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Protein

Pituitary tumor-transforming gene 1 protein-interacting protein

Gene

Pttg1ip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May facilitate PTTG1 nuclear translocation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary tumor-transforming gene 1 protein-interacting protein
Alternative name(s):
Pituitary tumor-transforming gene protein-binding factor
Short name:
PBF
Short name:
PTTG-binding factor
Gene namesi
Name:Pttg1ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2652132 Pttg1ip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 93ExtracellularSequence analysisAdd BLAST64
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 174CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002218530 – 174Pituitary tumor-transforming gene 1 protein-interacting proteinAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei171PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8R143
MaxQBiQ8R143
PaxDbiQ8R143
PeptideAtlasiQ8R143
PRIDEiQ8R143

PTM databases

iPTMnetiQ8R143
PhosphoSitePlusiQ8R143
SwissPalmiQ8R143

Expressioni

Gene expression databases

BgeeiENSMUSG00000009291 Expressed in 319 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiQ8R143 baseline and differential
GenevisibleiQ8R143 MM

Interactioni

Subunit structurei

Interacts with PTTG1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009435

Structurei

3D structure databases

SMRiQ8R143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 89PSIAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili127 – 163Sequence analysisAdd BLAST37

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXF7 Eukaryota
ENOG4111WR4 LUCA
GeneTreeiENSGT00390000004977
HOGENOMiHOG000015370
HOVERGENiHBG000902
InParanoidiQ8R143
OMAiELSSARW
OrthoDBiEOG091G0X6V
PhylomeDBiQ8R143
TreeFamiTF329310

Family and domain databases

InterProiView protein in InterPro
IPR016201 PSI
SMARTiView protein in SMART
SM00423 PSI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8R143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPANLGLTP HWVMLLGAVL LLLLSGASAQ EPPRVGCSEY TNRSCEECLR
60 70 80 90 100
NVSCLWCNEN KACMDYPVRK ILPPASLCKL SSARWGVCWV NFEALIITMS
110 120 130 140 150
VLGGSVLLGI TVCCCYCCRR KKSRKPDKSD ERAMREQEER RVRQEERRAE
160 170
MKSRHDEIRK KYGLFKEQNP YEKF
Length:174
Mass (Da):19,965
Last modified:June 1, 2002 - v1
Checksum:i78FC04B6D4752FA0
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CY65E0CY65_MOUSE
Pituitary tumor-transforming gene 1...
Pttg1ip
120Annotation score:
F6TFF2F6TFF2_MOUSE
Pituitary tumor-transforming 1 inte...
Pttg1ip mCG_3380
111Annotation score:
E0CXB5E0CXB5_MOUSE
Pituitary tumor-transforming gene 1...
Pttg1ip
111Annotation score:
E0CXQ8E0CXQ8_MOUSE
Pituitary tumor-transforming gene 1...
Pttg1ip
46Annotation score:
E0CXX2E0CXX2_MOUSE
Pituitary tumor-transforming gene 1...
Pttg1ip
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → R in BAC40985 (PubMed:16141072).Curated1
Sequence conflicti120R → W in BAC40985 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035696 mRNA Translation: BAC29156.1
AK075773 mRNA Translation: BAC35947.1
AK088813 mRNA Translation: BAC40589.1
AK089887 mRNA Translation: BAC40985.1
AK098093 mRNA Translation: BAC05231.1
AK152366 mRNA Translation: BAE31156.1
AK159987 mRNA Translation: BAE35537.1
AK167972 mRNA Translation: BAE39966.1
AK168164 mRNA Translation: BAE40125.1
AK170802 mRNA Translation: BAE42037.1
AK170971 mRNA Translation: BAE42150.1
AK170972 mRNA Translation: BAE42151.1
AK171140 mRNA Translation: BAE42273.1
BC025533 mRNA Translation: AAH25533.1
BC023961 mRNA Translation: AAH23961.1
BC029144 mRNA Translation: AAH29144.1
BC032184 mRNA Translation: AAH32184.1
CCDSiCCDS23957.1
RefSeqiNP_666037.1, NM_145925.2
UniGeneiMm.28853

Genome annotation databases

EnsembliENSMUST00000009435; ENSMUSP00000009435; ENSMUSG00000009291
GeneIDi108705
KEGGimmu:108705
UCSCiuc007fvx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035696 mRNA Translation: BAC29156.1
AK075773 mRNA Translation: BAC35947.1
AK088813 mRNA Translation: BAC40589.1
AK089887 mRNA Translation: BAC40985.1
AK098093 mRNA Translation: BAC05231.1
AK152366 mRNA Translation: BAE31156.1
AK159987 mRNA Translation: BAE35537.1
AK167972 mRNA Translation: BAE39966.1
AK168164 mRNA Translation: BAE40125.1
AK170802 mRNA Translation: BAE42037.1
AK170971 mRNA Translation: BAE42150.1
AK170972 mRNA Translation: BAE42151.1
AK171140 mRNA Translation: BAE42273.1
BC025533 mRNA Translation: AAH25533.1
BC023961 mRNA Translation: AAH23961.1
BC029144 mRNA Translation: AAH29144.1
BC032184 mRNA Translation: AAH32184.1
CCDSiCCDS23957.1
RefSeqiNP_666037.1, NM_145925.2
UniGeneiMm.28853

3D structure databases

SMRiQ8R143
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009435

PTM databases

iPTMnetiQ8R143
PhosphoSitePlusiQ8R143
SwissPalmiQ8R143

Proteomic databases

EPDiQ8R143
MaxQBiQ8R143
PaxDbiQ8R143
PeptideAtlasiQ8R143
PRIDEiQ8R143

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009435; ENSMUSP00000009435; ENSMUSG00000009291
GeneIDi108705
KEGGimmu:108705
UCSCiuc007fvx.1 mouse

Organism-specific databases

CTDi754
MGIiMGI:2652132 Pttg1ip

Phylogenomic databases

eggNOGiENOG410IXF7 Eukaryota
ENOG4111WR4 LUCA
GeneTreeiENSGT00390000004977
HOGENOMiHOG000015370
HOVERGENiHBG000902
InParanoidiQ8R143
OMAiELSSARW
OrthoDBiEOG091G0X6V
PhylomeDBiQ8R143
TreeFamiTF329310

Miscellaneous databases

ChiTaRSiPttg1ip mouse
PROiPR:Q8R143
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009291 Expressed in 319 organ(s), highest expression level in sciatic nerve
ExpressionAtlasiQ8R143 baseline and differential
GenevisibleiQ8R143 MM

Family and domain databases

InterProiView protein in InterPro
IPR016201 PSI
SMARTiView protein in SMART
SM00423 PSI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTTG_MOUSE
AccessioniPrimary (citable) accession number: Q8R143
Secondary accession number(s): Q3TVT1, Q8BJ96, Q8N7P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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