Slc25a28

Functionⁱ

Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe²⁺, is then probably delivered to ferrochelatase to catalyze Fe²⁺ incorporation into protoprophyrin IX to make heme (Probable).2 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

iron import into the mitochondrion Source: GO_Central
iron ion homeostasis Source: GO_Central
mitochondrial transport Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Iron transport, Transport
Ligand	Iron

Protein family/group databases

TCDBⁱ	2.A.29.5.4 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.5.4 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitoferrin-2 Alternative name(s): Mitochondrial RNA-splicing protein 3/4 homolog Short name: MRS3/4 Mitochondrial iron transporter 2 Solute carrier family 25 member 28
Gene namesⁱ	Name:Slc25a28 Synonyms:Mfrn2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:2180509 Slc25a28

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	72 – 91	Helical; Name=1Sequence analysisAdd BLAST	20
Transmembraneⁱ	133 – 152	Helical; Name=2Sequence analysisAdd BLAST	20
Transmembraneⁱ	170 – 189	Helical; Name=3Sequence analysisAdd BLAST	20
Transmembraneⁱ	227 – 246	Helical; Name=4Sequence analysisAdd BLAST	20
Transmembraneⁱ	261 – 280	Helical; Name=5Sequence analysisAdd BLAST	20
Transmembraneⁱ	327 – 346	Helical; Name=6Sequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000235256	1 – 364	Mitoferrin-2Add BLAST		364

Proteomic databases

PaxDbⁱ	Q8R0Z5
PeptideAtlas More...PeptideAtlasⁱ	Q8R0Z5
PRIDEⁱ	Q8R0Z5

PTM databases

PhosphoSitePlusⁱ	Q8R0Z5

PhosphoSitePlusⁱ

Q8R0Z5

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed at low level. Expressed at higher level in heart, liver, kidney and testis. Expression does not vary during erythroid maturation.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000040414
CleanExⁱ	MM_SLC25A28
Genevisibleⁱ	Q8R0Z5 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000036913

STRINGⁱ

10090.ENSMUSP00000036913

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8R0Z5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	70 – 158	Solcar 1Add BLAST	89
Repeatⁱ	168 – 252	Solcar 2Add BLAST	85
Repeatⁱ	263 – 352	Solcar 3Add BLAST	90

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0760 Eukaryota ENOG410XNT2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074721
HOGENOMⁱ	HOG000038810
HOVERGENⁱ	HBG079464
InParanoidⁱ	Q8R0Z5
KEGG Orthology (KO) More...KOⁱ	K15113
OMAⁱ	EHAVMFP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PU8
PhylomeDBⁱ	Q8R0Z5
TreeFamⁱ	TF314118

Family and domain databases

Gene3Dⁱ	1.50.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8R0Z5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELEGRSAGG VAGGPAAGPG RSPGESALLD GWLQRGVGRG AGGGEAGAYQ 
        60         70         80         90        100
PPVRLDPESG PEYEALPAGA TVTTHMVAGA VAGILEHCVM YPIDCVKTRM 
       110        120        130        140        150
QSLQPDPAAR YRNVLEALWR IMRTEGLWRP MRGLNVTATG AGPAHALYFA 
       160        170        180        190        200
CYEKLKKTLS DVIHPGGNSH IANGAAGCVA TLLHDAAMNP AEVVKQRMQM 
       210        220        230        240        250
YNSPYHRVTD CVRAVWQNEG AGAFYRSYTT QLTMNVPFQA IHFMTYEFLQ 
       260        270        280        290        300
EHFNPQRRYN PSSHVLCGAC AGAVAAAATT PLDVCKTLLN TQESLALNSN 
       310        320        330        340        350
ITGHITGMAS AFRTVYQVGG VTAYFRGVQA RVIYQIPSTA IAWSVYEFFK 
       360 
YLITKRQEEW RAGK

Length:364

Mass (Da):39,358

Last modified:June 1, 2002 - v1

Checksum:ⁱE21D1DED9E9D5AC5

GO

Isoform 2 (identifier: Q8R0Z5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-187: Missing.

« Hide

        10         20         30         40         50
MNPAEVVKQR MQMYNSPYHR VTDCVRAVWQ NEGAGAFYRS YTTQLTMNVP 
        60         70         80         90        100
FQAIHFMTYE FLQEHFNPQR RYNPSSHVLC GACAGAVAAA ATTPLDVCKT 
       110        120        130        140        150
LLNTQESLAL NSNITGHITG MASAFRTVYQ VGGVTAYFRG VQARVIYQIP 
       160        170 
STAIAWSVYE FFKYLITKRQ EEWRAGK

Show »

Length:177

Mass (Da):20,038

Checksum:ⁱE088099CBEFC2848

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	276	A → D in AAH23172 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018416	1 – 187	Missing in isoform 2. 2 PublicationsAdd BLAST		187

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF377993 mRNA Translation: AAM46109.1 AF377994 mRNA Translation: AAM46110.1 BC023172 mRNA Translation: AAH23172.1 BC025908 mRNA Translation: AAH25908.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29834.1 [Q8R0Z5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_660138.1, NM_145156.1 [Q8R0Z5-1] XP_006527161.1, XM_006527098.3
UniGeneⁱ	Mm.23827

Genome annotation databases

Ensemblⁱ	ENSMUST00000046038; ENSMUSP00000036913; ENSMUSG00000040414 [Q8R0Z5-1]
GeneIDⁱ	246696
KEGGⁱ	mmu:246696
UCSC genome browser More...UCSCⁱ	uc008hom.2 mouse [Q8R0Z5-2] uc008hon.2 mouse [Q8R0Z5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8R0Z5	Mitoferrin-2		HUMAN		364
Mitoferrin-2		MACMU		364
Solute carrier family 25 member 28		PANTR		364
Solute carrier family 25 member 28		CERAT		364
Solute carrier family 25 member 28		PAPAN		364
+105

Protein	Similar proteins		Species	Score	Length
Q8R0Z5	Mitoferrin-2		HUMAN		364
Mitoferrin-2		MACMU		364
Solute carrier family 25 member 28		PANTR		364
Solute carrier family 25 member 28		CERAT		364
Solute carrier family 25 member 28		PAPAN		364
+190

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF377993 mRNA Translation: AAM46109.1 AF377994 mRNA Translation: AAM46110.1 BC023172 mRNA Translation: AAH23172.1 BC025908 mRNA Translation: AAH25908.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29834.1 [Q8R0Z5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_660138.1, NM_145156.1 [Q8R0Z5-1] XP_006527161.1, XM_006527098.3
UniGeneⁱ	Mm.23827

3D structure databases

ProteinModelPortalⁱ	Q8R0Z5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000036913

STRINGⁱ

10090.ENSMUSP00000036913

Protein family/group databases

TCDBⁱ	2.A.29.5.4 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.5.4 the mitochondrial carrier (mc) family

PTM databases

PhosphoSitePlusⁱ	Q8R0Z5

PhosphoSitePlusⁱ

Q8R0Z5

Proteomic databases

PaxDbⁱ	Q8R0Z5
PeptideAtlas More...PeptideAtlasⁱ	Q8R0Z5
PRIDEⁱ	Q8R0Z5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000046038; ENSMUSP00000036913; ENSMUSG00000040414 [Q8R0Z5-1]
GeneIDⁱ	246696
KEGGⁱ	mmu:246696
UCSC genome browser More...UCSCⁱ	uc008hom.2 mouse [Q8R0Z5-2] uc008hon.2 mouse [Q8R0Z5-1]

Organism-specific databases

CTDⁱ	81894
MGIⁱ	MGI:2180509 Slc25a28

Phylogenomic databases

eggNOGⁱ	KOG0760 Eukaryota ENOG410XNT2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074721
HOGENOMⁱ	HOG000038810
HOVERGENⁱ	HBG079464
InParanoidⁱ	Q8R0Z5
KEGG Orthology (KO) More...KOⁱ	K15113
OMAⁱ	EHAVMFP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PU8
PhylomeDBⁱ	Q8R0Z5
TreeFamⁱ	TF314118

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8R0Z5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040414
CleanExⁱ	MM_SLC25A28
Genevisibleⁱ	Q8R0Z5 MM

Family and domain databases

Gene3Dⁱ	1.50.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MFRN2_MOUSE
Accessionⁱ	Q8R0Z5Primary (citable) accession number: Q8R0Z5 Secondary accession number(s): Q8K4J8, Q8K4J9, Q8R578
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	June 1, 2002
	Last modified:	April 25, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8R0Z5 (MFRN2_MOUSE)

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Mitoferrin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ