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Protein

Mitoferrin-2

Gene

Slc25a28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme (Probable).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Protein family/group databases

TCDBi2.A.29.5.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-2
Alternative name(s):
Mitochondrial RNA-splicing protein 3/4 homolog
Short name:
MRS3/4
Mitochondrial iron transporter 2
Solute carrier family 25 member 28
Gene namesi
Name:Slc25a28
Synonyms:Mfrn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2180509 Slc25a28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 91Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei133 – 152Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei170 – 189Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei227 – 246Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei261 – 280Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei327 – 346Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352561 – 364Mitoferrin-2Add BLAST364

Proteomic databases

PaxDbiQ8R0Z5
PeptideAtlasiQ8R0Z5
PRIDEiQ8R0Z5

PTM databases

PhosphoSitePlusiQ8R0Z5

Expressioni

Tissue specificityi

Ubiquitously expressed at low level. Expressed at higher level in heart, liver, kidney and testis. Expression does not vary during erythroid maturation.2 Publications

Gene expression databases

BgeeiENSMUSG00000040414
CleanExiMM_SLC25A28
GenevisibleiQ8R0Z5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036913

Structurei

3D structure databases

ProteinModelPortaliQ8R0Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 158Solcar 1Add BLAST89
Repeati168 – 252Solcar 2Add BLAST85
Repeati263 – 352Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760 Eukaryota
ENOG410XNT2 LUCA
GeneTreeiENSGT00550000074721
HOGENOMiHOG000038810
HOVERGENiHBG079464
InParanoidiQ8R0Z5
KOiK15113
OMAiEHAVMFP
OrthoDBiEOG091G0PU8
PhylomeDBiQ8R0Z5
TreeFamiTF314118

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0Z5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELEGRSAGG VAGGPAAGPG RSPGESALLD GWLQRGVGRG AGGGEAGAYQ
60 70 80 90 100
PPVRLDPESG PEYEALPAGA TVTTHMVAGA VAGILEHCVM YPIDCVKTRM
110 120 130 140 150
QSLQPDPAAR YRNVLEALWR IMRTEGLWRP MRGLNVTATG AGPAHALYFA
160 170 180 190 200
CYEKLKKTLS DVIHPGGNSH IANGAAGCVA TLLHDAAMNP AEVVKQRMQM
210 220 230 240 250
YNSPYHRVTD CVRAVWQNEG AGAFYRSYTT QLTMNVPFQA IHFMTYEFLQ
260 270 280 290 300
EHFNPQRRYN PSSHVLCGAC AGAVAAAATT PLDVCKTLLN TQESLALNSN
310 320 330 340 350
ITGHITGMAS AFRTVYQVGG VTAYFRGVQA RVIYQIPSTA IAWSVYEFFK
360
YLITKRQEEW RAGK
Length:364
Mass (Da):39,358
Last modified:June 1, 2002 - v1
Checksum:iE21D1DED9E9D5AC5
GO
Isoform 2 (identifier: Q8R0Z5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Show »
Length:177
Mass (Da):20,038
Checksum:iE088099CBEFC2848
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276A → D in AAH23172 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0184161 – 187Missing in isoform 2. 2 PublicationsAdd BLAST187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF377993 mRNA Translation: AAM46109.1
AF377994 mRNA Translation: AAM46110.1
BC023172 mRNA Translation: AAH23172.1
BC025908 mRNA Translation: AAH25908.1
CCDSiCCDS29834.1 [Q8R0Z5-1]
RefSeqiNP_660138.1, NM_145156.1 [Q8R0Z5-1]
XP_006527161.1, XM_006527098.3
UniGeneiMm.23827

Genome annotation databases

EnsembliENSMUST00000046038; ENSMUSP00000036913; ENSMUSG00000040414 [Q8R0Z5-1]
GeneIDi246696
KEGGimmu:246696
UCSCiuc008hom.2 mouse [Q8R0Z5-2]
uc008hon.2 mouse [Q8R0Z5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMFRN2_MOUSE
AccessioniPrimary (citable) accession number: Q8R0Z5
Secondary accession number(s): Q8K4J8, Q8K4J9, Q8R578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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