Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable palmitoyltransferase ZDHHC1

Gene

Zdhhc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC1 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 1
Short name:
DHHC-1
Gene namesi
Name:Zdhhc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1918046 Zdhhc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128581 – 484Probable palmitoyltransferase ZDHHC1Add BLAST484

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8R0N9
PRIDEiQ8R0N9

PTM databases

PhosphoSitePlusiQ8R0N9
SwissPalmiQ8R0N9

Expressioni

Tissue specificityi

Expressed at high levels in fetal lung and heart. Expressed at lower levels in fetal liver and brain. Also detected in adult islet cells of pancreas, Leydig cells of testis, retina and molecular layer of cerebellum.1 Publication

Gene expression databases

BgeeiENSMUSG00000039199
CleanExiMM_ZDHHC1
GenevisibleiQ8R0N9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036471

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 181DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000120122
HOVERGENiHBG059666
InParanoidiQ8R0N9
KOiK20027
OMAiQEAKGAH
OrthoDBiEOG091G0A1N
PhylomeDBiQ8R0N9
TreeFamiTF317498

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R0N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNICNKPSNK TAPEKSVWTA PSQDSGPSPE LQGQRSRRNG WSWPPHPLQI
60 70 80 90 100
VAWLLYLFFA VIGFGVLVPL LPHHWVPAGY ACMGAIFAGH LVVHLTAVSI
110 120 130 140 150
DPADANVRDK SYSGPLPIFN RSQHAHVIED LHCNLCDVDV SARSKHCSAC
160 170 180 190 200
NKCVCGFDHH CKWLNNCVGE RNYRLFLHSV ASALLGVLLL VLVATYVFVE
210 220 230 240 250
FFVNPMRLRT NQHFEVLKNH TDVWFVFLPA APVETQAPAI LALAALLILL
260 270 280 290 300
GLLSTALLGH LLCFHIYLMW HKLTTYEYIV QHRPAQEAKE THKELESCPR
310 320 330 340 350
KVRSIQEMEF YMRTFSHVRP EPSGQARTAA LNANPSQFLA TQGQVEPPLP
360 370 380 390 400
SSSDTLALPP RIQPQKKRKR RVYRLPRSGV LDRELPLPRL RETGTPSRRS
410 420 430 440 450
SSSSDSTSAS PVHAGGSAGA YYSASAESME EIPVAQTRLG SAALGAPGAR
460 470 480
GRESGLALQA RSPAVFVSPS SGEPGTPGGG DGLP
Length:484
Mass (Da):52,979
Last modified:October 24, 2003 - v2
Checksum:iF80783E2EF8B2E68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038593 mRNA Translation: BAC30059.1
BC026570 mRNA Translation: AAH26570.2
BC119378 mRNA Translation: AAI19379.1
CCDSiCCDS22603.1
RefSeqiNP_780369.1, NM_175160.3
XP_006531420.1, XM_006531357.3
XP_011246802.1, XM_011248500.2
XP_011246803.1, XM_011248501.2
UniGeneiMm.100917

Genome annotation databases

EnsembliENSMUST00000044286; ENSMUSP00000036471; ENSMUSG00000039199
ENSMUST00000212303; ENSMUSP00000148381; ENSMUSG00000039199
GeneIDi70796
KEGGimmu:70796
UCSCiuc009ndd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZDHC1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0N9
Secondary accession number(s): Q0VE36, Q8BJ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 24, 2003
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health