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Entry version 113 (13 Feb 2019)
Sequence version 3 (14 Oct 2015)
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Protein

Indoleamine 2,3-dioxygenase 2

Gene

Ido2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism (PubMed:17499941, PubMed:17499941). Involved in immune regulation (PubMed:25477879).1 Publication1 Publication

Miscellaneous

Ido1 and Ido2 are 2 distinct enzymes which catalyze the same reaction. Ido2 Km for tryptophan is much higher than that of Ido1. Ido2 may play a role as a negative regulator of Ido1 by competing for heme-binding with Ido1. Low efficiency Ido2 enzymes have been conserved throughout vertebrate evolution, whereas higher efficiency Ido1 enzymes are dispensable in many lower vertebrate lineages. Ido1 may have arisen by gene duplication of a more ancient proto-IDO gene before the divergence of marsupial and eutherian (placental) mammals.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarityNote: Binds 1 heme group per subunit.By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan).1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Do not accept D-tryptophan as substrate.
  1. KM=38.85 mM for L-tryptophan1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-tryptophan degradation via kynurenine pathway

    This protein is involved in step 1 of the subpathway that synthesizes L-kynurenine from L-tryptophan.
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. Tryptophan 2,3-dioxygenase (Tdo2), Tryptophan 2,3-dioxygenase (Tdo2), Tryptophan 2,3-dioxygenase (Tdo2), Indoleamine 2,3-dioxygenase 2 (Ido2)
    2. Kynurenine formamidase (Afmid)
    This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi347Iron (heme proximal ligand)By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDioxygenase, Oxidoreductase
    Biological processImmunity, Tryptophan catabolism
    LigandHeme, Iron, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.13.11.52 3474

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-71240 Tryptophan catabolism

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00333;UER00453

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Indoleamine 2,3-dioxygenase 2 (EC:1.13.11.-1 Publication)
    Short name:
    IDO-2
    Alternative name(s):
    Indoleamine 2,3-dioxygenase-like protein 1
    Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Ido2
    Synonyms:Indol1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2142489 Ido2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Knockout mice have no apparent defects in embryonic development or hematopoietic differentiation and have wild-type profiles for kynurenine in blood serum and for immune cells in spleen, lymph nodes, peritoneum, thymus and bone marrow. Knockout mice exhibit defects in IDO-mediated T-cell regulation and inflammatory responses (PubMed:25691885). They exhibit defects in allergic or autoimmune responses (PubMed:24402311).1 Publication1 Publication

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2189159

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002852631 – 405Indoleamine 2,3-dioxygenase 2Add BLAST405

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8R0V5

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8R0V5

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8R0V5

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8R0V5

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8R0V5

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8R0V5

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed mainly in antigen-presenting immune cells, liver, kidney, brain, and placenta (PubMed:25691885, PubMed:17671174). Highly expressed in kidney, followed by epididymis and liver (at protein level) (PubMed:17499941). Detected in the tails of the spermatozoa in the testis and in the kidney tubules (at protein level) (PubMed:17499941). Constitutively expressed in brain.1 Publication2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000031549 Expressed in 26 organ(s), highest expression level in liver

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    Q8R0V5, 1 interactor

    Molecular INTeraction database

    More...
    MINTi
    Q8R0V5

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000113979

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q8R0V5

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q8R0V5

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8R0V5

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the indoleamine 2,3-dioxygenase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IGEY Eukaryota
    ENOG410XQHE LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161813

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000190192

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG006100

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8R0V5

    KEGG Orthology (KO)

    More...
    KOi
    K00463

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GQMHDYV

    Database of Orthologous Groups

    More...
    OrthoDBi
    1206249at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8R0V5

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF330978

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000898 Indolamine_dOase
    IPR037217 Trp/Indoleamine_2_3_dOase-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR28657 PTHR28657, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01231 IDO, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF140959 SSF140959, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8R0V5-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEPQSQSMTL EVPLSLGRYH ISEEYGFLLP NPLEALPDHY KPWMEIALRL
    60 70 80 90 100
    PHLIENRQLR AHVYRMPLLD CRFLKSYREQ RLAHMALAAI TMGFVWQEGE
    110 120 130 140 150
    GQPQKVLPRS LAIPFVEVSR NLGLPPILVH SDLVLTNWTK RNPEGPLEIS
    160 170 180 190 200
    NLETIISFPG GESLRGFILV TVLVEKAAVP GLKALVQGME AIRQHSQDTL
    210 220 230 240 250
    LEALQQLRLS IQDITRALAQ MHDYVDPDIF YSVIRIFLSG WKDNPAMPVG
    260 270 280 290 300
    LVYEGVATEP LKYSGGSAAQ SSVLHAFDEF LGIEHCKESV GFLHRMRDYM
    310 320 330 340 350
    PPSHKAFLED LHVAPSLRDY ILASGPGDCL MAYNQCVEAL GELRSYHINV
    360 370 380 390 400
    VARYIISAAT RARSRGLTNP SPHALEDRGT GGTAMLSFLK SVREKTMEAL

    LCPGA
    Length:405
    Mass (Da):45,255
    Last modified:October 14, 2015 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCDFD1A09842E96B
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH26393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti256V → A in AAH26393 (PubMed:15489334).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    EF137182 mRNA Translation: ABO33433.1
    AC114602 Genomic DNA No translation available.
    CH466580 Genomic DNA Translation: EDL32857.1
    BC026393 mRNA Translation: AAH26393.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS40298.2

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_666061.3, NM_145949.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Mm.219580

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000121992; ENSMUSP00000113979; ENSMUSG00000031549

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    209176

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:209176

    UCSC genome browser

    More...
    UCSCi
    uc009ley.2 mouse
    uc009lez.2 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    EF137182 mRNA Translation: ABO33433.1
    AC114602 Genomic DNA No translation available.
    CH466580 Genomic DNA Translation: EDL32857.1
    BC026393 mRNA Translation: AAH26393.1 Different initiation.
    CCDSiCCDS40298.2
    RefSeqiNP_666061.3, NM_145949.2
    UniGeneiMm.219580

    3D structure databases

    ProteinModelPortaliQ8R0V5
    SMRiQ8R0V5
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ8R0V5, 1 interactor
    MINTiQ8R0V5
    STRINGi10090.ENSMUSP00000113979

    Chemistry databases

    BindingDBiQ8R0V5
    ChEMBLiCHEMBL2189159

    PTM databases

    iPTMnetiQ8R0V5
    PhosphoSitePlusiQ8R0V5

    Proteomic databases

    jPOSTiQ8R0V5
    MaxQBiQ8R0V5
    PaxDbiQ8R0V5
    PRIDEiQ8R0V5

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000121992; ENSMUSP00000113979; ENSMUSG00000031549
    GeneIDi209176
    KEGGimmu:209176
    UCSCiuc009ley.2 mouse
    uc009lez.2 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    169355
    MGIiMGI:2142489 Ido2

    Phylogenomic databases

    eggNOGiENOG410IGEY Eukaryota
    ENOG410XQHE LUCA
    GeneTreeiENSGT00940000161813
    HOGENOMiHOG000190192
    HOVERGENiHBG006100
    InParanoidiQ8R0V5
    KOiK00463
    OMAiGQMHDYV
    OrthoDBi1206249at2759
    PhylomeDBiQ8R0V5
    TreeFamiTF330978

    Enzyme and pathway databases

    UniPathwayi
    UPA00333;UER00453

    BRENDAi1.13.11.52 3474
    ReactomeiR-MMU-71240 Tryptophan catabolism

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q8R0V5

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000031549 Expressed in 26 organ(s), highest expression level in liver

    Family and domain databases

    InterProiView protein in InterPro
    IPR000898 Indolamine_dOase
    IPR037217 Trp/Indoleamine_2_3_dOase-like
    PANTHERiPTHR28657 PTHR28657, 1 hit
    PfamiView protein in Pfam
    PF01231 IDO, 1 hit
    SUPFAMiSSF140959 SSF140959, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI23O2_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R0V5
    Secondary accession number(s): A4UHF3, E9QKA9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 14, 2015
    Last modified: February 13, 2019
    This is version 113 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    UniProt is an ELIXIR core data resource
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