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Protein

Mth938 domain-containing protein

Gene

Aamdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in preadipocyte differentiation and adipogenesis.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: MGI
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Mth938 domain-containing protein
Alternative name(s):
LI2
Gene namesi
Name:Aamdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913523 Aamdc

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398151 – 122Mth938 domain-containing proteinAdd BLAST122

Proteomic databases

PaxDbiQ8R0P4
PRIDEiQ8R0P4

PTM databases

iPTMnetiQ8R0P4
PhosphoSitePlusiQ8R0P4

Expressioni

Tissue specificityi

Widely expressed, with high expression in the adipose tissue and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000035642
CleanExiMM_1810020D17RIK
ExpressionAtlasiQ8R0P4 baseline and differential
GenevisibleiQ8R0P4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115672

Structurei

3D structure databases

ProteinModelPortaliQ8R0P4
SMRiQ8R0P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 122MTH138-like domainAdd BLAST117

Sequence similaritiesi

Belongs to the AAMDC family.Curated

Phylogenomic databases

eggNOGiENOG410IXVS Eukaryota
ENOG41120BN LUCA
GeneTreeiENSGT00390000011958
HOGENOMiHOG000223243
HOVERGENiHBG081222
InParanoidiQ8R0P4
PhylomeDBiQ8R0P4
TreeFamiTF332083

Family and domain databases

CDDicd05126 Mth938, 1 hit
Gene3Di3.40.1230.10, 1 hit
InterProiView protein in InterPro
IPR034096 AAMDC
IPR036748 MTH938-like_sf
IPR007523 NDUFAF3/AAMDC
PfamiView protein in Pfam
PF04430 DUF498, 1 hit
SUPFAMiSSF64076 SSF64076, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8R0P4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPKIASLS WGQMKVQGST LTYKDCKVWP GGSRAWDWRE TGTEHSPGVQ
60 70 80 90 100
PADVKEVAEK GVQTLVIGRG MSEALKVPPS TVEYLEKQGI DVRVLQTEQA
110 120
VKEYNALVAQ GVRVGGVFHS TC
Length:122
Mass (Da):13,244
Last modified:June 1, 2002 - v1
Checksum:i1E9BFD4770DC03FE
GO
Isoform 2 (identifier: Q8R0P4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-76: Missing.

Show »
Length:90
Mass (Da):9,930
Checksum:i45413770571D0B61
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01927045 – 76Missing in isoform 2. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007558 mRNA Translation: BAC25178.1
AK008195 mRNA Translation: BAC25205.1
BC026557 mRNA Translation: AAH26557.1
BC062811 mRNA Translation: AAH62811.1
CCDSiCCDS21461.1 [Q8R0P4-1]
CCDS52314.1 [Q8R0P4-2]
RefSeqiNP_001171416.1, NM_001177945.1
NP_001171417.1, NM_001177946.1
NP_001171418.1, NM_001177947.1 [Q8R0P4-2]
NP_899074.2, NM_183251.3 [Q8R0P4-1]
XP_006508177.1, XM_006508114.3 [Q8R0P4-1]
XP_006508178.1, XM_006508115.2 [Q8R0P4-2]
UniGeneiMm.41583

Genome annotation databases

EnsembliENSMUST00000136757; ENSMUSP00000121940; ENSMUSG00000035642 [Q8R0P4-1]
ENSMUST00000138060; ENSMUSP00000116214; ENSMUSG00000035642 [Q8R0P4-2]
GeneIDi66273
KEGGimmu:66273
UCSCiuc009ijl.2 mouse [Q8R0P4-2]
uc012fpj.1 mouse [Q8R0P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAAMDC_MOUSE
AccessioniPrimary (citable) accession number: Q8R0P4
Secondary accession number(s): Q8BH71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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