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Protein

Putative hydroxypyruvate isomerase

Gene

Hyi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).By similarity

Catalytic activityi

Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Proton donor/acceptorBy similarity1
Active sitei249Proton donor/acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxypyruvate isomerase (EC:5.3.1.22)
Gene namesi
Name:Hyi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915430 Hyi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892421 – 277Putative hydroxypyruvate isomeraseAdd BLAST277

Proteomic databases

MaxQBiQ8R1F5
PeptideAtlasiQ8R1F5
PRIDEiQ8R1F5

2D gel databases

UCD-2DPAGEiQ8R1F5

PTM databases

PhosphoSitePlusiQ8R1F5

Expressioni

Gene expression databases

CleanExiMM_HYI

Interactioni

Protein-protein interaction databases

IntActiQ8R1F5, 2 interactors
MINTiQ8R1F5

Structurei

3D structure databases

ProteinModelPortaliQ8R1F5
SMRiQ8R1F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hyi family.Curated

Phylogenomic databases

HOGENOMiHOG000218197
HOVERGENiHBG056845
InParanoidiQ8R1F5
KOiK01816
PhylomeDBiQ8R1F5

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8R1F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLRFSANV SWLFPELPGL PERLHAAGRA GFKAAEVAWP YTESPQALAS
60 70 80 90 100
AAQTAGLRLV LINTPRGDHE KGEMGLGAVP GRQAAFREGL EQAVLYAKAL
110 120 130 140 150
GCPRIHLMAG RVPQGADRAA VKGEMETVFV ENLKHAAGVL AQENLVGLLE
160 170 180 190 200
PINTRITDPQ YFLDTPRQAA AILQKVGRPN LQLQMDIFHW QIMDGNLTGN
210 220 230 240 250
IREFLPTVGH VQVAQVPDRG EPGSSGELDF TYLFQLLEDE GYQGFVGCEY
260 270
RPRGDTVEGL SWLRSYWDRR GHPRTGQ
Length:277
Mass (Da):30,449
Last modified:May 29, 2007 - v2
Checksum:iEDAA961B61181444
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QLT0E9QLT0_MOUSE
Putative hydroxypyruvate isomerase
Hyi
267Annotation score:
Z4YKI7Z4YKI7_MOUSE
Putative hydroxypyruvate isomerase
Hyi
69Annotation score:

Sequence cautioni

The sequence CAM15196 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127T → A in AAH24619 (PubMed:15489334).Curated1
Sequence conflicti127T → A in AAI00402 (PubMed:15489334).Curated1
Sequence conflicti223G → S in AAH24619 (PubMed:15489334).Curated1
Sequence conflicti223G → S in AAI00402 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627212 Genomic DNA Translation: CAM15196.1 Sequence problems.
BC024619 mRNA Translation: AAH24619.1
BC100401 mRNA Translation: AAI00402.1
RefSeqiNP_080877.3, NM_026601.3
UniGeneiMm.193212

Genome annotation databases

GeneIDi68180
KEGGimmu:68180
UCSCiuc008ujr.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627212 Genomic DNA Translation: CAM15196.1 Sequence problems.
BC024619 mRNA Translation: AAH24619.1
BC100401 mRNA Translation: AAI00402.1
RefSeqiNP_080877.3, NM_026601.3
UniGeneiMm.193212

3D structure databases

ProteinModelPortaliQ8R1F5
SMRiQ8R1F5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8R1F5, 2 interactors
MINTiQ8R1F5

PTM databases

PhosphoSitePlusiQ8R1F5

2D gel databases

UCD-2DPAGEiQ8R1F5

Proteomic databases

MaxQBiQ8R1F5
PeptideAtlasiQ8R1F5
PRIDEiQ8R1F5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi68180
KEGGimmu:68180
UCSCiuc008ujr.3 mouse

Organism-specific databases

CTDi81888
MGIiMGI:1915430 Hyi

Phylogenomic databases

HOGENOMiHOG000218197
HOVERGENiHBG056845
InParanoidiQ8R1F5
KOiK01816
PhylomeDBiQ8R1F5

Miscellaneous databases

PROiPR:Q8R1F5
SOURCEiSearch...

Gene expression databases

CleanExiMM_HYI

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYI_MOUSE
AccessioniPrimary (citable) accession number: Q8R1F5
Secondary accession number(s): A2A9C1, Q497S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: February 28, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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