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Protein

Probable fibrosin-1

Gene

Fbrs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Prakash et al. cloned a partial cDNA corresponding to the 3'UTR of the last exon of the gene (PubMed:7892239). They have shown that a synthetic peptide derived from this sequence could stimulate fibroblasts growth in vitro, and that this protein could be a fibrogenic lymphokine, that could stimulate several biological activities related to scarring. It would be expressed several cell types including CD4+ lymphocytes and fibroblasts. However, it was not confirmed by in vivo data.1 Publication

GO - Molecular functioni

  • growth factor activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Probable fibrosin-1
Gene namesi
Name:Fbrs
Synonyms:Fbs, Fbs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104648 Fbrs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872071 – 466Probable fibrosin-1Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei229Asymmetric dimethylarginineCombined sources1
Modified residuei239Asymmetric dimethylarginineBy similarity1
Modified residuei281PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8R089
PaxDbiQ8R089
PRIDEiQ8R089

PTM databases

iPTMnetiQ8R089
PhosphoSitePlusiQ8R089

Expressioni

Gene expression databases

BgeeiENSMUSG00000042423 Expressed in 189 organ(s), highest expression level in thymus
CleanExiMM_FBRS
ExpressionAtlasiQ8R089 baseline and differential
GenevisibleiQ8R089 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043682

Structurei

3D structure databases

SMRiQ8R089
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 334Ala-richAdd BLAST24
Compositional biasi348 – 461Pro-richAdd BLAST114

Phylogenomic databases

eggNOGiENOG410IK36 Eukaryota
ENOG4111ADK LUCA
GeneTreeiENSGT00390000001466
HOVERGENiHBG051563
InParanoidiQ8R089
OrthoDBiEOG091G01SH
TreeFamiTF331929

Family and domain databases

InterProiView protein in InterPro
IPR023246 AUTS2
PANTHERiPTHR14429 PTHR14429, 1 hit
PfamiView protein in Pfam
PF15336 Auts2, 1 hit
PRINTSiPR02044 FIBROSIN1LPF

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8R089-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEKYPGKME GLFRHNPYMA FPPAVPGLPP GLPPAVSFGS LQGAFQPKNT
60 70 80 90 100
NPELPPRLGP VLSGLPQKGT QIPDHFRPPL RKPGKWCAMH VRVAYMILRH
110 120 130 140 150
QEKMKGDSHK LDFRNDLLPC LPGPYGALPP GQELSHPASL FTATGAVHAA
160 170 180 190 200
ANPFTTAPGA HGPFLSPSTH IDPFGRPTSF ASLAALSNGA FGGLGSPTFN
210 220 230 240 250
SSAVFAQKES PGAPPAFASP PDPWGRLHRS PLAFPAWVRP PETARTPGSD
260 270 280 290 300
KERPMERREP SVTKEEKDRD LPFSRPQLRV SPATPKARAG EEGARPAKES
310 320 330 340 350
VRVKEERKEE AAAAAAAAAA AAAAAAAAAA AAAATTGPQG LHLLLERPRP
360 370 380 390 400
PPFLGPSLPE RCAGFPEPTW LAGPPRLARP PRFYEAGEEL TGPGAMAAAR
410 420 430 440 450
LYSLDPAHPL LYSRLAPPPP PTATPGTPHL LSKTPPGALL GAPPPLVPAP
460
RPSSPPRAPG PARADR
Length:466
Mass (Da):49,038
Last modified:May 3, 2011 - v2
Checksum:i9852DF3F13B97FAE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1N9PTV1A0A1N9PTV1_MOUSE
Probable fibrosin-1
Fbrs
980Annotation score:
A0A0U1RPV5A0A0U1RPV5_MOUSE
Probable fibrosin-1
Fbrs
378Annotation score:
A0A0U1RNY3A0A0U1RNY3_MOUSE
Probable fibrosin-1
Fbrs
364Annotation score:
A0A0U1RNQ7A0A0U1RNQ7_MOUSE
Probable fibrosin-1
Fbrs
254Annotation score:

Sequence cautioni

The sequence AAH27193 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AK037952 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AK037952 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283A → T in AK037952 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136146 Genomic DNA No translation available.
BC027193 mRNA Translation: AAH27193.1 Different initiation.
AK037952 mRNA No translation available.
CCDSiCCDS52408.1
RefSeqiNP_034313.1, NM_010183.1
UniGeneiMm.323505

Genome annotation databases

EnsembliENSMUST00000048896; ENSMUSP00000043682; ENSMUSG00000042423
GeneIDi14123
KEGGimmu:14123
UCSCiuc009jvs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136146 Genomic DNA No translation available.
BC027193 mRNA Translation: AAH27193.1 Different initiation.
AK037952 mRNA No translation available.
CCDSiCCDS52408.1
RefSeqiNP_034313.1, NM_010183.1
UniGeneiMm.323505

3D structure databases

SMRiQ8R089
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043682

PTM databases

iPTMnetiQ8R089
PhosphoSitePlusiQ8R089

Proteomic databases

MaxQBiQ8R089
PaxDbiQ8R089
PRIDEiQ8R089

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048896; ENSMUSP00000043682; ENSMUSG00000042423
GeneIDi14123
KEGGimmu:14123
UCSCiuc009jvs.2 mouse

Organism-specific databases

CTDi64319
MGIiMGI:104648 Fbrs

Phylogenomic databases

eggNOGiENOG410IK36 Eukaryota
ENOG4111ADK LUCA
GeneTreeiENSGT00390000001466
HOVERGENiHBG051563
InParanoidiQ8R089
OrthoDBiEOG091G01SH
TreeFamiTF331929

Miscellaneous databases

PROiPR:Q8R089
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042423 Expressed in 189 organ(s), highest expression level in thymus
CleanExiMM_FBRS
ExpressionAtlasiQ8R089 baseline and differential
GenevisibleiQ8R089 MM

Family and domain databases

InterProiView protein in InterPro
IPR023246 AUTS2
PANTHERiPTHR14429 PTHR14429, 1 hit
PfamiView protein in Pfam
PF15336 Auts2, 1 hit
PRINTSiPR02044 FIBROSIN1LPF
ProtoNetiSearch...

Entry informationi

Entry nameiFBRS_MOUSE
AccessioniPrimary (citable) accession number: Q8R089
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 3, 2011
Last modified: November 7, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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