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UniProtKB - Q8R1D1 (ZN426_MOUSE)
Protein
Zinc finger protein 426
Gene
Znf426
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
CuratedRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 219 – 241 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 274 – 296 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 302 – 324 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 330 – 352 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 380 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 464 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 470 – 492 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 498 – 522 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 528 – 550 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 426 |
Gene namesi | Name:Znf426 Synonyms:Kiaa4237Imported, Zfp426 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920248, Zfp426 |
VEuPathDBi | HostDB:ENSMUSG00000059475 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284700 | 1 – 550 | Zinc finger protein 426Add BLAST | 550 |
Proteomic databases
PaxDbi | Q8R1D1 |
PRIDEi | Q8R1D1 |
PTM databases
iPTMneti | Q8R1D1 |
PhosphoSitePlusi | Q8R1D1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000059475, Expressed in cerebellum and 294 other tissues |
ExpressionAtlasi | Q8R1D1, baseline and differential |
Genevisiblei | Q8R1D1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000127045 |
Miscellaneous databases
RNActi | Q8R1D1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 110 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 219 – 241 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 274 – 296 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 302 – 324 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 330 – 352 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 380 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 464 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 470 – 492 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 498 – 522 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 528 – 550 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163292 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | Q8R1D1 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8R1D1 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q8R1D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPASSHGP SEDSGCLQER KIAAEMMLVD CLTDDQELVS FEDVIVDFTQ
60 70 80 90 100
EEWSSLNPDQ RNLYRDVMLE NYQNLATVGY QLIKPSLISW LEQEEFSKGQ
110 120 130 140 150
KIVFPEWKLQ LETKCSAFQQ EFLRGNISSR MQMQTGINRG RELCDGTQYG
160 170 180 190 200
DFFSELSPLR TDMKTQPAQD NYGCSQYRKD FLMLQRKNCA GEKLSEFSQS
210 220 230 240 250
EETGMTPVKE KIDTQEKGFE CSDCGKSFMS QSHLQTHQRT HSGDKLYEWN
260 270 280 290 300
ECGRSFINSR LAVLIETLNA KKPHRCKECG KGYRYPAYLN IHMRTHTGEK
310 320 330 340 350
PYECKECGKA FNYSNSFQIH GRTHTGEKPY VCSQCGKAFT QHSGLSIHVR
360 370 380 390 400
SHTGDKPYGC KECGKAFLTS SRLIQHIRTH TGEKPFVCVK CGKAFAISSN
410 420 430 440 450
LNGHLKLHAE EKTCECKICG KAFGYLSCLN NHMRTHNAKK SYTCKECGKA
460 470 480 490 500
FNYSTHLKIH MRIHTGEKPY ECKQCGKAFS HSTSFQIHER THTGEKPYEC
510 520 530 540 550
KECGKAFICP SSFRIHEISH THTEEKPYKC QQCGKAYSHP RSLRRHERIH
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E8Y1 | G5E8Y1_MOUSE | Zinc finger protein 426 | Zfp426 | 549 | Annotation score: | ||
G5E8Z9 | G5E8Z9_MOUSE | Zinc finger protein 426 | Zfp426 | 564 | Annotation score: | ||
E9Q951 | E9Q951_MOUSE | Zinc finger protein 426 | Zfp426 | 483 | Annotation score: | ||
E9PZX9 | E9PZX9_MOUSE | Zinc finger protein 426 | Zfp426 | 157 | Annotation score: | ||
E9Q8C8 | E9Q8C8_MOUSE | Zinc finger protein 426 | Zfp426 | 68 | Annotation score: | ||
E9Q775 | E9Q775_MOUSE | Zinc finger protein 426 | Zfp426 | 85 | Annotation score: | ||
E9Q7W5 | E9Q7W5_MOUSE | Zinc finger protein 426 | Zfp426 | 93 | Annotation score: | ||
E9PYE0 | E9PYE0_MOUSE | Zinc finger protein 426 | Zfp426 | 24 | Annotation score: | ||
E9Q9D9 | E9Q9D9_MOUSE | Zinc finger protein 426 | Zfp426 | 44 | Annotation score: |
Sequence cautioni
The sequence BAC29636 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | R → G in AAH23931 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 54 | S → T in AAH23931 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 134 | Missing in AAH23931 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 252 | C → Y in BAC29636 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK036912 mRNA Translation: BAC29636.1 Different initiation. AK085144 mRNA Translation: BAC39374.1 BC023931 mRNA Translation: AAH23931.1 BC024805 mRNA Translation: AAH24805.1 AK220563 mRNA Translation: BAD90329.1 Sequence problems. |
CCDSi | CCDS40544.1 |
RefSeqi | NP_001103779.1, NM_001110309.1 NP_001297671.1, NM_001310742.1 NP_666333.1, NM_146221.4 |
Genome annotation databases
Ensembli | ENSMUST00000080386; ENSMUSP00000079250; ENSMUSG00000059475 ENSMUST00000115562; ENSMUSP00000111224; ENSMUSG00000059475 ENSMUST00000166005; ENSMUSP00000129727; ENSMUSG00000059475 |
GeneIDi | 235028 |
KEGGi | mmu:235028 |
UCSCi | uc009oiq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK036912 mRNA Translation: BAC29636.1 Different initiation. AK085144 mRNA Translation: BAC39374.1 BC023931 mRNA Translation: AAH23931.1 BC024805 mRNA Translation: AAH24805.1 AK220563 mRNA Translation: BAD90329.1 Sequence problems. |
CCDSi | CCDS40544.1 |
RefSeqi | NP_001103779.1, NM_001110309.1 NP_001297671.1, NM_001310742.1 NP_666333.1, NM_146221.4 |
3D structure databases
AlphaFoldDBi | Q8R1D1 |
SMRi | Q8R1D1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000127045 |
PTM databases
iPTMneti | Q8R1D1 |
PhosphoSitePlusi | Q8R1D1 |
Proteomic databases
PaxDbi | Q8R1D1 |
PRIDEi | Q8R1D1 |
Protocols and materials databases
Antibodypediai | 12609, 132 antibodies from 23 providers |
DNASUi | 235028 |
Genome annotation databases
Ensembli | ENSMUST00000080386; ENSMUSP00000079250; ENSMUSG00000059475 ENSMUST00000115562; ENSMUSP00000111224; ENSMUSG00000059475 ENSMUST00000166005; ENSMUSP00000129727; ENSMUSG00000059475 |
GeneIDi | 235028 |
KEGGi | mmu:235028 |
UCSCi | uc009oiq.2, mouse |
Organism-specific databases
CTDi | 235028 |
MGIi | MGI:1920248, Zfp426 |
VEuPathDBi | HostDB:ENSMUSG00000059475 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163292 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | Q8R1D1 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8R1D1 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 235028, 2 hits in 73 CRISPR screens |
ChiTaRSi | Zfp426, mouse |
PROi | PR:Q8R1D1 |
RNActi | Q8R1D1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000059475, Expressed in cerebellum and 294 other tissues |
ExpressionAtlasi | Q8R1D1, baseline and differential |
Genevisiblei | Q8R1D1, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN426_MOUSE | |
Accessioni | Q8R1D1Primary (citable) accession number: Q8R1D1 Secondary accession number(s): Q5DTF7, Q8BJ29, Q8CIG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot