 120 130 140 150
ATRFQGSLRT HRDSQSSQRS ACFSPVSLSP RPCSPFSTPP PTSPVALSKE
160 170 180 190 200
DMIGCSFQSL THSPGLAAAH HLTYPGHPTS QQAGHSSPSD SAVRVLLHSP
210 220 230 240 250
GRPSSPRFSS LDLEEDSEVF KMLQENRQGR AAPRQSSSFR LLQEALEAEE
260 270 280 290 300
RGGTPAFVPS SLSSQASLPT SRALATPPKL HTCEKCSVNI SNQAVRIQEG
310 320 330 340
RYRHPGCYTC ADCGLNLKMR GHFWVGNELY CEKHARQRYS MPGTLNSRA
Length:349
Mass (Da):37,703
Last modified:June 1, 2002 - v1
Checksum:i9809D7F1AF2BD907
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7C957F7C957_MOUSE
PDZ and LIM domain protein 2
Pdlim2
151Annotation score:
A0A087WPL1A0A087WPL1_MOUSE
PDZ and LIM domain protein 2
Pdlim2
128Annotation score:
E9Q996E9Q996_MOUSE
PDZ and LIM domain protein 2
Pdlim2
217Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024556 mRNA Translation: AAH24556.1
CCDSiCCDS27248.1 [Q8R1G6-1]
RefSeqiNP_001240665.1, NM_001253736.1 [Q8R1G6-1]
NP_666090.1, NM_145978.2 [Q8R1G6-1]
XP_011243308.1, XM_011245006.2 [Q8R1G6-1]
UniGeneiMm.283968

Genome annotation databases

EnsembliENSMUST00000022681; ENSMUSP00000022681; ENSMUSG00000022090 [Q8R1G6-1]
ENSMUST00000153735; ENSMUSP00000116200; ENSMUSG00000022090 [Q8R1G6-1]
GeneIDi213019
KEGGimmu:213019
UCSCiuc007uni.1 mouse [Q8R1G6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024556 mRNA Translation: AAH24556.1
CCDSiCCDS27248.1 [Q8R1G6-1]
RefSeqiNP_001240665.1, NM_001253736.1 [Q8R1G6-1]
NP_666090.1, NM_145978.2 [Q8R1G6-1]
XP_011243308.1, XM_011245006.2 [Q8R1G6-1]
UniGeneiMm.283968

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VB7NMR-A3-83[»]
ProteinModelPortaliQ8R1G6
SMRiQ8R1G6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229389, 4 interactors
IntActiQ8R1G6, 2 interactors
MINTiQ8R1G6
STRINGi10090.ENSMUSP00000022681

PTM databases

iPTMnetiQ8R1G6
PhosphoSitePlusiQ8R1G6

Proteomic databases

EPDiQ8R1G6
MaxQBiQ8R1G6
PaxDbiQ8R1G6
PeptideAtlasiQ8R1G6
PRIDEiQ8R1G6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022681; ENSMUSP00000022681; ENSMUSG00000022090 [Q8R1G6-1]
ENSMUST00000153735; ENSMUSP00000116200; ENSMUSG00000022090 [Q8R1G6-1]
GeneIDi213019
KEGGimmu:213019
UCSCiuc007uni.1 mouse [Q8R1G6-1]

Organism-specific databases

CTDi64236
MGIiMGI:2384850 Pdlim2

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00590000082980
HOGENOMiHOG000290704
HOVERGENiHBG061371
InParanoidiQ8R1G6
OMAiFQSLAHS
OrthoDBiEOG091G0A6C
PhylomeDBiQ8R1G6
TreeFamiTF106408

Miscellaneous databases

EvolutionaryTraceiQ8R1G6
PROiPR:Q8R1G6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022090 Expressed in 216 organ(s), highest expression level in right lung
CleanExiMM_PDLIM2
ExpressionAtlasiQ8R1G6 baseline and differential
GenevisibleiQ8R1G6 MM

Family and domain databases

InterProiView protein in InterPro
IPR031847 DUF4749
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF15936 DUF4749, 1 hit
PF00412 LIM, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDLI2_MOUSE
AccessioniPrimary (citable) accession number: Q8R1G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again