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Protein

E3 ubiquitin-protein ligase TRIM31

Gene

Trim31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have E3 ubiquitin-protein ligase activity (By similarity). Regulator of Src-induced anchorage independent cell growth.By similarity1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 56RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri89 – 130B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM31 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM31Curated
Tripartite motif-containing protein 31
Gene namesi
Name:Trim31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2385051 Trim31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003866391 – 507E3 ubiquitin-protein ligase TRIM31Add BLAST507

Post-translational modificationi

Auto-ubiquitinated (in vitro).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8R0K2
PaxDbiQ8R0K2
PeptideAtlasiQ8R0K2
PRIDEiQ8R0K2

PTM databases

iPTMnetiQ8R0K2
PhosphoSitePlusiQ8R0K2

Expressioni

Tissue specificityi

Highly expressed in the gastrointestrinal tract, with high expression in the small intestine, moderate in the large intestine and weak in the stomach and esophagus.1 Publication

Gene expression databases

BgeeiENSMUSG00000058063
GenevisibleiQ8R0K2 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with isoform p52shc of SHC1.By similarity1 Publication

Protein-protein interaction databases

BioGridi230316, 1 interactor
STRINGi10090.ENSMUSP00000077535

Structurei

3D structure databases

ProteinModelPortaliQ8R0K2
SMRiQ8R0K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 507B30.2/SPRYPROSITE-ProRule annotationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili176 – 241Sequence analysisAdd BLAST66
Coiled coili269 – 298Sequence analysisAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 56RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri89 – 130B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
InParanoidiQ8R0K2
KOiK12011
OMAiEFQFLNP
OrthoDBiEOG091G07DI
PhylomeDBiQ8R0K2
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8R0K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQPLACQL QEEVTCPICM EILQDPVTID CGHNFCLQCI SQVGKTSEKI
60 70 80 90 100
QCPLCKLSVN KNTFRPNKLL ASLAEKIQSM DPADIQAEKE DSRCQRHKEK
110 120 130 140 150
LHYFCEQDGA FLCVVCRDSK DHKSHNVTLI DEAAQNYKVQ IESQAQDLGQ
160 170 180 190 200
KDKKIIEEKK QGEGAIWAFR AQVDLEKLKI HEEFKLLRQR LDEEESFLLS
210 220 230 240 250
RLDWLEQQGA KQLRQYVTVT EKQLNSLRKL TKSLKIRLQS SSMELLKDIK
260 270 280 290 300
DALSRGKEFQ FLNPNPVPED LEKKCSEAKA RHESIIKTLT ELKDDMNAEG
310 320 330 340 350
KRDKSAFMNS LNKEEKESWS LLQKNNSVLP TSVPVTLDKS SADPDLTFSQ
360 370 380 390 400
DLKKVTLYIV AGKASNRQAK PRPFYPFHCV RGSPGLSSGR QVWEAEIRGP
410 420 430 440 450
SGGACIVGVV TELARGAQSQ TVSAQSYIWA LRISPSGCQP FTNCKAQEYL
460 470 480 490 500
QVCLKKVGVY VNHDCGEVVF YDAITSKHIY TFQTSFDGKV FPLFGLQVAC

SHITLSP
Length:507
Mass (Da):57,127
Last modified:June 1, 2002 - v1
Checksum:i086106A2E1BC31FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033650 mRNA Translation: BAC28407.1
CH466559 Genomic DNA Translation: EDL23309.1
BC026666 mRNA Translation: AAH26666.1
CCDSiCCDS28728.1
RefSeqiNP_666189.1, NM_146077.2
UniGeneiMm.213417

Genome annotation databases

EnsembliENSMUST00000078438; ENSMUSP00000077535; ENSMUSG00000058063
GeneIDi224762
KEGGimmu:224762
UCSCiuc008cll.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTRI31_MOUSE
AccessioniPrimary (citable) accession number: Q8R0K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: January 31, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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