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Entry version 139 (02 Jun 2021)
Sequence version 3 (09 Jan 2007)
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Protein

Dedicator of cytokinesis protein 7

Gene

Dock7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity).

As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity).

Has a role in pigmentation (PubMed:19202056).

Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (PubMed:22842144).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Guanine-nucleotide releasing factor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8875555, MET activates RAP1 and RAC1
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 7
Alternative name(s):
Protein moonlight1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock7
Synonyms:Gm430, Kiaa1771, Mnlt1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914549, Dock7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Dock7 are responsible for the moonlight phenotype (mnlt). mnlt/mnlt mice display an overall lightened coat color and hypopigmentation of the belly and distal extremities, particularly the paws, tail tip, and genitalia.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899961 – 2130Dedicator of cytokinesis protein 7Add BLAST2130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineCombined sources1
Modified residuei180PhosphoserineBy similarity1
Modified residuei182PhosphoserineCombined sources1
Modified residuei381N6-methyllysineBy similarity1
Modified residuei450PhosphothreonineCombined sources1
Modified residuei452PhosphoserineBy similarity1
Modified residuei862PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei882PhosphoserineBy similarity1
Modified residuei888PhosphoserineBy similarity1
Modified residuei896PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei905PhosphoserineBy similarity1
Modified residuei907PhosphothreonineCombined sources1
Modified residuei909PhosphothreonineBy similarity1
Modified residuei910PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei963PhosphoserineBy similarity1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1420PhosphoserineCombined sources1
Modified residuei1422PhosphoserineCombined sources1
Modified residuei1424PhosphoserineCombined sources1
Modified residuei1428PhosphoserineCombined sources1
Modified residuei1952N6-acetyllysineCombined sources1
Modified residuei2119PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8R1A4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R1A4

PeptideAtlas

More...
PeptideAtlasi
Q8R1A4

PRoteomics IDEntifications database

More...
PRIDEi
Q8R1A4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
279758 [Q8R1A4-1]
279759 [Q8R1A4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R1A4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R1A4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DOCK7-induced septin displacement/DISP complex, at least composed of DOCK7, LRCH3 and MYO6 (By similarity).

Interacts with TSC1 (By similarity).

Interacts with nucleotide-free RAC1 and RAC3 (By similarity).

Interacts with TACC3.

Interacts with CRY1.

Interacts with NOD2 (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8R1A4, 11 interactors

Molecular INTeraction database

More...
MINTi
Q8R1A4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000030286

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R1A4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R1A4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini561 – 727C2 DOCK-typePROSITE-ProRule annotationAdd BLAST167
Domaini1668 – 2104DOCKERPROSITE-ProRule annotationAdd BLAST437

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni137 – 175DisorderedSequence analysisAdd BLAST39
Regioni888 – 966DisorderedSequence analysisAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili365 – 395Sequence analysisAdd BLAST31
Coiled coili2076 – 2102Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi144 – 158Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi888 – 914Polar residuesSequence analysisAdd BLAST27
Compositional biasi922 – 966Polar residuesSequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain mediates GEF activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R1A4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R1A4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08696, C2_Dock-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037808, C2_Dock-C
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C

The PANTHER Classification System

More...
PANTHERi
PTHR23317, PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R1A4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP
60 70 80 90 100
LTEAVDPVDL EDYLVTHPLS GDSGPLRDLV EFPPDDIEVV YSPRDCRTLV
110 120 130 140 150
SAVPEESEMD PHVRDCIRSY TEDWAVVVRK YHKLGTGFNP NTLDKQKERQ
160 170 180 190 200
KGLPRQVFES DEAPDGSSYQ DEQDDLKRRS MSIDDTPRGS WACSIFDLKN
210 220 230 240 250
SLPDALLPNL LDRTPNEEID HQNDDQRKSN RHKELFALHP SPDEEEPIER
260 270 280 290 300
LSVPDVPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF
310 320 330 340 350
YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL
360 370 380 390 400
QQGDIGECAE PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW
410 420 430 440 450
TAIHLMNIVS SAGSLERDST EVEISTGERK GSWSERRNSS LVGRRSLERT
460 470 480 490 500
TSGDDACNLT SFRPATLTVA NFFKQEGDRL SDEDLYKFLA DMRRPSSVLR
510 520 530 540 550
RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR PTREILEFPA
560 570 580 590 600
RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP
610 620 630 640 650
VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF
660 670 680 690 700
YHVSCQQKQN TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV
710 720 730 740 750
LSPEVPLPGM KWVDNHKGVF NVEVVAVSSI HTQDPYLDKF FALVNALDEH
760 770 780 790 800
MFPVRIGDMR IMENNLESEL KSSISALNSS QLEPVVRFLH LLLDKLILLV
810 820 830 840 850
VRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG RNNLLASYIY
860 870 880 890 900
YVFRLPNTYP NSPSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS
910 920 930 940 950
NPDISGTPTS PDDEVRSIIG SKGLDRSNSW VNTGPKAAPW GSNPSPSAES
960 970 980 990 1000
TQAMDRSCNR MSSHTETSSF LQTLTGRLPT KKLFHEELAL QWVVCSGSVR
1010 1020 1030 1040 1050
ESALQQAWFF FELMVKSMVH HLYFNDKLDA PRESRFPERF MDDIAALVST
1060 1070 1080 1090 1100
IAGDVVSRFQ KDTEMVERLN TSLAFFLNDL LSVMDRGFVF SLIKSCYKQV
1110 1120 1130 1140 1150
SAKLYSLPNP SVLVSLRLDF LRIICSHEHY VTLNLPCSLL TPPASPSPSV
1160 1170 1180 1190 1200
SSATSQSSGF STSVQDQKIA NMFELSLPFR QQHYLAGLVL TELALILDPD
1210 1220 1230 1240 1250
AEGLFGLHKK VINMVHNLLS THDSDPRYSD PQIKARVAML YLPLIGIIME
1260 1270 1280 1290 1300
TVPQLYDFTE SHNQRGRPIC IAPDDYDSES GSMISQTVAM AIAGTSVPQL
1310 1320 1330 1340 1350
TRPGSFLLTS TSGRQHTTFS AESSRSLLIC LLWVLKNADE TVLQKWFTDL
1360 1370 1380 1390 1400
SVLQLNRLLD LLYLCVSCFE YKGKKVFERM NSLTFKKSKD MRAKLEEAIL
1410 1420 1430 1440 1450
GSIGARQEMV RRSRGQLERS PSGSAFGSQE NLRWRKDMTH WRQNSEKLDK
1460 1470 1480 1490 1500
SRAEIEHEAL IDGNLATEAN LIILDTLEII VQTVSVTESK ESILGGVLKV
1510 1520 1530 1540 1550
LLQSMACNQS AVYLQHCFAT QRALVSKFPE LLFEEETEQC ADLCLRLLRH
1560 1570 1580 1590 1600
CSSSISTIRS HASASLYLLM RQNFEIGNNF ARVKMQVTMS LSSLVGTSQN
1610 1620 1630 1640 1650
FNEEFLRRSL KTILTYAEED LELRETTFPD QVQDLVFNLH MILSDTVKMK
1660 1670 1680 1690 1700
EHQEDPEMLI DLMYRIAKGY QTSPDLRLTW LQNMAGKHSE RSNHAEAAQC
1710 1720 1730 1740 1750
LVHSAALVAE YLSMLEDRKY LPVGCVTFQN ISSNVLEESA VSDDVVSPDE
1760 1770 1780 1790 1800
EGICSGKYFT ESGLVGLLEQ AAASFSMAGM YEAVNEVYKV LIPIHEANRD
1810 1820 1830 1840 1850
AKKLSTIHGK LQEAFSKIVH QSTGWERMFG TYFRVGFYGT KFGDLDEQEF
1860 1870 1880 1890 1900
VYKEPAITKL AEISHRLEGF YGERFGEDVL EVIKDSNPVD KCKLDPNKAY
1910 1920 1930 1940 1950
IQITYVEPFF DTYEMKDRIT YFDKNYNLRR FMYCTPFTLD GRAHGELHEQ
1960 1970 1980 1990 2000
FKRKTILTTS HAFPYIKTRV NVTHKEEIIL TPIEVAIEDM QKKTQELAFA
2010 2020 2030 2040 2050
THQDPADPKM LQMVLQGSVG TTVNQGPLEV AQVFLSEIPG DPKLFRHHNK
2060 2070 2080 2090 2100
LRLCFKDFTK RCEDALRKNK SLIGPDQKEY QRELERNYHR LKEALQPLIN
2110 2120 2130
RKIPQLYKAV LPVTCHRDSF SRMSLRKMEL
Length:2,130
Mass (Da):241,438
Last modified:January 9, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i936B564638C1FC1D
GO
Isoform 2 (identifier: Q8R1A4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1822-1826: STGWE → DGK

Show »
Length:2,128
Mass (Da):241,178
Checksum:iF9EC4C5783631CE4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A9M4A2A9M4_MOUSE
Dedicator of cytokinesis protein 7
Dock7
2,130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A9M5A2A9M5_MOUSE
Dedicator of cytokinesis protein 7
Dock7
2,128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PX48E9PX48_MOUSE
Dedicator of cytokinesis protein 7
Dock7
2,100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNK7A0A0U1RNK7_MOUSE
Dedicator of cytokinesis protein 7
Dock7
2,098Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNY4A0A0U1RNY4_MOUSE
Dedicator of cytokinesis protein 7
Dock7
811Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AW79A2AW79_MOUSE
Dedicator of cytokinesis protein 7
Dock7
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RP53A0A0U1RP53_MOUSE
Dedicator of cytokinesis protein 7
Dock7
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPH6A0A0U1RPH6_MOUSE
Dedicator of cytokinesis protein 7
Dock7
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZJ55F6ZJ55_MOUSE
Dedicator of cytokinesis protein 7
Dock7
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24823 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH86672 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB28798 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0077081822 – 1826STGWE → DGK in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL627349 Genomic DNA No translation available.
AL935325 Genomic DNA No translation available.
DQ109674 mRNA Translation: AAZ17650.1
BC024823 mRNA Translation: AAH24823.2 Different initiation.
BC024917 mRNA Translation: AAH24917.3
BC086672 mRNA Translation: AAH86672.1 Different initiation.
AK122554 mRNA Translation: BAC65836.1
AK013336 mRNA Translation: BAB28798.3 Different initiation.
AK014226 mRNA Translation: BAB29215.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS71425.1 [Q8R1A4-2]
CCDS89783.1 [Q8R1A4-1]

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc008tup.2, mouse [Q8R1A4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627349 Genomic DNA No translation available.
AL935325 Genomic DNA No translation available.
DQ109674 mRNA Translation: AAZ17650.1
BC024823 mRNA Translation: AAH24823.2 Different initiation.
BC024917 mRNA Translation: AAH24917.3
BC086672 mRNA Translation: AAH86672.1 Different initiation.
AK122554 mRNA Translation: BAC65836.1
AK013336 mRNA Translation: BAB28798.3 Different initiation.
AK014226 mRNA Translation: BAB29215.1
CCDSiCCDS71425.1 [Q8R1A4-2]
CCDS89783.1 [Q8R1A4-1]

3D structure databases

SMRiQ8R1A4
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8R1A4, 11 interactors
MINTiQ8R1A4
STRINGi10090.ENSMUSP00000030286

PTM databases

iPTMnetiQ8R1A4
PhosphoSitePlusiQ8R1A4

Proteomic databases

jPOSTiQ8R1A4
PaxDbiQ8R1A4
PeptideAtlasiQ8R1A4
PRIDEiQ8R1A4
ProteomicsDBi279758 [Q8R1A4-1]
279759 [Q8R1A4-2]

Genome annotation databases

UCSCiuc008tup.2, mouse [Q8R1A4-1]

Organism-specific databases

MGIiMGI:1914549, Dock7

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1997, Eukaryota
InParanoidiQ8R1A4
PhylomeDBiQ8R1A4

Enzyme and pathway databases

ReactomeiR-MMU-8875555, MET activates RAP1 and RAC1
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dock7, mouse

Protein Ontology

More...
PROi
PR:Q8R1A4
RNActiQ8R1A4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd08696, C2_Dock-C, 1 hit
Gene3Di1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037808, C2_Dock-C
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
PANTHERiPTHR23317, PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
PROSITEiView protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R1A4
Secondary accession number(s): Q45V78
, Q5PRE6, Q6PJ17, Q9CSB6, Q9CXM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 9, 2007
Last modified: June 2, 2021
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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