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Entry version 116 (17 Jun 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Protein C1orf43 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein C1orf43 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914027 4933434E20Rik

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892571 – 253Protein C1orf43 homologAdd BLAST253

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8R092

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8R092

PRoteomics IDEntifications database

More...
PRIDEi
Q8R092

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8R092

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8R092

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027942 Expressed in skeletal muscle tissue and 276 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8R092 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000124028

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8R092 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

N-terminal region is required for phagocytosis of Gram negative bacterium.By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJYI Eukaryota
ENOG410XP22 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047366

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_068266_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8R092

Identification of Orthologs from Complete Genome Data

More...
OMAi
EADHHQS

Database of Orthologous Groups

More...
OrthoDBi
1581753at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8R092

TreeFam database of animal gene trees

More...
TreeFami
TF324880

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010876 NICE-3_prd

The PANTHER Classification System

More...
PANTHERi
PTHR21425 PTHR21425, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07406 NICE-3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8R092-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSNWLSG VNVVLVMAYG SLVFVLLFIF VKRQIMRFAM KSRRGPHVPV
60 70 80 90 100
GHNAPKDLKE EIDIRLSRVQ DIKYEPQLLA DDDTRLLQLE TQGNQSCYNY
110 120 130 140 150
LYRMKALDAI RASEIPFHAE GRHPCSLMGK NFRSYLLDLR NTSTPFKGVG
160 170 180 190 200
KALIDTLLDG YETARYGTGV FGQSEYLRYQ EALSELATVV KARIGSSQRQ
210 220 230 240 250
HQSAAKDLTQ SPEMSPTTIQ VTYLPSSQKS KRPKHFLELK SFKDNYNTLE

STL
Length:253
Mass (Da):28,691
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i610A1138B9F03569
GO
Isoform 2 (identifier: Q8R092-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-199: VKARIGSSQR → FTYFMYMSTL
     200-253: Missing.

Show »
Length:199
Mass (Da):22,730
Checksum:i9E7BE0A02A17F009
GO
Isoform 3 (identifier: Q8R092-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-253: Missing.

Show »
Length:189
Mass (Da):21,445
Checksum:iA8FBB76C37917F48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYZ4E0CYZ4_MOUSE
RIKEN cDNA 4933434E20 gene
4933434E20Rik
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BX33H7BX33_MOUSE
RIKEN cDNA 4933434E20 gene
4933434E20Rik
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8MQ10A0A5F8MQ10_MOUSE
Uncharacterized protein
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4S → N in BAB30964 (PubMed:16141072).Curated1
Sequence conflicti4S → N in BAC28820 (PubMed:16141072).Curated1
Sequence conflicti192A → S in BAB26242 (PubMed:16141072).Curated1
Sequence conflicti203S → A in BAC34568 (PubMed:16141072).Curated1
Sequence conflicti242F → L in AAH22598 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014422190 – 253Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_014423190 – 199VKARIGSSQR → FTYFMYMSTL in isoform 2. 1 Publication10
Alternative sequenceiVSP_014424200 – 253Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY533135 mRNA Translation: AAS21302.1
AK009362 mRNA Translation: BAB26242.1
AK017833 mRNA Translation: BAB30964.2
AK034749 mRNA Translation: BAC28820.1
AK051238 mRNA Translation: BAC34568.1
AK077215 mRNA Translation: BAC36688.1
AK151002 mRNA Translation: BAE30026.1
BC022598 mRNA Translation: AAH22598.1
BC027190 mRNA Translation: AAH27190.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17520.1 [Q8R092-3]
CCDS50967.1 [Q8R092-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001274016.1, NM_001287087.1 [Q8R092-3]
NP_080038.1, NM_025762.3 [Q8R092-3]
NP_081776.2, NM_027500.4 [Q8R092-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000029552; ENSMUSP00000029552; ENSMUSG00000027942 [Q8R092-2]
ENSMUST00000159064; ENSMUSP00000124554; ENSMUSG00000027942 [Q8R092-3]
ENSMUST00000160640; ENSMUSP00000124028; ENSMUSG00000027942 [Q8R092-3]
ENSMUST00000162114; ENSMUSP00000124822; ENSMUSG00000027942 [Q8R092-1]
ENSMUST00000239076; ENSMUSP00000159150; ENSMUSG00000118504 [Q8R092-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
99650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:99650

UCSC genome browser

More...
UCSCi
uc008qba.3 mouse [Q8R092-3]
uc008qbb.3 mouse [Q8R092-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533135 mRNA Translation: AAS21302.1
AK009362 mRNA Translation: BAB26242.1
AK017833 mRNA Translation: BAB30964.2
AK034749 mRNA Translation: BAC28820.1
AK051238 mRNA Translation: BAC34568.1
AK077215 mRNA Translation: BAC36688.1
AK151002 mRNA Translation: BAE30026.1
BC022598 mRNA Translation: AAH22598.1
BC027190 mRNA Translation: AAH27190.1
CCDSiCCDS17520.1 [Q8R092-3]
CCDS50967.1 [Q8R092-2]
RefSeqiNP_001274016.1, NM_001287087.1 [Q8R092-3]
NP_080038.1, NM_025762.3 [Q8R092-3]
NP_081776.2, NM_027500.4 [Q8R092-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124028

PTM databases

iPTMnetiQ8R092
PhosphoSitePlusiQ8R092

Proteomic databases

MaxQBiQ8R092
PaxDbiQ8R092
PRIDEiQ8R092

Genome annotation databases

EnsembliENSMUST00000029552; ENSMUSP00000029552; ENSMUSG00000027942 [Q8R092-2]
ENSMUST00000159064; ENSMUSP00000124554; ENSMUSG00000027942 [Q8R092-3]
ENSMUST00000160640; ENSMUSP00000124028; ENSMUSG00000027942 [Q8R092-3]
ENSMUST00000162114; ENSMUSP00000124822; ENSMUSG00000027942 [Q8R092-1]
ENSMUST00000239076; ENSMUSP00000159150; ENSMUSG00000118504 [Q8R092-3]
GeneIDi99650
KEGGimmu:99650
UCSCiuc008qba.3 mouse [Q8R092-3]
uc008qbb.3 mouse [Q8R092-1]

Organism-specific databases

MGIiMGI:1914027 4933434E20Rik

Phylogenomic databases

eggNOGiENOG410IJYI Eukaryota
ENOG410XP22 LUCA
GeneTreeiENSGT00510000047366
HOGENOMiCLU_068266_0_0_1
InParanoidiQ8R092
OMAiEADHHQS
OrthoDBi1581753at2759
PhylomeDBiQ8R092
TreeFamiTF324880

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
99650 3 hits in 12 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8R092
RNActiQ8R092 protein

Gene expression databases

BgeeiENSMUSG00000027942 Expressed in skeletal muscle tissue and 276 other tissues
GenevisibleiQ8R092 MM

Family and domain databases

InterProiView protein in InterPro
IPR010876 NICE-3_prd
PANTHERiPTHR21425 PTHR21425, 1 hit
PfamiView protein in Pfam
PF07406 NICE-3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCA043_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8R092
Secondary accession number(s): Q3UBD8
, Q8BII4, Q8BIP7, Q8R240, Q9CV59, Q9CYB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2002
Last modified: June 17, 2020
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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