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Entry version 107 (13 Feb 2019)
Sequence version 1 (01 Jun 2002)
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Protein

SEC14-like protein 4

Gene

Sec14l4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SEC14-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sec14l4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2144095 Sec14l4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002107611 – 403SEC14-like protein 4Add BLAST403

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8R0F9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8R0F9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R0F9

PeptideAtlas

More...
PeptideAtlasi
Q8R0F9

PRoteomics IDEntifications database

More...
PRIDEi
Q8R0F9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R0F9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R0F9

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q8R0F9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000019368 Expressed in 57 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R0F9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
222134, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000019512

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8R0F9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8R0F9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 249CRAL-TRIOPROSITE-ProRule annotationAdd BLAST174
Domaini275 – 383GOLDPROSITE-ProRule annotationAdd BLAST109

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1471 Eukaryota
ENOG410XRSQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162471

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232201

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055336

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8R0F9

Identification of Orthologs from Complete Genome Data

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OMAi
HECELQT

Database of Orthologous Groups

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OrthoDBi
1133487at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R0F9

TreeFam database of animal gene trees

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TreeFami
TF313988

Family and domain databases

Conserved Domains Database

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CDDi
cd00170 SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00650 CRAL_TRIO, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8R0F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGQVGDLSP QQQEALARFR ETLQDLLPTL PKADDYFLLR WLRARNFDLK
60 70 80 90 100
KSEDMLRKHV EFRNQQNLDQ ILTWQAPEVI QLYDSGGLSG YDYEGCPVWF
110 120 130 140 150
DIIGTMDPKG LFMSASKQDM IRKRIKVCEM LLHECELQSQ KLGRKIERMV
160 170 180 190 200
MVFDMEGLSL RHLWKPAVEV YQQFFAILEA NYPETVKNLI IIRAPKLFPV
210 220 230 240 250
AFNLVKSFMG EETQKKIVIL GGNWKQELVK FVSPDQLPVE FGGTMTDPDG
260 270 280 290 300
NPKCLTKINY GGEVPKRYYL SNQERPQYEH SVVVGRGSSH QVENEILFPG
310 320 330 340 350
CVLRWQFASD GGDIGFGVFL KTRMGERQKA GEMVEVLPSQ RYNAHMVPED
360 370 380 390 400
GSLNCLKAGV YVLRFDNTYS LLHTKKVGYT AEVLLPDKAC EEKLQGLGSV

SPP
Length:403
Mass (Da):46,053
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5758BCD814EDE1D6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC026948 mRNA Translation: AAH26948.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24374.1

NCBI Reference Sequences

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RefSeqi
NP_666125.1, NM_146013.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.337476

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000019512; ENSMUSP00000019512; ENSMUSG00000019368

Database of genes from NCBI RefSeq genomes

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GeneIDi
103655

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:103655

UCSC genome browser

More...
UCSCi
uc007hue.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026948 mRNA Translation: AAH26948.1
CCDSiCCDS24374.1
RefSeqiNP_666125.1, NM_146013.1
UniGeneiMm.337476

3D structure databases

ProteinModelPortaliQ8R0F9
SMRiQ8R0F9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222134, 1 interactor
STRINGi10090.ENSMUSP00000019512

PTM databases

iPTMnetiQ8R0F9
PhosphoSitePlusiQ8R0F9
SwissPalmiQ8R0F9

Proteomic databases

jPOSTiQ8R0F9
MaxQBiQ8R0F9
PaxDbiQ8R0F9
PeptideAtlasiQ8R0F9
PRIDEiQ8R0F9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019512; ENSMUSP00000019512; ENSMUSG00000019368
GeneIDi103655
KEGGimmu:103655
UCSCiuc007hue.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284904
MGIiMGI:2144095 Sec14l4

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00940000162471
HOGENOMiHOG000232201
HOVERGENiHBG055336
InParanoidiQ8R0F9
OMAiHECELQT
OrthoDBi1133487at2759
PhylomeDBiQ8R0F9
TreeFamiTF313988

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sec14l4 mouse

Protein Ontology

More...
PROi
PR:Q8R0F9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019368 Expressed in 57 organ(s), highest expression level in liver
GenevisibleiQ8R0F9 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS14L4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R0F9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: June 1, 2002
Last modified: February 13, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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