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Protein

Acylpyruvase FAHD1, mitochondrial

Gene

Fahd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). Also has oxaloacetate decarboxylase activity (PubMed:25575590).By similarity1 Publication

Catalytic activityi

A 3-acylpyruvate + H2O = a carboxylate + pyruvate.By similarity
Oxaloacetate = pyruvate + CO2.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Divalent metal cationBy similarity1
Metal bindingi76Divalent metal cationBy similarity1
Metal bindingi105Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Lyase
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Acylpyruvase FAHD1, mitochondrial (EC:3.7.1.5)
Alternative name(s):
Fumarylacetoacetate hydrolase domain-containing protein 1
Oxaloacetate decarboxylaseBy similarity (EC:4.1.1.3By similarity)
Short name:
OAA decarboxylaseBy similarity
Gene namesi
Name:Fahd1
ORF Names:MNCb-4134
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1915886 Fahd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Elevated oxaloacetate levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000015683031 – 227Acylpyruvase FAHD1, mitochondrialAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Modified residuei116N6-acetyllysineCombined sources1
Modified residuei118N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8R0F8
PaxDbiQ8R0F8
PeptideAtlasiQ8R0F8
PRIDEiQ8R0F8

PTM databases

iPTMnetiQ8R0F8
PhosphoSitePlusiQ8R0F8
SwissPalmiQ8R0F8

Expressioni

Tissue specificityi

Ubiquitous with higher expression in the liver and the kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000045316 Expressed in 258 organ(s), highest expression level in heart
CleanExiMM_FAHD1
GenevisibleiQ8R0F8 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8R0F8, 5 interactors
MINTiQ8R0F8
STRINGi10090.ENSMUSP00000055827

Structurei

3D structure databases

ProteinModelPortaliQ8R0F8
SMRiQ8R0F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1535 Eukaryota
COG0179 LUCA
GeneTreeiENSGT00530000063832
HOGENOMiHOG000063753
HOVERGENiHBG057495
InParanoidiQ8R0F8
KOiK01557
OMAiSRFWEWG
OrthoDBiEOG091G0I6G
TreeFamiTF300911

Family and domain databases

Gene3Di3.90.850.10, 1 hit
InterProiView protein in InterPro
IPR011234 Fumarylacetoacetase-like_C
IPR036663 Fumarylacetoacetase_C_sf
PfamiView protein in Pfam
PF01557 FAA_hydrolase, 1 hit
SUPFAMiSSF56529 SSF56529, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8R0F8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQSCTMAST KPLSRFWEWG KNIVCVGRNY ADHVKEMRST VLSEPVLFLK
60 70 80 90 100
PSTAYAPEGS PVLMPAYCRN LHHEVELGVL LGKRGEAIPE AAAMDYVAGY
110 120 130 140 150
ALCLDMTARD VQEECKKKGL PWTLAKSFTS SCPVSAFVPK EKIPDPHALR
160 170 180 190 200
LWLKVNGELR QEGKTSSMIF SIPYIISYVS KIITLEEGDL ILTGTPKGVG
210 220
PIKENDEIEA GIDGVVSMRF KVKRSEY
Length:227
Mass (Da):25,172
Last modified:October 3, 2012 - v2
Checksum:i62C5AEA14F8F38C5
GO

Sequence cautioni

The sequence BAC32142 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → R in BAC32142 (PubMed:16141072).Curated1
Sequence conflicti202I → V in BAE34035 (PubMed:16141072).Curated1
Sequence conflicti202I → V in AAH26949 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041600 mRNA Translation: BAA95083.1
AK044920 mRNA Translation: BAC32142.1 Different initiation.
AK157292 mRNA Translation: BAE34035.1
AK141973 mRNA Translation: BAE24904.1
AC166102 Genomic DNA No translation available.
BC026949 mRNA Translation: AAH26949.1
CCDSiCCDS37496.1
RefSeqiNP_075969.1, NM_023480.2
UniGeneiMm.347964

Genome annotation databases

EnsembliENSMUST00000049642; ENSMUSP00000055827; ENSMUSG00000045316
GeneIDi68636
KEGGimmu:68636
UCSCiuc008ayl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFAHD1_MOUSE
AccessioniPrimary (citable) accession number: Q8R0F8
Secondary accession number(s): Q3U020
, Q3UQY4, Q8BLJ7, Q9JJB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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